Convalescent Plasmodium falciparum-specific seroreactivity does not correlate with paediatric malaria severity or Plasmodium antigen exposure.

abstract：BACKGROUND:The intraerythrocytic development cycle (IDC) of the rodent malaria Plasmodium chabaudi is coordinated with host circadian rhythms. When this coordination is disrupted, parasites suffer a 50% reduction in both asexual stages and sexual stage gametocytes over the acute phase of infection. Reduced gametocyte d...

journal_title：Malaria journal

authors： Westwood ML,O'Donnell AJ,Schneider P,Albery GF,Prior KF,Reece SE

更新日期：2020-01-14 00:00:00

abstract：BACKGROUND:An intensive effort to control malaria in Zimbabwe has produced dramatic reductions in the burden of the disease over the past 13 years. The successes have prompted the Zimbabwe's National Malaria Control Programme to commit to elimination of malaria. It is critical to analyse the changes in the morbidity tr...

journal_title：Malaria journal

authors： Sande S,Zimba M,Mberikunashe J,Tangwena A,Chimusoro A

更新日期：2017-07-24 00:00:00

abstract：BACKGROUND:Anopheles nuneztovari sensu lato comprises cryptic species in northern South America, and the Brazilian populations encompass distinct genetic lineages within the Brazilian Amazon region. This study investigated, based on two molecular markers, whether these lineages might actually deserve species status. M...

journal_title：Malaria journal

authors： Scarpassa VM,Cunha-Machado AS,Saraiva JF

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:Automated detection of malaria and dengue infection has been actively researched for more than two decades. Although many improvements have been achieved, these solutions remain too expensive for most laboratories and clinics in developing countries. The low range HORIBA Medical Haematology Analyzer, Yumizen...

journal_title：Malaria journal

authors： Dharap P,Raimbault S

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:The Cascades region, Burkina Faso, has a high malaria burden despite reported high insecticide-treated mosquito net (ITN) use. Human and vector activities outside the hours when indoor interventions offer direct protection from infectious bites potentially increase exposure risk to bites from malaria-transmi...

journal_title：Malaria journal

authors： Guglielmo F,Sanou A,Churcher T,Ferguson HM,Ranson H,Sherrard-Smith E

更新日期：2021-01-18 00:00:00

abstract：:In the 2010 second edition of WHO's guidelines for the treatment of malaria, the relatively new fixed dose combination dihydroartemisinin-piperaquine is included as one of the recommended artemisinin combination therapies. However, experimental testing demonstrates that, due to its intrinsic chemical instability, dihy...

journal_title：Malaria journal

authors： Jansen FH

更新日期：2010-07-22 00:00:00

abstract：BACKGROUND:Primaquine is an important gametocytocidal drug that is combined with conventional malaria treatment for prevention of Plasmodium falciparum malaria transmission. Primaquine has been administered together on the first or the last day of conventional treatment but the impact of primaquine timing has never bee...

journal_title：Malaria journal

authors： Shekalaghe S,Mosha D,Hamad A,Mbaga TA,Mihayo M,Bousema T,Drakeley C,Abdulla S

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:Effective and timely treatment is an essential aspect of malaria control, but remains a challenge in many parts of sub-Saharan Africa. The objective of this study was to describe young children's access to malaria treatment in Nouna Health District, Burkina Faso. METHODS:In February/March 2006, a survey was...

journal_title：Malaria journal

authors： Tipke M,Louis VR,Yé M,De Allegri M,Beiersmann C,Sié A,Mueller O,Jahn A

更新日期：2009-11-24 00:00:00

abstract：BACKGROUND:Plasmodium knowlesi is the fifth Plasmodium species that can infect humans. The Plasmodium merozoite surface protein-1(42) (MSP-1(42)) is a potential candidate for malaria vaccine. However, limited studies have focused on P. knowlesi MSP-1(42). METHODS:A ~42 kDa recombinant P. knowlesi MSP-1(42) (pkMSP-1(42...

journal_title：Malaria journal

authors： Cheong FW,Fong MY,Lau YL,Mahmud R

更新日期：2013-12-19 00:00:00

abstract：BACKGROUND:Five species of Plasmodium are known to infect humans. For proper treatment of malaria, accurate identification of the parasite species is crucial. The current gold standard for malaria diagnosis is microscopic examination of Giemsa-stained blood smears. Since the parasite species are identified by microscop...

journal_title：Malaria journal

authors： Hashimoto M,Sakamoto H,Ido Y,Tanaka M,Yatsushiro S,Kajimoto K,Kataoka M

更新日期：2018-06-19 00:00:00

abstract：BACKGROUND:Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country's malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is underway for a possible introduction, as soon as one becomes available...

journal_title：Malaria journal

authors： Bingham A,Gaspar F,Lancaster K,Conjera J,Collymore Y,Ba-Nguz A

更新日期：2012-11-28 00:00:00

abstract：BACKGROUND:A deeper understanding of the ecology and small-scale heterogeneity of malaria transmission is essential for the design of effective prevention, control and elimination interventions. The spatial and temporal distribution of malaria vectors was investigated in five villages in close proximity to a hydro-agri...

journal_title：Malaria journal

authors： Diakité NR,Guindo-Coulibaly N,Adja AM,Ouattara M,Coulibaly JT,Utzinger J,N'Goran EK

更新日期：2015-09-05 00:00:00

abstract：BACKGROUND:Malaria is reportedly receding in different epidemiological settings, but local long-term surveys are limited. At Mlomp dispensary in south-western Senegal, an area of moderate malaria transmission, year-round, clinically-suspected malaria was treated with monotherapy as per WHO and national policy in the 19...

journal_title：Malaria journal

authors： Brasseur P,Badiane M,Cisse M,Agnamey P,Vaillant MT,Olliaro PL

更新日期：2011-07-25 00:00:00

abstract：BACKGROUND:Malaria that is caused by Plasmodium vivax is the most widely distributed human malaria. Its recent resurgence in many parts of the world, including the Republic of Korea (ROK), emphasizes the importance of improved access to the early and accurate detection of P. vivax to reduce disease burden. In this stud...

journal_title：Malaria journal

authors： Dinzouna-Boutamba SD,Yang HW,Joo SY,Jeong S,Na BK,Inoue N,Lee WK,Kong HH,Chung DI,Goo YK,Hong Y

更新日期：2014-06-30 00:00:00

abstract：BACKGROUND:In Uganda, over half of under-five child mortality is attributed to three infectious diseases: malaria, pneumonia and diarrhoea. Integrated community case management (iCCM) trains village health workers (VHWs) to provide in-home diagnosis and treatment of these common childhood illnesses. For severely ill ch...

journal_title：Malaria journal

authors： English L,Miller JS,Mbusa R,Matte M,Kenney J,Bwambale S,Ntaro M,Patel P,Mulogo E,Stone GS

更新日期：2016-04-29 00:00:00

abstract：BACKGROUND:In south-eastern Senegal, malaria and onchocerciasis are co-endemic. Onchocerciasis in this region has been controlled by once or twice yearly mass drug administration (MDA) with ivermectin (IVM) for over fifteen years. Since laboratory-raised Anopheles gambiae s.s. are susceptible to ivermectin at concentra...

journal_title：Malaria journal

authors： Sylla M,Kobylinski KC,Gray M,Chapman PL,Sarr MD,Rasgon JL,Foy BD

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:Artemisinin is the current drug of choice for treatment of malaria and a number of other diseases. It is obtained from the annual herb, Artemisia annua and some microbial sources by genetic engineering. There is a great concern that the artemisinin production at current rate will not meet the increasing dema...

journal_title：Malaria journal

authors： Mannan A,Ahmed I,Arshad W,Asim MF,Qureshi RA,Hussain I,Mirza B

更新日期：2010-11-04 00:00:00

abstract：BACKGROUND:Plasmodium falciparum merozoite antigens elicit antibody responses in malaria-endemic populations, some of which are clinically protective, which is one of the reasons why merozoite antigens are the focus of malaria vaccine development efforts. Polymorphisms in several merozoite antigen-encoding genes are th...

journal_title：Malaria journal

authors： Ochola-Oyier LI,Okombo J,Wagatua N,Ochieng J,Tetteh KK,Fegan G,Bejon P,Marsh K

更新日期：2016-05-06 00:00:00

abstract：BACKGROUND:Data collected in clinical trials have been used to develop scoring systems that identify adults with malaria at greatest risk of death. One of these, the RCAM score, can be simply determined by measuring a patient's Glasgow Coma Score and respiratory rate on admission to hospital. However the safety of usin...

journal_title：Malaria journal

authors： Kaung M,Kyi TT,Aung NM,Kyaw MP,Min M,Htet ZW,Anstey NM,Kyi MM,Hanson J

更新日期：2015-02-07 00:00:00

abstract：BACKGROUND:For future eradication strategies of malaria it is important to control the transmission of gametocytes from humans to the anopheline vector which causes the spread of the disease. Sensitive, non-invasive methods to detect gametocytes under field conditions can play a role in monitoring transmission potentia...

journal_title：Malaria journal

authors： Kast K,Berens-Riha N,Zeynudin A,Abduselam N,Eshetu T,Löscher T,Wieser A,Shock J,Pritsch M

更新日期：2013-12-04 00:00:00

abstract：BACKGROUND:Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. ...

journal_title：Malaria journal

authors： Culleton RL,Mita T,Ndounga M,Unger H,Cravo PV,Paganotti GM,Takahashi N,Kaneko A,Eto H,Tinto H,Karema C,D'Alessandro U,do Rosário V,Kobayakawa T,Ntoumi F,Carter R,Tanabe K

更新日期：2008-09-11 00:00:00

abstract：BACKGROUND:Malaria rapid diagnostic tests (RDTs) are assumed to be simple-to-use and mobile technologies that have the capacity to standardize parasitological diagnosis for malaria across a variety of clinical settings. In order to evaluate these tests, it is important to consider how such assumptions play out in pract...

journal_title：Malaria journal

authors： Beisel U,Umlauf R,Hutchinson E,Chandler CI

更新日期：2016-02-05 00:00:00

abstract：BACKGROUND:Malaria control has been dramatically scaled up the past decade, mainly thanks to increasing international donor financing since 2003. This study assessed progress up to 2010 towards global malaria impact targets, in relation to Global Fund, other donor and domestic malaria programme financing over 2003 to 2...

journal_title：Malaria journal

authors： Korenromp EL,Hosseini M,Newman RD,Cibulskis RE

更新日期：2013-01-14 00:00:00

abstract：BACKGROUND:Knowledge of the ecological differences between the molecular forms of Anopheles gambiae and their sibling species, An. arabiensis might lead to understanding their unique contribution to disease transmission and to better vector control as well as to understanding the evolutionary forces that have separated...

journal_title：Malaria journal

authors： Yaro AS,Dao A,Adamou A,Crawford JE,Ribeiro JM,Gwadz R,Traoré SF,Lehmann T

更新日期：2006-03-22 00:00:00

abstract：:An improved methodology is presented here for transgenic Plasmodium berghei lines that express the negative selectable marker yFCU (a bifunctional protein that combines yeast cytosine deaminase and uridyl phosphoribosyl transferase (UPRT)) and substitutes delivery of selection drug 5-fluorocytosine (5FC) by intraperit...

journal_title：Malaria journal

authors： Orr RY,Philip N,Waters AP

更新日期：2012-03-31 00:00:00

abstract：BACKGROUND:Adequate coverage and proper use of long-lasting insecticidal nets (LLINs) and indoor residual spaying (IRS) reduce density of indoor-resting mosquitoes, man-mosquito contact and malaria infection. However, distribution, ownership and usage of the interventions may vary among households in a malarious area, ...

journal_title：Malaria journal

authors： Animut A,Negash Y,Kebede N

更新日期：2014-09-10 00:00:00

abstract：BACKGROUND:Development of resistance to different classes of insecticides is a potential threat to malaria control. With the increasing coverage of long-lasting insecticide-treated nets in Tanzania, the continued monitoring of resistance in vector populations is crucial. It may facilitate the development of novel strat...

journal_title：Malaria journal

authors： Matowo J,Kulkarni MA,Mosha FW,Oxborough RM,Kitau JA,Tenu F,Rowland M

更新日期：2010-07-07 00:00:00

abstract：BACKGROUND:Parasites from the genus Plasmodium, the aetiological agent of malaria in humans, can also infect non-human primates (NHP), increasing the potential risk of zoonotic transmission with its associated global public health concerns. In Colombia, there are no recent studies on Plasmodium spp. infecting free-rang...

journal_title：Malaria journal

authors： Rondón S,León C,Link A,González C

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Plasmodium ovale, considered the rarest of the malaria parasites of humans, consists of two morphologically identical but genetically distinct sympatric species, Plasmodium ovale curtisi and Plasmodium ovale wallikeri. These parasites resemble morphologically to Plasmodium vivax with which they also share a ...

journal_title：Malaria journal

authors： Chavatte JM,Tan SB,Snounou G,Lin RT

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) have become the most common diagnostic tool for detection of Plasmodium falciparum malaria, in particular in remote areas. RDT blood spots provide a source of parasite DNA for molecular analysis. In this study, the utility of RDTs for molecular analysis and the performance of di...

journal_title：Malaria journal

authors： Srisutham S,Suwannasin K,Mathema VB,Sriprawat K,Smithuis FM,Nosten F,White NJ,Dondorp AM,Imwong M

更新日期：2020-05-27 00:00:00