Screening for adulticidal bioactivity of South African plants against Anopheles arabiensis.

abstract：BACKGROUND:Improving the way artemether-lumefantrine (AL) is provided to patients attending clinics is critical to maximize the benefit of this new medicine. In 2007, a new initiative was launched in one part of Kenya to improve malaria case-management through enhanced in-service training and provision of job aids. ME...

journal_title：Malaria journal

authors： Wasunna B,Zurovac D,Bruce J,Jones C,Webster J,Snow RW

更新日期：2010-09-18 00:00:00

abstract：BACKGROUND:Laboratory studies have demonstrated that a variety of immune signaling pathways regulate malaria parasite infection in Anopheles gambiae, the primary vector species in Africa. METHODS:To begin to understand the importance of these associations under natural conditions, an association mapping approach was a...

journal_title：Malaria journal

authors： Horton AA,Lee Y,Coulibaly CA,Rashbrook VK,Cornel AJ,Lanzaro GC,Luckhart S

更新日期：2010-06-11 00:00:00

abstract：BACKGROUND:In order to sustain the gains achieved by current malaria control strategies, robust surveillance systems that monitor dynamics of vectors and their roles in malaria transmission over time are essential. This longitudinal study demonstrates the trends in malaria vector dynamics and their relative contributio...

journal_title：Malaria journal

authors： Lwetoijera DW,Harris C,Kiware SS,Dongus S,Devine GJ,McCall PJ,Majambere S

更新日期：2014-08-24 00:00:00

abstract：BACKGROUND:With less than one severe case per year in average, Plasmodium vivax is very rarely associated with severe imported malaria in France. Two cases of P. vivax severe malaria occurred in patients with no evident co-morbidity. Interestingly, both cases did not occur at the primary infection but during relapses. ...

journal_title：Malaria journal

authors： Izri A,Cojean S,Leblanc C,Cohen Y,Bouchaud O,Durand R

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated the deletion of the histidine-rich protein 2 (PfHRP2) gene (pfhrp2) in field isolates of Plasmodium falciparum, which could result in false negative test results when PfHRP2-based rapid diagnostic tests (RDTs) are used for malaria diagnosis. Although primary diagnosis of mala...

journal_title：Malaria journal

authors： Abdallah JF,Okoth SA,Fontecha GA,Torres RE,Banegas EI,Matute ML,Bucheli ST,Goldman IF,de Oliveira AM,Barnwell JW,Udhayakumar V

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Immunization with attenuated malaria sporozoites protects humans from experimental malaria challenge by mosquito bite. Protection in humans is strongly correlated with the production of T cells targeting a heterogeneous population of pre-erythrocyte antigen proteoforms, including liver stage antigens. Curren...

journal_title：Malaria journal

authors： Winer B,Edgel KA,Zou X,Sellau J,Hadiwidjojo S,Garver LS,McDonough CE,Kelleher NL,Thomas PM,Villasante E,Ploss A,Gerbasi VR

更新日期：2020-01-07 00:00:00

abstract：BACKGROUND:Malaria is one of the most severe global public health problems worldwide, particularly in Africa, where Nigeria has the greatest number of malaria cases. This community-based study was designed to investigate the prevalence and risk factors of malaria and to evaluate the knowledge, attitudes, and practices ...

journal_title：Malaria journal

authors： Dawaki S,Al-Mekhlafi HM,Ithoi I,Ibrahim J,Atroosh WM,Abdulsalam AM,Sady H,Elyana FN,Adamu AU,Yelwa SI,Ahmed A,Al-Areeqi MA,Subramaniam LR,Nasr NA,Lau YL

更新日期：2016-07-08 00:00:00

abstract：BACKGROUND:Intensive malaria transmission along international borders is a significant impediment to malaria elimination in the Greater Mekong Subregion (GMS) of Southeast Asia. Passive case detection (PCD) was used to study the dynamics and trends of malaria transmission at the China-Myanmar border to provide epidemio...

journal_title：Malaria journal

authors： Geng J,Malla P,Zhang J,Xu S,Li C,Zhao Y,Wang Q,Kyaw MP,Cao Y,Yang Z,Cui L

更新日期：2019-09-12 00:00:00

abstract：BACKGROUND:In view of the need to continuously feed the pipeline with new anti-malarial agents adapted to differentiated and more stringent target product profiles (e.g., new modes of action, transmission-blocking activity or long-duration chemo-protection), a chemical library consisting of more than 250,000 compounds ...

journal_title：Malaria journal

authors： Avery VM,Bashyam S,Burrows JN,Duffy S,Papadatos G,Puthukkuti S,Sambandan Y,Singh S,Spangenberg T,Waterson D,Willis P

更新日期：2014-05-27 00:00:00

abstract：BACKGROUND:There remains a need for techniques that improve the sensitive detection of viable Plasmodium falciparum as part of diagnosis and therapeutic monitoring in clinical studies and usual-care management of malaria infections. A non-invasive breath test based on P. falciparum-associated specific volatile organic ...

journal_title：Malaria journal

authors： Wong RP,Flematti GR,Davis TM

更新日期：2012-09-07 00:00:00

abstract：BACKGROUND:Standard methods for defining clinical malaria in intervention trials in endemic areas do not guarantee that efficacy estimates will be unbiased, and do not indicate whether the intervention has its effect by modifying the force of infection, the parasite density, or the risk of pathology at given parasite d...

journal_title：Malaria journal

authors： Smith TA

更新日期：2007-05-02 00:00:00

abstract：BACKGROUND:The incidence of malaria in the Amazon basin is closely related to social inequalities, given that precarious economic and socio-environmental conditions represent favourable factors for the transmission of the disease in tropical regions, such as the Brazilian state of Pará. In the present study, an associa...

journal_title：Malaria journal

authors： Junior SG,Pamplona VM,Corvelo TC,Ramos EM

更新日期：2014-03-10 00:00:00

abstract：BACKGROUND:In 2017, nearly 80% of malaria morbidity and mortality occurred in sub-Saharan African (SSA) countries and India. Rapid diagnostic tests (RDTs), especially those targeting histidine-rich protein 2 (PfHRP2) of Plasmodium falciparum, have become an important diagnostic tool in these malaria-endemic areas. Howe...

journal_title：Malaria journal

authors： Kojom LP,Singh V

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:Policy makers, governments and donors are faced with an information gap when considering ways to improve access to artemisinin-based combination therapy (ACT) and malaria diagnostics including rapid diagnostic tests (RDTs). To help address some of these gaps, a five-year multi-country research project called...

journal_title：Malaria journal

authors： Shewchuk T,O'Connell KA,Goodman C,Hanson K,Chapman S,Chavasse D

更新日期：2011-10-31 00:00:00

abstract：BACKGROUND:Complement (C) can be activated during malaria, C components consumed and inflammatory mediators produced. This has potential to impair host innate defence. METHODS:In a case-control study, C activation was assessed by measuring serum haemolytic activity (CH50), functional activity of each pathway and level...

journal_title：Malaria journal

authors： Nyakoe NK,Taylor RP,Makumi JN,Waitumbi JN

更新日期：2009-01-09 00:00:00

abstract：BACKGROUND:Sub-Saharan Africa (SSA) has embarked on a new era of dam building to improve food security and promote economic development. Nonetheless, the future impacts of dams on malaria transmission are poorly understood and seldom investigated in the context of climate and demographic change. METHODS:The distributi...

journal_title：Malaria journal

authors： Kibret S,Lautze J,McCartney M,Nhamo L,Wilson GG

更新日期：2016-09-05 00:00:00

abstract：BACKGROUND:Most rapid diagnostic tests (RDTs) currently used for malaria diagnosis cannot distinguish the various Plasmodium infections. The development of a Plasmodium vivax specific RDTs with high sensitivity to sufficiently differentiate the two most common Plasmodium infections would be very crucial for disease tre...

journal_title：Malaria journal

authors： Dzakah EE,Kang K,Ni C,Wang H,Wu P,Tang S,Wang J,Wang J,Wang X

更新日期：2013-06-12 00:00:00

abstract：BACKGROUND:Asymptomatic carriage of Plasmodium falciparum is widespread in adults and children living in malaria-endemic countries. This study identified the prevalence of malaria parasites and the corresponding levels of naturally acquired anti-parasite antibody levels in afebrile adults living in two communities in t...

journal_title：Malaria journal

authors： Acquah FK,Lo AC,Akyea-Mensah K,Abagna HB,Faye B,Theisen M,Gyan BA,Amoah LE

更新日期：2020-02-10 00:00:00

abstract：BACKGROUND:Anti-malarial drugs are the major focus in the prevention and treatment of malaria. Artemisinin-based combination therapy (ACT) is the WHO recommended first-line treatment for Plasmodium falciparum malaria across the endemic world. Also ACT is increasingly relied upon in treating Plasmodium vivax malaria whe...

journal_title：Malaria journal

authors： Njokah MJ,Kang'ethe JN,Kinyua J,Kariuki D,Kimani FT

更新日期：2016-07-22 00:00:00

abstract：BACKGROUND:Numerous countries around the world are approaching malaria elimination. Until global eradication is achieved, countries that successfully eliminate the disease will contend with parasite reintroduction through international movement of infected people. Human-mediated parasite mobility is also important with...

journal_title：Malaria journal

authors： Ruktanonchai NW,Bhavnani D,Sorichetta A,Bengtsson L,Carter KH,Córdoba RC,Le Menach A,Lu X,Wetter E,Zu Erbach-Schoenberg E,Tatem AJ

更新日期：2016-05-11 00:00:00

abstract：BACKGROUND:Malaria antibody responses measured at delivery have been associated with protection from maternal anaemia and low birth weight deliveries. Whether malarial antibodies present in the first half of pregnancy may protect from these or other poor birth outcomes is unclear. To determine whether malaria antibodie...

journal_title：Malaria journal

authors： Chandrasiri UP,Fowkes FJ,Beeson JG,Richards JS,Kamiza S,Maleta K,Ashorn P,Rogerson SJ

更新日期：2016-11-09 00:00:00

abstract：BACKGROUND:The present study evaluated the SD Bioline Malaria Ag 05FK40 (SDFK40), a three-band RDT detecting Plasmodium falciparum-specific parasite lactate dehydrogenase (Pf-pLDH) and pan Plasmodium-specific pLDH (pan-pLDH), in a reference setting. METHODS:The SDFK40 was retrospectively and prospectively tested again...

journal_title：Malaria journal

authors： Maltha J,Gillet P,Cnops L,Bottieau E,Van Esbroeck M,Bruggeman C,Jacobs J

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Malaria in Southeast Asia frequently clusters along international borders. For example, while most of Thailand is malaria free, the border region shared with Myanmar continues to have endemic malaria. This spatial pattern is the result of complex interactions between landscape, humans, mosquito vectors, and ...

journal_title：Malaria journal

authors： Parker DM,Carrara VI,Pukrittayakamee S,McGready R,Nosten FH

更新日期：2015-10-05 00:00:00

abstract：BACKGROUND:Recently, a real-time PCR assay known as photo-induced electron transfer (PET)-PCR which relies on self-quenching primers for the detection of Plasmodium spp. and Plasmodium falciparum was described. PET-PCR assay was found to be robust, and easier to use when compared to currently available real-time PCR me...

journal_title：Malaria journal

authors： Lucchi NW,Karell MA,Journel I,Rogier E,Goldman I,Ljolje D,Huber C,Mace KE,Jean SE,Akom EE,Oscar R,Buteau J,Boncy J,Barnwell JW,Udhayakumar V

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chlo...

journal_title：Malaria journal

authors： Mvumbi DM,Boreux R,Sacheli R,Lelo M,Lengu B,Nani-Tuma S,Melin P,Ntumba K,Lunganza K,DeMol P,Hayette MP

更新日期：2013-12-20 00:00:00

abstract：BACKGROUND:The 2016 World Health Organization (WHO) World Malaria Report documents substantial progress towards control and elimination of malaria. However, major challenges remain. In some regions of Southeast Asia, the simian parasite Plasmodium knowlesi has emerged as an important cause of human malaria, and the aut...

journal_title：Malaria journal

authors： Barber BE,Rajahram GS,Grigg MJ,William T,Anstey NM

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:In children with malaria caused by Plasmodium falciparum, quinine administered rectally may be easier to use and less painful than intramuscular or intravenous administration. The objective of this review was to compare the effectiveness of intrarectal with intravenous or intramuscular quinine for treating f...

journal_title：Malaria journal

authors： Eisenhut M,Omari A,MacLehose HG

更新日期：2005-05-18 00:00:00

abstract：:While significant advances have been made in the prevention and treatment of malaria in recent years, these successes continue to fall short of the World Health Organization (WHO) goals for malaria control and elimination. For elimination strategies to be effective, limited disease transmission, achieved through rapid...

journal_title：Malaria journal

authors： Makanga M

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:There is evidence that suggests that undernutrition has a detrimental effect on malarial immunity in children. The aim of the study was to discover whether nutrient supplementation improved development of malarial antibody immunity in children up to 18 months of age. METHODS:The study was conducted with a s...

journal_title：Malaria journal

authors： Barua P,Chandrasiri UP,Beeson JG,Dewey KG,Maleta K,Ashorn P,Rogerson SJ

更新日期：2018-02-07 00:00:00

abstract：BACKGROUND:Several anti-malarial drugs are associated with adverse cardiovascular effects. These effects may be exacerbated when different anti-malarials are used in combination. There has been no report yet on the potential cardiac effects of the combination artesunate-amodiaquine. METHODS:Electrocardiographic (ECG) ...

journal_title：Malaria journal

authors： Adjei GO,Oduro-Boatey C,Rodrigues OP,Hoegberg LC,Alifrangis M,Kurtzhals JA,Goka BQ

更新日期：2012-12-17 00:00:00