Why don't health workers prescribe ACT? A qualitative study of factors affecting the prescription of artemether-lumefantrine.

Abstract:

BACKGROUND:Kenya recently changed its antimalarial drug policy to a specific artemisinin-based combination therapy (ACT), artemether-lumefantrine (AL). New national guidelines on the diagnosis, treatment and prevention were developed and disseminated to health workers together with in-service training. METHODS:Between January and March 2007, 36 in-depth interviews were conducted in five rural districts with health workers who attended in-service training and were non-adherent to the new guidelines. A further 20 interviews were undertaken with training facilitators and members of District Health Management Teams (DHMTs) to explore reasons underlying health workers' non-adherence. RESULTS:Health workers generally perceived AL as being tolerable and efficacious as compared to amodiaquine and sulphadoxine-pyremethamine. However, a number of key reasons for non-adherence were identified. Insufficient supply of AL was a major issue and hence fears of stock outs and concern about AL costs was an impediment to AL prescription. Training messages that contradicted the recommended guidelines also led to health worker non-adherence, compounded by a lack of follow-up supervision. In addition, the availability of non-recommended antimalarials such as amodiaquine caused prescription confusion. Some health workers and DHMT members maintained that shortage of staff had resulted in increased patient caseload affecting the delivery of the desirable quality of care and adherence to guidelines. CONCLUSION:The introduction of free efficacious ACTs in the public health sector in Kenya and other countries has major potential public health benefits for Africa. These may not be realized if provider prescription practices do not conform to the recommended treatment guidelines. It is essential that high quality training, drug supply and supervision work synergistically to ensure appropriate case management.

journal_name

Malar J

journal_title

Malaria journal

authors

Wasunna B,Zurovac D,Goodman CA,Snow RW

doi

10.1186/1475-2875-7-29

subject

Has Abstract

pub_date

2008-02-05 00:00:00

pages

29

issn

1475-2875

pii

1475-2875-7-29

journal_volume

7

pub_type

杂志文章,多中心研究
  • Is there malaria transmission in urban settings in Colombia?

    abstract:BACKGROUND:Colombia contributes a significant proportion of malaria cases in the Americas, which are predominantly rural. However, in the last 8 years ~ 10 % of the endemic municipalities have also reported urban and peri-urban malaria cases, a growing concern for health authorities. This study focused on the character...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-015-0956-0

    authors: Padilla JC,Chaparro PE,Molina K,Arevalo-Herrera M,Herrera S

    更新日期:2015-11-14 00:00:00

  • Field study site selection, species abundance and monthly distribution of anopheline mosquitoes in the northern Kruger National Park, South Africa.

    abstract:BACKGROUND:Knowledge of the ecology and behaviour of a target species is a prerequisite for the successful development of any vector control strategy. Before the implementation of any strategy it is essential to have comprehensive information on the bionomics of species in the targeted area. The aims of this study were...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-13-27

    authors: Munhenga G,Brooke BD,Spillings B,Essop L,Hunt RH,Midzi S,Govender D,Braack L,Koekemoer LL

    更新日期:2014-01-24 00:00:00

  • Knowledge, attitudes, and practices regarding malaria control among the slash and burn cultivators in Rangamati Hill tracts of Bangladesh.

    abstract:BACKGROUND:Slash and burn cultivators are a significant risk group for malaria in South-East Asia. As envisaged in the National Strategic Plan for Malaria Elimination, Bangladesh aims to achieve zero indigenous malaria transmission by 2030. For the national plan to move from malaria control to malaria elimination, targ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-019-2849-0

    authors: Saha A,Sarker M,Kabir M,Lu G,Müller O

    更新日期:2019-06-25 00:00:00

  • Transcript and protein expression profile of PF11_0394, a Plasmodium falciparum protein expressed in salivary gland sporozoites.

    abstract:BACKGROUND:Plasmodium falciparum malaria is a significant problem around the world today, thus there is still a need for new control methods to be developed. Because the sporozoite displays dual infectivity for both the mosquito salivary glands and vertebrate host tissue, it is a good target for vaccine development. M...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-11-80

    authors: Schlarman MS,Roberts RN,Kariuki MM,LaCrue AN,Ou R,Beerntsen BT

    更新日期:2012-03-23 00:00:00

  • Comparative population structure of Plasmodium malariae and Plasmodium falciparum under different transmission settings in Malawi.

    abstract:BACKGROUND:Described here is the first population genetic study of Plasmodium malariae, the causative agent of quartan malaria. Although not as deadly as Plasmodium falciparum, P. malariae is more common than previously thought, and is frequently in sympatry and co-infection with P. falciparum, making its study increas...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-10-38

    authors: Bruce MC,Macheso A,McConnachie A,Molyneux ME

    更新日期:2011-02-11 00:00:00

  • Synergism from combinations of infection-blocking malaria vaccines.

    abstract::Plasmodium falciparum infections present novel challenges for vaccine development, including parasite replication dynamics not previously encountered for viral pathogens, and enormous diversity in target antigens. These challenges are illustrated by using a mathematical model to describe the association between the pr...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-12-280

    authors: White MT,Smith DL

    更新日期:2013-08-08 00:00:00

  • Primaquine-thiazolidinones block malaria transmission and development of the liver exoerythrocytic forms.

    abstract:BACKGROUND:Primaquine is an anti-malarial used to prevent Plasmodium vivax relapses and malaria transmission. However, PQ metabolites cause haemolysis in patients deficient in the enzyme glucose-6-phosphate dehydrogenase (G6PD). Fifteen PQ-thiazolidinone derivatives, synthesized through one-post reactions from primaqui...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-017-1755-6

    authors: Aguiar AC,Figueiredo FJ,Neuenfeldt PD,Katsuragawa TH,Drawanz BB,Cunico W,Sinnis P,Zavala F,Krettli AU

    更新日期:2017-03-09 00:00:00

  • Malaria mortality characterization and the relationship between malaria mortality and climate in Chimoio, Mozambique.

    abstract:BACKGROUND:The United Nation's sustainable development goal for 2030 is to eradicate the global malaria epidemic, primarily as the disease continues to be one of the major concerns for public health in sub-Saharan Africa. In 2015, the region accounted for 90% of malaria deaths. Mozambique recorded a malaria mortality r...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-017-1866-0

    authors: Ferrão JL,Mendes JM,Painho M,Zacarias S

    更新日期:2017-05-22 00:00:00

  • Quantifying late-stage host-seeking behaviour of Anopheles gambiae at the insecticidal net interface using a baited-box bioassay.

    abstract:BACKGROUND:Insecticide-treated nets (ITNs) are losing efficacy against pyrethroid-resistant malaria vector populations throughout Africa. Safeguarding bed net efficacy, vital for effective malaria control, requires greater knowledge of mosquito-ITN interactions and how this impacts on the mosquito. METHODS:A purpose-b...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-020-03213-9

    authors: Hughes A,Foster GM,Guy A,Matope A,Abe M,Towers D,McCall PJ

    更新日期:2020-04-07 00:00:00

  • Improving ability to identify malaria and correctly use chloroquine in children at household level in Nakonde District, Northern Province of Zambia.

    abstract::BACKGROUND: This study investigated causes of malaria and how cases were managed at household level, in order to improve the ability to identify malaria and ensure correct use of chloroquine. It was conducted in Nakonde District, Northern Province of Zambia, between 2000 and 2001. Nakonde district is in a hyperendemic...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-2-43

    authors: Kaona FA,Tuba M

    更新日期:2003-11-19 00:00:00

  • A novel in vitro model reveals distinctive modulatory roles of Plasmodium falciparum and Plasmodium vivax on naïve cell-mediated immunity.

    abstract:BACKGROUND:To date, human peripheral blood mononuclear cells (PBMCs) have been used mainly in immune stimulation assays and the interpretation of data can be influenced by the previous immunological history of donors and cross reactivity with other infectious agents. Resolving these limitations requires an alternative ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-017-1781-4

    authors: Chitsanoor S,Somsri S,Panburana P,Mungthin M,Ubalee R,Emyeam M,Jongwutiwes S,Sattabongkot J,Udomsangpetch R

    更新日期:2017-03-27 00:00:00

  • 'Some anti-malarials are too strong for your body, they will harm you.' Socio-cultural factors influencing pregnant women's adherence to anti-malarial treatment in rural Gambia.

    abstract:BACKGROUND:Despite declining prevalence of malaria in The Gambia, non-adherence to anti-malarial treatment still remains a challenge to control efforts. There is limited evidence on the socio-cultural factors that influence adherence to anti-malarial treatment in pregnancy. This study explored perceptions of malaria in...

    journal_title:Malaria journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/s12936-016-1255-0

    authors: Jaiteh F,Dierickx S,Gryseels C,O'Neill S,D'Alessandro U,Scott S,Balen J,Grietens KP

    更新日期:2016-04-11 00:00:00

  • Addition of histamine to subcutaneously injected Plasmodium berghei sporozoites increases the parasite liver load and could facilitate whole-parasite vaccination.

    abstract:BACKGROUND:Whole-parasite immunization remains the benchmark in malaria vaccine development. A major bottleneck in the translation of whole-parasite immunization towards routine vaccination is the mode of administration, since high degrees of protection are currently only achieved by intravenous, and not by intradermal...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-015-0552-3

    authors: Pfeil J,Heine JF,Mueller AK

    更新日期:2015-01-28 00:00:00

  • Mass drug administration can be a valuable addition to the malaria elimination toolbox.

    abstract::The Global Technical Strategy 2016-2030 of the World Health Organization (WHO) has the ambitious goal of malaria being eliminated from at least 35 countries by 2030. However, in areas with once-stable malaria transmission, the reservoir of human infection may be intermittently symptomatic or fully silent yet still lea...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-019-2906-8

    authors: Eisele TP

    更新日期:2019-08-22 00:00:00

  • Malaria risk in young male travellers but local transmission persists: a case-control study in low transmission Namibia.

    abstract:BACKGROUND:A key component of malaria elimination campaigns is the identification and targeting of high risk populations. To characterize high risk populations in north central Namibia, a prospective health facility-based case-control study was conducted from December 2012-July 2014. Cases (n = 107) were all patients p...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-017-1719-x

    authors: Smith JL,Auala J,Haindongo E,Uusiku P,Gosling R,Kleinschmidt I,Mumbengegwi D,Sturrock HJ

    更新日期:2017-02-10 00:00:00

  • Institutional evolution of a community-based programme for malaria control through larval source management in Dar es Salaam, United Republic of Tanzania.

    abstract:BACKGROUND:Community-based service delivery is vital to the effectiveness, affordability and sustainability of vector control generally, and to labour-intensive larval source management (LSM) programmes in particular. CASE DESCRIPTION:The institutional evolution of a city-level, community-based LSM programme over 14 y...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-13-245

    authors: Chaki PP,Kannady K,Mtasiwa D,Tanner M,Mshinda H,Kelly AH,Killeen GF

    更新日期:2014-06-25 00:00:00

  • Mass testing and treatment for malaria in low transmission areas in Amhara Region, Ethiopia.

    abstract:BACKGROUND:In areas with ongoing malaria transmission, strategies to clear parasites from populations can reduce infection and transmission. The objective of this paper was to describe a malaria mass testing and treatment (MTAT) intervention implemented in six kebeles (villages) in Amhara Region, Ethiopia, at the begin...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-016-1333-3

    authors: Scott CA,Yeshiwondim AK,Serda B,Guinovart C,Tesfay BH,Agmas A,Zeleke MT,Guesses GS,Ayenew AL,Workie WM,Steketee RW,Earle D,Bezabih B,Getachew A

    更新日期:2016-06-02 00:00:00

  • Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy.

    abstract:BACKGROUND:With the introduction of artemisinin-based combination therapy (ACT) in 2005, monitoring of anti-malarial drug efficacy, which includes the use of molecular tools to detect known genetic markers of parasite resistance, is important for first-hand information on the changes in parasite susceptibility to drugs...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-12-377

    authors: Duah NO,Matrevi SA,de Souza DK,Binnah DD,Tamakloe MM,Opoku VS,Onwona CO,Narh CA,Quashie NB,Abuaku B,Duplessis C,Kronmann KC,Koram KA

    更新日期:2013-10-30 00:00:00

  • High-throughput sorting of mosquito larvae for laboratory studies and for future vector control interventions.

    abstract:BACKGROUND:Mosquito transgenesis offers new promises for the genetic control of vector-borne infectious diseases such as malaria and dengue fever. Genetic control strategies require the release of large number of male mosquitoes into field populations, whether they are based on the use of sterile males (sterile insect ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-11-302

    authors: Marois E,Scali C,Soichot J,Kappler C,Levashina EA,Catteruccia F

    更新日期:2012-08-28 00:00:00

  • Screening and hit evaluation of a chemical library against blood-stage Plasmodium falciparum.

    abstract:BACKGROUND:In view of the need to continuously feed the pipeline with new anti-malarial agents adapted to differentiated and more stringent target product profiles (e.g., new modes of action, transmission-blocking activity or long-duration chemo-protection), a chemical library consisting of more than 250,000 compounds ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-13-190

    authors: Avery VM,Bashyam S,Burrows JN,Duffy S,Papadatos G,Puthukkuti S,Sambandan Y,Singh S,Spangenberg T,Waterson D,Willis P

    更新日期:2014-05-27 00:00:00

  • Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China.

    abstract:BACKGROUND:Recent progress in malaria control has caused renewed interest in mass drug administration (MDA) as a potential elimination strategy but the evidence base is limited. China has extensive experience with MDA, but it is not well documented. METHODS:An ecological study was conducted to describe the use of MDA ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-12-383

    authors: Hsiang MS,Hwang J,Tao AR,Liu Y,Bennett A,Shanks GD,Cao J,Kachur SP,Feachem RG,Gosling RD,Gao Q

    更新日期:2013-11-01 00:00:00

  • Avian Plasmodium in Eastern Austrian mosquitoes.

    abstract:BACKGROUND:Insect vectors, namely mosquitoes (Diptera: Culicidae), are compulsory for malaria parasites (Plasmodium spp.) to complete their life cycle. Despite this, little is known about vector competence of different mosquito species for the transmission of avian malaria parasites. METHODS:In this study, nested PCR ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-017-2035-1

    authors: Schoener E,Uebleis SS,Butter J,Nawratil M,Cuk C,Flechl E,Kothmayer M,Obwaller AG,Zechmeister T,Rubel F,Lebl K,Zittra C,Fuehrer HP

    更新日期:2017-09-29 00:00:00

  • Molecular surveillance of the Pfmdr1 N86Y allele among Congolese pregnant women with asymptomatic malaria.

    abstract:BACKGROUND:Malaria in pregnancy is associated with considerable morbidity and mortality. Regular surveillance of artemisinin-based combination therapy tolerance, or molecular makers of resistance, is vital for effective malaria treatment, control and eradication programmes. Plasmodium falciparum multiple drug resistanc...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-020-03246-0

    authors: Dossou-Yovo LR,Ntoumi F,Koukouikila-Koussounda F,Vouvoungui JC,Adedoja A,Nderu D,Velavan TP,Lenga A

    更新日期:2020-05-08 00:00:00

  • Assessment of pfcrt 72-76 haplotypes eight years after chloroquine withdrawal in Kinshasa, Democratic Republic of Congo.

    abstract:BACKGROUND:In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chlo...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-12-459

    authors: Mvumbi DM,Boreux R,Sacheli R,Lelo M,Lengu B,Nani-Tuma S,Melin P,Ntumba K,Lunganza K,DeMol P,Hayette MP

    更新日期:2013-12-20 00:00:00

  • Five years of malaria control in the continental region, Equatorial Guinea.

    abstract:BACKGROUND:A successful malaria control programme began in 2004 on Bioko Island, Equatorial Guinea. From 2007, the same multiple malaria interventions, though reduced in scope for funding reasons, were introduced to the four mainland provinces of Equatorial Guinea (the continental region) aiming to recreate Bioko's suc...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-12-154

    authors: Rehman AM,Mann AG,Schwabe C,Reddy MR,Roncon Gomes I,Slotman MA,Yellott L,Matias A,Caccone A,Nseng Nchama G,Kleinschmidt I

    更新日期:2013-05-07 00:00:00

  • Investigating portable fluorescent microscopy (CyScope) as an alternative rapid diagnostic test for malaria in children and women of child-bearing age.

    abstract:BACKGROUND:Prompt and correct diagnosis of malaria is crucial for accurate epidemiological assessment and better case management, and while the gold standard of light microscopy is often available, it requires both expertise and time. Portable fluorescent microscopy using the CyScope offers a potentially quicker, easie...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-9-245

    authors: Sousa-Figueiredo JC,Oguttu D,Adriko M,Besigye F,Nankasi A,Arinaitwe M,Namukuta A,Betson M,Kabatereine NB,Stothard JR

    更新日期:2010-08-27 00:00:00

  • Detection of a substantial number of sub-microscopic Plasmodium falciparum infections by polymerase chain reaction: a potential threat to malaria control and diagnosis in Ethiopia.

    abstract:BACKGROUND:Prompt and effective malaria diagnosis not only alleviates individual suffering, but also decreases malaria transmission at the community level. The commonly used diagnostic methods, microscopy and rapid diagnostic tests, are usually insensitive at very low-density parasitaemia. Molecular techniques, on the ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-12-352

    authors: Golassa L,Enweji N,Erko B,Aseffa A,Swedberg G

    更新日期:2013-10-03 00:00:00

  • The challenge to avoid anti-malarial medicine stock-outs in an era of funding partners: the case of Tanzania.

    abstract:BACKGROUND:Between 2007 and 2013, the Tanzanian public sector received 93.1 million doses of first-line anti-malarial artemisinin-based combination therapy (ACT) in the form of artemether-lumefantrine entirely supplied by funding partners. The introduction of a health facility ACT stock monitoring system using SMS tech...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/1475-2875-13-181

    authors: Mikkelsen-Lopez I,Shango W,Barrington J,Ziegler R,Smith T,deSavigny D

    更新日期:2014-05-11 00:00:00

  • Polymorphisms in Pvkelch12 and gene amplification of Pvplasmepsin4 in Plasmodium vivax from Thailand, Lao PDR and Cambodia.

    abstract:BACKGROUND:Mutations in Pfkelch13 and Pfplasmepsin2/3 gene amplification are well-established markers for artemisinin and piperaquine resistance in Plasmodium falciparum, a widespread problem in the Greater Mekong Subregion (GMS). The Plasmodium vivax parasite population has experienced varying drug pressure dependent ...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-019-2749-3

    authors: Duanguppama J,Mathema VB,Tripura R,Day NPJ,Maxay M,Nguon C,von Seidlein L,Dhorda M,Peto TJ,Nosten F,White NJ,Dondorp AM,Imwong M

    更新日期:2019-04-02 00:00:00

  • New endoperoxides highly active in vivo and in vitro against artemisinin-resistant Plasmodium falciparum.

    abstract:BACKGROUND:The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. METHODS:A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screened for in vitro and i...

    journal_title:Malaria journal

    pub_type: 杂志文章

    doi:10.1186/s12936-018-2281-x

    authors: Lobo L,Cabral LIL,Sena MI,Guerreiro B,Rodrigues AS,de Andrade-Neto VF,Cristiano MLS,Nogueira F

    更新日期:2018-04-03 00:00:00