Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing.

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) has been adopted by the World Health Organization as a first-line treatment for uncomplicated Plasmodium falciparum malaria. In endemic regions, it has proven more effective in treating the disease, and even in reducing its transmission. Nonetheless, there is a sca...

journal_title：Malaria journal

authors： Pousibet-Puerto J,Salas-Coronas J,Sánchez-Crespo A,Molina-Arrebola MA,Soriano-Pérez MJ,Giménez-López MJ,Vázquez-Villegas J,Cabezas-Fernández MT

更新日期：2016-07-02 00:00:00

abstract：BACKGROUND:Eradication of malaria is difficult because of the ability of hypnozoite, the dormant liver-stage form of Plasmodium vivax, to cause relapse in patients. Research efforts to better understand the biology of P. vivax hypnozoite and design relapse prevention strategies have been hampered by the lack of a robus...

journal_title：Malaria journal

authors： Pewkliang Y,Rungin S,Lerdpanyangam K,Duangmanee A,Kanjanasirirat P,Suthivanich P,Sa-Ngiamsuntorn K,Borwornpinyo S,Sattabongkot J,Patrapuvich R,Hongeng S

更新日期：2018-01-25 00:00:00

abstract：BACKGROUND:Two major cities in West Africa, Accra, the capital of Ghana, and Lagos, the largest city of Nigeria, have significant problems with substandard pharmaceuticals. Both have actively combated the problem in recent years, particularly by screening products on the market using the Global Pharma Health Fund e.V. ...

journal_title：Malaria journal

authors： Bate R,Hess K

更新日期：2010-06-11 00:00:00

abstract：BACKGROUND:The massive deployment of life saving malaria interventions has not only resulted in a decline in disease burden but a change in the risk of infection and disease. The study reassesses the importance of known risk factors and reviews demographic and socio-economic determinants of malaria risk in the populati...

journal_title：Malaria journal

authors： Okebe J,Mwesigwa J,Kama EL,Ceesay SJ,Njie F,Correa S,Bojang K

更新日期：2014-08-08 00:00:00

abstract：BACKGROUND:Health care demand studies help to examine the behaviour of individuals and households during illnesses. Few of existing health care demand studies examine the choice of treatment services for childhood illnesses. Besides, in their analyses, many of the existing studies compare alternative treatment options ...

journal_title：Malaria journal

authors： Nonvignon J,Aikins MK,Chinbuah MA,Abbey M,Gyapong M,Garshong BN,Fia S,Gyapong JO

更新日期：2010-06-28 00:00:00

abstract：BACKGROUND:Information is needed on the expected durability of insecticidal nets under operational conditions. The persistence of insecticidal efficacy is important to estimate the median serviceable life of nets under field conditions and to plan for net replacement. METHODS:Deltamethrin residue levels were evaluated...

journal_title：Malaria journal

authors： Anshebo GY,Graves PM,Smith SC,Wills AB,Damte M,Endeshaw T,Shargie EB,Gebre T,Mosher AW,Patterson AE,Emerson PM

更新日期：2014-03-06 00:00:00

abstract：BACKGROUND:A deeper understanding of the ecology and small-scale heterogeneity of malaria transmission is essential for the design of effective prevention, control and elimination interventions. The spatial and temporal distribution of malaria vectors was investigated in five villages in close proximity to a hydro-agri...

journal_title：Malaria journal

authors： Diakité NR,Guindo-Coulibaly N,Adja AM,Ouattara M,Coulibaly JT,Utzinger J,N'Goran EK

更新日期：2015-09-05 00:00:00

abstract：BACKGROUND:Heads of Government from Asia and the Pacific have committed to a malaria-free region by 2030. In 2015, the total number of confirmed cases reported to the World Health Organization by 22 Asia Pacific countries was 2,461,025. However, this was likely a gross underestimate due in part to incidence data not be...

journal_title：Malaria journal

authors： Mercado CE,Ekapirat N,Dondorp AM,Maude RJ

更新日期：2017-03-21 00:00:00

abstract：BACKGROUND:Inter-individual variability in plasma concentration-time profiles might contribute to differences in anti-malarial treatment response. This study investigated the pharmacokinetics of three different forms of artemisinin combination therapy (ACT) in Tanzania and Cambodia to quantify and identify potential so...

journal_title：Malaria journal

authors： Staehli Hodel EM,Guidi M,Zanolari B,Mercier T,Duong S,Kabanywanyi AM,Ariey F,Buclin T,Beck HP,Decosterd LA,Olliaro P,Genton B,Csajka C

更新日期：2013-07-10 00:00:00

abstract：BACKGROUND:Monitoring and evaluation of malaria programmes may require a combination of approaches to detect any effects of control. This is particularly true at lower transmission levels where detecting both infection and exposure to infection will provide additional evidence of any change. This paper describes use of...

journal_title：Malaria journal

authors： Stevenson JC,Stresman GH,Baidjoe A,Okoth A,Oriango R,Owaga C,Marube E,Bousema T,Cox J,Drakeley C

更新日期：2015-10-26 00:00:00

abstract：BACKGROUND:Automated detection of malaria and dengue infection has been actively researched for more than two decades. Although many improvements have been achieved, these solutions remain too expensive for most laboratories and clinics in developing countries. The low range HORIBA Medical Haematology Analyzer, Yumizen...

journal_title：Malaria journal

authors： Dharap P,Raimbault S

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:A high prevalence of spherocytes was detected in blood smears of children enrolled in a case control study conducted in the malaria holoendemic Lake Victoria basin. It was speculated that the spherocytes reflect intraerythrocytic removal of malarial parasites with a concurrent removal of RBC membrane through...

journal_title：Malaria journal

authors： Anyona SB,Schrier SL,Gichuki CW,Waitumbi JN

更新日期：2006-07-31 00:00:00

abstract：BACKGROUND:Laboratory studies have demonstrated that a variety of immune signaling pathways regulate malaria parasite infection in Anopheles gambiae, the primary vector species in Africa. METHODS:To begin to understand the importance of these associations under natural conditions, an association mapping approach was a...

journal_title：Malaria journal

authors： Horton AA,Lee Y,Coulibaly CA,Rashbrook VK,Cornel AJ,Lanzaro GC,Luckhart S

更新日期：2010-06-11 00:00:00

abstract：BACKGROUND:Developing thermostable vaccines is a challenge for pharmaceutical companies due to the inherent instability of biological molecules in aqueous solution. The problem is even more stringent in regions subjected to high temperatures in which protective cold chain is difficult to maintain due to a lack of infra...

journal_title：Malaria journal

authors： Fortpied J,Collignon S,Moniotte N,Renaud F,Bayat B,Lemoine D

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Aggregated haemozoin crystals within malaria-infected erythrocytes confer susceptibility of parasitized cells to a magnetic field. Here the utility of this method for diagnosis of human malaria is evaluated in a malaria-endemic region of Papua New Guinea (PNG). METHODS AND FINDINGS:Individuals with Plasmodi...

journal_title：Malaria journal

authors： Karl S,David M,Moore L,Grimberg BT,Michon P,Mueller I,Zborowski M,Zimmerman PA

更新日期：2008-04-25 00:00:00

abstract：BACKGROUND:Public health pesticides has been the mainstay control of vectors of malaria and other diseases, and public health pests, but there is increasing concern over how these pesticides are being managed. Poor pesticide management could lead to risks to human health and the environment, or diminish the effectivene...

journal_title：Malaria journal

authors： van den Berg H,Yadav RS,Zaim M

更新日期：2014-09-18 00:00:00

abstract：BACKGROUND:Malaria during pregnancy is associated with poor maternal and pregnancy outcome and the World Health Organization recommends the administration of intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) and distribution of insecticide-treated mosquito nets (ITNs) to all preg...

journal_title：Malaria journal

authors： Salomão C,Sacarlal J,Gudo ES

更新日期：2017-05-25 00:00:00

abstract：BACKGROUND:Malaria presents a diagnostic challenge in tribal belt of central India where two Plasmodium species, Plasmodium falciparum and Plasmodium vivax, are prevalent. In these areas, rapid detection of the malaria parasites and early treatment of infection remain the most important goals of disease management. The...

journal_title：Malaria journal

authors： Bharti PK,Silawat N,Singh PP,Singh MP,Shukla M,Chand G,Dash AP,Singh N

更新日期：2008-07-11 00:00:00

abstract：BACKGROUND:Understanding spatio-temporal variation in malaria incidence provides a basis for effective disease control planning and monitoring. METHODS:Monthly surveillance data between 1991 and 2006 for Plasmodium vivax and Plasmodium falciparum malaria across 128 counties were assembled for Yunnan, a province of Chi...

journal_title：Malaria journal

authors： Clements AC,Barnett AG,Cheng ZW,Snow RW,Zhou HN

更新日期：2009-07-31 00:00:00

abstract：BACKGROUND:Drug resistance in Plasmodium falciparum is common in many endemic and other settings but there is no clear recommendation on when to change therapy when there is delay in parasite clearance after initiation of therapy in African children. METHODS:The factors contributing to delay in parasite clearance, def...

journal_title：Malaria journal

authors： Sowunmi A,Adewoye EO,Gbotsho GO,Happi CT,Sijuade A,Folarin OA,Okuboyejo TM,Michael OS

更新日期：2010-02-15 00:00:00

abstract：BACKGROUND:Interest in the use of fungal entomopathogens against malaria vectors is growing. Fungal spores infect insects via the cuticle and can be applied directly on the insect to evaluate infectivity. For flying insects such as mosquitoes, however, application of fungal suspensions on resting surfaces is more reali...

journal_title：Malaria journal

authors： Farenhorst M,Knols BG

更新日期：2010-01-20 00:00:00

abstract：BACKGROUND:The use of insecticide-treated nets (ITN) is an important tool in the Roll Back Malaria (RBM) strategy. For ITNs to be effective they need to be used correctly. Previous studies have shown that many factors, such as wealth, access to health care, education, ethnicity and gender, determine the ownership and u...

journal_title：Malaria journal

authors： Toé LP,Skovmand O,Dabiré KR,Diabaté A,Diallo Y,Guiguemdé TR,Doannio JM,Akogbeto M,Baldet T,Gruénais ME

更新日期：2009-07-29 00:00:00

abstract：BACKGROUND:Mutations in Pfkelch13 and Pfplasmepsin2/3 gene amplification are well-established markers for artemisinin and piperaquine resistance in Plasmodium falciparum, a widespread problem in the Greater Mekong Subregion (GMS). The Plasmodium vivax parasite population has experienced varying drug pressure dependent ...

journal_title：Malaria journal

authors： Duanguppama J,Mathema VB,Tripura R,Day NPJ,Maxay M,Nguon C,von Seidlein L,Dhorda M,Peto TJ,Nosten F,White NJ,Dondorp AM,Imwong M

更新日期：2019-04-02 00:00:00

abstract：BACKGROUND:The Plasmodium falciparum multidrug resistance 1 transporter, PfMDR1, contains five amino acid polymorphisms that are suggested to be involved in altered drug transport from the parasite's cytosol into the digestive vacuole (DV). Transport of a substrate into another intracellular compartment influences drug...

journal_title：Malaria journal

authors： Reiling SJ,Rohrbach P

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:In the context of malaria elimination/eradication, drugs that are effective against the different developmental stages of the parasite are highly desirable. The oldest synthetic anti-malarial drug, the thiazine dye methylene blue (MB), is known for its activity against Plasmodium blood stages, including game...

journal_title：Malaria journal

authors： Bosson-Vanga H,Franetich JF,Soulard V,Sossau D,Tefit M,Kane B,Vaillant JC,Borrmann S,Müller O,Dereuddre-Bosquet N,Le Grand R,Silvie O,Mazier D

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Malaria is responsible for up to a 600,000 deaths per year; conveying an urgent need for the development of a malaria vaccine. Studies with whole sporozoite vaccines in mice and non-human primates have shown that sporozoite-induced CD8+ T cells targeting liver stage antigens can mediate sterile protection. T...

journal_title：Malaria journal

authors： Schwenk R,Banania G,Epstein J,Kim Y,Peters B,Belmonte M,Ganeshan H,Huang J,Reyes S,Stryhn A,Ockenhouse CF,Buus S,Richie TL,Sedegah M

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of residual malaria infections usually requires a large study size, therefore sampling and diagnostic...

journal_title：Malaria journal

authors： Grossenbacher B,Holzschuh A,Hofmann NE,Omar KA,Stuck L,Fakih BS,Ali A,Yukich J,Hetzel MW,Felger I

更新日期：2020-01-29 00:00:00

abstract：BACKGROUND:Convulsions is one of the key signs of severe malaria among children under five years of age, potentially leading to serious complications or death. Several studies of care-seeking behaviour have revealed that local illness concepts linked to convulsions (referred to as degedege in Tanzanian Kiswahili) calle...

journal_title：Malaria journal

authors： Dillip A,Hetzel MW,Gosoniu D,Kessy F,Lengeler C,Mayumana I,Mshana C,Mshinda H,Schulze A,Makemba A,Pfeiffer C,Weiss MG,Obrist B

更新日期：2009-06-29 00:00:00

abstract：BACKGROUND:IPTi delivered through EPI has been shown to reduce the incidence of clinical malaria by 20-59%. However, new health interventions can only be effective if they are also socially and culturally acceptable. It is also crucial to ensure that attitudes to IPTi do not negatively influence attitudes to and uptake...

journal_title：Malaria journal

authors： Gysels M,Pell C,Mathanga DP,Adongo P,Odhiambo F,Gosling R,Akweongo P,Mwangi R,Okello G,Mangesho P,Slutsker L,Kremsner PG,Grobusch MP,Hamel MJ,Newman RD,Pool R

更新日期：2009-08-10 00:00:00

abstract：BACKGROUND:The malaria parasite disposes of host-derived ferrihaem (iron(III)protoporphyrin IX, Fe(III)PPIX) by conversion to crystalline haemozoin in close association with neutral lipids. Lipids mediate synthetic haemozoin (β-haematin) formation very efficiently. However, the effect on reaction rates of concentration...

journal_title：Malaria journal

authors： Ambele MA,Egan TJ

更新日期：2012-10-08 00:00:00