Molecular surveillance of the Pfmdr1 N86Y allele among Congolese pregnant women with asymptomatic malaria.

abstract：BACKGROUND:Saglin, a 100 kDa protein composed of two 50 kDa homodimers, is present in the salivary glands of Anopheles gambiae and has been considered an essential receptor for sporozoites (SPZ) of Plasmodium berghei and Plasmodium falciparum (Pf), allowing SPZ to recognize, bind to, and infect mosquito salivary glands...

journal_title：Malaria journal

authors： O'Brochta DA,Alford R,Harrell R,Aluvihare C,Eappen AG,Li T,Chakravarty S,Sim BKL,Hoffman SL,Billingsley PF

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated the deletion of the histidine-rich protein 2 (PfHRP2) gene (pfhrp2) in field isolates of Plasmodium falciparum, which could result in false negative test results when PfHRP2-based rapid diagnostic tests (RDTs) are used for malaria diagnosis. Although primary diagnosis of mala...

journal_title：Malaria journal

authors： Abdallah JF,Okoth SA,Fontecha GA,Torres RE,Banegas EI,Matute ML,Bucheli ST,Goldman IF,de Oliveira AM,Barnwell JW,Udhayakumar V

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:The counterfeiting of anti-malarials represents a form of attack on global public health in which fake and substandard anti-malarials serve as de facto weapons of mass destruction, particularly in resource-constrained endemic settings, where malaria causes nearly 660,000 preventable deaths and threatens mill...

journal_title：Malaria journal

authors： Karunamoorthi K

更新日期：2014-06-02 00:00:00

abstract：BACKGROUND:Most rapid diagnostic tests (RDTs) currently used for malaria diagnosis cannot distinguish the various Plasmodium infections. The development of a Plasmodium vivax specific RDTs with high sensitivity to sufficiently differentiate the two most common Plasmodium infections would be very crucial for disease tre...

journal_title：Malaria journal

authors： Dzakah EE,Kang K,Ni C,Wang H,Wu P,Tang S,Wang J,Wang J,Wang X

更新日期：2013-06-12 00:00:00

abstract：BACKGROUND:Successful reduction of malaria transmission to very low levels has made Isabel Province, Solomon Islands, a target for early elimination by 2014. High malaria transmission in neighbouring provinces and the potential for local asymptomatic infections to cause malaria resurgence highlights the need for sub-na...

journal_title：Malaria journal

authors： Atkinson JA,Johnson ML,Wijesinghe R,Bobogare A,Losi L,O'Sullivan M,Yamaguchi Y,Kenilorea G,Vallely A,Cheng Q,Ebringer A,Bain L,Gray K,Harris I,Whittaker M,Reid H,Clements A,Shanks D

更新日期：2012-03-30 00:00:00

abstract：BACKGROUND:Indonesia is home to a variety of malaria vectors whose specific bionomic traits remain largely uncharacterized. Species-specific behaviours, such as host feeding preferences, impact the dynamics of malaria transmission and the effectiveness of vector control interventions. METHODS:To examine species-specif...

journal_title：Malaria journal

authors： St Laurent B,Burton TA,Zubaidah S,Miller HC,Asih PB,Baharuddin A,Kosasih S,Shinta,Firman S,Hawley WA,Burkot TR,Syafruddin D,Sukowati S,Collins FH,Lobo NF

更新日期：2017-08-02 00:00:00

abstract：BACKGROUND:In a malaria-endemic area the distribution of patients is neither constant in time nor homogeneous in space. The WHO recommends the stratification of malaria risk on a fine geographical scale. In the village of Cacao in French Guiana, the study of the spatial and temporal distribution of malaria cases, durin...

journal_title：Malaria journal

authors： Basurko C,Demattei C,Han-Sze R,Grenier C,Joubert M,Nacher M,Carme B

更新日期：2013-03-11 00:00:00

abstract：BACKGROUND:Acute kidney injury (AKI) is a frequently encountered complication of imported Plasmodium falciparum infection. Markers of structural kidney damage have been found to detect AKI earlier than serum creatinine-based prediction models but have not yet been evaluated in imported malaria. This pilot study aims to...

journal_title：Malaria journal

authors： van Wolfswinkel ME,Koopmans LC,Hesselink DA,Hoorn EJ,Koelewijn R,van Hellemond JJ,van Genderen PJ

更新日期：2016-09-09 00:00:00

abstract：BACKGROUND:Azithromycin (AZM) is a macrolide antibiotic that displays an excellent safety profile even in children and pregnant women and has been shown to have anti-malarial activity against blood stage Plasmodium falciparum. This study evaluated the transmission-blocking effect of AZM using a rodent malaria model. M...

journal_title：Malaria journal

authors： Shimizu S,Osada Y,Kanazawa T,Tanaka Y,Arai M

更新日期：2010-03-10 00:00:00

abstract：:The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and...

journal_title：Malaria journal

authors： Thriemer K,Bobogare A,Ley B,Gudo CS,Alam MS,Anstey NM,Ashley E,Baird JK,Gryseels C,Jambert E,Lacerda M,Laihad F,Marfurt J,Pasaribu AP,Poespoprodjo JR,Sutanto I,Taylor WR,van den Boogaard C,Battle KE,Dysoley L,Ghim

更新日期：2018-06-20 00:00:00

abstract：BACKGROUND:The Duffy-binding protein II of Plasmodium vivax (PvDBPII) has been considered as an attractive target for vaccine-mediated immunity despite a possible highly polymorphic nature. Among seven PvDBP domains, domain II has been shown to exhibit a high rate of nonsynonymous polymorphism, which has been suggested...

journal_title：Malaria journal

authors： Gosi P,Khusmith S,Khalambaheti T,Lanar DE,Schaecher KE,Fukuda MM,Miller SR

更新日期：2008-06-26 00:00:00

abstract：BACKGROUND:Plasmodium vivax is very rarely seen in West Africa, although specific detection methods are not widely applied in the region, and it is now considered to be absent from North Africa. However, this parasite species has recently been reported to account for most malaria cases in Nouakchott, the capital of Mau...

journal_title：Malaria journal

authors： Ba H,Duffy CW,Ahouidi AD,Deh YB,Diallo MY,Tandia A,Conway DJ

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:Long-lasting insecticidal nets are an effective tool for malaria prevention, and "universal coverage" with such nets is increasingly the goal of national malaria control programmes. However, national level campaigns in several countries have run out of nets in the course of distribution, indicating a problem...

journal_title：Malaria journal

authors： Kilian A,Boulay M,Koenker H,Lynch M

更新日期：2010-11-18 00:00:00

abstract：BACKGROUND:Plasmodium vivax preferentially infects Duffy-positive reticulocytes and infections typically have few parasite-infected cells in the peripheral circulation. These features complicate detection and quantification by flow cytometry (FC) using standard nucleic acid-based staining methods. A simple antibody-bas...

journal_title：Malaria journal

authors： Roobsoong W,Maher SP,Rachaphaew N,Barnes SJ,Williamson KC,Sattabongkot J,Adams JH

更新日期：2014-02-14 00:00:00

abstract：BACKGROUND:The use of rapid diagnostic tests (RDTs) to diagnose malaria is common in sub-Saharan African laboratories, remote primary health facilities and in the community. Currently, there is a lack of reliable methods to ascertain health worker competency to accurately use RDTs in the testing and diagnosis of malari...

journal_title：Malaria journal

authors： Dorkenoo AM,Kouassi KC,Koura AK,Adams ML,Gbada K,Katawa G,Yakpa K,Charlebois R,Milgotina E,Merkel MO,Aidoo M

更新日期：2021-01-20 00:00:00

abstract：BACKGROUND:Insecticide-treated bed nets (ITN) have been shown to be efficacious in reducing malaria morbidity and mortality in many regions. Unfortunately in some areas, malaria has persisted despite the scale up of ITNs. Recent reports indicate that human behaviour and mosquito behaviour are potential threats to the e...

journal_title：Malaria journal

authors： Mangeni JN,Menya D,Obala A,Platt A,O'Meara WP

更新日期：2016-11-08 00:00:00

abstract：BACKGROUND:A recent randomized trial showed that artemisinin-naphthoquine (AN) was non-inferior to artemether-lumefantrine (AL) for falciparum malaria and superior for vivax malaria in young Papua New Guinean children. The aim of this study was to compare the cost-effectiveness of these two regimens. METHODS:An increm...

journal_title：Malaria journal

authors： Moore BR,Davis WA,Clarke PM,Robinson LJ,Laman M,Davis TME

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:The immunological mechanisms responsible for protection against malaria infection vary among Plasmodium species, host species and the developmental stage of parasite, and are poorly understood. A challenge with live parasites is the most relevant approach to testing the efficacy of experimental malaria vacci...

journal_title：Malaria journal

authors： Leitner WW,Bergmann-Leitner ES,Angov E

更新日期：2010-05-27 00:00:00

abstract：BACKGROUND:Within the context of increasing antimalarial costs and or decreasing malaria transmission, the importance of limiting antimalarial treatment to only those confirmed as having malaria parasites becomes paramount. This motivates for this assessment of the cost-effectiveness of routine use of rapid diagnostic ...

journal_title：Malaria journal

authors： Zikusooka CM,McIntyre D,Barnes KI

更新日期：2008-09-15 00:00:00

abstract：BACKGROUND:Mexico is in the malaria pre-elimination phase; therefore, continuous assessment and understanding of the social and behavioural risk factors related to exposure to malaria are necessary to achieve the overall goal. The aim of this research was to investigate socio-economic backgrounds, attitudes and practic...

journal_title：Malaria journal

authors： Mora-Ruiz M,Penilla RP,Ordóñez JG,López AD,Solis F,Torres-Estrada JL,Rodríguez AD

更新日期：2014-04-23 00:00:00

abstract：BACKGROUND:North East Kenya is an area of semi-arid terrain, prone to malaria epidemics. The distribution of long-lasting insecticidal nets (LLINs) has long been a key malaria intervention, however, for nomadic populations who live and sleep outside, in harsh climates and areas with increasing reports of exophagic beha...

journal_title：Malaria journal

authors： Gore-Langton GR,Mungai J,Alenwi N,Abagira A,Bicknell OM,Harrison R,Hassan FA,Munga S,Njoroge F,Juma E,Allan R

更新日期：2015-02-05 00:00:00

abstract：BACKGROUND:In Ghana, malaria is endemic and perennial (with significant seasonal variations in the three Northern Regions), accounting for 33 % of all deaths among children under 5 years old, with prevalence rates in children under-five ranging from 11 % in Greater Accra to 40 % in Northern Region. Ghana adopted the WH...

journal_title：Malaria journal

authors： Nonvignon J,Aryeetey GC,Issah S,Ansah P,Malm KL,Ofosu W,Tagoe T,Agyemang SA,Aikins M

更新日期：2016-07-16 00:00:00

abstract：BACKGROUND:As a result of the reintroduction of malaria in the Republic of Korea (ROK) in 1993 and the threat to military and civilian populations, the Korea Military National Defense (MND) increased emphasis on vector control in 2012 at ROK Army (ROKA) installations located near the DMZ, while decreasing chemoprophyla...

journal_title：Malaria journal

authors： Chang KS,Yoo DH,Ju YR,Lee WG,Roh JY,Kim HC,Klein TA,Shin EH

更新日期：2016-05-05 00:00:00

abstract：BACKGROUND:Malaria antibody responses measured at delivery have been associated with protection from maternal anaemia and low birth weight deliveries. Whether malarial antibodies present in the first half of pregnancy may protect from these or other poor birth outcomes is unclear. To determine whether malaria antibodie...

journal_title：Malaria journal

authors： Chandrasiri UP,Fowkes FJ,Beeson JG,Richards JS,Kamiza S,Maleta K,Ashorn P,Rogerson SJ

更新日期：2016-11-09 00:00:00

abstract：BACKGROUND:Malaria prevalence has recently declined markedly in many parts of Tanzania and other sub-Saharan African countries due to scaling-up of control interventions including more efficient treatment regimens (e.g. artemisinin-based combination therapy) and insecticide-treated bed nets. Although continued molecula...

journal_title：Malaria journal

authors： Ishengoma DS,Lwitiho S,Madebe RA,Nyagonde N,Persson O,Vestergaard LS,Bygbjerg IC,Lemnge MM,Alifrangis M

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Knowledge of the ecological differences between the molecular forms of Anopheles gambiae and their sibling species, An. arabiensis might lead to understanding their unique contribution to disease transmission and to better vector control as well as to understanding the evolutionary forces that have separated...

journal_title：Malaria journal

authors： Yaro AS,Dao A,Adamou A,Crawford JE,Ribeiro JM,Gwadz R,Traoré SF,Lehmann T

更新日期：2006-03-22 00:00:00

abstract：BACKGROUND:The massive deployment of life saving malaria interventions has not only resulted in a decline in disease burden but a change in the risk of infection and disease. The study reassesses the importance of known risk factors and reviews demographic and socio-economic determinants of malaria risk in the populati...

journal_title：Malaria journal

authors： Okebe J,Mwesigwa J,Kama EL,Ceesay SJ,Njie F,Correa S,Bojang K

更新日期：2014-08-08 00:00:00

abstract：BACKGROUND:Recently, a real-time PCR assay known as photo-induced electron transfer (PET)-PCR which relies on self-quenching primers for the detection of Plasmodium spp. and Plasmodium falciparum was described. PET-PCR assay was found to be robust, and easier to use when compared to currently available real-time PCR me...

journal_title：Malaria journal

authors： Lucchi NW,Karell MA,Journel I,Rogier E,Goldman I,Ljolje D,Huber C,Mace KE,Jean SE,Akom EE,Oscar R,Buteau J,Boncy J,Barnwell JW,Udhayakumar V

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:As the ecology of mosquito larvae can be complex there is need to develop a rational framework for undertaking larval ecological studies. Local environmental characteristics, such as altitude, climate and land use, can significantly impact on phenology and population dynamics of mosquito larvae, and indirect...

journal_title：Malaria journal

authors： Imbahale SS,Paaijmans KP,Mukabana WR,van Lammeren R,Githeko AK,Takken W

更新日期：2011-04-10 00:00:00

abstract：BACKGROUND:Between 2007 and 2013, the Tanzanian public sector received 93.1 million doses of first-line anti-malarial artemisinin-based combination therapy (ACT) in the form of artemether-lumefantrine entirely supplied by funding partners. The introduction of a health facility ACT stock monitoring system using SMS tech...

journal_title：Malaria journal

authors： Mikkelsen-Lopez I,Shango W,Barrington J,Ziegler R,Smith T,deSavigny D

更新日期：2014-05-11 00:00:00