Abstract:
:BACKGROUND: This study investigated causes of malaria and how cases were managed at household level, in order to improve the ability to identify malaria and ensure correct use of chloroquine. It was conducted in Nakonde District, Northern Province of Zambia, between 2000 and 2001. Nakonde district is in a hyperendemic malaria province, where Plasmodium falciparum is predominant. The district has a total population of 153, 548 people, the majority of whom are peasant farmers. The main aim of the post intervention survey was to establish the proportion of caretakers of children five years and below, who were able to identify simple and severe malaria and treat it correctly using chloroquine in the home. METHODS: A baseline survey was conducted in five wards divided into intervention and control.Intervention and control wards were compared. Village health motivators and vendors were identified and trained in three intervention wards, as a channel through which information on correct chloroquine dose could be transmitted. A total of 575 carers, who were 15 years old and above and had a child who had suffered from malaria 14 days before the survey commenced, were interviewed. The two control wards received no intervention. 345 caretakers were from the intervention wards, while 230 came from the control wards. Identification of malaria and correct use of anti-malarial drugs was assessed in terms of household diagnosis of malaria in children under five years, type and dose of anti-malarial drugs used, self medication and the source of these anti-malarials. RESULTS: The majority of respondents in the study were females (81%). Chloroquine was the most frequently used anti-malarial (48.5%) in both the intervention and control wards. There was no difference between the intervention and control wards at pre-intervention (P = 0.266 and P = 0.956), in the way mothers and other caretakers identified simple and severe malaria. At baseline, knowledge on correct chloroquine dosage in the under five children was comparable between intervention and control wards. Post-intervention revealed that mothers and other caretakers were 32% and 51%, respectively, more likely to identify simple and severe malaria. There was a 60% increase on correct chloroquine dosage in all age groups among carers living in post-intervention wards. CONCLUSION: Compliance with standard therapeutic doses and correct identification of malaria was poorest in control wards, where no motivators and vendors were trained.
journal_name
Malar Jjournal_title
Malaria journalauthors
Kaona FA,Tuba Mdoi
10.1186/1475-2875-2-43keywords:
subject
Has Abstractpub_date
2003-11-19 00:00:00pages
43issue
1issn
1475-2875pii
1475-2875-2-43journal_volume
2pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:Malaria is a major public health burden in Southeastern Bangladesh, particularly in the Chittagong Hill Tracts region. Malaria is endemic in 13 districts of Bangladesh and the highest prevalence occurs in Khagrachari (15.47%). METHODS:A risk map was developed and geographic risk factors identified using a B...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-120
更新日期:2010-05-09 00:00:00
abstract:BACKGROUND:The reemergence of Plasmodium vivax in South Korea since 1993 represents a serious public health concern. Despite the importance in understanding genetic diversity for control strategies, however, studies remain inconclusive with the general premise that due to low rate of malaria transmission, there is gene...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-257
更新日期:2011-09-07 00:00:00
abstract:BACKGROUND:Sulfadoxine-pyrimethamine (SP) is a cornerstone of malaria chemoprophylaxis and is considered for programmes in the Democratic Republic of Congo (DRC). However, SP efficacy is threatened by drug resistance, that is conferred by mutations in the dhfr and dhps genes. The World Health Organization has specified...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-3057-7
更新日期:2019-12-18 00:00:00
abstract:BACKGROUND:Experimental vaccines targeting Plasmodium falciparum have had some success in recent years. These vaccines use attenuated parasites, recombinant sporozoite proteins, or DNA and virus combinations to induce cell-mediated immune responses and/or antibodies targeting sporozoite surface proteins. To capitalize ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-394
更新日期:2013-11-05 00:00:00
abstract:BACKGROUND:Major investments have been made since 2001, with intensification of malaria control interventions after 2006. Interventions included free distribution of insecticide-treated nets (ITN) to pregnant women and children under 5 years old, the introduction of artemisinin combination therapy (ACT) for malaria tre...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2573-1
更新日期:2018-11-14 00:00:00
abstract:BACKGROUND:Seasonal malaria chemoprevention (SMC) is a new strategy to reduce malaria burden in young children in Sahelian countries. It consists of the administration of full treatment courses of sulfadoxine-pyrimethamine plus amodiaquine to children at monthly intervals during the malaria season. However, it is not c...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1935-4
更新日期:2017-07-18 00:00:00
abstract:BACKGROUND:Chloroquine has been the treatment of choice for acute vivax malaria for more than 60 years. Malaria caused by Plasmodium vivax has recently shown resistance to chloroquine in some places. This study compared the efficacy and safety of fixed dose combination (FDC) of arterolane maleate and piperaquine phosph...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/s12936-016-1084-1
更新日期:2016-01-27 00:00:00
abstract:BACKGROUND:The screening of lead compounds against in vitro parasite cultures is an essential step in the development of novel anti-malarial drugs, but currently relies on laboratory parasite lines established in vitro during the last century. This study sought to establish in continuous culture a series of recent Plas...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-320
更新日期:2013-09-13 00:00:00
abstract:BACKGROUND:Whole-parasite immunization remains the benchmark in malaria vaccine development. A major bottleneck in the translation of whole-parasite immunization towards routine vaccination is the mode of administration, since high degrees of protection are currently only achieved by intravenous, and not by intradermal...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0552-3
更新日期:2015-01-28 00:00:00
abstract:BACKGROUND:Polyclonal B-cell activation is well known to occur in Plasmodium infections, but its role in pathogenesis or protection remains unclear. However, protective properties of natural antibodies have previously been demonstrated in other contexts. METHODS:Sera from asymptomatic and symptomatic Plasmodium-infect...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-4-5
更新日期:2005-01-20 00:00:00
abstract:BACKGROUND:Early diagnosis and prompt treatment including appropriate home-based treatment of malaria is a major strategy for malaria control. A major determinant of clinical outcome in case management is compliance and adherence to effective antimalarial regimen. Home-based malaria treatment with inappropriate medicin...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-143
更新日期:2008-07-29 00:00:00
abstract:BACKGROUND:The role of the liver for survival of blood-stage malaria is only poorly understood. In experimental blood-stage malaria with Plasmodium chabaudi, protective vaccination induces healing and, thus, survival of otherwise lethal infections. This model is appropriate to study the role of the liver in vaccination...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2366-6
更新日期:2018-05-29 00:00:00
abstract:BACKGROUND:Environmental temperature is an important driver of malaria transmission dynamics. Both the parasite and vector are sensitive to mean ambient temperatures and daily temperature variation. To understand transmission ecology, therefore, it is important to determine the range of microclimatic temperatures exper...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-84
更新日期:2013-03-02 00:00:00
abstract:BACKGROUND:Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of residual malaria infections usually requires a large study size, therefore sampling and diagnostic...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-3127-x
更新日期:2020-01-29 00:00:00
abstract::Monitoring and evaluation of malaria control in pregnancy is essential for assessing the efficacy and effectiveness of health interventions aimed at reducing the major burden of this disease on women living in endemic areas. Yet there is no currently integrated strategic approach on how this should be achieved. Malari...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-7-S1-S6
更新日期:2008-12-11 00:00:00
abstract:BACKGROUND:Residents of malaria-endemic communities spend several hours outdoors performing different activities, e.g. cooking, story-telling or eating, thereby exposing themselves to potentially-infectious mosquitoes. This compromises effectiveness of indoor interventions, notably long-lasting insecticide-treated nets...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03180-1
更新日期:2020-03-10 00:00:00
abstract:BACKGROUND:Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp. trophozoite, the stage when haemoglobin catabolism is maximal. H...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-94
更新日期:2008-05-27 00:00:00
abstract:BACKGROUND:Acute kidney injury (AKI) is a common complication of malaria. In low resource settings, a lack of diagnostic tools and delayed treatment of malaria associated AKI lead to significant morbidity and mortality. The aim of this study was to assess the diagnostic performance of salivary urea nitrogen (SUN) dipst...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2627-4
更新日期:2018-12-18 00:00:00
abstract:BACKGROUND:Several anti-malarial drugs are associated with adverse cardiovascular effects. These effects may be exacerbated when different anti-malarials are used in combination. There has been no report yet on the potential cardiac effects of the combination artesunate-amodiaquine. METHODS:Electrocardiographic (ECG) ...
journal_title:Malaria journal
pub_type: 临床试验,杂志文章
doi:10.1186/1475-2875-11-420
更新日期:2012-12-17 00:00:00
abstract:BACKGROUND:Azithromycin (AZM) is a macrolide antibiotic that displays an excellent safety profile even in children and pregnant women and has been shown to have anti-malarial activity against blood stage Plasmodium falciparum. This study evaluated the transmission-blocking effect of AZM using a rodent malaria model. M...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-73
更新日期:2010-03-10 00:00:00
abstract:BACKGROUND:T1BT* is a peptide construct containing the T1 and B epitopes located in the 5' minor repeat and the 3' major repeat of the central repeat region of the Plasmodium falciparum circumsporozoite protein (CSP), respectively, and the universal T* epitope located in the C-terminus of the same protein. This peptide...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-104
更新日期:2013-03-18 00:00:00
abstract::Plasmodium falciparum infections present novel challenges for vaccine development, including parasite replication dynamics not previously encountered for viral pathogens, and enormous diversity in target antigens. These challenges are illustrated by using a mathematical model to describe the association between the pr...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-280
更新日期:2013-08-08 00:00:00
abstract:BACKGROUND:Rosetting is associated with severe malaria and a primary cause of death in Plasmodium falciparum infections. Detailed understanding of this adhesive phenomenon may enable the development of new therapies interfering with rosette formation. For this, it is crucial to determine parameters such as rosetting an...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1243-4
更新日期:2016-04-18 00:00:00
abstract:BACKGROUND:The development of insecticide resistance and the increased outdoor-biting behaviour of malaria vectors reduce the efficiency of indoor vector control methods. Attractive toxic sugar baits (ATSBs), a method targeting the sugar-feeding behaviours of vectors both indoors and outdoors, is a promising supplement...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-1012-9
更新日期:2015-12-08 00:00:00
abstract:BACKGROUND:Several malaria vaccines are currently in clinical trials and are expected to provide an improved strategy for malaria control. Prior to introduction of a new vaccine, policymakers must consider the socio cultural environment of the region to ensure widespread community approval. This study investigated the ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-172
更新日期:2014-05-05 00:00:00
abstract:BACKGROUND:The United Nation's sustainable development goal for 2030 is to eradicate the global malaria epidemic, primarily as the disease continues to be one of the major concerns for public health in sub-Saharan Africa. In 2015, the region accounted for 90% of malaria deaths. Mozambique recorded a malaria mortality r...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1866-0
更新日期:2017-05-22 00:00:00
abstract:BACKGROUND:Malaria is a major public health issue in Burundi in terms of both morbidity and mortality, with around 2.5 million clinical cases and more than 15,000 deaths each year. It is still the single main cause of mortality in pregnant women and children below five years of age. Because of the severe health and eco...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-234
更新日期:2011-08-11 00:00:00
abstract:BACKGROUND:In Uganda, treatment of clinical malaria and intermittent preventive treatment with sulphadoxine-pyrimethamine (SP) are common during pregnancy. As a result, both formal and informal reports from antenatal sources suggest possible misuse of SP for malaria treatment among pregnant women. The objective of this...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0702-7
更新日期:2015-05-03 00:00:00
abstract:BACKGROUND:Increases in the coverage of long-lasting insecticidal nets (LLINs) have significantly reduced the abundance of Anopheles gambiae sensu stricto in several African settings, leaving its more zoophagic sibling species Anopheles arabiensis as the primary vector. This study investigated the impact of livestock o...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-014-0536-8
更新日期:2015-01-21 00:00:00
abstract::This opinion article deals with the diagnostic clinical challenges faced by clinicians or health care workers in malaria-endemic areas when a severely sick child presents to the clinic with fever, coma or respiratory distress. Indeed, the coexistence of malaria with other severe infections like meningitis, invasive ba...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2533-9
更新日期:2018-10-22 00:00:00