Bone marrow suppression and severe anaemia associated with persistent Plasmodium falciparum infection in African children with microscopically undetectable parasitaemia.


BACKGROUND:Severe anaemia can develop in the aftermath of Plasmodium falciparum malaria because of protracted bone marrow suppression, possibly due to residual subpatent parasites. MATERIALS AND METHODS:Blood was collected from patients with recent malaria and negative malaria microscopy. Detection of the Plasmodium antigens, lactate dehydrogenase (Optimal), aldolase and histidine rich protein 2 (Now malaria) were used to differentiate between patients with (1) no malaria, (2) recent cleared malaria, (3) persistent P. falciparum infection. Red cell distribution width (RDW), plasma levels of soluble transferrin receptor (sTfR) and erythropoietin (EPO) were measured as markers of erythropoiesis. Interleukin (IL) 10 and tumour necrosis factor (TNF)alpha were used as inflammation markers. RESULTS:EPO was correlated with haemoglobin, irrespective of malaria (R = -0.36, P < 0.001). Persistent P. falciparum infection, but not recent malaria without residual parasites, was associated with bone marrow suppression i.e., low RDW (P < 0.001 vs. P = 0.56) and sTfR (P = 0.02 vs. P = 0.36). TNF-alpha and IL-10 levels were not associated with bone marrow suppression. CONCLUSION:In the treatment of malaria, complete eradication of parasites may prevent subsequent development of anaemia. Severely anaemic children may benefit from antimalarial treatment if antigen tests are positive, even when no parasites can be demonstrated by microscopy.


Malar J


Malaria journal


Helleberg M,Goka BQ,Akanmori BD,Obeng-Adjei G,Rodriques O,Kurtzhals JA





Has Abstract


2005-12-01 00:00:00










  • Early home-based recognition of anaemia via general danger signs, in young children, in a malaria endemic community in north-east Tanzania.

    abstract:BACKGROUND:Ethnographic studies from East Africa suggest that cerebral malaria and anaemia are not classified in local knowledge as malaria complications, but as illnesses in their own right. Cerebral malaria 'degedege' has been most researched, in spite of anaemia being a much more frequent complication in infants, an...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Ringsted FM,Bygbjerg IC,Samuelsen H

    更新日期:2006-11-20 00:00:00

  • Quantifying primaquine effectiveness and improving adherence: a round table discussion of the APMEN Vivax Working Group.

    abstract::The goal to eliminate malaria from the Asia-Pacific by 2030 will require the safe and widespread delivery of effective radical cure of malaria. In October 2017, the Asia Pacific Malaria Elimination Network Vivax Working Group met to discuss the impediments to primaquine (PQ) radical cure, how these can be overcome and...

    journal_title:Malaria journal



    authors: Thriemer K,Bobogare A,Ley B,Gudo CS,Alam MS,Anstey NM,Ashley E,Baird JK,Gryseels C,Jambert E,Lacerda M,Laihad F,Marfurt J,Pasaribu AP,Poespoprodjo JR,Sutanto I,Taylor WR,van den Boogaard C,Battle KE,Dysoley L,Ghim

    更新日期:2018-06-20 00:00:00

  • A novel field-based molecular assay to detect validated artemisinin-resistant k13 mutants.

    abstract:BACKGROUND:Given the risk of artemisinin resistance spreading from the Greater Mekong sub-region, prospective monitoring in sub-Saharan Africa should be expedited. Molecular biology techniques used for monitoring rely on the detection of k13 validated mutants by using PCR and Sanger sequencing approach, usually not ava...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Vachot-Ganée L,Khim N,Iannello A,Legrand E,Kim S,Eam R,Khean C,Ken M,Ashley E,Tun KM,Dhorda M,Nosten F,Souleymane IM,Blein S,Pachot A,Ariey F,Kaiser K,Ménard D

    更新日期:2018-04-24 00:00:00

  • Most outdoor malaria transmission by behaviourally-resistant Anopheles arabiensis is mediated by mosquitoes that have previously been inside houses.

    abstract:BACKGROUND:Anopheles arabiensis is stereotypical of diverse vectors that mediate residual malaria transmission globally, because it can feed outdoors upon humans or cattle, or enter but then rapidly exit houses without fatal exposure to insecticidal nets or sprays. METHODS:Life histories of a well-characterized An. ar...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Killeen GF,Govella NJ,Lwetoijera DW,Okumu FO

    更新日期:2016-04-19 00:00:00

  • Antiplasmodial dihetarylthioethers target the coenzyme A synthesis pathway in Plasmodium falciparum erythrocytic stages.

    abstract:BACKGROUND:Malaria is a widespread infectious disease that threatens a large proportion of the population in tropical and subtropical areas. Given the emerging resistance against the current standard anti-malaria chemotherapeutics, the development of alternative drugs is urgently needed. New anti-malarials representing...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Weidner T,Lucantoni L,Nasereddin A,Preu L,Jones PG,Dzikowski R,Avery VM,Kunick C

    更新日期:2017-05-15 00:00:00

  • Prevalence of Plasmodium falciparum field isolates with deletions in histidine-rich protein 2 and 3 genes in context with sub-Saharan Africa and India: a systematic review and meta-analysis.

    abstract:BACKGROUND:In 2017, nearly 80% of malaria morbidity and mortality occurred in sub-Saharan African (SSA) countries and India. Rapid diagnostic tests (RDTs), especially those targeting histidine-rich protein 2 (PfHRP2) of Plasmodium falciparum, have become an important diagnostic tool in these malaria-endemic areas. Howe...

    journal_title:Malaria journal

    pub_type: 杂志文章,meta分析


    authors: Kojom LP,Singh V

    更新日期:2020-01-28 00:00:00

  • Inferring selection in the Anopheles gambiae species complex: an example from immune-related serine protease inhibitors.

    abstract:BACKGROUND:Mosquitoes of the Anopheles gambiae species complex are the primary vectors of human malaria in sub-Saharan Africa. Many host genes have been shown to affect Plasmodium development in the mosquito, and so are expected to engage in an evolutionary arms race with the pathogen. However, there is little conclusi...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Obbard DJ,Welch JJ,Little TJ

    更新日期:2009-06-04 00:00:00

  • Safety of primaquine in infants with Plasmodium vivax malaria in Papua, Indonesia.

    abstract:BACKGROUND:Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited. METHODS:A retrospective, hospital-based cohort study of infants aged 1-12 months with vivax malaria was...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Setyadi A,Arguni E,Kenangalem E,Hasanuddin A,Lampah DA,Thriemer K,Anstey NM,Sugiarto P,Simpson JA,Price RN,Douglas NM,Poespoprodjo JR

    更新日期:2019-04-02 00:00:00

  • Drug resistance markers within an evolving efficacy of anti-malarial drugs in Cameroon: a systematic review and meta-analysis (1998-2020).

    abstract:BACKGROUND:Malaria remains highly endemic in Cameroon. The rapid emergence and spread of drug resistance was responsible for the change from monotherapies to artemisinin-based combinations. This systematic review and meta-analysis aimed to determine the prevalence and distribution of Plasmodium falciparum drug resistan...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Niba PTN,Nji AM,Evehe MS,Ali IM,Netongo PM,Ngwafor R,Moyeh MN,Ngum LN,Ndum OE,Acho FA,Mbu'u CM,Fosah DA,Atogho-Tiedeu B,Achonduh-Atijegbe O,Djokam-Dadjeu R,Chedjou JPK,Bigoga JD,Moukoko CEE,Ajua A,Achidi E,Tallah

    更新日期:2021-01-09 00:00:00

  • PET-PCR method for the molecular detection of malaria parasites in a national malaria surveillance study in Haiti, 2011.

    abstract:BACKGROUND:Recently, a real-time PCR assay known as photo-induced electron transfer (PET)-PCR which relies on self-quenching primers for the detection of Plasmodium spp. and Plasmodium falciparum was described. PET-PCR assay was found to be robust, and easier to use when compared to currently available real-time PCR me...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Lucchi NW,Karell MA,Journel I,Rogier E,Goldman I,Ljolje D,Huber C,Mace KE,Jean SE,Akom EE,Oscar R,Buteau J,Boncy J,Barnwell JW,Udhayakumar V

    更新日期:2014-11-26 00:00:00

  • Decreased motivation in the use of insecticide-treated nets in a malaria endemic area in Burkina Faso.

    abstract:BACKGROUND:The use of insecticide-treated nets (ITN) is an important tool in the Roll Back Malaria (RBM) strategy. For ITNs to be effective they need to be used correctly. Previous studies have shown that many factors, such as wealth, access to health care, education, ethnicity and gender, determine the ownership and u...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Toé LP,Skovmand O,Dabiré KR,Diabaté A,Diallo Y,Guiguemdé TR,Doannio JM,Akogbeto M,Baldet T,Gruénais ME

    更新日期:2009-07-29 00:00:00

  • Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes.

    abstract::The general paradigm that emerges from the analysis of the transcriptome of the malaria parasite Plasmodium falciparum is that the expression clusters of genes that code for enzymes engaged in the same cellular function is coordinated. Here the consistency of this perception is examined by analysing specific pathways ...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Bozdech Z,Ginsburg H

    更新日期:2005-03-18 00:00:00

  • Local perceptions of intermittent screening and treatment for malaria in school children on the south coast of Kenya.

    abstract:BACKGROUND:The intermittent screening and treatment (IST) of school children for malaria is one possible intervention strategy that could help reduce the burden of malaria among school children. Future implementation of IST will not only depend on its efficacy and cost-effectiveness but also on its acceptability to par...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Okello G,Ndegwa SN,Halliday KE,Hanson K,Brooker SJ,Jones C

    更新日期:2012-06-08 00:00:00

  • Molecular evidence for relapse of an imported Plasmodium ovale wallikeri infection.

    abstract:BACKGROUND:Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce. CASE PRESENTATION:He...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Veletzky L,Groger M,Lagler H,Walochnik J,Auer H,Fuehrer HP,Ramharter M

    更新日期:2018-02-09 00:00:00

  • Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy.

    abstract:BACKGROUND:Mozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in 2009. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance. The prevalence of pfmdr1 d...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Lobo E,de Sousa B,Rosa S,Figueiredo P,Lobo L,Pateira S,Fernandes N,Nogueira F

    更新日期:2014-08-06 00:00:00

  • Identification of minimal human MHC-restricted CD8+ T-cell epitopes within the Plasmodium falciparum circumsporozoite protein (CSP).

    abstract:BACKGROUND:Plasmodium falciparum circumsporozoite protein (CSP) is a leading malaria vaccine candidate antigen, known to elicit protective antibody responses in humans (RTS,S vaccine). Recently, a DNA prime / adenovirus (Ad) vector boost vaccine encoding CSP and a second P. falciparum antigen, apical membrane antigen-1...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Sedegah M,Kim Y,Ganeshan H,Huang J,Belmonte M,Abot E,Banania JG,Farooq F,McGrath S,Peters B,Sette A,Soisson L,Diggs C,Doolan DL,Tamminga C,Villasante E,Hollingdale MR,Richie TL

    更新日期:2013-06-05 00:00:00

  • Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania.

    abstract:BACKGROUND:The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention programmes. METHODS:A 6-month longitudinal study monitoring risk factors for anaemia and febrile malaria epis...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Lusingu JP,Vestergaard LS,Mmbando BP,Drakeley CJ,Jones C,Akida J,Savaeli ZX,Kitua AY,Lemnge MM,Theander TG

    更新日期:2004-07-28 00:00:00

  • Annual variations in the number of malaria cases related to two different patterns of Anopheles darlingi transmission potential in the Maroni area of French Guiana.

    abstract:BACKGROUND:With an Annual Parasite Incidence (API) of 132.1, in the high and moderate risks zones, the Maroni area of French Guiana has the second highest malaria incidence of South-America after Guyana (API = 183.54) and far above Brazil (API = 28.25). Malaria transmission is occurring despite strong medical assistanc...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Fouque F,Gaborit P,Carinci R,Issaly J,Girod R

    更新日期:2010-03-22 00:00:00

  • Towards improved uptake of malaria chemoprophylaxis among West African travellers: identification of behavioural determinants.

    abstract:BACKGROUND:Malaria is a potentially lethal illness for which preventive measures are not optimally used among all travellers. Travellers visiting friends and relatives in their country of origin (VFRs) are known to use chemoprophylaxis less consistently compared to tourist travellers. In this study, factors explaining ...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Wieten RW,Harting J,Biemond PM,Grobusch MP,van Vugt M

    更新日期:2013-10-10 00:00:00

  • Community-based intermittent mass testing and treatment for malaria in an area of high transmission intensity, western Kenya: study design and methodology for a cluster randomized controlled trial.

    abstract::Most human Plasmodium infections in western Kenya are asymptomatic and are believed to contribute importantly to malaria transmission. Elimination of asymptomatic infections requires active treatment approaches, such as mass testing and treatment (MTaT) or mass drug administration (MDA), as infected persons do not see...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Samuels AM,Awino N,Odongo W,Abong'o B,Gimnig J,Otieno K,Shi YP,Were V,Allen DR,Were F,Sang T,Obor D,Williamson J,Hamel MJ,Patrick Kachur S,Slutsker L,Lindblade KA,Kariuki S,Desai M

    更新日期:2017-06-07 00:00:00

  • Biochemical basis of permethrin resistance in Anopheles arabiensis from Lower Moshi, north-eastern Tanzania.

    abstract:BACKGROUND:Development of resistance to different classes of insecticides is a potential threat to malaria control. With the increasing coverage of long-lasting insecticide-treated nets in Tanzania, the continued monitoring of resistance in vector populations is crucial. It may facilitate the development of novel strat...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Matowo J,Kulkarni MA,Mosha FW,Oxborough RM,Kitau JA,Tenu F,Rowland M

    更新日期:2010-07-07 00:00:00

  • Epidemiologic features of overseas imported malaria in the People's Republic of China.

    abstract:BACKGROUND:With the dramatic increase in international travel among Chinese people, the risk of malaria importation from malaria-endemic regions threatens the achievement of the malaria elimination goal of China. METHODS:Epidemiological investigations of all imported malaria cases were conducted in nine provinces of C...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Li Z,Zhang Q,Zheng C,Zhou S,Sun J,Zhang Z,Geng Q,Zhang H,Wang L,Lai S,Hu W,Clements AC,Zhou XN,Yang W

    更新日期:2016-03-05 00:00:00

  • The role of extracellular vesicles in malaria biology and pathogenesis.

    abstract::In the past decade, research on the functions of extracellular vesicles in malaria has expanded dramatically. Investigations into the various vesicle types, from both host and parasite origin, has revealed important roles for extracellular vesicles in disease pathogenesis and susceptibility, as well as cell-cell commu...

    journal_title:Malaria journal

    pub_type: 杂志文章,评审


    authors: Sampaio NG,Cheng L,Eriksson EM

    更新日期:2017-06-09 00:00:00

  • Malaria parasites in macaques in Thailand: stump-tailed macaques (Macaca arctoides) are new natural hosts for Plasmodium knowlesi, Plasmodium inui, Plasmodium coatneyi and Plasmodium fieldi.

    abstract:BACKGROUND:Certain species of macaques are natural hosts of Plasmodium knowlesi and Plasmodium cynomolgi, which can both cause malaria in humans, and Plasmodium inui, which can be experimentally transmitted to humans. A significant number of zoonotic malaria cases have been reported in humans throughout Southeast Asia,...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Fungfuang W,Udom C,Tongthainan D,Kadir KA,Singh B

    更新日期:2020-10-01 00:00:00

  • Chicken volatiles repel host-seeking malaria mosquitoes.

    abstract:BACKGROUND:Anopheles arabiensis is a dominant vector of malaria in sub-Saharan Africa, which feeds indoors and outdoors on human and other vertebrate hosts, making it a difficult species to control with existing control methods. Novel methods that reduce human-vector interactions are, therefore, required to improve the...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Jaleta KT,Hill SR,Birgersson G,Tekie H,Ignell R

    更新日期:2016-07-21 00:00:00

  • Therapeutic efficacy of artemether-lumefantrine in uncomplicated falciparum malaria in India.

    abstract:BACKGROUND:Artemisinin-based combination therapy (ACT) is the treatment of choice for uncomplicated falciparum malaria. Artemether-lumefantrine (AL), a fixed dose co-formulation, has recently been approved for marketing in India, although it is not included in the National Drug Policy for treatment of malaria. Efficacy...

    journal_title:Malaria journal

    pub_type: 临床试验,杂志文章


    authors: Valecha N,Srivastava P,Mohanty SS,Mittra P,Sharma SK,Tyagi PK,Pradhan K,Dev V,Singh R,Dash AP,Sharma YD

    更新日期:2009-05-19 00:00:00

  • Community response to intermittent preventive treatment of malaria in infants (IPTi) delivered through the expanded programme of immunization in five African settings.

    abstract:BACKGROUND:IPTi delivered through EPI has been shown to reduce the incidence of clinical malaria by 20-59%. However, new health interventions can only be effective if they are also socially and culturally acceptable. It is also crucial to ensure that attitudes to IPTi do not negatively influence attitudes to and uptake...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Gysels M,Pell C,Mathanga DP,Adongo P,Odhiambo F,Gosling R,Akweongo P,Mwangi R,Okello G,Mangesho P,Slutsker L,Kremsner PG,Grobusch MP,Hamel MJ,Newman RD,Pool R

    更新日期:2009-08-10 00:00:00

  • Traditional medicines as a mechanism for driving research innovation in Africa.

    abstract::The outcomes from recent high profile deliberations concerning African health research and economic development all point towards the need for a mechanism to support health innovation on the continent. The mission of the African Network for Drugs and Diagnostics Innovation (ANDI), is to promote and sustain African-led...

    journal_title:Malaria journal

    pub_type: 杂志文章,评审


    authors: Addae-Mensah I,Fakorede F,Holtel A,Nwaka S

    更新日期:2011-03-15 00:00:00

  • Introgression between Anopheles gambiae and Anopheles coluzzii in Burkina Faso and its associations with kdr resistance and Plasmodium infection.

    abstract:BACKGROUND:Insecticide resistance in Anopheles coluzzii mosquitoes has become widespread throughout West Africa including in Burkina Faso. The insecticide resistance allele (kdr or L1014F) is a prime indicator that is highly correlated with phenotypic resistance in West Africa. Studies from Benin, Ghana and Mali have s...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Hanemaaijer MJ,Higgins H,Eralp I,Yamasaki Y,Becker N,Kirstein OD,Lanzaro GC,Lee Y

    更新日期:2019-04-11 00:00:00

  • A heteroskedastic error covariance matrix estimator using a first-order conditional autoregressive Markov simulation for deriving asympotical efficient estimates from ecological sampled Anopheles arabiensis aquatic habitat covariates.

    abstract:BACKGROUND:Autoregressive regression coefficients for Anopheles arabiensis aquatic habitat models are usually assessed using global error techniques and are reported as error covariance matrices. A global statistic, however, will summarize error estimates from multiple habitat locations. This makes it difficult to iden...

    journal_title:Malaria journal

    pub_type: 杂志文章


    authors: Jacob BG,Griffith DA,Muturi EJ,Caamano EX,Githure JI,Novak RJ

    更新日期:2009-09-21 00:00:00