Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda.

abstract：BACKGROUND:Current available malaria diagnostic methods each have some limitations to meet the need for real-time and large-scale screening of asymptomatic and low density malaria infection at community level. It was proposed that malaria parasite-specific low molecular-weight metabolites could be used as biomarkers fo...

journal_title：Malaria journal

authors： Park YH,Shi YP,Liang B,Medriano CA,Jeon YH,Torres E,Uppal K,Slutsker L,Jones DP

更新日期：2015-03-24 00:00:00

abstract：BACKGROUND:Rosetting is associated with severe malaria and a primary cause of death in Plasmodium falciparum infections. Detailed understanding of this adhesive phenomenon may enable the development of new therapies interfering with rosette formation. For this, it is crucial to determine parameters such as rosetting an...

journal_title：Malaria journal

authors： Kudella PW,Moll K,Wahlgren M,Wixforth A,Westerhausen C

更新日期：2016-04-18 00:00:00

abstract：BACKGROUND:The objective of this work was to develop a model to predict malaria incidence in an area of unstable transmission by studying the association between environmental variables and disease dynamics. METHODS:The study was carried out in Karuzi, a province in the Burundi highlands, using time series of monthly ...

journal_title：Malaria journal

authors： Gomez-Elipe A,Otero A,van Herp M,Aguirre-Jaime A

更新日期：2007-09-24 00:00:00

abstract：BACKGROUND:Malaria in pregnancy is associated with immunological abnormalities in the newborns, such as hampered T-helper 1 responses and increased T-regulatory responses, while the effect of maternal Plasmodium falciparum infection on foetal innate immunity is still controversial. MATERIALS AND METHODS:The immunophen...

journal_title：Malaria journal

authors： Fievet N,Varani S,Ibitokou S,Briand V,Louis S,Perrin RX,Massougbogji A,Hosmalin A,Troye-Blomberg M,Deloron P

更新日期：2009-11-05 00:00:00

abstract：BACKGROUND:There is an urgent need to develop and test novel compounds against malaria infection. Carrageenans, sulphated polysaccharides derived from seaweeds, have been previously shown to inhibit Plasmodium falciparum in vitro. However, they are inflammatory and alter the permeability of the blood-brain barrier, rai...

journal_title：Malaria journal

authors： Recuenco FC,Takano R,Chiba S,Sugi T,Takemae H,Murakoshi F,Ishiwa A,Inomata A,Horimoto T,Kobayashi Y,Horiuchi N,Kato K

更新日期：2014-12-11 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) have become an essential tool in the contemporary malaria control and management programmes in the world. This study aims to evaluate the performance of two commonly used RDTs for malaria diagnosis in the China-Myanmar border area. METHODS:A total 606 febrile patients in the Ch...

journal_title：Malaria journal

authors： Yan J,Li N,Wei X,Li P,Zhao Z,Wang L,Li S,Li X,Wang Y,Li S,Yang Z,Zheng B,Zhou G,Yan G,Cui L,Cao Y,Fan Q

更新日期：2013-02-22 00:00:00

abstract：BACKGROUND:Successful reduction of malaria transmission to very low levels has made Isabel Province, Solomon Islands, a target for early elimination by 2014. High malaria transmission in neighbouring provinces and the potential for local asymptomatic infections to cause malaria resurgence highlights the need for sub-na...

journal_title：Malaria journal

authors： Atkinson JA,Johnson ML,Wijesinghe R,Bobogare A,Losi L,O'Sullivan M,Yamaguchi Y,Kenilorea G,Vallely A,Cheng Q,Ebringer A,Bain L,Gray K,Harris I,Whittaker M,Reid H,Clements A,Shanks D

更新日期：2012-03-30 00:00:00

abstract：BACKGROUND:Malaria is known as tazo or tazomoka in local terminology in Madagascar. Within the context of traditional practice, malaria (and/or malaria symptoms) is commonly treated by decoctions or infusions from bitter plants. One possible approach to the identification of new antimalarial drug candidates is to searc...

journal_title：Malaria journal

authors： Randrianarivelojosia M,Rasidimanana VT,Rabarison H,Cheplogoi PK,Ratsimbason M,Mulholland DA,Mauclère P

更新日期：2003-07-24 00:00:00

abstract：BACKGROUND:Increased resistance by Plasmodium falciparum parasites led to the withdrawal of the antimalarial drugs chloroquine and sulphadoxine-pyrimethamine in Ethiopia. Since 2004 artemether-lumefantrine has served to treat uncomplicated P. falciparum malaria. However, increasing reports on delayed parasite clearance...

journal_title：Malaria journal

authors： Mekonnen SK,Aseffa A,Berhe N,Teklehaymanot T,Clouse RM,Gebru T,Medhin G,Velavan TP

更新日期：2014-06-25 00:00:00

abstract：BACKGROUND:As the ecology of mosquito larvae can be complex there is need to develop a rational framework for undertaking larval ecological studies. Local environmental characteristics, such as altitude, climate and land use, can significantly impact on phenology and population dynamics of mosquito larvae, and indirect...

journal_title：Malaria journal

authors： Imbahale SS,Paaijmans KP,Mukabana WR,van Lammeren R,Githeko AK,Takken W

更新日期：2011-04-10 00:00:00

abstract：:The sterile insect technique (SIT) has been shown to be an effective and sustainable genetic approach to control populations of selected major pest insects, when part of area-wide integrated pest management (AW-IPM) programmes. The technique introduces genetic sterility in females of the target population in the field...

journal_title：Malaria journal

authors： Robinson AS,Knols BG,Voigt G,Hendrichs J

更新日期：2009-11-16 00:00:00

abstract：BACKGROUND:Conventional diagnosis of malaria has relied upon either clinical diagnosis or microscopic examination of peripheral blood smears. These methods, if not carried out exactly, easily result in the over- or under-diagnosis of malaria. The reliability and accuracy of malaria RDTs, even in extremely challenging h...

journal_title：Malaria journal

authors： Diggle E,Asgary R,Gore-Langton G,Nahashon E,Mungai J,Harrison R,Abagira A,Eves K,Grigoryan Z,Soti D,Juma E,Allan R

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Antiplasmodial activities of angiotensin II and its analogues have been extensively investigated in Plasmodium gallinaceum and Plasmodium falciparum parasite species. Due to its vasoconstrictor property angiotensin II cannot be used as an anti-malarial drug. METHODS:This work presents the solid-phase synthe...

journal_title：Malaria journal

authors： Silva AF,Torres MD,Silva Lde S,Alves FL,Pinheiro AA,Miranda A,Capurro ML,Oliveira VX Jr

更新日期：2015-11-04 00:00:00

abstract：BACKGROUND:In insects, including Anopheles mosquitoes, Dscam (Down syndrome cell adhesion molecule) appears to be involved in phagocytosis of pathogens, and shows pathogen-specific splice-form expression between divergent pathogen (or parasite) types (e.g. between bacteria and Plasmodium or between Plasmodium berghei a...

journal_title：Malaria journal

authors： Smith PH,Mwangi JM,Afrane YA,Yan G,Obbard DJ,Ranford-Cartwright LC,Little TJ

更新日期：2011-06-08 00:00:00

abstract：BACKGROUND:Asymptomatic carriage of Plasmodium falciparum is widespread in adults and children living in malaria-endemic countries. This study identified the prevalence of malaria parasites and the corresponding levels of naturally acquired anti-parasite antibody levels in afebrile adults living in two communities in t...

journal_title：Malaria journal

authors： Acquah FK,Lo AC,Akyea-Mensah K,Abagna HB,Faye B,Theisen M,Gyan BA,Amoah LE

更新日期：2020-02-10 00:00:00

abstract：BACKGROUND:The emergence of Plasmodium falciparum resistance to artemisinins threatens to undermine the effectiveness of artemisinin-based combination anti-malarial therapy. Developing suitable drugs to replace artemisinins requires the identification of new compounds that display rapid parasite killing kinetics. Howev...

journal_title：Malaria journal

authors： Linares M,Viera S,Crespo B,Franco V,Gómez-Lorenzo MG,Jiménez-Díaz MB,Angulo-Barturen Í,Sanz LM,Gamo FJ

更新日期：2015-11-05 00:00:00

abstract：BACKGROUND:As South Africa strives to achieve malaria elimination by 2018 (zero local cases) the country needs to strengthen its disease surveillance system by reducing the timeliness from case diagnosis to notification of key stakeholders in the malaria programme. This study evaluated the feasibility of a 24-h mobile ...

journal_title：Malaria journal

authors： Baloyi RE,Shandukani MB,Graffy R,Misiani E,Mayet N,Mabunda E,Mabuza A,Qwabe B,Ngwenyama B,Reddy C,Moonasar D

更新日期：2018-08-23 00:00:00

abstract：:The classic formulae in malaria epidemiology are reviewed that relate entomological parameters to malaria transmission, including mosquito survivorship and age-at-infection, the stability index (S), the human blood index (HBI), proportion of infected mosquitoes, the sporozoite rate, the entomological inoculation rate ...

journal_title：Malaria journal

authors： Smith DL,McKenzie FE

更新日期：2004-06-04 00:00:00

abstract：:Artesunate (AS) is a clinically versatile artemisinin derivative utilized for the treatment of mild to severe malaria infection. Given the therapeutic significance of AS and the necessity of appropriate AS dosing, substantial research has been performed investigating the pharmacokinetics of AS and its active metabolit...

journal_title：Malaria journal

authors： Morris CA,Duparc S,Borghini-Fuhrer I,Jung D,Shin CS,Fleckenstein L

更新日期：2011-09-13 00:00:00

abstract：BACKGROUND:Monitoring and evaluation of malaria programmes may require a combination of approaches to detect any effects of control. This is particularly true at lower transmission levels where detecting both infection and exposure to infection will provide additional evidence of any change. This paper describes use of...

journal_title：Malaria journal

authors： Stevenson JC,Stresman GH,Baidjoe A,Okoth A,Oriango R,Owaga C,Marube E,Bousema T,Cox J,Drakeley C

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:In the Republic of Korea (ROK), six sibling species of the Anopheles sinensis complex are considered the vector species of malaria, but data on their susceptibilities to malaria and vector capacities have been controversial. The intensive use of insecticides has contributed to the rapid development and sprea...

journal_title：Malaria journal

authors： Kang S,Jung J,Lee S,Hwang H,Kim W

更新日期：2012-05-03 00:00:00

abstract：BACKGROUND:This study was conducted to evaluate whether a selection of South African ethnomedicinal plants included in this study displayed insecticidal properties when screened against adult stages of the mosquito. METHODS:381 crude extracts of 80 plant taxa in 42 families were sprayed onto ceramic tiles and screened...

journal_title：Malaria journal

authors： Maharaj R,Maharaj V,Crouch NR,Bhagwandin N,Folb PI,Pillay P,Gayaram R

更新日期：2011-08-11 00:00:00

abstract：BACKGROUND:The effects that artemether-lumefantrine (AL) has on gametocyte dynamics in the short-term have recently been described. However there is limited long-term longitudinal data on the effect of AL on gametocyte dynamics in asymptomatic children. METHODS:An epidemiological study was conducted in Kombewa, Wester...

journal_title：Malaria journal

authors： Andagalu B,Mativo J,Kamau E,Ogutu B

更新日期：2014-07-09 00:00:00

abstract：BACKGROUND:In endemic areas, children develop slowly and naturally anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity in West African young children. However, SMC may impact on the na...

journal_title：Malaria journal

authors： Mahaman Moustapha L,Adamou R,Ibrahim ML,Abdoulaye Louis Padounou M,Diallo A,Courtin D,Testa J,Ndiaye JLA

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country's malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is underway for a possible introduction, as soon as one becomes available...

journal_title：Malaria journal

authors： Bingham A,Gaspar F,Lancaster K,Conjera J,Collymore Y,Ba-Nguz A

更新日期：2012-11-28 00:00:00

abstract：BACKGROUND:Over the past 15 years, mortality and morbidity due to malaria have been reduced substantially in sub-Saharan Africa and local elimination has been achieved in some settings. This study addresses the bio-ecology of larval and adult stages of malaria vectors, Plasmodium infection in Anopheles gambiae s.l. in ...

journal_title：Malaria journal

authors： Kouassi BL,de Souza DK,Goepogui A,Balde SM,Diakité L,Sagno A,Djameh GI,Chammartin F,Vounatsou P,Bockarie MJ,Utzinger J,Koudou BG

更新日期：2016-03-18 00:00:00

abstract：BACKGROUND:Behaviour change communication (BCC) can improve malaria prevention and treatment behaviour. As a one of the activities under Myanmar Artemisinin Resistance Containment (MARC) programme, BCC have been conducting. This study aimed to evaluate the effectiveness of the behaviour change communication and communi...

journal_title：Malaria journal

authors： Nyunt MH,Aye KM,Kyaw MP,Wai KT,Oo T,Than A,Oo HW,Phway HP,Han SS,Htun T,San KK

更新日期：2015-12-23 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) is the treatment of choice for uncomplicated falciparum malaria. Artemether-lumefantrine (AL), a fixed dose co-formulation, has recently been approved for marketing in India, although it is not included in the National Drug Policy for treatment of malaria. Efficacy...

journal_title：Malaria journal

authors： Valecha N,Srivastava P,Mohanty SS,Mittra P,Sharma SK,Tyagi PK,Pradhan K,Dev V,Singh R,Dash AP,Sharma YD

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:With the increase in use of point-of-care diagnostic tests for malaria and other diseases comes the necessity of storing the diagnostic kits and the drugs required for subsequent management, in remote areas, where temperatures are high and electricity supply is unreliable or unavailable. METHODS:To address ...

journal_title：Malaria journal

authors： Chanthap L,Ariey F,Socheat D,Tsuyuoka R,Bell D

更新日期：2010-01-23 00:00:00

abstract：BACKGROUND:Glucose 6-phosphate dehydrogenase (G6PD) is an enzyme involved in prevention of cellular oxidative damage, particularly protecting erythrocytes from haemolysis. An estimated 400 million people present variable degrees of inherited G6PD deficiency (G6PDd) which puts them at risk for developing haemolysis trig...

journal_title：Malaria journal

authors： Valencia SH,Ocampo ID,Arce-Plata MI,Recht J,Arévalo-Herrera M

更新日期：2016-05-26 00:00:00