Bone marrow suppression and severe anaemia associated with persistent Plasmodium falciparum infection in African children with microscopically undetectable parasitaemia.

abstract：BACKGROUND:Ethnographic studies from East Africa suggest that cerebral malaria and anaemia are not classified in local knowledge as malaria complications, but as illnesses in their own right. Cerebral malaria 'degedege' has been most researched, in spite of anaemia being a much more frequent complication in infants, an...

journal_title：Malaria journal

authors： Ringsted FM,Bygbjerg IC,Samuelsen H

更新日期：2006-11-20 00:00:00

abstract：:The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and...

journal_title：Malaria journal

authors： Thriemer K,Bobogare A,Ley B,Gudo CS,Alam MS,Anstey NM,Ashley E,Baird JK,Gryseels C,Jambert E,Lacerda M,Laihad F,Marfurt J,Pasaribu AP,Poespoprodjo JR,Sutanto I,Taylor WR,van den Boogaard C,Battle KE,Dysoley L,Ghim

更新日期：2018-06-20 00:00:00

abstract：BACKGROUND:Given the risk of artemisinin resistance spreading from the Greater Mekong sub-region, prospective monitoring in sub-Saharan Africa should be expedited. Molecular biology techniques used for monitoring rely on the detection of k13 validated mutants by using PCR and Sanger sequencing approach, usually not ava...

journal_title：Malaria journal

authors： Vachot-Ganée L,Khim N,Iannello A,Legrand E,Kim S,Eam R,Khean C,Ken M,Ashley E,Tun KM,Dhorda M,Nosten F,Souleymane IM,Blein S,Pachot A,Ariey F,Kaiser K,Ménard D

更新日期：2018-04-24 00:00:00

abstract：BACKGROUND:Anopheles arabiensis is stereotypical of diverse vectors that mediate residual malaria transmission globally, because it can feed outdoors upon humans or cattle, or enter but then rapidly exit houses without fatal exposure to insecticidal nets or sprays. METHODS:Life histories of a well-characterized An. ar...

journal_title：Malaria journal

authors： Killeen GF,Govella NJ,Lwetoijera DW,Okumu FO

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Malaria is a widespread infectious disease that threatens a large proportion of the population in tropical and subtropical areas. Given the emerging resistance against the current standard anti-malaria chemotherapeutics, the development of alternative drugs is urgently needed. New anti-malarials representing...

journal_title：Malaria journal

authors： Weidner T,Lucantoni L,Nasereddin A,Preu L,Jones PG,Dzikowski R,Avery VM,Kunick C

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:In 2017, nearly 80% of malaria morbidity and mortality occurred in sub-Saharan African (SSA) countries and India. Rapid diagnostic tests (RDTs), especially those targeting histidine-rich protein 2 (PfHRP2) of Plasmodium falciparum, have become an important diagnostic tool in these malaria-endemic areas. Howe...

journal_title：Malaria journal

authors： Kojom LP,Singh V

更新日期：2020-01-28 00:00:00

abstract：BACKGROUND:Mosquitoes of the Anopheles gambiae species complex are the primary vectors of human malaria in sub-Saharan Africa. Many host genes have been shown to affect Plasmodium development in the mosquito, and so are expected to engage in an evolutionary arms race with the pathogen. However, there is little conclusi...

journal_title：Malaria journal

authors： Obbard DJ,Welch JJ,Little TJ

更新日期：2009-06-04 00:00:00

abstract：BACKGROUND:Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited. METHODS:A retrospective, hospital-based cohort study of infants aged 1-12 months with vivax malaria was...

journal_title：Malaria journal

authors： Setyadi A,Arguni E,Kenangalem E,Hasanuddin A,Lampah DA,Thriemer K,Anstey NM,Sugiarto P,Simpson JA,Price RN,Douglas NM,Poespoprodjo JR

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:Malaria remains highly endemic in Cameroon. The rapid emergence and spread of drug resistance was responsible for the change from monotherapies to artemisinin-based combinations. This systematic review and meta-analysis aimed to determine the prevalence and distribution of Plasmodium falciparum drug resistan...

journal_title：Malaria journal

authors： Niba PTN,Nji AM,Evehe MS,Ali IM,Netongo PM,Ngwafor R,Moyeh MN,Ngum LN,Ndum OE,Acho FA,Mbu'u CM,Fosah DA,Atogho-Tiedeu B,Achonduh-Atijegbe O,Djokam-Dadjeu R,Chedjou JPK,Bigoga JD,Moukoko CEE,Ajua A,Achidi E,Tallah

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:Recently, a real-time PCR assay known as photo-induced electron transfer (PET)-PCR which relies on self-quenching primers for the detection of Plasmodium spp. and Plasmodium falciparum was described. PET-PCR assay was found to be robust, and easier to use when compared to currently available real-time PCR me...

journal_title：Malaria journal

authors： Lucchi NW,Karell MA,Journel I,Rogier E,Goldman I,Ljolje D,Huber C,Mace KE,Jean SE,Akom EE,Oscar R,Buteau J,Boncy J,Barnwell JW,Udhayakumar V

更新日期：2014-11-26 00:00:00

abstract：BACKGROUND:The use of insecticide-treated nets (ITN) is an important tool in the Roll Back Malaria (RBM) strategy. For ITNs to be effective they need to be used correctly. Previous studies have shown that many factors, such as wealth, access to health care, education, ethnicity and gender, determine the ownership and u...

journal_title：Malaria journal

authors： Toé LP,Skovmand O,Dabiré KR,Diabaté A,Diallo Y,Guiguemdé TR,Doannio JM,Akogbeto M,Baldet T,Gruénais ME

更新日期：2009-07-29 00:00:00

abstract：:The general paradigm that emerges from the analysis of the transcriptome of the malaria parasite Plasmodium falciparum is that the expression clusters of genes that code for enzymes engaged in the same cellular function is coordinated. Here the consistency of this perception is examined by analysing specific pathways ...

journal_title：Malaria journal

authors： Bozdech Z,Ginsburg H

更新日期：2005-03-18 00:00:00

abstract：BACKGROUND:The intermittent screening and treatment (IST) of school children for malaria is one possible intervention strategy that could help reduce the burden of malaria among school children. Future implementation of IST will not only depend on its efficacy and cost-effectiveness but also on its acceptability to par...

journal_title：Malaria journal

authors： Okello G,Ndegwa SN,Halliday KE,Hanson K,Brooker SJ,Jones C

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce. CASE PRESENTATION:He...

journal_title：Malaria journal

authors： Veletzky L,Groger M,Lagler H,Walochnik J,Auer H,Fuehrer HP,Ramharter M

更新日期：2018-02-09 00:00:00

abstract：BACKGROUND:Mozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in 2009. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance. The prevalence of pfmdr1 d...

journal_title：Malaria journal

authors： Lobo E,de Sousa B,Rosa S,Figueiredo P,Lobo L,Pateira S,Fernandes N,Nogueira F

更新日期：2014-08-06 00:00:00

abstract：BACKGROUND:Plasmodium falciparum circumsporozoite protein (CSP) is a leading malaria vaccine candidate antigen, known to elicit protective antibody responses in humans (RTS,S vaccine). Recently, a DNA prime / adenovirus (Ad) vector boost vaccine encoding CSP and a second P. falciparum antigen, apical membrane antigen-1...

journal_title：Malaria journal

authors： Sedegah M,Kim Y,Ganeshan H,Huang J,Belmonte M,Abot E,Banania JG,Farooq F,McGrath S,Peters B,Sette A,Soisson L,Diggs C,Doolan DL,Tamminga C,Villasante E,Hollingdale MR,Richie TL

更新日期：2013-06-05 00:00:00

abstract：BACKGROUND:The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention programmes. METHODS:A 6-month longitudinal study monitoring risk factors for anaemia and febrile malaria epis...

journal_title：Malaria journal

authors： Lusingu JP,Vestergaard LS,Mmbando BP,Drakeley CJ,Jones C,Akida J,Savaeli ZX,Kitua AY,Lemnge MM,Theander TG

更新日期：2004-07-28 00:00:00

abstract：BACKGROUND:With an Annual Parasite Incidence (API) of 132.1, in the high and moderate risks zones, the Maroni area of French Guiana has the second highest malaria incidence of South-America after Guyana (API = 183.54) and far above Brazil (API = 28.25). Malaria transmission is occurring despite strong medical assistanc...

journal_title：Malaria journal

authors： Fouque F,Gaborit P,Carinci R,Issaly J,Girod R

更新日期：2010-03-22 00:00:00

abstract：BACKGROUND:Malaria is a potentially lethal illness for which preventive measures are not optimally used among all travellers. Travellers visiting friends and relatives in their country of origin (VFRs) are known to use chemoprophylaxis less consistently compared to tourist travellers. In this study, factors explaining ...

journal_title：Malaria journal

authors： Wieten RW,Harting J,Biemond PM,Grobusch MP,van Vugt M

更新日期：2013-10-10 00:00:00

abstract：:Most human Plasmodium infections in western Kenya are asymptomatic and are believed to contribute importantly to malaria transmission. Elimination of asymptomatic infections requires active treatment approaches, such as mass testing and treatment (MTaT) or mass drug administration (MDA), as infected persons do not see...

journal_title：Malaria journal

authors： Samuels AM,Awino N,Odongo W,Abong'o B,Gimnig J,Otieno K,Shi YP,Were V,Allen DR,Were F,Sang T,Obor D,Williamson J,Hamel MJ,Patrick Kachur S,Slutsker L,Lindblade KA,Kariuki S,Desai M

更新日期：2017-06-07 00:00:00

abstract：BACKGROUND:Development of resistance to different classes of insecticides is a potential threat to malaria control. With the increasing coverage of long-lasting insecticide-treated nets in Tanzania, the continued monitoring of resistance in vector populations is crucial. It may facilitate the development of novel strat...

journal_title：Malaria journal

authors： Matowo J,Kulkarni MA,Mosha FW,Oxborough RM,Kitau JA,Tenu F,Rowland M

更新日期：2010-07-07 00:00:00

abstract：BACKGROUND:With the dramatic increase in international travel among Chinese people, the risk of malaria importation from malaria-endemic regions threatens the achievement of the malaria elimination goal of China. METHODS:Epidemiological investigations of all imported malaria cases were conducted in nine provinces of C...

journal_title：Malaria journal

authors： Li Z,Zhang Q,Zheng C,Zhou S,Sun J,Zhang Z,Geng Q,Zhang H,Wang L,Lai S,Hu W,Clements AC,Zhou XN,Yang W

更新日期：2016-03-05 00:00:00

abstract：:In the past decade, research on the functions of extracellular vesicles in malaria has expanded dramatically. Investigations into the various vesicle types, from both host and parasite origin, has revealed important roles for extracellular vesicles in disease pathogenesis and susceptibility, as well as cell-cell commu...

journal_title：Malaria journal

authors： Sampaio NG,Cheng L,Eriksson EM

更新日期：2017-06-09 00:00:00

abstract：BACKGROUND:Certain species of macaques are natural hosts of Plasmodium knowlesi and Plasmodium cynomolgi, which can both cause malaria in humans, and Plasmodium inui, which can be experimentally transmitted to humans. A significant number of zoonotic malaria cases have been reported in humans throughout Southeast Asia,...

journal_title：Malaria journal

authors： Fungfuang W,Udom C,Tongthainan D,Kadir KA,Singh B

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Anopheles arabiensis is a dominant vector of malaria in sub-Saharan Africa, which feeds indoors and outdoors on human and other vertebrate hosts, making it a difficult species to control with existing control methods. Novel methods that reduce human-vector interactions are, therefore, required to improve the...

journal_title：Malaria journal

authors： Jaleta KT,Hill SR,Birgersson G,Tekie H,Ignell R

更新日期：2016-07-21 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) is the treatment of choice for uncomplicated falciparum malaria. Artemether-lumefantrine (AL), a fixed dose co-formulation, has recently been approved for marketing in India, although it is not included in the National Drug Policy for treatment of malaria. Efficacy...

journal_title：Malaria journal

authors： Valecha N,Srivastava P,Mohanty SS,Mittra P,Sharma SK,Tyagi PK,Pradhan K,Dev V,Singh R,Dash AP,Sharma YD

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:IPTi delivered through EPI has been shown to reduce the incidence of clinical malaria by 20-59%. However, new health interventions can only be effective if they are also socially and culturally acceptable. It is also crucial to ensure that attitudes to IPTi do not negatively influence attitudes to and uptake...

journal_title：Malaria journal

authors： Gysels M,Pell C,Mathanga DP,Adongo P,Odhiambo F,Gosling R,Akweongo P,Mwangi R,Okello G,Mangesho P,Slutsker L,Kremsner PG,Grobusch MP,Hamel MJ,Newman RD,Pool R

更新日期：2009-08-10 00:00:00

abstract：:The outcomes from recent high profile deliberations concerning African health research and economic development all point towards the need for a mechanism to support health innovation on the continent. The mission of the African Network for Drugs and Diagnostics Innovation (ANDI), is to promote and sustain African-led...

journal_title：Malaria journal

authors： Addae-Mensah I,Fakorede F,Holtel A,Nwaka S

更新日期：2011-03-15 00:00:00

abstract：BACKGROUND:Insecticide resistance in Anopheles coluzzii mosquitoes has become widespread throughout West Africa including in Burkina Faso. The insecticide resistance allele (kdr or L1014F) is a prime indicator that is highly correlated with phenotypic resistance in West Africa. Studies from Benin, Ghana and Mali have s...

journal_title：Malaria journal

authors： Hanemaaijer MJ,Higgins H,Eralp I,Yamasaki Y,Becker N,Kirstein OD,Lanzaro GC,Lee Y

更新日期：2019-04-11 00:00:00

abstract：BACKGROUND:Autoregressive regression coefficients for Anopheles arabiensis aquatic habitat models are usually assessed using global error techniques and are reported as error covariance matrices. A global statistic, however, will summarize error estimates from multiple habitat locations. This makes it difficult to iden...

journal_title：Malaria journal

authors： Jacob BG,Griffith DA,Muturi EJ,Caamano EX,Githure JI,Novak RJ

更新日期：2009-09-21 00:00:00