A comparative case control study of the determinants of clinical malaria in The Gambia.

abstract：:BACKGROUND: In areas of high-level, year-round malaria transmission, morbidity and mortality due to malaria decrease after the first two to three years of life. This reduction may be related to the development of cellular immunity to specific antigens expressed in the different life-cycle stages of Plasmodium falcipar...

journal_title：Malaria journal

authors： Chelimo K,Sumba PO,Kazura JW,Ofula AV,John CC

更新日期：2003-11-05 00:00:00

abstract：BACKGROUND:The role of the liver for survival of blood-stage malaria is only poorly understood. In experimental blood-stage malaria with Plasmodium chabaudi, protective vaccination induces healing and, thus, survival of otherwise lethal infections. This model is appropriate to study the role of the liver in vaccination...

journal_title：Malaria journal

authors： Al-Quraishy S,Dkhil MA,Al-Shaebi EM,Abdel-Baki AS,Araúzo-Bravo MJ,Delic D,Wunderlich F

更新日期：2018-05-29 00:00:00

abstract：:The incidence and mortality of COVID-19, according to the World Health Organization reports, shows a noticeable difference between North America, Western Europe, and South Asia on one hand and most African countries on the other hand, especially the malaria-endemic countries. Although this observation could be attribu...

journal_title：Malaria journal

authors： Hussein MIH,Albashir AAD,Elawad OAMA,Homeida A

更新日期：2020-12-23 00:00:00

abstract：BACKGROUND:The WHO has reported that RDT and microscopy-confirmed malaria cases have declined in recent years. However, it is still unclear if this reflects a real decrease in incidence in Bangladesh, as particularly the hilly and forested areas of the Chittagong Hill Tract (CHT) Districts report more than 80% of all c...

journal_title：Malaria journal

authors： Starzengruber P,Fuehrer HP,Ley B,Thriemer K,Swoboda P,Habler VE,Jung M,Graninger W,Khan WA,Haque R,Noedl H

更新日期：2014-01-09 00:00:00

abstract：BACKGROUND:Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation. METHODS:Retrospective analysis of data collected through the Manhiça morbidity surveillance sy...

journal_title：Malaria journal

authors： Guinovart C,Bassat Q,Sigaúque B,Aide P,Sacarlal J,Nhampossa T,Bardají A,Nhacolo A,Macete E,Mandomando I,Aponte JJ,Menéndez C,Alonso PL

更新日期：2008-02-26 00:00:00

abstract：BACKGROUND:Given the risk of artemisinin resistance spreading from the Greater Mekong sub-region, prospective monitoring in sub-Saharan Africa should be expedited. Molecular biology techniques used for monitoring rely on the detection of k13 validated mutants by using PCR and Sanger sequencing approach, usually not ava...

journal_title：Malaria journal

authors： Vachot-Ganée L,Khim N,Iannello A,Legrand E,Kim S,Eam R,Khean C,Ken M,Ashley E,Tun KM,Dhorda M,Nosten F,Souleymane IM,Blein S,Pachot A,Ariey F,Kaiser K,Ménard D

更新日期：2018-04-24 00:00:00

abstract：BACKGROUND:In clinical trials of therapy for uncomplicated Plasmodium falciparum, there are usually some patients who fail treatment even in the absence of drug resistance. Treatment failures, which can be due to recrudescence or re-infection, are categorized as 'clinical' or 'parasitological' failures, the former indi...

journal_title：Malaria journal

authors： Mumtaz R,Okell LC,Challenger JD

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Malaria remains a major human health problem, with no licensed vaccine currently available. Malaria infections initiate when infectious Plasmodium sporozoites are transmitted by Anopheline mosquitoes during their blood meal. Investigations of the malaria sporozoite are, therefore, of clear medical importance...

journal_title：Malaria journal

authors： Kennedy M,Fishbaugher ME,Vaughan AM,Patrapuvich R,Boonhok R,Yimamnuaychok N,Rezakhani N,Metzger P,Ponpuak M,Sattabongkot J,Kappe SH,Hume JC,Lindner SE

更新日期：2012-12-17 00:00:00

abstract：BACKGROUND:Models of Plasmodium falciparum malaria epidemiology that provide realistic quantitative predictions of likely epidemiological outcomes of existing vector control strategies have the potential to assist in planning for the control and elimination of malaria. This work investigates the applicability of mathem...

journal_title：Malaria journal

authors： Stuckey EM,Stevenson JC,Cooke MK,Owaga C,Marube E,Oando G,Hardy D,Drakeley C,Smith TA,Cox J,Chitnis N

更新日期：2012-10-29 00:00:00

abstract：BACKGROUND:Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp. trophozoite, the stage when haemoglobin catabolism is maximal. H...

journal_title：Malaria journal

authors： Sharrock WW,Suwanarusk R,Lek-Uthai U,Edstein MD,Kosaisavee V,Travers T,Jaidee A,Sriprawat K,Price RN,Nosten F,Russell B

更新日期：2008-05-27 00:00:00

abstract：BACKGROUND:Autoregressive regression coefficients for Anopheles arabiensis aquatic habitat models are usually assessed using global error techniques and are reported as error covariance matrices. A global statistic, however, will summarize error estimates from multiple habitat locations. This makes it difficult to iden...

journal_title：Malaria journal

authors： Jacob BG,Griffith DA,Muturi EJ,Caamano EX,Githure JI,Novak RJ

更新日期：2009-09-21 00:00:00

abstract：BACKGROUND:Two major cities in West Africa, Accra, the capital of Ghana, and Lagos, the largest city of Nigeria, have significant problems with substandard pharmaceuticals. Both have actively combated the problem in recent years, particularly by screening products on the market using the Global Pharma Health Fund e.V. ...

journal_title：Malaria journal

authors： Bate R,Hess K

更新日期：2010-06-11 00:00:00

abstract：BACKGROUND:Plasmodium falciparum merozoite antigens elicit antibody responses in malaria-endemic populations, some of which are clinically protective, which is one of the reasons why merozoite antigens are the focus of malaria vaccine development efforts. Polymorphisms in several merozoite antigen-encoding genes are th...

journal_title：Malaria journal

authors： Ochola-Oyier LI,Okombo J,Wagatua N,Ochieng J,Tetteh KK,Fegan G,Bejon P,Marsh K

更新日期：2016-05-06 00:00:00

abstract：BACKGROUND:Plasmodium ovale, considered the rarest of the malaria parasites of humans, consists of two morphologically identical but genetically distinct sympatric species, Plasmodium ovale curtisi and Plasmodium ovale wallikeri. These parasites resemble morphologically to Plasmodium vivax with which they also share a ...

journal_title：Malaria journal

authors： Chavatte JM,Tan SB,Snounou G,Lin RT

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:This study was designed to evaluate the efficacy of exchange transfusion in patients with severe imported falciparum malaria. Twelve patients who met the diagnostic criteria for severe malaria were treated with exchange transfusion 14 times according to a conventional anti-malarial treatment. This study eval...

journal_title：Malaria journal

authors： Lin J,Huang X,Qin G,Zhang S,Sun W,Wang Y,Ren K,Xu J,Han X

更新日期：2018-01-16 00:00:00

abstract：BACKGROUND:Saglin, a 100 kDa protein composed of two 50 kDa homodimers, is present in the salivary glands of Anopheles gambiae and has been considered an essential receptor for sporozoites (SPZ) of Plasmodium berghei and Plasmodium falciparum (Pf), allowing SPZ to recognize, bind to, and infect mosquito salivary glands...

journal_title：Malaria journal

authors： O'Brochta DA,Alford R,Harrell R,Aluvihare C,Eappen AG,Li T,Chakravarty S,Sim BKL,Hoffman SL,Billingsley PF

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:New World vultures (Cathartiformes: Cathartidae) are obligate scavengers comprised of seven species in five genera throughout the Americas. Of these, turkey vultures (Cathartes aura) and black vultures (Coragyps atratus) are the most widespread and, although ecologically similar, have evolved differences in ...

journal_title：Malaria journal

authors： Yabsley MJ,Vanstreels RET,Martinsen ES,Wickson AG,Holland AE,Hernandez SM,Thompson AT,Perkins SL,West CJ,Bryan AL,Cleveland CA,Jolly E,Brown JD,McRuer D,Behmke S,Beasley JC

更新日期：2018-01-08 00:00:00

abstract：BACKGROUND:Anopheles nuneztovari sensu lato comprises cryptic species in northern South America, and the Brazilian populations encompass distinct genetic lineages within the Brazilian Amazon region. This study investigated, based on two molecular markers, whether these lineages might actually deserve species status. M...

journal_title：Malaria journal

authors： Scarpassa VM,Cunha-Machado AS,Saraiva JF

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Transmission of Plasmodium vivax malaria is dependent on vector availability, biting rates and parasite development. In turn, each of these is influenced by climatic conditions. Correlations have previously been detected between seasonal rainfall, temperature and malaria incidence patterns in various setting...

journal_title：Malaria journal

authors： Wardrop NA,Barnett AG,Atkinson JA,Clements AC

更新日期：2013-12-18 00:00:00

abstract：BACKGROUND:The 2016 World Health Organization (WHO) World Malaria Report documents substantial progress towards control and elimination of malaria. However, major challenges remain. In some regions of Southeast Asia, the simian parasite Plasmodium knowlesi has emerged as an important cause of human malaria, and the aut...

journal_title：Malaria journal

authors： Barber BE,Rajahram GS,Grigg MJ,William T,Anstey NM

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:Mutations in Pfkelch13 and Pfplasmepsin2/3 gene amplification are well-established markers for artemisinin and piperaquine resistance in Plasmodium falciparum, a widespread problem in the Greater Mekong Subregion (GMS). The Plasmodium vivax parasite population has experienced varying drug pressure dependent ...

journal_title：Malaria journal

authors： Duanguppama J,Mathema VB,Tripura R,Day NPJ,Maxay M,Nguon C,von Seidlein L,Dhorda M,Peto TJ,Nosten F,White NJ,Dondorp AM,Imwong M

更新日期：2019-04-02 00:00:00

abstract：:In the 2010 second edition of WHO's guidelines for the treatment of malaria, the relatively new fixed dose combination dihydroartemisinin-piperaquine is included as one of the recommended artemisinin combination therapies. However, experimental testing demonstrates that, due to its intrinsic chemical instability, dihy...

journal_title：Malaria journal

authors： Jansen FH

更新日期：2010-07-22 00:00:00

abstract：BACKGROUND:Premature death of Plasmodium-infected erythrocytes is considered to favourably influence the clinical course of malaria. Aurothiomalate has previously been shown to trigger erythrocyte death or eryptosis, which is characterized by cell membrane scrambling leading to phosphatidylserine exposure at the cell s...

journal_title：Malaria journal

authors： Alesutan I,Bobbala D,Qadri SM,Estremera A,Föller M,Lang F

更新日期：2010-05-07 00:00:00

abstract：BACKGROUND:Many malaria-related studies depend on infected red blood cells (iRBCs) as fundamental material; however, infected blood samples from human or animal models include leukocytes (white blood cells or WBCs), especially difficult to separate from iRBCs in cases involving Plasmodium vivax. These host WBCs are a s...

journal_title：Malaria journal

authors： Tao ZY,Xia H,Cao J,Gao Q

更新日期：2011-08-25 00:00:00

abstract：BACKGROUND:Larviciding is a key strategy used in many vector control programmes around the world. Costs could be reduced if larvicides could be manufactured locally. The potential of natural products as larvicides against the main African malaria vector, Anopheles gambiae s.s was evaluated. METHODS:To assess the larvi...

journal_title：Malaria journal

authors： Okumu FO,Knols BG,Fillinger U

更新日期：2007-05-22 00:00:00

abstract：BACKGROUND:Malaria is still an important parasitic infectious disease that affecting poor and vulnerable communities in many developing countries, including Indonesia. During the period of 2010-2017, there have been approximately 2.2 million confirmed malaria cases reported across Indonesia. This study aimed to identif...

journal_title：Malaria journal

authors： Dhewantara PW,Ipa M,Widawati M

更新日期：2019-04-04 00:00:00

abstract：BACKGROUND:Malaria presents a diagnostic challenge in tribal belt of central India where two Plasmodium species, Plasmodium falciparum and Plasmodium vivax, are prevalent. In these areas, rapid detection of the malaria parasites and early treatment of infection remain the most important goals of disease management. The...

journal_title：Malaria journal

authors： Bharti PK,Silawat N,Singh PP,Singh MP,Shukla M,Chand G,Dash AP,Singh N

更新日期：2008-07-11 00:00:00

abstract：BACKGROUND:This study aimed to identify factors at individual and community level influencing insecticide-treated net (ITN) usage among groups of women of childbearing age (WOCBA) in Malawi. METHODS:Factors influencing ITN usage in Malawi were assessed through interviews with 16,130 WOCBA (15-49 years) across 850 comm...

journal_title：Malaria journal

authors： Nkoka O,Chuang TW,Chuang KY,Chen YH

更新日期：2018-10-19 00:00:00

abstract：BACKGROUND:Iron deficiency is the most widespread nutrient deficiency and an important cause of developmental impairment in children. However, some studies have indicated that iron deficiency can also protect against malaria, which is a leading cause of childhood morbidity and mortality in large parts of the world. Thi...

journal_title：Malaria journal

authors： Castberg FC,Maretty L,Staalsoe T,Hempel C,Clasen-Linde E,Hviid L,Kurtzhals JAL

更新日期：2018-01-16 00:00:00

abstract：:The substantial impact of cross-border collaborative control efforts on the burden of malaria in southern Africa has previously been demonstrated through the successes of the Lubombo Spatial Development Initiative. Increases in malaria cases recorded in the three partner countries (Mozambique, South Africa, Swaziland)...

journal_title：Malaria journal

authors： Moonasar D,Maharaj R,Kunene S,Candrinho B,Saute F,Ntshalintshali N,Morris N

更新日期：2016-08-18 00:00:00