Analysis of innate defences against Plasmodium falciparum in immunodeficient mice.

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) have become an essential tool in the contemporary malaria control and management programmes in the world. This study aims to evaluate the performance of two commonly used RDTs for malaria diagnosis in the China-Myanmar border area. METHODS:A total 606 febrile patients in the Ch...

journal_title：Malaria journal

authors： Yan J,Li N,Wei X,Li P,Zhao Z,Wang L,Li S,Li X,Wang Y,Li S,Yang Z,Zheng B,Zhou G,Yan G,Cui L,Cao Y,Fan Q

更新日期：2013-02-22 00:00:00

abstract：BACKGROUND:A previous study showed for Anopheles gambiae s.s. a gradation of feeding preference on common plant species growing in a malaria holoendemic area in western Kenya. The present follow-up study determines whether there is a relationship between the mosquito's preferences and its survival and fecundity. METHO...

journal_title：Malaria journal

authors： Manda H,Gouagna LC,Foster WA,Jackson RR,Beier JC,Githure JI,Hassanali A

更新日期：2007-08-21 00:00:00

abstract：BACKGROUND:Thrombocytopaenia is the most frequent malaria-associated haematologic alteration observed with all five Plasmodium parasites causing disease in humans. Although not included in the World Health Organization criteria for severe Plasmodium falciparum malaria, severe thrombocytopaenia has been increasingly men...

journal_title：Malaria journal

authors： Antinori S,Corona A,Ridolfo AL,Galimberti L,Ricaboni D,Milazzo L,Corbellino M

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:In formerly endemic areas where malaria transmission has declined, levels of population immunity to Plasmodium falciparum provide information on continued malaria transmission and potentially susceptible populations. Traditional techniques for measuring serological responses to P. falciparum antigens use pla...

journal_title：Malaria journal

authors： Chidi AP,Chishimba S,Kobayashi T,Hamapumbu H,Mharakurwa S,Thuma PE,Moss WJ

更新日期：2011-06-10 00:00:00

abstract：BACKGROUND:The reemergence of Plasmodium vivax in South Korea since 1993 represents a serious public health concern. Despite the importance in understanding genetic diversity for control strategies, however, studies remain inconclusive with the general premise that due to low rate of malaria transmission, there is gene...

journal_title：Malaria journal

authors： Honma H,Kim JY,Palacpac NM,Mita T,Lee W,Horii T,Tanabe K

更新日期：2011-09-07 00:00:00

abstract：BACKGROUND:Most malaria rapid diagnostic tests (RDTs) use HRP2 detection, including Paracheck-Pf(R), but their utility is limited by persistent false positivity after treatment. PLDH-based tests become negative more quickly, but sensitivity has been reported below the recommended standard of 90%. A new pLDH test, CareS...

journal_title：Malaria journal

authors： Gerstl S,Dunkley S,Mukhtar A,De Smet M,Baker S,Maikere J

更新日期：2010-01-21 00:00:00

abstract：BACKGROUND:There has been much debate about the appropriate statistical methodology for the evaluation of malaria field studies and the challenges in interpreting data arising from these trials. METHODS:The present paper describes, for a pivotal phase III efficacy of the RTS, S/AS01 malaria vaccine, the methods of the...

journal_title：Malaria journal

authors： Lievens M,Aponte JJ,Williamson J,Mmbando B,Mohamed A,Bejon P,Leach A

更新日期：2011-08-04 00:00:00

abstract：BACKGROUND:Larviciding is a key strategy used in many vector control programmes around the world. Costs could be reduced if larvicides could be manufactured locally. The potential of natural products as larvicides against the main African malaria vector, Anopheles gambiae s.s was evaluated. METHODS:To assess the larvi...

journal_title：Malaria journal

authors： Okumu FO,Knols BG,Fillinger U

更新日期：2007-05-22 00:00:00

abstract：BACKGROUND:There remains a need for techniques that improve the sensitive detection of viable Plasmodium falciparum as part of diagnosis and therapeutic monitoring in clinical studies and usual-care management of malaria infections. A non-invasive breath test based on P. falciparum-associated specific volatile organic ...

journal_title：Malaria journal

authors： Wong RP,Flematti GR,Davis TM

更新日期：2012-09-07 00:00:00

abstract：BACKGROUND:Patterns of decreasing malaria transmission intensity make presumptive treatment of malaria an unjustifiable approach in many African settings. The controlled use of anti-malarials after laboratory confirmed diagnosis is preferable in low endemic areas. Diagnosis may be facilitated by malaria rapid diagnosti...

journal_title：Malaria journal

authors： Bastiaens GJ,Schaftenaar E,Ndaro A,Keuter M,Bousema T,Shekalaghe SA

更新日期：2011-04-02 00:00:00

abstract：BACKGROUND:Reported malaria cases continue to decline globally, and this has been attributed to strategic implementation of multiple malaria control tools. Gains made would however need to be sustained through continuous monitoring to ensure malaria elimination and eradication. Entomological inoculation rate (EIR) is c...

journal_title：Malaria journal

authors： Kusi KA,Bosomprah S,Dodoo D,Kyei-Baafour E,Dickson EK,Mensah D,Angov E,Dutta S,Sedegah M,Koram KA

更新日期：2014-03-17 00:00:00

abstract：BACKGROUND:Prompt and effective malaria diagnosis not only alleviates individual suffering, but also decreases malaria transmission at the community level. The commonly used diagnostic methods, microscopy and rapid diagnostic tests, are usually insensitive at very low-density parasitaemia. Molecular techniques, on the ...

journal_title：Malaria journal

authors： Golassa L,Enweji N,Erko B,Aseffa A,Swedberg G

更新日期：2013-10-03 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy is the first-line anti-malarial treatment for uncomplicated Plasmodium falciparum infection in Angola. To date, the prevalence of polymorphisms in the pfk13 gene, associated with artemisinin resistance, and pfmdr1, associated with lumefantrine resistance, have not been s...

journal_title：Malaria journal

authors： Ljolje D,Dimbu PR,Kelley J,Goldman I,Nace D,Macaia A,Halsey ES,Ringwald P,Fortes F,Udhayakumar V,Talundzic E,Lucchi NW,Plucinski MM

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:Insect vectors, namely mosquitoes (Diptera: Culicidae), are compulsory for malaria parasites (Plasmodium spp.) to complete their life cycle. Despite this, little is known about vector competence of different mosquito species for the transmission of avian malaria parasites. METHODS:In this study, nested PCR ...

journal_title：Malaria journal

authors： Schoener E,Uebleis SS,Butter J,Nawratil M,Cuk C,Flechl E,Kothmayer M,Obwaller AG,Zechmeister T,Rubel F,Lebl K,Zittra C,Fuehrer HP

更新日期：2017-09-29 00:00:00

abstract：BACKGROUND:The close relationship between vector-borne diseases and their environment is well documented, especially for diseases with water-dependent vectors such as avian malaria. Mosquitoes are the primary vectors of avian malaria and also the definitive hosts in the disease life cycle. Factors pertinent to mosquito...

journal_title：Malaria journal

authors： Okanga S,Cumming GS,Hockey PA

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Successful reduction of malaria transmission to very low levels has made Isabel Province, Solomon Islands, a target for early elimination by 2014. High malaria transmission in neighbouring provinces and the potential for local asymptomatic infections to cause malaria resurgence highlights the need for sub-na...

journal_title：Malaria journal

authors： Atkinson JA,Johnson ML,Wijesinghe R,Bobogare A,Losi L,O'Sullivan M,Yamaguchi Y,Kenilorea G,Vallely A,Cheng Q,Ebringer A,Bain L,Gray K,Harris I,Whittaker M,Reid H,Clements A,Shanks D

更新日期：2012-03-30 00:00:00

abstract：BACKGROUND:The Plasmodium falciparum chloroquine transporter gene (pfcrt) is known to be involved in chloroquine and amodiaquine resistance, and more particularly the mutations on the loci 72 to 76 localized within the second exon. Additionally, new mutations (T93S, H97Y, C101F, F145I, M343L, C350R and G353V) were rece...

journal_title：Malaria journal

authors： Foguim FT,Bogreau H,Gendrot M,Mosnier J,Fonta I,Benoit N,Amalvict R,Madamet M,Wein S,Pradines B,French National Reference Centre for Imported Malaria Study Group.

更新日期：2020-06-05 00:00:00

abstract：BACKGROUND:Antananarivo, the capital of Madagascar, is located at an altitude of over 1,200 m. The environment at this altitude is not particularly favourable to malaria transmission, but malaria nonetheless remains a major public health problem. The aim of this study was to evaluate exposure to malaria in the urban po...

journal_title：Malaria journal

authors： Domarle O,Razakandrainibe R,Rakotomalala E,Jolivet L,Randremanana RV,Rakotomanana F,Ramarokoto CE,Soares JL,Ariey F

更新日期：2006-11-10 00:00:00

abstract：BACKGROUND:Effective surveillance systems are required to track malaria testing and treatment practices. A 26-week study "SMS for Life" was piloted in five rural districts of Kenya to examine whether SMS reported surveillance data could ensure real-time visibility of accurate data and their use by district managers to ...

journal_title：Malaria journal

authors： Githinji S,Kigen S,Memusi D,Nyandigisi A,Wamari A,Muturi A,Jagoe G,Ziegler R,Snow RW,Zurovac D

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Whole-parasite immunization remains the benchmark in malaria vaccine development. A major bottleneck in the translation of whole-parasite immunization towards routine vaccination is the mode of administration, since high degrees of protection are currently only achieved by intravenous, and not by intradermal...

journal_title：Malaria journal

authors： Pfeil J,Heine JF,Mueller AK

更新日期：2015-01-28 00:00:00

abstract：BACKGROUND:Mosquitoes of the Anopheles gambiae species complex are the primary vectors of human malaria in sub-Saharan Africa. Many host genes have been shown to affect Plasmodium development in the mosquito, and so are expected to engage in an evolutionary arms race with the pathogen. However, there is little conclusi...

journal_title：Malaria journal

authors： Obbard DJ,Welch JJ,Little TJ

更新日期：2009-06-04 00:00:00

abstract：BACKGROUND:Development of resistance to different classes of insecticides is a potential threat to malaria control. With the increasing coverage of long-lasting insecticide-treated nets in Tanzania, the continued monitoring of resistance in vector populations is crucial. It may facilitate the development of novel strat...

journal_title：Malaria journal

authors： Matowo J,Kulkarni MA,Mosha FW,Oxborough RM,Kitau JA,Tenu F,Rowland M

更新日期：2010-07-07 00:00:00

abstract：BACKGROUND:Understanding spatio-temporal variation in malaria incidence provides a basis for effective disease control planning and monitoring. METHODS:Monthly surveillance data between 1991 and 2006 for Plasmodium vivax and Plasmodium falciparum malaria across 128 counties were assembled for Yunnan, a province of Chi...

journal_title：Malaria journal

authors： Clements AC,Barnett AG,Cheng ZW,Snow RW,Zhou HN

更新日期：2009-07-31 00:00:00

abstract：BACKGROUND:Malaria is a major public health problem in Uganda and the current policy recommends introduction of rapid diagnostic tests for malaria (RDTs) to facilitate effective case management. However, provision of RDTs in drug shops potentially raises a new set of issues, such as adherence to RDTs results, managemen...

journal_title：Malaria journal

authors： Mbonye AK,Clarke SE,Lal S,Chandler CI,Hutchinson E,Hansen KS,Magnussen P

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:A successful malaria control programme began in 2004 on Bioko Island, Equatorial Guinea. From 2007, the same multiple malaria interventions, though reduced in scope for funding reasons, were introduced to the four mainland provinces of Equatorial Guinea (the continental region) aiming to recreate Bioko's suc...

journal_title：Malaria journal

authors： Rehman AM,Mann AG,Schwabe C,Reddy MR,Roncon Gomes I,Slotman MA,Yellott L,Matias A,Caccone A,Nseng Nchama G,Kleinschmidt I

更新日期：2013-05-07 00:00:00

abstract：BACKGROUND:Anti-malarial resistance in Plasmodium falciparum remains an obstacle for malaria control. Resistance-associated genes were analysed in Brazilian samples over four decades to evaluate the impact of different treatment regimens on the parasite genetic profile. METHODS:Samples were collected on filter paper f...

journal_title：Malaria journal

authors： Inoue J,Lopes D,do Rosário V,Machado M,Hristov AD,Lima GF,Costa-Nascimento MJ,Segurado AC,Di Santi SM

更新日期：2014-09-19 00:00:00

abstract：BACKGROUND:Data collected in clinical trials have been used to develop scoring systems that identify adults with malaria at greatest risk of death. One of these, the RCAM score, can be simply determined by measuring a patient's Glasgow Coma Score and respiratory rate on admission to hospital. However the safety of usin...

journal_title：Malaria journal

authors： Kaung M,Kyi TT,Aung NM,Kyaw MP,Min M,Htet ZW,Anstey NM,Kyi MM,Hanson J

更新日期：2015-02-07 00:00:00

abstract：BACKGROUND:Malaria remains the most important public health problem in tropical and subtropical areas. Mothers' or caregivers' ability to recognize childhood malaria-related morbidity is crucial as knowledge, attitudes and health seeking behavior of caregivers towards childhood malaria could influence response to signs...

journal_title：Malaria journal

authors： Yewhalaw D,Kassahun W,Woldemichael K,Tushune K,Sudaker M,Kaba D,Duchateau L,Van Bortel W,Speybroeck N

更新日期：2010-02-11 00:00:00

abstract：BACKGROUND:In individuals living in malaria-endemic regions, parasitaemia thresholds for the onset of clinical symptoms vary with transmission intensity. The mechanisms that mediate this relationship are however, unclear. Since inflammatory responses to parasite infection contribute to the clinical manifestation of mal...

journal_title：Malaria journal

authors： Ademolue TW,Aniweh Y,Kusi KA,Awandare GA

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:A high-resolution surveillance-response system has been developed within a geographic information system (GIS) to support malaria elimination in the Pacific. This paper examines the application of a GIS-based spatial decision support system (SDSS) to automatically locate and map the distribution of confirmed...

journal_title：Malaria journal

authors： Kelly GC,Hale E,Donald W,Batarii W,Bugoro H,Nausien J,Smale J,Palmer K,Bobogare A,Taleo G,Vallely A,Tanner M,Vestergaard LS,Clements AC

更新日期：2013-03-21 00:00:00