Increasing role of Anopheles funestus and Anopheles arabiensis in malaria transmission in the Kilombero Valley, Tanzania.

Abstract:

BACKGROUND:In order to sustain the gains achieved by current malaria control strategies, robust surveillance systems that monitor dynamics of vectors and their roles in malaria transmission over time are essential. This longitudinal study demonstrates the trends in malaria vector dynamics and their relative contribution to malaria transmission in hyperendemic transmission settings in Tanzania. METHODS:The study was conducted in two villages within the Kilombero Valley, in rural Tanzania for five consecutive years (2008-2012). Seventy-two houses were selected per village and each house was sampled for mosquitoes monthly using a CDC light trap. Collected mosquitoes were assessed for species identity and sporozoite infection status using PCR and ELISA, respectively. Anopheles funestus and Anopheles arabiensis susceptibility to insecticides was assessed using WHO guidelines. RESULTS:A total of 100,810 malaria vectors were collected, of which 76% were Anopheles gambiae s. l. and 24% were An. funestus. Of all An. funestus samples that amplified with PCR (n = 2,737), 97% were An. funestus s.s., 2% were Anopheles rivorulum and 1% Anopheles leesoni. Whereas for An. gambiae s.l. (n = 8,117), 93% were An. arabiensis and 7% were Anopheles gambiae s.s. The proportion of An. gambiae s.s. identified by PCR (2,924) declined from 0.2% in the year 2008 to undetectable levels in 2012. Malaria transmission intensity significantly decreased from an EIR of 78.14 infectious bites/person/year in 2008 to 35 ib/p/yr in 2011 but rebounded to 226 ib/p/yr in 2012 coinciding with an increased role of An. funestus in malaria transmission. Insecticide susceptibility tests indicated high levels of resistance in An. funestus against deltamethrin (87%), permethrin (65%), lambda cyhalothrin (74%), bendiocarb (65%), and DDT (66%). Similarly, An. arabiensis showed insecticide resistance to deltamethrin (64%), permethrin (77%) and lambda cyhalothrin (42%) in 2014. CONCLUSION:The results indicate the continuing role of An. arabiensis and the increasing importance of An. funestus in malaria transmission, and pyrethroid resistance development in both species. Complementary vector control and surveillance tools are needed that target the ecology, behaviour and insecticide resistance management of these vector species, in order to preserve the efficacy of LLINs.

journal_name

Malar J

journal_title

Malaria journal

authors

Lwetoijera DW,Harris C,Kiware SS,Dongus S,Devine GJ,McCall PJ,Majambere S

doi

10.1186/1475-2875-13-331

subject

Has Abstract

pub_date

2014-08-24 00:00:00

pages

331

issn

1475-2875

pii

1475-2875-13-331

journal_volume

13

pub_type

杂志文章
  • Progress towards malaria control targets in relation to national malaria programme funding.

    abstract:BACKGROUND:Malaria control has been dramatically scaled up the past decade, mainly thanks to increasing international donor financing since 2003. This study assessed progress up to 2010 towards global malaria impact targets, in relation to Global Fund, other donor and domestic malaria programme financing over 2003 to 2...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-12-18

    authors: Korenromp EL,Hosseini M,Newman RD,Cibulskis RE

    更新日期:2013-01-14 00:00:00

  • World Malaria Report: time to acknowledge Plasmodium knowlesi malaria.

    abstract:BACKGROUND:The 2016 World Health Organization (WHO) World Malaria Report documents substantial progress towards control and elimination of malaria. However, major challenges remain. In some regions of Southeast Asia, the simian parasite Plasmodium knowlesi has emerged as an important cause of human malaria, and the aut...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-017-1787-y

    authors: Barber BE,Rajahram GS,Grigg MJ,William T,Anstey NM

    更新日期:2017-03-31 00:00:00

  • A rapid and scalable density gradient purification method for Plasmodium sporozoites.

    abstract:BACKGROUND:Malaria remains a major human health problem, with no licensed vaccine currently available. Malaria infections initiate when infectious Plasmodium sporozoites are transmitted by Anopheline mosquitoes during their blood meal. Investigations of the malaria sporozoite are, therefore, of clear medical importance...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-11-421

    authors: Kennedy M,Fishbaugher ME,Vaughan AM,Patrapuvich R,Boonhok R,Yimamnuaychok N,Rezakhani N,Metzger P,Ponpuak M,Sattabongkot J,Kappe SH,Hume JC,Lindner SE

    更新日期:2012-12-17 00:00:00

  • Plasmodium vivax aldolase-specific monoclonal antibodies and its application in clinical diagnosis of malaria infections in China.

    abstract:BACKGROUND:Most rapid diagnostic tests (RDTs) currently used for malaria diagnosis cannot distinguish the various Plasmodium infections. The development of a Plasmodium vivax specific RDTs with high sensitivity to sufficiently differentiate the two most common Plasmodium infections would be very crucial for disease tre...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-12-199

    authors: Dzakah EE,Kang K,Ni C,Wang H,Wu P,Tang S,Wang J,Wang J,Wang X

    更新日期:2013-06-12 00:00:00

  • Changing patterns of malaria during 1996-2010 in an area of moderate transmission in southern Senegal.

    abstract:BACKGROUND:Malaria is reportedly receding in different epidemiological settings, but local long-term surveys are limited. At Mlomp dispensary in south-western Senegal, an area of moderate malaria transmission, year-round, clinically-suspected malaria was treated with monotherapy as per WHO and national policy in the 19...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-10-203

    authors: Brasseur P,Badiane M,Cisse M,Agnamey P,Vaillant MT,Olliaro PL

    更新日期:2011-07-25 00:00:00

  • Artemisinin-naphthoquine combination (ARCO) therapy for uncomplicated falciparum malaria in adults of Papua New Guinea: a preliminary report on safety and efficacy.

    abstract:BACKGROUND:The use of anti-malarial drug combinations with artemisinin or with one of its derivatives is now widely recommended to overcome drug resistance in falciparum as well as vivax malaria. The fixed oral dose artemisinin-naphthoquine combination (ANQ, ARCO) is a newer artemisinin-based combination (ACT) therapy ...

    journal_title:Malaria journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1475-2875-8-196

    authors: Hombhanje FW,Linge D,Saweri A,Kuanch C,Jones R,Toraso S,Geita J,Masta A,Kevau I,Hiawalyer G,Sapuri M

    更新日期:2009-08-12 00:00:00

  • Factors affecting providers' delivery of intermittent preventive treatment for malaria in pregnancy: a five-country analysis of national service provision assessment surveys.

    abstract:BACKGROUND:Intermittent preventive treatment in pregnancy (IPTp) delivered during antenatal care (ANC) visits has been shown to be a highly efficacious and cost-effective intervention. Given the high rates of ANC attendance in sub-Saharan Africa, the current low IPTp coverage represents considerable missed opportunitie...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-13-440

    authors: Maheu-Giroux M,Castro MC

    更新日期:2014-11-20 00:00:00

  • Primaquine ineligibility in anti-relapse therapy of Plasmodium vivax malaria: the problem of G6PD deficiency and cytochrome P-450 2D6 polymorphisms.

    abstract::The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and opportunity for ultimately eradicating this species. It is silent and cannot be diagnosed until it awakens and provokes a clinical attack with attendant morbidity, risk of mortality, and opportunities for onward transmission. The on...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-018-2190-z

    authors: Baird JK,Battle KE,Howes RE

    更新日期:2018-01-22 00:00:00

  • Improving ability to identify malaria and correctly use chloroquine in children at household level in Nakonde District, Northern Province of Zambia.

    abstract::BACKGROUND: This study investigated causes of malaria and how cases were managed at household level, in order to improve the ability to identify malaria and ensure correct use of chloroquine. It was conducted in Nakonde District, Northern Province of Zambia, between 2000 and 2001. Nakonde district is in a hyperendemic...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-2-43

    authors: Kaona FA,Tuba M

    更新日期:2003-11-19 00:00:00

  • Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study.

    abstract:BACKGROUND:Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear. METHODS:Data from a longitudinal cohort study conducted in 3 sub-counties in Uganda was used to quan...

    journal_title:Malaria journal

    pub_type: 杂志文章,多中心研究

    doi:10.1186/s12936-020-3105-3

    authors: Kakande E,Greenhouse B,Bajunirwe F,Drakeley C,Nankabirwa JI,Walakira A,Nsobya SL,Katureebe A,Rek J,Arinaitwe E,Rosenthal PJ,Kamya MR,Dorsey G,Rodriguez-Barraquer I

    更新日期:2020-01-15 00:00:00

  • Indoor and outdoor malaria vector surveillance in western Kenya: implications for better understanding of residual transmission.

    abstract:BACKGROUND:The widespread use of indoor-based malaria vector control interventions has been shown to alter the behaviour of vectors in Africa. There is an increasing concern that such changes could sustain residual transmission. This study was conducted to assess vector species composition, feeding behaviour and their ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-017-2098-z

    authors: Degefa T,Yewhalaw D,Zhou G,Lee MC,Atieli H,Githeko AK,Yan G

    更新日期:2017-11-06 00:00:00

  • Determining and addressing obstacles to the effective use of long-lasting insecticide-impregnated nets in rural Tanzania.

    abstract:BACKGROUND:The objective of this project was to achieve high, sustainable levels of net coverage in a village in rural Tanzania by combining free distribution of long-lasting insecticide-impregnated nets (LLINs) with community-tailored education. In Tanzania, malaria is the leading cause of morbidity and mortality. Alt...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-8-315

    authors: Widmar M,Nagel CJ,Ho DY,Benziger PW,Hennig N

    更新日期:2009-12-31 00:00:00

  • Introducing rapid diagnostic tests for malaria into registered drug shops in Uganda: lessons learned and policy implications.

    abstract:BACKGROUND:Malaria is a major public health problem in Uganda and the current policy recommends introduction of rapid diagnostic tests for malaria (RDTs) to facilitate effective case management. However, provision of RDTs in drug shops potentially raises a new set of issues, such as adherence to RDTs results, managemen...

    journal_title:Malaria journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12936-015-0979-6

    authors: Mbonye AK,Clarke SE,Lal S,Chandler CI,Hutchinson E,Hansen KS,Magnussen P

    更新日期:2015-11-14 00:00:00

  • G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon.

    abstract:BACKGROUND:Plasmodium vivax parasites are the predominant cause of malaria infections in the Brazilian Amazon. Infected individuals are treated with primaquine, which can induce haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals and may lead to severe and fatal complications. This X-li...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-017-1889-6

    authors: Dombrowski JG,Souza RM,Curry J,Hinton L,Silva NRM,Grignard L,Gonçalves LA,Gomes AR,Epiphanio S,Drakeley C,Huggett J,Clark TG,Campino S,Marinho CRF

    更新日期:2017-06-15 00:00:00

  • Plasmodium yoelii blood-stage primes macrophage-mediated innate immune response through modulation of toll-like receptor signalling.

    abstract:BACKGROUND:Toll-like receptors (TLRs) signalling is reported to be primed by the infection of human malaria parasite, Plasmodium falciparum. However, little is known about the regulation of macrophages TLR signalling by the infection of lethal or non-lethal strain of rodent malaria parasites. METHODS:BALB/c mice were ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-11-104

    authors: Fu Y,Ding Y,Zhou T,Fu X,Xu W

    更新日期:2012-04-01 00:00:00

  • Cytokine and chemokine profile of the innate and adaptive immune response of Schistosoma haematobium and Plasmodium falciparum single and co-infected school-aged children from an endemic area of Lambaréné, Gabon.

    abstract:BACKGROUND:Helminths and malaria are among the most prevalent infectious diseases in the world. They both occur in tropical area where they often affect the same populations. There are studies suggesting an effect of helminths on malariometric indices. For example, malaria attacks as well as disease severity has been s...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-015-0608-4

    authors: Ateba-Ngoa U,Adegnika AA,Zinsou JF,Kassa Kassa RF,Smits H,Massinga-Loembe M,Mordmüller B,Kremsner PG,Yazdanbakhsh M

    更新日期:2015-02-25 00:00:00

  • Factors contributing to delay in parasite clearance in uncomplicated falciparum malaria in children.

    abstract:BACKGROUND:Drug resistance in Plasmodium falciparum is common in many endemic and other settings but there is no clear recommendation on when to change therapy when there is delay in parasite clearance after initiation of therapy in African children. METHODS:The factors contributing to delay in parasite clearance, def...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-9-53

    authors: Sowunmi A,Adewoye EO,Gbotsho GO,Happi CT,Sijuade A,Folarin OA,Okuboyejo TM,Michael OS

    更新日期:2010-02-15 00:00:00

  • Spatial prediction of malaria prevalence in an endemic area of Bangladesh.

    abstract:BACKGROUND:Malaria is a major public health burden in Southeastern Bangladesh, particularly in the Chittagong Hill Tracts region. Malaria is endemic in 13 districts of Bangladesh and the highest prevalence occurs in Khagrachari (15.47%). METHODS:A risk map was developed and geographic risk factors identified using a B...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-9-120

    authors: Haque U,Magalhães RJ,Reid HL,Clements AC,Ahmed SM,Islam A,Yamamoto T,Haque R,Glass GE

    更新日期:2010-05-09 00:00:00

  • Increased Plasmodium chabaudi malaria mortality in mice with nutritional iron deficiency can be reduced by short-term adjunctive iron supplementation.

    abstract:BACKGROUND:Iron deficiency is the most widespread nutrient deficiency and an important cause of developmental impairment in children. However, some studies have indicated that iron deficiency can also protect against malaria, which is a leading cause of childhood morbidity and mortality in large parts of the world. Thi...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-018-2186-8

    authors: Castberg FC,Maretty L,Staalsoe T,Hempel C,Clasen-Linde E,Hviid L,Kurtzhals JAL

    更新日期:2018-01-16 00:00:00

  • Avian haemosporidian persistence and co-infection in great tits at the individual level.

    abstract:BACKGROUND:Many studies have tracked the distribution and persistence of avian haemosporidian communities across space and time at the population level, but few studies have investigated these aspects of infection at the individual level over time. Important aspects of parasite infection at the individual level can be ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-12-40

    authors: van Rooyen J,Lalubin F,Glaizot O,Christe P

    更新日期:2013-01-30 00:00:00

  • Forecasting malaria incidence based on monthly case reports and environmental factors in Karuzi, Burundi, 1997-2003.

    abstract:BACKGROUND:The objective of this work was to develop a model to predict malaria incidence in an area of unstable transmission by studying the association between environmental variables and disease dynamics. METHODS:The study was carried out in Karuzi, a province in the Burundi highlands, using time series of monthly ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-6-129

    authors: Gomez-Elipe A,Otero A,van Herp M,Aguirre-Jaime A

    更新日期:2007-09-24 00:00:00

  • Comparing ownership and use of bed nets at two sites with differential malaria transmission in western Kenya.

    abstract:BACKGROUND:Challenges persist in ensuring access to and optimal use of long-lasting, insecticidal bed nets (LLINs). Factors associated with ownership and use may differ depending on the history of malaria and prevention control efforts in a specific region. Understanding how the cultural and social-environmental contex...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-016-1262-1

    authors: Ernst KC,Hayden MH,Olsen H,Cavanaugh JL,Ruberto I,Agawo M,Munga S

    更新日期:2016-04-14 00:00:00

  • Plasmodium prevalence and artemisinin-resistant falciparum malaria in Preah Vihear Province, Cambodia: a cross-sectional population-based study.

    abstract:BACKGROUND:Intensified efforts are urgently needed to contain and eliminate artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion. Médecins Sans Frontières plans to support the Ministry of Health in eliminating P. falciparum in an area with artemisinin resistance in the north-east of Cambodia. As ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-13-394

    authors: Bosman P,Stassijns J,Nackers F,Canier L,Kim N,Khim S,Alipon SC,Chuor Char M,Chea N,Dysoley L,Van den Bergh R,Etienne W,De Smet M,Ménard D,Kindermans JM

    更新日期:2014-10-06 00:00:00

  • Aquatic habitats of the malaria vector Anopheles funestus in rural south-eastern Tanzania.

    abstract:BACKGROUND:In rural south-eastern Tanzania, Anopheles funestus is a major malaria vector, and has been implicated in nearly 90% of all infective bites. Unfortunately, little is known about the natural ecological requirements and survival strategies of this mosquito species. METHODS:Potential mosquito aquatic habitats ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-020-03295-5

    authors: Nambunga IH,Ngowo HS,Mapua SA,Hape EE,Msugupakulya BJ,Msaky DS,Mhumbira NT,Mchwembo KR,Tamayamali GZ,Mlembe SV,Njalambaha RM,Lwetoijera DW,Finda MF,Govella NJ,Matoke-Muhia D,Kaindoa EW,Okumu FO

    更新日期:2020-06-23 00:00:00

  • A stakeholder workshop about modelled maps of key malaria indicator survey indicators in Madagascar.

    abstract::The Demographic and Health Surveys (DHS) Program has supported three household Malaria Indicator Surveys (MIS) in Madagascar. The results of 13 key malaria indicators from these surveys have been mapped as continuous surfaces using model-based geostatistical methods. The opportunities and limitations of these mapped o...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-019-2729-7

    authors: Howes RE,Hawa K,Andriamamonjy VF,Franchard T,Miarimbola R,Mioramalala SA,Rafamatanantsoa JF,Rahantamalala MAM,Rajaobary SH,Rajaonera HDG,Rakotonindrainy AP,Rakotoson Andrianjatonavalona C,Randriamiarinjatovo DNAL,Randrianasolo

    更新日期:2019-03-22 00:00:00

  • Quality of life and the risk of contracting malaria by multivariate analysis in the Brazilian Amazon region.

    abstract:BACKGROUND:The incidence of malaria in the Amazon basin is closely related to social inequalities, given that precarious economic and socio-environmental conditions represent favourable factors for the transmission of the disease in tropical regions, such as the Brazilian state of Pará. In the present study, an associa...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-13-86

    authors: Junior SG,Pamplona VM,Corvelo TC,Ramos EM

    更新日期:2014-03-10 00:00:00

  • Socioeconomic factors, attitudes and practices associated with malaria prevention in the coastal plain of Chiapas, Mexico.

    abstract:BACKGROUND:Mexico is in the malaria pre-elimination phase; therefore, continuous assessment and understanding of the social and behavioural risk factors related to exposure to malaria are necessary to achieve the overall goal. The aim of this research was to investigate socio-economic backgrounds, attitudes and practic...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-13-157

    authors: Mora-Ruiz M,Penilla RP,Ordóñez JG,López AD,Solis F,Torres-Estrada JL,Rodríguez AD

    更新日期:2014-04-23 00:00:00

  • Changes in vector species composition and current vector biology and behaviour will favour malaria elimination in Santa Isabel Province, Solomon Islands.

    abstract:BACKGROUND:In 2009, Santa Isabel Province in the Solomon Islands embarked on a malaria elimination programme. However, very little is known in the Province about the anopheline fauna, which species are vectors, their bionomics and how they may respond to intensified intervention measures. The purpose of this study was ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-10-287

    authors: Bugoro H,Iro'ofa C,Mackenzie DO,Apairamo A,Hevalao W,Corcoran S,Bobogare A,Beebe NW,Russell TL,Chen CC,Cooper RD

    更新日期:2011-09-30 00:00:00

  • Multiple insecticide resistance in Anopheles gambiae from Tanzania: a major concern for malaria vector control.

    abstract:BACKGROUND:Malaria vector control in Tanzania is based on use of long-lasting insecticide treated nets (LLINs) and indoor residual spraying (IRS), which both rely on the use of chemical insecticides. The effectiveness of these control tools is endangered by the development of insecticide resistance in the major malaria...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-017-2087-2

    authors: Kisinza WN,Nkya TE,Kabula B,Overgaard HJ,Massue DJ,Mageni Z,Greer G,Kaspar N,Mohamed M,Reithinger R,Moore S,Lorenz LM,Magesa S

    更新日期:2017-10-30 00:00:00

  • Artemether-lumefantrine versus artemisinin-naphthoquine in Papua New Guinean children with uncomplicated malaria: a six months post-treatment follow-up study.

    abstract:BACKGROUND:In a recent trial of artemisinin-naphthoquine (artemisinin-NQ) and artemether-lumefantrine (AM-LM) therapy in young children from Papua New Guinea (PNG), there were no treatment failures in artemisinin-NQ-treated children with Plasmodium falciparum or Plasmodium vivax compared with 2.2% and 30.0%, respective...

    journal_title:Malaria journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12936-015-0624-4

    authors: Laman M,Benjamin JM,Moore BR,Salib M,Tawat S,Davis WA,Siba PM,Robinson LJ,Davis TM

    更新日期:2015-03-21 00:00:00