Abstract:
BACKGROUND:Heads of Government from Asia and the Pacific have committed to a malaria-free region by 2030. In 2015, the total number of confirmed cases reported to the World Health Organization by 22 Asia Pacific countries was 2,461,025. However, this was likely a gross underestimate due in part to incidence data not being available from the wide variety of known sources. There is a recognized need for an accurate picture of malaria over time and space to support the goal of elimination. A survey was conducted to gain a deeper understanding of the collection of malaria incidence data for surveillance by National Malaria Control Programmes in 22 countries identified by the Asia Pacific Leaders Malaria Alliance. METHODS:In 2015-2016, a short questionnaire on malaria surveillance was distributed to 22 country National Malaria Control Programmes (NMCP) in the Asia Pacific. It collected country-specific information about the extent of inclusion of the range of possible sources of malaria incidence data and the role of the private sector in malaria treatment. The findings were used to produce recommendations for the regional heads of government on improving malaria surveillance to inform regional efforts towards malaria elimination. RESULTS:A survey response was received from all 22 target countries. Most of the malaria incidence data collected by NMCPs originated from government health facilities, while many did not collect comprehensive data from mobile and migrant populations, the private sector or the military. All data from village health workers were included by 10/20 countries and some by 5/20. Other sources of data included by some countries were plantations, police and other security forces, sentinel surveillance sites, research or academic institutions, private laboratories and other government ministries. Malaria was treated in private health facilities in 19/21 countries, while anti-malarials were available in private pharmacies in 16/21 and private shops in 6/21. Most countries use primarily paper-based reporting. CONCLUSIONS:Most collected malaria incidence data in the Asia Pacific is from government health facilities while data from a wide variety of other known sources are often not included in national surveillance databases. In particular, there needs to be a concerted regional effort to support inclusion of data on mobile and migrant populations and the private sector. There should also be an emphasis on electronic reporting and data harmonization across organizations. This will provide a more accurate and up to date picture of the true burden and distribution of malaria and will be of great assistance in helping realize the goal of malaria elimination in the Asia Pacific by 2030.
journal_name
Malar Jjournal_title
Malaria journalauthors
Mercado CE,Ekapirat N,Dondorp AM,Maude RJdoi
10.1186/s12936-017-1774-3subject
Has Abstractpub_date
2017-03-21 00:00:00pages
127issue
1issn
1475-2875pii
10.1186/s12936-017-1774-3journal_volume
16pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:The Plasmodium falciparum multidrug resistance 1 transporter, PfMDR1, contains five amino acid polymorphisms that are suggested to be involved in altered drug transport from the parasite's cytosol into the digestive vacuole (DV). Transport of a substrate into another intracellular compartment influences drug...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0791-3
更新日期:2015-07-15 00:00:00
abstract:BACKGROUND:Standard methods for defining clinical malaria in intervention trials in endemic areas do not guarantee that efficacy estimates will be unbiased, and do not indicate whether the intervention has its effect by modifying the force of infection, the parasite density, or the risk of pathology at given parasite d...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-53
更新日期:2007-05-02 00:00:00
abstract:BACKGROUND:In many low-income countries, the private commercial sector plays an important role in the provision of malaria treatment. However, the quality of care it provides is often poor, with artemisinin combination therapy (ACT) generally being too costly for consumers. Decreasing ACT prices is critical for improvi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0737-9
更新日期:2015-05-30 00:00:00
abstract:BACKGROUND:Transmission of malaria from man to mosquito depends on the presence of gametocytes, the sexual stage of Plasmodium parasites in the infected host. Naturally acquired antibodies against gametocytes exist and may play a role in controlling transmission by limiting the gametocyte development in the circulation...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1827-7
更新日期:2017-04-26 00:00:00
abstract:BACKGROUND:Sulfadoxine-pyrimethamine (SP) is a cornerstone of malaria chemoprophylaxis and is considered for programmes in the Democratic Republic of Congo (DRC). However, SP efficacy is threatened by drug resistance, that is conferred by mutations in the dhfr and dhps genes. The World Health Organization has specified...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-3057-7
更新日期:2019-12-18 00:00:00
abstract:BACKGROUND:The emergence of Plasmodium falciparum resistance to artemisinins threatens to undermine the effectiveness of artemisinin-based combination anti-malarial therapy. Developing suitable drugs to replace artemisinins requires the identification of new compounds that display rapid parasite killing kinetics. Howev...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0962-2
更新日期:2015-11-05 00:00:00
abstract:BACKGROUND:Described here is the first population genetic study of Plasmodium malariae, the causative agent of quartan malaria. Although not as deadly as Plasmodium falciparum, P. malariae is more common than previously thought, and is frequently in sympatry and co-infection with P. falciparum, making its study increas...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-38
更新日期:2011-02-11 00:00:00
abstract:BACKGROUND:IPTi delivered through EPI has been shown to reduce the incidence of clinical malaria by 20-59%. However, new health interventions can only be effective if they are also socially and culturally acceptable. It is also crucial to ensure that attitudes to IPTi do not negatively influence attitudes to and uptake...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-191
更新日期:2009-08-10 00:00:00
abstract:BACKGROUND:Plasmodium falciparum malaria is a significant problem around the world today, thus there is still a need for new control methods to be developed. Because the sporozoite displays dual infectivity for both the mosquito salivary glands and vertebrate host tissue, it is a good target for vaccine development. M...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-80
更新日期:2012-03-23 00:00:00
abstract:BACKGROUND:Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp. trophozoite, the stage when haemoglobin catabolism is maximal. H...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-94
更新日期:2008-05-27 00:00:00
abstract:BACKGROUND:During malaria infection the Toll-like receptor 9 (TLR9) is activated through induction with plasmodium DNA or another malaria motif not yet identified. Although TLR9 activation by malaria parasites is well reported, the implication to the susceptibility to severe malaria is not clear. The aim of this study ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-44
更新日期:2009-03-13 00:00:00
abstract:BACKGROUND:In Uganda, treatment of clinical malaria and intermittent preventive treatment with sulphadoxine-pyrimethamine (SP) are common during pregnancy. As a result, both formal and informal reports from antenatal sources suggest possible misuse of SP for malaria treatment among pregnant women. The objective of this...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0702-7
更新日期:2015-05-03 00:00:00
abstract::After publication of the article [1], it has been brought to our attention that a funding acknowledgement has been omitted from the original article. The authors would like to include the following, "The study was undertaken as part of the Target Malaria consortium, which receives core funding from the Bill & Melinda ...
journal_title:Malaria journal
pub_type: 已发布勘误
doi:10.1186/s12936-017-2030-6
更新日期:2017-09-19 00:00:00
abstract:BACKGROUND:Antibody immunity is thought to be essential to prevent severe Plasmodium falciparum infection, but the exact correlates of protection are unknown. Over time, children in endemic areas acquire non-sterile immunity to malaria that correlates with development of antibodies to merozoite invasion proteins and pa...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2323-4
更新日期:2018-04-25 00:00:00
abstract:BACKGROUND:The decline in efficacy of artesunate (AS) and mefloquine (MQ) is now the major concern in areas along the Thai-Cambodian and Thai-Myanmar borders. METHODS:The correlation between polymorphisms of pfatp6, pfcrt, pfmdr1 and pfmrp1 genes and in vitro sensitivity of Plasmodium falciparum isolates to the artemi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-23
更新日期:2014-01-15 00:00:00
abstract:BACKGROUND:Interest in the use of fungal entomopathogens against malaria vectors is growing. Fungal spores infect insects via the cuticle and can be applied directly on the insect to evaluate infectivity. For flying insects such as mosquitoes, however, application of fungal suspensions on resting surfaces is more reali...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-27
更新日期:2010-01-20 00:00:00
abstract:BACKGROUND:Donor financing for malaria has declined since 2010 and this trend is projected to continue for the foreseeable future. These reductions have a significant impact on lower burden countries actively pursuing elimination, which are usually a lesser priority for donors. While domestic spending on malaria has be...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1890-0
更新日期:2017-07-14 00:00:00
abstract::In the past decade, research on the functions of extracellular vesicles in malaria has expanded dramatically. Investigations into the various vesicle types, from both host and parasite origin, has revealed important roles for extracellular vesicles in disease pathogenesis and susceptibility, as well as cell-cell commu...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/s12936-017-1891-z
更新日期:2017-06-09 00:00:00
abstract::India has committed to eliminate malaria by 2030. The national framework for malaria elimination released by the Government of India plans to achieve this goal through strategic planning in a phased manner. Since vector control is a major component of disease management and vector elimination, it requires a thorough u...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/s12936-019-3011-8
更新日期:2019-12-03 00:00:00
abstract::Monitoring and evaluation of malaria control in pregnancy is essential for assessing the efficacy and effectiveness of health interventions aimed at reducing the major burden of this disease on women living in endemic areas. Yet there is no currently integrated strategic approach on how this should be achieved. Malari...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-7-S1-S6
更新日期:2008-12-11 00:00:00
abstract:BACKGROUND:Artemisinin-based combination therapy (ACT) has been adopted by the World Health Organization as a first-line treatment for uncomplicated Plasmodium falciparum malaria. In endemic regions, it has proven more effective in treating the disease, and even in reducing its transmission. Nonetheless, there is a sca...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1408-1
更新日期:2016-07-02 00:00:00
abstract:BACKGROUND:Herbal medicine has been a rich source of new drugs exemplified by quinine and artemisinin. In this study, a variety of Japanese traditional herbal medicine ('Kampo') were examined for their potential anti-malarial activities. METHODS:A comprehensive screening methods were designed to identify novel anti-ma...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03273-x
更新日期:2020-06-08 00:00:00
abstract:BACKGROUND:Whole-parasite immunization remains the benchmark in malaria vaccine development. A major bottleneck in the translation of whole-parasite immunization towards routine vaccination is the mode of administration, since high degrees of protection are currently only achieved by intravenous, and not by intradermal...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0552-3
更新日期:2015-01-28 00:00:00
abstract:BACKGROUND:Clinical profiling of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in a final multi-valent vaccine formulation. This report describes the immunological characterization of linear and cycliz...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-314
更新日期:2009-12-30 00:00:00
abstract:BACKGROUND:Malaria is endemic in Garo hills of Meghalaya, and death cases are reported annually. Plasmodium falciparum is the major parasite, and is solely responsible for each malaria-attributable death case. Garo hills are categorized high-risk for drug-resistant malaria; however, there exists no data on malaria tran...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-263
更新日期:2010-09-22 00:00:00
abstract:BACKGROUND:Private sector availability and use of malaria rapid diagnostic tests (RDTs) lags behind the public sector in Kenya. Increasing channels through which quality malaria diagnostic services are available can improve access to testing and help meet the target of universal diagnostic testing. Registered pharmacie...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2267-8
更新日期:2018-03-13 00:00:00
abstract:BACKGROUND:Major investments have been made since 2001, with intensification of malaria control interventions after 2006. Interventions included free distribution of insecticide-treated nets (ITN) to pregnant women and children under 5 years old, the introduction of artemisinin combination therapy (ACT) for malaria tre...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2573-1
更新日期:2018-11-14 00:00:00
abstract:BACKGROUND:As a result of the reintroduction of malaria in the Republic of Korea (ROK) in 1993 and the threat to military and civilian populations, the Korea Military National Defense (MND) increased emphasis on vector control in 2012 at ROK Army (ROKA) installations located near the DMZ, while decreasing chemoprophyla...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1301-y
更新日期:2016-05-05 00:00:00
abstract:BACKGROUND:The clinical use of mefloquine (MQ) has declined due to dose-related neurological events. Next generation quinoline methanols (NGQMs) that do not accumulate in the central nervous system (CNS) to the same extent may have utility. In this study, CNS levels of NGQMs relative to MQ were measured and an early le...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-150
更新日期:2011-06-06 00:00:00
abstract:BACKGROUND:Severe malarial anaemia requiring blood transfusion is a life-threatening condition affecting millions of children in sub-Saharan Africa. Up to 40% of children with severe malarial anaemia have associated lactic acidosis. Lactic acidosis in these children is strongly associated with fatal outcomes and is cor...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-12-55
更新日期:2013-02-06 00:00:00