Beneficial effect of aurothiomalate on murine malaria.

abstract：BACKGROUND:Molecular tools are very sensitive and specific and could be an alternative for the diagnosis of malaria. The complexity and need for expensive equipment may hamper implementation and, therefore, simplifications to current protocols are warranted. METHODS:A PCR detecting the different Plasmodium species and...

journal_title：Malaria journal

authors： Mens PF,Moers AP,de Bes LM,Flint J,Sak JR,Keereecharoen L,van Overmeir C,Verweij JJ,Hallett RL,Wihokhoen B,Proux S,Schallig HD,van Amerongen A

更新日期：2012-08-17 00:00:00

abstract：BACKGROUND:Several malaria vaccines are currently in clinical trials and are expected to provide an improved strategy for malaria control. Prior to introduction of a new vaccine, policymakers must consider the socio cultural environment of the region to ensure widespread community approval. This study investigated the ...

journal_title：Malaria journal

authors： Ojakaa DI,Jarvis JD,Matilu MI,Thiam S

更新日期：2014-05-05 00:00:00

abstract：BACKGROUND:Prompt and effective malaria diagnosis not only alleviates individual suffering, but also decreases malaria transmission at the community level. The commonly used diagnostic methods, microscopy and rapid diagnostic tests, are usually insensitive at very low-density parasitaemia. Molecular techniques, on the ...

journal_title：Malaria journal

authors： Golassa L,Enweji N,Erko B,Aseffa A,Swedberg G

更新日期：2013-10-03 00:00:00

abstract：BACKGROUND:Conventional diagnosis of malaria has relied upon either clinical diagnosis or microscopic examination of peripheral blood smears. These methods, if not carried out exactly, easily result in the over- or under-diagnosis of malaria. The reliability and accuracy of malaria RDTs, even in extremely challenging h...

journal_title：Malaria journal

authors： Diggle E,Asgary R,Gore-Langton G,Nahashon E,Mungai J,Harrison R,Abagira A,Eves K,Grigoryan Z,Soti D,Juma E,Allan R

更新日期：2014-12-17 00:00:00

abstract：BACKGROUND:Plasmodium malariae is the most neglected of the six human malaria species and it is still unknown which is the mechanism underlying the long latency of this Plasmodium. CASE PRESENTATION:A case of PCR-confirmed P. malariae recurrence in a 52-year old Italian man was observed 5 months after a primary attack...

journal_title：Malaria journal

authors： Grande R,Antinori S,Meroni L,Menegon M,Severini C

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Extensive genetic diversity in the Plasmodium falciparum circumsporozoite protein (PfCSP) is a major contributing factor to the moderate efficacy of the RTS,S/AS01 vaccine. The transmission intensity and rates of recombination within and between populations influence the extent of its genetic diversity. Unde...

journal_title：Malaria journal

authors： Amegashie EA,Amenga-Etego L,Adobor C,Ogoti P,Mbogo K,Amambua-Ngwa A,Ghansah A

更新日期：2020-11-27 00:00:00

abstract：BACKGROUND:Malaria treatment policy recommends regular monitoring of drug utilization to generate information for ensuring effective use of anti-malarial drugs in Nigeria. This information is currently limited in the retail sector which constitutes a major source of malaria treatment in Nigeria, but are characterized b...

journal_title：Malaria journal

authors： Ezenduka CC,Ogbonna BO,Ekwunife OI,Okonta MJ,Esimone CO

更新日期：2014-06-24 00:00:00

abstract：BACKGROUND:Chloroquine has been the treatment of choice for acute vivax malaria for more than 60 years. Malaria caused by Plasmodium vivax has recently shown resistance to chloroquine in some places. This study compared the efficacy and safety of fixed dose combination (FDC) of arterolane maleate and piperaquine phosph...

journal_title：Malaria journal

authors： Valecha N,Savargaonkar D,Srivastava B,Rao BH,Tripathi SK,Gogtay N,Kochar SK,Kumar NB,Rajadhyaksha GC,Lakhani JD,Solanki BB,Jalali RK,Arora S,Roy A,Saha N,Iyer SS,Sharma P,Anvikar AR

更新日期：2016-01-27 00:00:00

abstract：BACKGROUND:The emergence of Plasmodium falciparum resistance to artemisinins threatens to undermine the effectiveness of artemisinin-based combination anti-malarial therapy. Developing suitable drugs to replace artemisinins requires the identification of new compounds that display rapid parasite killing kinetics. Howev...

journal_title：Malaria journal

authors： Linares M,Viera S,Crespo B,Franco V,Gómez-Lorenzo MG,Jiménez-Díaz MB,Angulo-Barturen Í,Sanz LM,Gamo FJ

更新日期：2015-11-05 00:00:00

abstract：BACKGROUND:Mass distribution campaigns of insecticide-treated nets for malaria prevention are usually accompanied by intensive behaviour change communication (BCC) to encourage hanging and use of nets. However, data on the effectiveness of these communication efforts are scarce. In preparation for the next round of mas...

journal_title：Malaria journal

authors： Kilian A,Lawford H,Ujuju CN,Abeku TA,Nwokolo E,Okoh F,Baba E

更新日期：2016-08-19 00:00:00

abstract：BACKGROUND:Effective surveillance systems are required to track malaria testing and treatment practices. A 26-week study "SMS for Life" was piloted in five rural districts of Kenya to examine whether SMS reported surveillance data could ensure real-time visibility of accurate data and their use by district managers to ...

journal_title：Malaria journal

authors： Githinji S,Kigen S,Memusi D,Nyandigisi A,Wamari A,Muturi A,Jagoe G,Ziegler R,Snow RW,Zurovac D

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:A reversal of chloroquine (CQ) resistance following a period of withdrawal has raised the possibility of its re-introduction. This study evaluated the current prevalence of Pfcrt and Pfmdr1 alleles in Plasmodium falciparum isolates, 11 years after CQ withdrawal in Southeast Nigeria. METHODS:Filter-paper blo...

journal_title：Malaria journal

authors： Ikegbunam MN,Nkonganyi CN,Thomas BN,Esimone CO,Velavan TP,Ojurongbe O

更新日期：2019-10-07 00:00:00

abstract：BACKGROUND:Due to the development of resistance to synthetic insecticides, adverse effects to human health, non-target organisms and the environment, there is an urgent need to develop new insecticides, which are effective, safe, biodegrable and target-specific. This study was undertaken to evaluate the adulticidal act...

journal_title：Malaria journal

authors： Mavundza EJ,Maharaj R,Chukwujekwu JC,Finnie JF,Van Staden J

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a deletion of the hrp2 gene yield false-negative RDTs and there are concerns the sensitivity of HRP2-ba...

journal_title：Malaria journal

authors： Kozycki CT,Umulisa N,Rulisa S,Mwikarago EI,Musabyimana JP,Habimana JP,Karema C,Krogstad DJ

更新日期：2017-03-20 00:00:00

abstract：BACKGROUND:A high-resolution surveillance-response system has been developed within a geographic information system (GIS) to support malaria elimination in the Pacific. This paper examines the application of a GIS-based spatial decision support system (SDSS) to automatically locate and map the distribution of confirmed...

journal_title：Malaria journal

authors： Kelly GC,Hale E,Donald W,Batarii W,Bugoro H,Nausien J,Smale J,Palmer K,Bobogare A,Taleo G,Vallely A,Tanner M,Vestergaard LS,Clements AC

更新日期：2013-03-21 00:00:00

abstract：BACKGROUND:With the increase in use of point-of-care diagnostic tests for malaria and other diseases comes the necessity of storing the diagnostic kits and the drugs required for subsequent management, in remote areas, where temperatures are high and electricity supply is unreliable or unavailable. METHODS:To address ...

journal_title：Malaria journal

authors： Chanthap L,Ariey F,Socheat D,Tsuyuoka R,Bell D

更新日期：2010-01-23 00:00:00

abstract：BACKGROUND:Malaria is a major public health problem in Uganda and the current policy recommends introduction of rapid diagnostic tests for malaria (RDTs) to facilitate effective case management. However, provision of RDTs in drug shops potentially raises a new set of issues, such as adherence to RDTs results, managemen...

journal_title：Malaria journal

authors： Mbonye AK,Clarke SE,Lal S,Chandler CI,Hutchinson E,Hansen KS,Magnussen P

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:The malaria vector Anopheles gambiae is polymorphic for chromosomal inversions on the right arm of chromosome 2 that segregate nonrandomly between assortatively mating populations in West Africa. One such inversion, 2Rj, is associated with the BAMAKO chromosomal form endemic to southern Mali and northern Gui...

journal_title：Malaria journal

authors： Coulibaly MB,Pombi M,Caputo B,Nwakanma D,Jawara M,Konate L,Dia I,Fofana A,Kern M,Simard F,Conway DJ,Petrarca V,della Torre A,Traoré S,Besansky NJ

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Plasmodium vivax preferentially infects Duffy-positive reticulocytes and infections typically have few parasite-infected cells in the peripheral circulation. These features complicate detection and quantification by flow cytometry (FC) using standard nucleic acid-based staining methods. A simple antibody-bas...

journal_title：Malaria journal

authors： Roobsoong W,Maher SP,Rachaphaew N,Barnes SJ,Williamson KC,Sattabongkot J,Adams JH

更新日期：2014-02-14 00:00:00

abstract：BACKGROUND:Helminths and malaria are among the most prevalent infectious diseases in the world. They both occur in tropical area where they often affect the same populations. There are studies suggesting an effect of helminths on malariometric indices. For example, malaria attacks as well as disease severity has been s...

journal_title：Malaria journal

authors： Ateba-Ngoa U,Adegnika AA,Zinsou JF,Kassa Kassa RF,Smits H,Massinga-Loembe M,Mordmüller B,Kremsner PG,Yazdanbakhsh M

更新日期：2015-02-25 00:00:00

abstract：BACKGROUND:Prompt, quality assured laboratory diagnosis is key to effective malaria case management and control, especially since the introduction of the more expensive artemisinin combination therapy (ACT). The malaria programme and its non-government partners, on the basis of WHO recommended Lot Quality Assurance met...

journal_title：Malaria journal

authors： Khan MA,Walley JD,Munir MA,Khan MA,Khokar NG,Tahir Z,Nazir A,Shams N

更新日期：2011-02-17 00:00:00

abstract：BACKGROUND:The diversity of genotyping markers of Plasmodium falciparum depends on transmission intensity. It has been reported that the diversity of the merozoite surface protein 2 (msp2) is greater in areas of high compared to low endemicity, however, results for msp1 were inconsistent. These previous reports relied ...

journal_title：Malaria journal

authors： Schoepflin S,Valsangiacomo F,Lin E,Kiniboro B,Mueller I,Felger I

更新日期：2009-10-30 00:00:00

abstract：BACKGROUND:Experimental vaccines targeting Plasmodium falciparum have had some success in recent years. These vaccines use attenuated parasites, recombinant sporozoite proteins, or DNA and virus combinations to induce cell-mediated immune responses and/or antibodies targeting sporozoite surface proteins. To capitalize ...

journal_title：Malaria journal

authors： Zou X,House BL,Zyzak MD,Richie TL,Gerbasi VR

更新日期：2013-11-05 00:00:00

abstract：BACKGROUND:Policy makers, governments and donors are faced with an information gap when considering ways to improve access to artemisinin-based combination therapy (ACT) and malaria diagnostics including rapid diagnostic tests (RDTs). To help address some of these gaps, a five-year multi-country research project called...

journal_title：Malaria journal

authors： Shewchuk T,O'Connell KA,Goodman C,Hanson K,Chapman S,Chavasse D

更新日期：2011-10-31 00:00:00

abstract：BACKGROUND:In order to sustain the gains achieved by current malaria control strategies, robust surveillance systems that monitor dynamics of vectors and their roles in malaria transmission over time are essential. This longitudinal study demonstrates the trends in malaria vector dynamics and their relative contributio...

journal_title：Malaria journal

authors： Lwetoijera DW,Harris C,Kiware SS,Dongus S,Devine GJ,McCall PJ,Majambere S

更新日期：2014-08-24 00:00:00

abstract：BACKGROUND:Severe anaemia can develop in the aftermath of Plasmodium falciparum malaria because of protracted bone marrow suppression, possibly due to residual subpatent parasites. MATERIALS AND METHODS:Blood was collected from patients with recent malaria and negative malaria microscopy. Detection of the Plasmodium a...

journal_title：Malaria journal

authors： Helleberg M,Goka BQ,Akanmori BD,Obeng-Adjei G,Rodriques O,Kurtzhals JA

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Malaria prevalence has recently declined markedly in many parts of Tanzania and other sub-Saharan African countries due to scaling-up of control interventions including more efficient treatment regimens (e.g. artemisinin-based combination therapy) and insecticide-treated bed nets. Although continued molecula...

journal_title：Malaria journal

authors： Ishengoma DS,Lwitiho S,Madebe RA,Nyagonde N,Persson O,Vestergaard LS,Bygbjerg IC,Lemnge MM,Alifrangis M

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Declining in clinical efficacy of artesunate-mefloquine combination has been documented in areas along the eastern border (Thai-Cambodian) of Thailand. In the present study, the clinical efficacy of the three-day combination regimen of artesunate-mefloquine as first-line treatment for acute uncomplicated fal...

journal_title：Malaria journal

authors： Na-Bangchang K,Ruengweerayut R,Mahamad P,Ruengweerayut K,Chaijaroenkul W

更新日期：2010-10-08 00:00:00

abstract：BACKGROUND:The malaria parasite disposes of host-derived ferrihaem (iron(III)protoporphyrin IX, Fe(III)PPIX) by conversion to crystalline haemozoin in close association with neutral lipids. Lipids mediate synthetic haemozoin (β-haematin) formation very efficiently. However, the effect on reaction rates of concentration...

journal_title：Malaria journal

authors： Ambele MA,Egan TJ

更新日期：2012-10-08 00:00:00

abstract：BACKGROUND:In the Republic of Korea (ROK), six sibling species of the Anopheles sinensis complex are considered the vector species of malaria, but data on their susceptibilities to malaria and vector capacities have been controversial. The intensive use of insecticides has contributed to the rapid development and sprea...

journal_title：Malaria journal

authors： Kang S,Jung J,Lee S,Hwang H,Kim W

更新日期：2012-05-03 00:00:00