Abstract:
BACKGROUND:Data collected in clinical trials have been used to develop scoring systems that identify adults with malaria at greatest risk of death. One of these, the RCAM score, can be simply determined by measuring a patient's Glasgow Coma Score and respiratory rate on admission to hospital. However the safety of using the RCAM score to define high-risk patients has not been assessed outside of the clinical trial setting. METHODS:A retrospective audit of medical records of all adults admitted with a diagnosis of malaria to two tertiary referral hospitals in Lower Myanmar in 2013 was undertaken. An RCAM score was calculated in all patients and related to their subsequent clinical course. RESULTS:The recent decline in malaria hospitalizations at both sites continued in 2013. During the year 90 adults were hospitalized with malaria; 62 (69%) had Plasmodium falciparum mono-infection, 11 (12%) had Plasmodium vivax mono-infection, 17 (19%) had mixed infection. All seven (7.7%) deaths occurred in patients infected with P. falciparum. An admission RCAM score <2 identified all the patients that would survive to discharge (positive predictive value (95% confidence interval (CI)) 100% (94.9-100%) and also predicted a requirement for less supportive care: 9/70 (13%) patients with an admission RCAM score <2 required supportive care (blood transfusion, vasopressor support or oxygen supplementation) during their hospitalization compared with 12/20 (60%) patients with an admission RCAM score ≥2 (p < 0.0001). No patient with P. vivax mono-infection required supportive care during their hospitalization. Patients with an oxygen saturation ≤95% on room air on admission were more likely to die before discharge (odds ratio 17.3 (95% CI: 2.9-101.2) than patients with a higher oxygen saturation (p = 0.002). CONCLUSIONS:Even outside a clinical trial setting the RCAM score reliably identifies adults with malaria who are at greatest risk of death and can be safely used in the initial triage and management of these patients.
journal_name
Malar Jjournal_title
Malaria journalauthors
Kaung M,Kyi TT,Aung NM,Kyaw MP,Min M,Htet ZW,Anstey NM,Kyi MM,Hanson Jdoi
10.1186/s12936-015-0549-ysubject
Has Abstractpub_date
2015-02-07 00:00:00pages
63issn
1475-2875pii
10.1186/s12936-015-0549-yjournal_volume
14pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:Understanding the dynamics of malaria transmission in diverse endemic settings is key for designing and implementing locally adapted and sustainable control and elimination strategies. A parasitological and epidemiological survey was conducted in September-October 2012, as a baseline underlying a 3-year popu...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1957-y
更新日期:2017-08-04 00:00:00
abstract:BACKGROUND:In recent years, malaria (Plasmodium vivax and Plasmodium falciparum) has been successfully controlled in the Ecuador-Peru coastal border region. The aim of this study was to document this control effort and to identify the best practices and lessons learned that are applicable to malaria control and to othe...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1630-x
更新日期:2016-11-28 00:00:00
abstract:BACKGROUND:Recent studies have demonstrated the deletion of the histidine-rich protein 2 (PfHRP2) gene (pfhrp2) in field isolates of Plasmodium falciparum, which could result in false negative test results when PfHRP2-based rapid diagnostic tests (RDTs) are used for malaria diagnosis. Although primary diagnosis of mala...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-014-0537-7
更新日期:2015-01-21 00:00:00
abstract:BACKGROUND:Saglin, a 100 kDa protein composed of two 50 kDa homodimers, is present in the salivary glands of Anopheles gambiae and has been considered an essential receptor for sporozoites (SPZ) of Plasmodium berghei and Plasmodium falciparum (Pf), allowing SPZ to recognize, bind to, and infect mosquito salivary glands...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2634-5
更新日期:2019-01-03 00:00:00
abstract:BACKGROUND:Malaria caused by Plasmodium falciparum in pregnancy can result in adverse maternal and fetal sequelae. This review evaluated the adherence of the national guidelines drawn from World Health Organization (WHO) regions, Africa, Eastern Mediterranean, Southeast Asia, and Western Pacific, to the WHO recommendat...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/s12936-020-03565-2
更新日期:2021-01-23 00:00:00
abstract:BACKGROUND:Malaria is a notifiable disease in the Netherlands, a non-endemic country. Imported malaria infections occur regularly among travellers, migrants and visitors. Surveillance data were analysed from 2008 to 2015. Trends in amounts of notifications among risk groups were analysed using Poisson regression. For a...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1711-5
更新日期:2017-02-02 00:00:00
abstract:BACKGROUND:The epidemiological control of malaria has been hampered by the appearance of parasite resistance to anti-malarial drugs and by the resistance of mosquito vectors to control measures. This has also been associated with weak transmission control, mostly due to poor control of asymptomatic patients associated ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-3142-y
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:Members of the Anopheles punctulatus group (AP group) are the primary vectors of human malaria in Papua New Guinea. The AP group includes 13 sibling species, most of them morphologically indistinguishable. Understanding why only certain species are able to transmit malaria requires a better comprehension of ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-64
更新日期:2013-02-14 00:00:00
abstract:BACKGROUND:Indonesia is home to a variety of malaria vectors whose specific bionomic traits remain largely uncharacterized. Species-specific behaviours, such as host feeding preferences, impact the dynamics of malaria transmission and the effectiveness of vector control interventions. METHODS:To examine species-specif...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1950-5
更新日期:2017-08-02 00:00:00
abstract:BACKGROUND:Malaria transmission in the peri-Iquitos region of Amazonian Peru has been designated as seasonal and hypo-endemic with recently described hyper-endemic hotspots. Despite relatively recent distribution of long-lasting insecticidal bed nets (LLINs), malaria in Amazonian Peru persists and increased substantial...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0804-2
更新日期:2015-07-30 00:00:00
abstract:BACKGROUND:In the last decade, several epidemiological studies have demonstrated the potential of using seroprevalence (SP) and seroconversion rate (SCR) as informative indicators of malaria burden in low transmission settings or in populations on the cusp of elimination. However, most of studies are designed to contro...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0661-z
更新日期:2015-04-03 00:00:00
abstract:BACKGROUND:Successful reduction of malaria transmission to very low levels has made Isabel Province, Solomon Islands, a target for early elimination by 2014. High malaria transmission in neighbouring provinces and the potential for local asymptomatic infections to cause malaria resurgence highlights the need for sub-na...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-101
更新日期:2012-03-30 00:00:00
abstract:BACKGROUND:Insecticide-treated nets (ITN) and long-lasting insecticidal treated nets (LLIN) are important means of malaria prevention. Although there is consensus regarding their importance, there is uncertainty as to which delivery strategies are optimal for dispensing these life saving interventions. A targeted mass ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-173
更新日期:2010-06-18 00:00:00
abstract:BACKGROUND:Cases of transfusion-transmitted malaria have been described around the world and highlighted in some studies. Semi-immune individuals are more likely to transmit malaria as they may be asymptomatic. Some countries allow blood donations only based on epidemiological criteria while others reinforce their crit...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1586-x
更新日期:2016-11-09 00:00:00
abstract:BACKGROUND:In a previous study, severe and cerebral malaria have been connected with acute cochlear malfunction in children, demonstrated by a decrease of transitory evoked otoacoustic emissions (TEOAEs) reproducibility. This study aims to determine whether cochlear malfunction persists for 4 years after recovery from ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2840-9
更新日期:2019-06-24 00:00:00
abstract:BACKGROUND:Azithromycin (AZM) is a macrolide antibiotic that displays an excellent safety profile even in children and pregnant women and has been shown to have anti-malarial activity against blood stage Plasmodium falciparum. This study evaluated the transmission-blocking effect of AZM using a rodent malaria model. M...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-73
更新日期:2010-03-10 00:00:00
abstract:BACKGROUND:Declining in clinical efficacy of artesunate-mefloquine combination has been documented in areas along the eastern border (Thai-Cambodian) of Thailand. In the present study, the clinical efficacy of the three-day combination regimen of artesunate-mefloquine as first-line treatment for acute uncomplicated fal...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-273
更新日期:2010-10-08 00:00:00
abstract:BACKGROUND:Malaria is endemic in Garo hills of Meghalaya, and death cases are reported annually. Plasmodium falciparum is the major parasite, and is solely responsible for each malaria-attributable death case. Garo hills are categorized high-risk for drug-resistant malaria; however, there exists no data on malaria tran...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-263
更新日期:2010-09-22 00:00:00
abstract:BACKGROUND:Data concerning antimalarial combination treatment for uncomplicated malaria in Madagascar are largely lacking. Randomized clinical trial was designed to assess therapeutic efficacies of chloroquine (CQ), amodiaquine (AQ), sulphadoxine-pyrimethamine (SP), amodiaquine plus sulphadoxine-pyrimethamine combinati...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1475-2875-6-65
更新日期:2007-05-22 00:00:00
abstract:BACKGROUND:The conserved centromere-associated proteins, CENH3 (or CENP-A) and CENP-C are indispensable for the functional centromere-kinetochore assembly, chromosome segregation, cell cycle progression, and viability. The presence and functions of centromere proteins in Plasmodium falciparum are not well studied. Iden...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-475
更新日期:2014-12-04 00:00:00
abstract::The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and opportunity for ultimately eradicating this species. It is silent and cannot be diagnosed until it awakens and provokes a clinical attack with attendant morbidity, risk of mortality, and opportunities for onward transmission. The on...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2190-z
更新日期:2018-01-22 00:00:00
abstract:BACKGROUND:Malaria is a major public health issue in Burundi in terms of both morbidity and mortality, with around 2.5 million clinical cases and more than 15,000 deaths each year. It is still the single main cause of mortality in pregnant women and children below five years of age. Because of the severe health and eco...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-234
更新日期:2011-08-11 00:00:00
abstract:BACKGROUND:The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs. METHODS:A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screened for in vitro and i...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2281-x
更新日期:2018-04-03 00:00:00
abstract::The splenic complications of acute malaria include two different prognostic and treatment entities: splenic infarction and splenic rupture. This is the first case of splenic infarction during an acute malaria due to Plasmodium ovale in a 34-year-old man. As in the majority other described cases of splenic infarction, ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-288
更新日期:2010-10-18 00:00:00
abstract:BACKGROUND:The recent reports on the decreasing susceptibility of Plasmodium falciparum to artemisinin derivatives along the Thailand and Myanmar border are worrying. Indeed it may spread to India and then Africa, repeating the same pattern observed for chloroquine resistance. Therefore, it is essential to start monito...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-207
更新日期:2014-05-31 00:00:00
abstract:BACKGROUND:Heads of Government from Asia and the Pacific have committed to a malaria-free region by 2030. In 2015, the total number of confirmed cases reported to the World Health Organization by 22 Asia Pacific countries was 2,461,025. However, this was likely a gross underestimate due in part to incidence data not be...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1774-3
更新日期:2017-03-21 00:00:00
abstract:BACKGROUND:The US FDA recently developed CD3+, a counterfeit detection tool that is based on sample illumination at specific wavelengths of light and visual comparison of suspect sample and packaging materials to an authentic sample. To test performance of the CD3+ in field conditions, a study was conducted in Ghana wh...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1180-2
更新日期:2016-02-25 00:00:00
abstract:BACKGROUND:There has been much debate about the appropriate statistical methodology for the evaluation of malaria field studies and the challenges in interpreting data arising from these trials. METHODS:The present paper describes, for a pivotal phase III efficacy of the RTS, S/AS01 malaria vaccine, the methods of the...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-10-222
更新日期:2011-08-04 00:00:00
abstract:BACKGROUND:Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP) is recommended for reducing the risk of malaria in pregnancy and its consequences on mothers and babies (IPTp-SP). Indicators of implementation and effects of IPTp-SP were collected in a rural clinic in Southern Senegal. METHODS:Women se...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-234
更新日期:2008-11-07 00:00:00
abstract:BACKGROUND:The diversity and abundance of Anopheles larvae has significant influence on the resulting adult mosquito population and hence the dynamics of malaria transmission. Studies were conducted to examine larval habitat dynamics and ecological factors affecting survivorship of aquatic stages of malaria vectors in ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-228
更新日期:2010-08-09 00:00:00