Abstract:
BACKGROUND:The number of Plasmodium falciparum malaria cases around the world has decreased substantially over the last 15 years, but with the spread of resistance against anti-malarial drugs and insecticides, this decline may not continue. There is an urgent need to consider alternative, accelerated strategies to eliminate malaria in countries like Lao PDR, where there are a few remaining endemic areas. A deterministic compartmental modelling tool was used to develop an integrated strategy for P. falciparum elimination in the Savannakhet province of Lao PDR. The model was designed to include key aspects of malaria transmission and integrated control measures, along with a user-friendly interface. RESULTS:Universal coverage was the foundation of the integrated strategy, which took the form of the deployment of community health workers who provided universal access to early diagnosis, treatment and long-lasting insecticidal nets. Acceleration was included as the deployment of three monthly rounds of mass drug administration targeted towards high prevalence villages, with the addition of three monthly doses of the RTS,S vaccine delivered en masse to the same high prevalence sub-population. A booster dose of vaccine was added 1 year later. The surveillance-as-intervention component of the package involved the screening and treatment of individuals entering the simulated population. CONCLUSIONS:In this modelling approach, the sequential introduction of a series of five available interventions in an integrated strategy was predicted to be sufficient to stop malaria transmission within a 3-year period. These interventions comprised universal access to early diagnosis and adequate treatment, improved access to long-lasting insecticidal nets, three monthly rounds of mass drug administration together with RTS,S vaccination followed by a booster dose of vaccine, and screening and treatment of imported cases.
journal_name
Malar Jjournal_title
Malaria journalauthors
Tun STT,von Seidlein L,Pongvongsa T,Mayxay M,Saralamba S,Kyaw SS,Chanthavilay P,Celhay O,Nguyen TD,Tran TN,Parker DM,Boni MF,Dondorp AM,White LJdoi
10.1186/s12936-017-2130-3subject
Has Abstractpub_date
2017-11-28 00:00:00pages
483issue
1issn
1475-2875pii
10.1186/s12936-017-2130-3journal_volume
16pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:Following the recognition that morbidity and mortality due to malaria had dramatically increased in the last three decades, in 2002 the government of Zambia reviewed its efforts to prevent and treat malaria. Convincing evidence of the failing efficacy of chloroquine resulted in the initiation of a process th...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-25
更新日期:2008-01-29 00:00:00
abstract:BACKGROUND:Malaria is reportedly receding in different epidemiological settings, but local long-term surveys are limited. At Mlomp dispensary in south-western Senegal, an area of moderate malaria transmission, year-round, clinically-suspected malaria was treated with monotherapy as per WHO and national policy in the 19...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-203
更新日期:2011-07-25 00:00:00
abstract:BACKGROUND:Colombia contributes a significant proportion of malaria cases in the Americas, which are predominantly rural. However, in the last 8 years ~ 10 % of the endemic municipalities have also reported urban and peri-urban malaria cases, a growing concern for health authorities. This study focused on the character...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0956-0
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:Complement (C) can be activated during malaria, C components consumed and inflammatory mediators produced. This has potential to impair host innate defence. METHODS:In a case-control study, C activation was assessed by measuring serum haemolytic activity (CH50), functional activity of each pathway and level...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-7
更新日期:2009-01-09 00:00:00
abstract:BACKGROUND:Molecular genotyping is performed in anti-malarial trials to determine whether recurrent parasitaemia after therapy represents a recrudescence (treatment failure) or new infection. The use of capillary instead of agarose gel electrophoresis for genotyping offers technical advantages, but it is unclear whethe...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-19
更新日期:2010-01-15 00:00:00
abstract:BACKGROUND:Insecticide-treated nets (ITNs) are losing efficacy against pyrethroid-resistant malaria vector populations throughout Africa. Safeguarding bed net efficacy, vital for effective malaria control, requires greater knowledge of mosquito-ITN interactions and how this impacts on the mosquito. METHODS:A purpose-b...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03213-9
更新日期:2020-04-07 00:00:00
abstract:BACKGROUND:Artemisinin-based combination therapy is the first-line anti-malarial treatment for uncomplicated Plasmodium falciparum infection in Angola. To date, the prevalence of polymorphisms in the pfk13 gene, associated with artemisinin resistance, and pfmdr1, associated with lumefantrine resistance, have not been s...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2233-5
更新日期:2018-02-20 00:00:00
abstract:BACKGROUND:In 2009, Santa Isabel Province in the Solomon Islands embarked on a malaria elimination programme. However, very little is known in the Province about the anopheline fauna, which species are vectors, their bionomics and how they may respond to intensified intervention measures. The purpose of this study was ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-287
更新日期:2011-09-30 00:00:00
abstract:BACKGROUND:Genetically-modified (GM) mosquitoes have been proposed as part of an integrated vector control strategy for malaria control. Public acceptance is essential prior to field trials, particularly since mosquitoes are a vector of human disease and genetically modified organisms (GMOs) face strong scepticism in d...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-128
更新日期:2010-05-14 00:00:00
abstract:BACKGROUND:In rural south-eastern Tanzania, Anopheles funestus is a major malaria vector, and has been implicated in nearly 90% of all infective bites. Unfortunately, little is known about the natural ecological requirements and survival strategies of this mosquito species. METHODS:Potential mosquito aquatic habitats ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03295-5
更新日期:2020-06-23 00:00:00
abstract:BACKGROUND:North East Kenya is an area of semi-arid terrain, prone to malaria epidemics. The distribution of long-lasting insecticidal nets (LLINs) has long been a key malaria intervention, however, for nomadic populations who live and sleep outside, in harsh climates and areas with increasing reports of exophagic beha...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0546-1
更新日期:2015-02-05 00:00:00
abstract:BACKGROUND:New World vultures (Cathartiformes: Cathartidae) are obligate scavengers comprised of seven species in five genera throughout the Americas. Of these, turkey vultures (Cathartes aura) and black vultures (Coragyps atratus) are the most widespread and, although ecologically similar, have evolved differences in ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-2165-5
更新日期:2018-01-08 00:00:00
abstract:BACKGROUND:Numerous countries around the world are approaching malaria elimination. Until global eradication is achieved, countries that successfully eliminate the disease will contend with parasite reintroduction through international movement of infected people. Human-mediated parasite mobility is also important with...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1315-5
更新日期:2016-05-11 00:00:00
abstract:BACKGROUND:The US FDA recently developed CD3+, a counterfeit detection tool that is based on sample illumination at specific wavelengths of light and visual comparison of suspect sample and packaging materials to an authentic sample. To test performance of the CD3+ in field conditions, a study was conducted in Ghana wh...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1180-2
更新日期:2016-02-25 00:00:00
abstract:BACKGROUND:A previous study showed for Anopheles gambiae s.s. a gradation of feeding preference on common plant species growing in a malaria holoendemic area in western Kenya. The present follow-up study determines whether there is a relationship between the mosquito's preferences and its survival and fecundity. METHO...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-113
更新日期:2007-08-21 00:00:00
abstract:BACKGROUND:Public health pesticides has been the mainstay control of vectors of malaria and other diseases, and public health pests, but there is increasing concern over how these pesticides are being managed. Poor pesticide management could lead to risks to human health and the environment, or diminish the effectivene...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-368
更新日期:2014-09-18 00:00:00
abstract::Artesunate (AS) is a clinically versatile artemisinin derivative utilized for the treatment of mild to severe malaria infection. Given the therapeutic significance of AS and the necessity of appropriate AS dosing, substantial research has been performed investigating the pharmacokinetics of AS and its active metabolit...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-10-263
更新日期:2011-09-13 00:00:00
abstract:BACKGROUND:Malaria in highland areas of Kenya affects children and adults. Local clinicians include symptoms other than fever when screening for malaria because they believe that fever alone does not capture all cases of malaria. METHODS:Individuals who presented to dispensaries in a highland Kenya site of low, unstab...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-163
更新日期:2014-04-30 00:00:00
abstract:BACKGROUND:Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp. trophozoite, the stage when haemoglobin catabolism is maximal. H...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-94
更新日期:2008-05-27 00:00:00
abstract:BACKGROUND:Insecticide-treated clothing (ITC) has long been used for military and outdoor recreational purposes and there is substantial evidence to show that it can protect against arthropod biting. As a complementary vector control measure, ITC could be used to address outdoor transmission of malaria, particularly am...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-017-1737-8
更新日期:2017-02-28 00:00:00
abstract:BACKGROUND:During malaria infection the Toll-like receptor 9 (TLR9) is activated through induction with plasmodium DNA or another malaria motif not yet identified. Although TLR9 activation by malaria parasites is well reported, the implication to the susceptibility to severe malaria is not clear. The aim of this study ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-44
更新日期:2009-03-13 00:00:00
abstract::The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture. This is the first case of splenic infarction during an acute malaria due to Plasmodium ovale in a 34-year-old man. As in the majority other described cases of splenic infarction, ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-288
更新日期:2010-10-18 00:00:00
abstract:BACKGROUND:With the dramatic increase in international travel among Chinese people, the risk of malaria importation from malaria-endemic regions threatens the achievement of the malaria elimination goal of China. METHODS:Epidemiological investigations of all imported malaria cases were conducted in nine provinces of C...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1188-7
更新日期:2016-03-05 00:00:00
abstract:BACKGROUND:Mice with genetic deficiencies in adaptive immunity are used for the grafting of human cells or pathogens, to study human diseases, however, the innate immune responses to xenografts in these mice has received little attention. Using the NOD/SCID Plasmodium falciparum mouse model an analysis of innate defenc...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-197
更新日期:2010-07-09 00:00:00
abstract:BACKGROUND:Community-based service delivery is vital to the effectiveness, affordability and sustainability of vector control generally, and to labour-intensive larval source management (LSM) programmes in particular. CASE DESCRIPTION:The institutional evolution of a city-level, community-based LSM programme over 14 y...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-245
更新日期:2014-06-25 00:00:00
abstract:BACKGROUND:The Democratic Republic of the Congo (DRC) bears a high burden of malaria, which is exacerbated in pregnant women. The VAR2CSA protein plays a crucial role in pregnancy-associated malaria (PAM), and hence quantifying diversity at the var2csa locus in the DRC is important in understanding the basic epidemiolo...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2193-9
更新日期:2018-01-24 00:00:00
abstract:BACKGROUND:Anopheles baimaii is a primary vector of human malaria in the forest settings of Southeast Asia including the north-eastern region of India. Here, the genetic population structure and the basic population genetic parameters of An. baimaii in north-east India were estimated using DNA sequences of the mitochon...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-76
更新日期:2012-03-20 00:00:00
abstract:BACKGROUND:The diversity and abundance of Anopheles larvae has significant influence on the resulting adult mosquito population and hence the dynamics of malaria transmission. Studies were conducted to examine larval habitat dynamics and ecological factors affecting survivorship of aquatic stages of malaria vectors in ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-228
更新日期:2010-08-09 00:00:00
abstract:BACKGROUND:Malaria prevention has remained a critical area in the absence of efficacious vaccines against malaria. Drugs currently used as chemotherapeutics are also used in chemoprophylaxis increasing possible drug resistance. Asiatic acid is a natural phytochemical with oxidant, antioxidant and anti-inflammatory prop...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1278-6
更新日期:2016-04-21 00:00:00
abstract:BACKGROUND:Surveillance is a core component of an effective system to support malaria elimination. Poor surveillance data will prevent countries from monitoring progress towards elimination and targeting interventions to the last remaining at-risk places. An evaluation of the performance of surveillance systems in 16 c...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2960-2
更新日期:2019-09-18 00:00:00