Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea.

abstract：BACKGROUND:Herbal medicine has been a rich source of new drugs exemplified by quinine and artemisinin. In this study, a variety of Japanese traditional herbal medicine ('Kampo') were examined for their potential anti-malarial activities. METHODS:A comprehensive screening methods were designed to identify novel anti-ma...

journal_title：Malaria journal

authors： Teklemichael AA,Mizukami S,Toume K,Mosaddeque F,Kamel MG,Kaneko O,Komatsu K,Karbwang J,Huy NT,Hirayama K

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Indonesia is home to a variety of malaria vectors whose specific bionomic traits remain largely uncharacterized. Species-specific behaviours, such as host feeding preferences, impact the dynamics of malaria transmission and the effectiveness of vector control interventions. METHODS:To examine species-specif...

journal_title：Malaria journal

authors： St Laurent B,Burton TA,Zubaidah S,Miller HC,Asih PB,Baharuddin A,Kosasih S,Shinta,Firman S,Hawley WA,Burkot TR,Syafruddin D,Sukowati S,Collins FH,Lobo NF

更新日期：2017-08-02 00:00:00

abstract：BACKGROUND:In the context of malaria elimination/eradication, drugs that are effective against the different developmental stages of the parasite are highly desirable. The oldest synthetic anti-malarial drug, the thiazine dye methylene blue (MB), is known for its activity against Plasmodium blood stages, including game...

journal_title：Malaria journal

authors： Bosson-Vanga H,Franetich JF,Soulard V,Sossau D,Tefit M,Kane B,Vaillant JC,Borrmann S,Müller O,Dereuddre-Bosquet N,Le Grand R,Silvie O,Mazier D

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Numerous countries around the world are approaching malaria elimination. Until global eradication is achieved, countries that successfully eliminate the disease will contend with parasite reintroduction through international movement of infected people. Human-mediated parasite mobility is also important with...

journal_title：Malaria journal

authors： Ruktanonchai NW,Bhavnani D,Sorichetta A,Bengtsson L,Carter KH,Córdoba RC,Le Menach A,Lu X,Wetter E,Zu Erbach-Schoenberg E,Tatem AJ

更新日期：2016-05-11 00:00:00

abstract：BACKGROUND:Molecular genotyping is performed in anti-malarial trials to determine whether recurrent parasitaemia after therapy represents a recrudescence (treatment failure) or new infection. The use of capillary instead of agarose gel electrophoresis for genotyping offers technical advantages, but it is unclear whethe...

journal_title：Malaria journal

authors： Gupta V,Dorsey G,Hubbard AE,Rosenthal PJ,Greenhouse B

更新日期：2010-01-15 00:00:00

abstract：BACKGROUND:Indoor-based anti-vector interventions remain the preferred means of reducing risk of malaria transmission in malaria endemic areas around the world. Despite demonstrated success in reducing human-mosquito interactions, these methods are effective solely against endophilic vectors. It may be that outdoor loc...

journal_title：Malaria journal

authors： Reddy MR,Overgaard HJ,Abaga S,Reddy VP,Caccone A,Kiszewski AE,Slotman MA

更新日期：2011-07-07 00:00:00

abstract：BACKGROUND:Malaria transmission in the peri-Iquitos region of Amazonian Peru has been designated as seasonal and hypo-endemic with recently described hyper-endemic hotspots. Despite relatively recent distribution of long-lasting insecticidal bed nets (LLINs), malaria in Amazonian Peru persists and increased substantial...

journal_title：Malaria journal

authors： Moreno M,Saavedra MP,Bickersmith SA,Lainhart W,Tong C,Alava F,Vinetz JM,Conn JE

更新日期：2015-07-30 00:00:00

abstract：BACKGROUND:As South Africa strives to achieve malaria elimination by 2018 (zero local cases) the country needs to strengthen its disease surveillance system by reducing the timeliness from case diagnosis to notification of key stakeholders in the malaria programme. This study evaluated the feasibility of a 24-h mobile ...

journal_title：Malaria journal

authors： Baloyi RE,Shandukani MB,Graffy R,Misiani E,Mayet N,Mabunda E,Mabuza A,Qwabe B,Ngwenyama B,Reddy C,Moonasar D

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:In Ghana, malaria is endemic and perennial (with significant seasonal variations in the three Northern Regions), accounting for 33 % of all deaths among children under 5 years old, with prevalence rates in children under-five ranging from 11 % in Greater Accra to 40 % in Northern Region. Ghana adopted the WH...

journal_title：Malaria journal

authors： Nonvignon J,Aryeetey GC,Issah S,Ansah P,Malm KL,Ofosu W,Tagoe T,Agyemang SA,Aikins M

更新日期：2016-07-16 00:00:00

abstract：BACKGROUND:Seasonal malaria chemoprevention (SMC) is a new strategy to reduce malaria burden in young children in Sahelian countries. It consists of the administration of full treatment courses of sulfadoxine-pyrimethamine plus amodiaquine to children at monthly intervals during the malaria season. However, it is not c...

journal_title：Malaria journal

authors： Mahamar A,Issiaka D,Barry A,Attaher O,Dembele AB,Traore T,Sissoko A,Keita S,Diarra BS,Narum DL,Duffy PE,Dicko A,Fried M

更新日期：2017-07-18 00:00:00

abstract：BACKGROUND:The reemergence of Plasmodium vivax in South Korea since 1993 represents a serious public health concern. Despite the importance in understanding genetic diversity for control strategies, however, studies remain inconclusive with the general premise that due to low rate of malaria transmission, there is gene...

journal_title：Malaria journal

authors： Honma H,Kim JY,Palacpac NM,Mita T,Lee W,Horii T,Tanabe K

更新日期：2011-09-07 00:00:00

abstract：:Anti-malarial drugs are now mainly deployed as combination therapy (CT), primarily as a mechanism to prevent or slow the spread of resistance. This strategy is justified by mathematical arguments that generally assume that drug 'resistance' is a binary all-or-nothing genetic trait. Herein, a pharmacological, rather th...

journal_title：Malaria journal

authors： Hastings IM,Hodel EM

更新日期：2014-02-20 00:00:00

abstract：BACKGROUND:Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp. trophozoite, the stage when haemoglobin catabolism is maximal. H...

journal_title：Malaria journal

authors： Sharrock WW,Suwanarusk R,Lek-Uthai U,Edstein MD,Kosaisavee V,Travers T,Jaidee A,Sriprawat K,Price RN,Nosten F,Russell B

更新日期：2008-05-27 00:00:00

abstract：BACKGROUND:The massive deployment of life saving malaria interventions has not only resulted in a decline in disease burden but a change in the risk of infection and disease. The study reassesses the importance of known risk factors and reviews demographic and socio-economic determinants of malaria risk in the populati...

journal_title：Malaria journal

authors： Okebe J,Mwesigwa J,Kama EL,Ceesay SJ,Njie F,Correa S,Bojang K

更新日期：2014-08-08 00:00:00

abstract：BACKGROUND:In recent years, the scale-up of long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) has greatly reduced malaria transmission. However, malaria remains a global public health concern with the majority of the disease burden in sub-Saharan Africa. Insecticide resistance is a growing probl...

journal_title：Malaria journal

authors： Stica C,Jeffries CL,Irish SR,Barry Y,Camara D,Yansane I,Kristan M,Walker T,Messenger LA

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:Programmes of pre-elimination of malaria have been implemented in Senegal since 2010, and the burden of malaria has decreased substantially. These changes in the epidemiology should be monitored with effective tools that allow changes in patterns of transmission to be estimated. In Dielmo and Ndiop, two vill...

journal_title：Malaria journal

authors： Diop F,Richard V,Diouf B,Sokhna C,Diagne N,Trape JF,Faye MM,Tall A,Diop G,Balde AT

更新日期：2014-03-06 00:00:00

abstract：BACKGROUND:The erythrocytic stage, where malaria parasites proliferate in human blood, is clinically significant as this causes the symptoms and illness of malaria. Experimental rodent models of malaria at the erythrocytic stage are used for the development of anti-malarial drugs and for biological analysis. An automat...

journal_title：Malaria journal

authors： Tougan T,Suzuki Y,Izuka M,Aono K,Okazaki T,Toya Y,Uchihashi K,Horii T

更新日期：2018-04-16 00:00:00

abstract：BACKGROUND:Plasmodium falciparum circumsporozoite protein (PfCSP) is one of the most extensively studied malaria vaccine candidates, but the genetic polymorphism of PfCSP within and among the global P. falciparum population raises concerns regarding the efficacy of a PfCSP-based vaccine efficacy. In this study, genetic...

journal_title：Malaria journal

authors： Lê HG,Kang JM,Moe M,Jun H,Thái TL,Lee J,Myint MK,Lin K,Sohn WM,Shin HJ,Kim TS,Na BK

更新日期：2018-10-12 00:00:00

abstract：BACKGROUND:IPTi delivered through EPI has been shown to reduce the incidence of clinical malaria by 20-59%. However, new health interventions can only be effective if they are also socially and culturally acceptable. It is also crucial to ensure that attitudes to IPTi do not negatively influence attitudes to and uptake...

journal_title：Malaria journal

authors： Gysels M,Pell C,Mathanga DP,Adongo P,Odhiambo F,Gosling R,Akweongo P,Mwangi R,Okello G,Mangesho P,Slutsker L,Kremsner PG,Grobusch MP,Hamel MJ,Newman RD,Pool R

更新日期：2009-08-10 00:00:00

abstract：BACKGROUND:The diversity of genotyping markers of Plasmodium falciparum depends on transmission intensity. It has been reported that the diversity of the merozoite surface protein 2 (msp2) is greater in areas of high compared to low endemicity, however, results for msp1 were inconsistent. These previous reports relied ...

journal_title：Malaria journal

authors： Schoepflin S,Valsangiacomo F,Lin E,Kiniboro B,Mueller I,Felger I

更新日期：2009-10-30 00:00:00

abstract：BACKGROUND:Marking mosquitoes is vital for mark-release-recapture and many laboratory studies, but their small size precludes the use of methods that are available for larger animals such as unique identifier tags and radio devices. Fluorescent dust is the most commonly used method to distinguish released individuals f...

journal_title：Malaria journal

authors： Aviles EI,Rotenberry RD,Collins CM,Dotson EM,Benedict MQ

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:Pyrethroid-resistant mosquitoes are an increasing threat to malaria vector control. The Global Plan for Insecticide Resistance Management (GPIRM) recommends rotation of non-pyrethroid insecticides for indoor residual spraying (IRS). The options from other classes are limited. The carbamate bendiocarb and the...

journal_title：Malaria journal

authors： Oxborough RM,Kitau J,Jones R,Feston E,Matowo J,Mosha FW,Rowland MW

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:Many recent studies have examined the impact of urbanization on Plasmodium falciparum malaria endemicity and found a general trend of reduced transmission in urban areas. However, none has examined the effect of urbanization on Plasmodium vivax malaria, which is the most widely distributed malaria species an...

journal_title：Malaria journal

authors： Qi Q,Guerra CA,Moyes CL,Elyazar IR,Gething PW,Hay SI,Tatem AJ

更新日期：2012-12-05 00:00:00

abstract：BACKGROUND:A previous study reported that the malaria parasite Plasmodium falciparum enters an altered growth state upon extracellular withdrawal of the essential amino acid isoleucine. Parasites slowed transit through the cell cycle when deprived of isoleucine prior to the onset of S-phase. METHODS:This project was u...

journal_title：Malaria journal

authors： McLean KJ,Jacobs-Lorena M

更新日期：2020-04-08 00:00:00

abstract：BACKGROUND:The resistance of malaria parasites to sulphadoxine-pyrimethamine (SP) in 2007 led to the Malawi Ministry of Health changing to artemether-lumefantrine (AL) as first-line for uncomplicated malaria treatment. This study determined the efficacy and safety of AL for the treatment of uncomplicated Plasmodium fal...

journal_title：Malaria journal

authors： Dambe R,Sande J,Ali D,Chilima B,Dodoli W,Michelo C,Malenga G,Phiri KS

更新日期：2015-04-23 00:00:00

abstract：BACKGROUND:The evolution of drug resistance in malaria parasites highlights a need to identify and evaluate strategies that could extend the useful therapeutic life of anti-malarial drugs. Such strategies are deployed to best effect before resistance has emerged, under conditions of great uncertainty. METHODS:Here, th...

journal_title：Malaria journal

authors： Smith DL,Klein EY,McKenzie FE,Laxminarayan R

更新日期：2010-07-23 00:00:00

abstract：BACKGROUND:In recent years, malaria (Plasmodium vivax and Plasmodium falciparum) has been successfully controlled in the Ecuador-Peru coastal border region. The aim of this study was to document this control effort and to identify the best practices and lessons learned that are applicable to malaria control and to othe...

journal_title：Malaria journal

authors： Krisher LK,Krisher J,Ambuludi M,Arichabala A,Beltrán-Ayala E,Navarrete P,Ordoñez T,Polhemus ME,Quintana F,Rochford R,Silva M,Bazo J,Stewart-Ibarra AM

更新日期：2016-11-28 00:00:00

abstract：BACKGROUND:With the introduction of artemisinin-based combination therapy (ACT) in 2005, monitoring of anti-malarial drug efficacy, which includes the use of molecular tools to detect known genetic markers of parasite resistance, is important for first-hand information on the changes in parasite susceptibility to drugs...

journal_title：Malaria journal

authors： Duah NO,Matrevi SA,de Souza DK,Binnah DD,Tamakloe MM,Opoku VS,Onwona CO,Narh CA,Quashie NB,Abuaku B,Duplessis C,Kronmann KC,Koram KA

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:The importance of net durability and the average useful life of a net is increasingly recognized as one of the critical factors that determine how often nets need to be replaced. A study to assess the effect of a net care and repair behaviour change communication (BCC) programme on net durability was conduct...

journal_title：Malaria journal

authors： Helinski MH,Namara G,Koenker H,Kilian A,Hunter G,Acosta A,Scandurra L,Selby RA,Mulondo K,Fotheringham M,Lynch M

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Arthropod vectors of disease may encounter more than one infected host during the course of their lifetime. The consequences of super-infection to parasite development are rarely investigated, but may have substantial epidemiological and evolutionary consequences. METHODS:Using a rodent malaria model system...

journal_title：Malaria journal

authors： Ferguson HM,Read AF

更新日期：2004-05-19 00:00:00