当前位置： SCI文献检索 > MALARIA JOURNAL期刊下所有文献 > Association between malaria immunity and pregnancy outcomes among Malawian pregnant women receiving nutrient supplementation.

Association between malaria immunity and pregnancy outcomes among Malawian pregnant women receiving nutrient supplementation.

Abstract：

BACKGROUND:Malaria antibody responses measured at delivery have been associated with protection from maternal anaemia and low birth weight deliveries. Whether malarial antibodies present in the first half of pregnancy may protect from these or other poor birth outcomes is unclear. To determine whether malaria antibodies in the first half of pregnancy predict pregnancy outcomes, antibodies were measured to a range of merozoite antigens and to antigens expressed on the surface of parasitized red blood cells (pRBCs) in plasma samples collected at 14-20 weeks of gestation from Malawian women. The latter antibodies were measured as total IgG to pRBCs, and antibodies promoting opsonic phagocytosis of pRBCs. Associations between antibodies and maternal haemoglobin in late pregnancy or newborn size were investigated, after adjusting for potential covariates. RESULTS:Antibodies to pRBC surface antigens were associated with higher haemoglobin concentration at 36 weeks. Total IgG to pRBCs was associated with 0.4 g/l [(95% confidence interval (0.04, 0.8)] increase in haemoglobin, and opsonizing antibody with 0.5 (0.05, 0.9) increase in haemoglobin for each 10% increase in antibody. These antibodies were not associated with birthweight, placental malaria, or newborn anthropometrics. Antibodies to merozoite antigens and non-placental-binding IEs were not associated with decreased risk of any of these outcomes. In some instances, they were negatively associated with outcomes of interest. CONCLUSION:Antibodies to placental-binding infected erythrocytes may be associated with higher haemoglobin levels in pregnancy, whereas antibodies to other malaria antigens may instead be markers of malaria exposure. Trial registration clinicaltrials.gov NCT01239693. Registered Nov 10, 2010.

journal_name

Malar J

journal_title

Malaria journal

authors

Chandrasiri UP,Fowkes FJ,Beeson JG,Richards JS,Kamiza S,Maleta K,Ashorn P,Rogerson SJ

doi

10.1186/s12936-016-1597-7

subject

Has Abstract

pub_date

2016-11-09 00:00:00

pages

547

issue

issn

1475-2875

pii

10.1186/s12936-016-1597-7

journal_volume

pub_type

杂志文章

在线工具

Association between malaria immunity and pregnancy outcomes among Malawian pregnant women receiving nutrient supplementation.