Abstract:
BACKGROUND:Increases in the coverage of long-lasting insecticidal nets (LLINs) have significantly reduced the abundance of Anopheles gambiae sensu stricto in several African settings, leaving its more zoophagic sibling species Anopheles arabiensis as the primary vector. This study investigated the impact of livestock ownership at the household level on the ecology and malaria infection rate of vectors in an area of Tanzania where An. arabiensis accounts for most malaria transmission. METHODS:Mosquito vectors were collected resting inside houses, animal sheds and in outdoor resting boxes at households with and without livestock over three years in ten villages of the Kilombero Valley, Tanzania. Additionally, the abundance and sporozoite rate of vectors attempting to bite indoors at these households was assessed as an index of malaria exposure. RESULTS:The mean abundance of An. gambiae s.l. biting indoors was similar at houses with and without livestock. In all years but one, the relative proportion of An. arabiensis within the An. gambiae s.l. species complex was higher at households with livestock. Livestock presence had a significant impact on malaria vector feeding and resting behaviour. Anopheles arabiensis were generally found resting in cattle sheds where livestock were present, and inside houses when absent. Correspondingly, the human blood index of An. arabiensis and An. funestus s.l. was significant reduced at households with livestock, whereas that of An. gambiae s.s. was unaffected. Whilst there was some evidence that sporozoite rates within the indoor-biting An. gambiae s.l population was significantly reduced at households with livestock, the significance of this effect varied depending on how background spatial variation was accounted for. CONCLUSIONS:These results confirm that the presence of cattle at the household level can significantly alter the local species composition, feeding and resting behaviour of malaria vectors. However, the net impact of this livestock-associated variation in mosquito ecology on malaria exposure risk was unclear. Further investigation is required to distinguish whether the apparently lower sporozoite rates observed in An. gambiae s.l. at households with livestock is really a direct effect of cattle presence, or an indirect consequence of reduced risk within areas where livestock keepers choose to live.
journal_name
Malar Jjournal_title
Malaria journalauthors
Mayagaya VS,Nkwengulila G,Lyimo IN,Kihonda J,Mtambala H,Ngonyani H,Russell TL,Ferguson HMdoi
10.1186/s12936-014-0536-8subject
Has Abstractpub_date
2015-01-21 00:00:00pages
17issn
1475-2875pii
s12936-014-0536-8journal_volume
14pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:In Vietnam, malaria transmission has been reduced to very low levels over the past 20 years, and as a consequence, the country aims to eliminate malaria by 2030. This study aimed to characterize the dynamics and extent of the parasite reservoir in Central Vietnam, in order to further target elimination strat...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2326-1
更新日期:2018-04-27 00:00:00
abstract:BACKGROUND:Donor financing for malaria has declined since 2010 and this trend is projected to continue for the foreseeable future. These reductions have a significant impact on lower burden countries actively pursuing elimination, which are usually a lesser priority for donors. While domestic spending on malaria has be...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1890-0
更新日期:2017-07-14 00:00:00
abstract:BACKGROUND:Artemisinin-based combination therapy (ACT) has been adopted by the World Health Organization as a first-line treatment for uncomplicated Plasmodium falciparum malaria. In endemic regions, it has proven more effective in treating the disease, and even in reducing its transmission. Nonetheless, there is a sca...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1408-1
更新日期:2016-07-02 00:00:00
abstract:BACKGROUND:Anti-malarial drugs are an important tool for malaria control and elimination. Alongside their direct benefit in the treatment of disease, drug use has a community-level effect, clearing the reservoir of infection and reducing onward transmission of the parasite. Different compounds potentially have differen...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1988-4
更新日期:2017-08-16 00:00:00
abstract:BACKGROUND:The WHO has reported that RDT and microscopy-confirmed malaria cases have declined in recent years. However, it is still unclear if this reflects a real decrease in incidence in Bangladesh, as particularly the hilly and forested areas of the Chittagong Hill Tract (CHT) Districts report more than 80% of all c...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-16
更新日期:2014-01-09 00:00:00
abstract:BACKGROUND:With less than one severe case per year in average, Plasmodium vivax is very rarely associated with severe imported malaria in France. Two cases of P. vivax severe malaria occurred in patients with no evident co-morbidity. Interestingly, both cases did not occur at the primary infection but during relapses. ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-3067-5
更新日期:2019-12-16 00:00:00
abstract:BACKGROUND:Primaquine is effective against the latent liver stage of Plasmodium vivax. Eliminating the latent liver stage of P. vivax is one of the necessary conditions to achieve the goal of malaria elimination in Lao People's Democratic Republic (PDR) by 2030. However, people with glucose-6-phosphate dehydrogenase (G...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2715-0
更新日期:2019-03-12 00:00:00
abstract::India has committed to eliminate malaria by 2030. The national framework for malaria elimination released by the Government of India plans to achieve this goal through strategic planning in a phased manner. Since vector control is a major component of disease management and vector elimination, it requires a thorough u...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/s12936-019-3011-8
更新日期:2019-12-03 00:00:00
abstract:BACKGROUND:Severe malarial anaemia requiring blood transfusion is a life-threatening condition affecting millions of children in sub-Saharan Africa. Up to 40% of children with severe malarial anaemia have associated lactic acidosis. Lactic acidosis in these children is strongly associated with fatal outcomes and is cor...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-12-55
更新日期:2013-02-06 00:00:00
abstract:BACKGROUND:Global efforts to address the burden of malaria have stagnated in recent years with malaria cases beginning to rise. Substandard and falsified anti-malarial treatments contribute to this stagnation. Poor quality anti-malarials directly affect health outcomes by increasing malaria morbidity and mortality, as ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2628-3
更新日期:2019-01-09 00:00:00
abstract:BACKGROUND:Malaria remains a worldwide public health concern and, in Colombia, despite the efforts to stop malaria transmission, the incidence of cases has increased over the last few years. In this context, it is necessary to evaluate vector diversity, infection rates, and spatial distribution, to better understand di...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-2076-5
更新日期:2017-10-27 00:00:00
abstract:BACKGROUND:In areas where non-falciparum malaria is common rapid diagnostic tests (RDTs) capable of distinguishing malaria species reliably are needed. Such tests are often based on the detection of parasite lactate dehydrogenase (pLDH). METHODS:In Dawei, southern Myanmar, three pLDH based RDTs (CareStart Malaria pLDH...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-241
更新日期:2009-10-27 00:00:00
abstract:BACKGROUND:Understanding spatio-temporal variation in malaria incidence provides a basis for effective disease control planning and monitoring. METHODS:Monthly surveillance data between 1991 and 2006 for Plasmodium vivax and Plasmodium falciparum malaria across 128 counties were assembled for Yunnan, a province of Chi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-180
更新日期:2009-07-31 00:00:00
abstract:BACKGROUND:Avian malaria vector competence studies are needed to understand more succinctly complex avian parasite-vector-relations. The lack of vector competence trials may be attributed to the difficulty of obtaining gametocytes for the majority of Plasmodium species and lineages. To conduct avian malaria infectivity...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1198-5
更新日期:2016-03-11 00:00:00
abstract:BACKGROUND:There remains a need for techniques that improve the sensitive detection of viable Plasmodium falciparum as part of diagnosis and therapeutic monitoring in clinical studies and usual-care management of malaria infections. A non-invasive breath test based on P. falciparum-associated specific volatile organic ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-314
更新日期:2012-09-07 00:00:00
abstract:BACKGROUND:Although chemoprophylaxis remains an important strategy for preventing malaria in travellers, its effectiveness may be compromised by lack of adherence. Inappropriate use of chemoprophylaxis is likely to increase the risk of acquiring malaria, but may probably also worsen the severity of imported cases. The ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-265
更新日期:2013-07-31 00:00:00
abstract:BACKGROUND:There is an urgent need for an effective vaccine to control and eradicate malaria, one of the most serious global infectious diseases. Plasmodium merozoite surface protein 4 (MSP4) has been listed as a blood-stage subunit vaccine candidate for malaria. Infection with Plasmodium ovale species including P. ova...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03207-7
更新日期:2020-03-30 00:00:00
abstract:BACKGROUND:Kohat district is one of the medium intensity malaria transmission areas in Pakistan where asymptomatic carriers are likely to form a reservoir of infection. This study was done to explore the possibility of using microscopy, rapid diagnostic testing (RDT), real time polymerase chain reaction (RT-PCR) and RT...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2191-y
更新日期:2018-01-22 00:00:00
abstract:BACKGROUND:Major investments have been made since 2001, with intensification of malaria control interventions after 2006. Interventions included free distribution of insecticide-treated nets (ITN) to pregnant women and children under 5 years old, the introduction of artemisinin combination therapy (ACT) for malaria tre...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2573-1
更新日期:2018-11-14 00:00:00
abstract:BACKGROUND:Community distribution of anti-malarials and antibiotics has been recommended as a strategy to reduce the under-five mortality due to febrile illnesses in sub-Saharan Africa. However, drugs distributed in these interventions have been considered weak by some caretakers and utilization of community medicine d...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-131
更新日期:2009-06-12 00:00:00
abstract:BACKGROUND:The ACT recommended by WHO is very effective and well-tolerated. However, these combinations need to be administered for three days, which may limit adherence to treatment.The combination of dihydroartemisinin-piperaquine phosphate-trimethoprim (Artecom®, Odypharm Ltd), which involves treatment over two days...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-10-185
更新日期:2011-07-08 00:00:00
abstract:BACKGROUND:The efficient allocation of financial resources for malaria control and the optimal distribution of appropriate interventions require accurate information on the geographic distribution of malaria risk and of the human populations it affects. Low population densities in rural areas and high population densit...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-218
更新日期:2008-10-27 00:00:00
abstract::The general paradigm that emerges from the analysis of the transcriptome of the malaria parasite Plasmodium falciparum is that the expression clusters of genes that code for enzymes engaged in the same cellular function is coordinated. Here the consistency of this perception is examined by analysing specific pathways ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-4-17
更新日期:2005-03-18 00:00:00
abstract:BACKGROUND:Molecular tools are very sensitive and specific and could be an alternative for the diagnosis of malaria. The complexity and need for expensive equipment may hamper implementation and, therefore, simplifications to current protocols are warranted. METHODS:A PCR detecting the different Plasmodium species and...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-279
更新日期:2012-08-17 00:00:00
abstract:BACKGROUND:In Uganda, over half of under-five child mortality is attributed to three infectious diseases: malaria, pneumonia and diarrhoea. Integrated community case management (iCCM) trains village health workers (VHWs) to provide in-home diagnosis and treatment of these common childhood illnesses. For severely ill ch...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1300-z
更新日期:2016-04-29 00:00:00
abstract:BACKGROUND:Kenya recently changed its antimalarial drug policy to a specific artemisinin-based combination therapy (ACT), artemether-lumefantrine (AL). New national guidelines on the diagnosis, treatment and prevention were developed and disseminated to health workers together with in-service training. METHODS:Between...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/1475-2875-7-29
更新日期:2008-02-05 00:00:00
abstract:BACKGROUND:Malaria transmission is strongly determined by the environmental temperature and the environment is rarely constant. Therefore, mosquitoes and parasites are not only exposed to the mean temperature, but also to daily temperature variation. Recently, both theoretical and laboratory work has shown, in addition...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-192
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:In insects, including Anopheles mosquitoes, Dscam (Down syndrome cell adhesion molecule) appears to be involved in phagocytosis of pathogens, and shows pathogen-specific splice-form expression between divergent pathogen (or parasite) types (e.g. between bacteria and Plasmodium or between Plasmodium berghei a...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-156
更新日期:2011-06-08 00:00:00
abstract:BACKGROUND:Surprisingly little is known about the geographical overlap between malaria and other tropical diseases, including helminth infections. This is despite the potential public health importance of co-infection and synergistic opportunities for control. METHODS:Statistical models are presented that predict the ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-5-99
更新日期:2006-11-03 00:00:00
abstract:BACKGROUND:In the context of malaria elimination/eradication, drugs that are effective against the different developmental stages of the parasite are highly desirable. The oldest synthetic anti-malarial drug, the thiazine dye methylene blue (MB), is known for its activity against Plasmodium blood stages, including game...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2300-y
更新日期:2018-04-03 00:00:00