Abstract:
:In the 2010 second edition of WHO's guidelines for the treatment of malaria, the relatively new fixed dose combination dihydroartemisinin-piperaquine is included as one of the recommended artemisinin combination therapies. However, experimental testing demonstrates that, due to its intrinsic chemical instability, dihydroartemisinin is not suitable to be used in pharmaceutical formulations. In addition, data show that the currently available dihydroartemisinin preparations fail to meet the internationally accepted stability requirements. At a time when many efforts aim to ban counterfeit and substandard drugs from the malaria market, the obvious question rises how WHO and public-private partnerships, such as Medicine for Malaria venture (MMV), can support the production and marketing of anti-malarial drugs that do not even meet the International Pharmacopoeia requirements?
journal_name
Malar Jjournal_title
Malaria journalauthors
Jansen FHdoi
10.1186/1475-2875-9-212subject
Has Abstractpub_date
2010-07-22 00:00:00pages
212issn
1475-2875pii
1475-2875-9-212journal_volume
9pub_type
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