Abstract:
BACKGROUND:Insecticide-treated clothing (ITC) has long been used for military and outdoor recreational purposes and there is substantial evidence to show that it can protect against arthropod biting. As a complementary vector control measure, ITC could be used to address outdoor transmission of malaria, particularly among mobile and migrant populations and night-time workers such as rubber tappers, who may be beyond the reach of core interventions. However, more information is required on acceptability and preferences of target groups towards ITC to understand whether it could be a viable strategy in Myanmar. METHODS:A cluster-randomized, double-blind, non-inferiority crossover trial was performed to determine acceptability of ITC versus identical, untreated clothing (NTC) among migrant rubber tappers. The study took place between January and May 2015 with 234 participants in 16 clusters in Thanbyuzayat Township, Mon State, Myanmar. Participants were randomly assigned to the order of clothing distribution and followed up at 2, 4 and 6 week intervals. Acceptability was assessed through structured questionnaires, focus group discussions and in-depth interviews. A cluster-level non-inferiority analysis was conducted using STATA, while qualitative data were digitally recorded, transcribed and content-analysed to identify patterns and themes, and managed thematically in Excel 2010®. RESULTS:Acceptability of both types of clothing was high. ITC was deduced to be non-inferior to NTC for seven out of eight indicators regarding perceptions (looks nice, is durable, is pleasant to wear for nighttime work, reduces mosquito bites, would recommend the clothing, would buy the clothing, like the clothing overall). A high proportion of respondents reported that the clothing reduced mosquito bites (ITC-98%; NTC-94%). Clothing was worn regularly (about 11 times in the previous two weeks). The most common reasons for not wearing the clothing every night were that it was being washed or dried, or the participant did not go to work. CONCLUSIONS:The high level of acceptability suggests that ITC could be an appropriate strategy for personal protection amongst migrant rubber tappers in outdoor transmission settings in Myanmar. However, more research is needed into the feasibility and protective efficacy of ITC before it can be considered for wider roll-out. Trial registration Clinical trials ACTRN12615000432516.
journal_name
Malar Jjournal_title
Malaria journalauthors
Crawshaw AF,Maung TM,Shafique M,Sint N,Nicholas S,Li MS,Roca-Feltrer A,Hii Jdoi
10.1186/s12936-017-1737-8subject
Has Abstractpub_date
2017-02-28 00:00:00pages
92issue
1issn
1475-2875pii
10.1186/s12936-017-1737-8journal_volume
16pub_type
杂志文章,随机对照试验相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:Artemisinin-based combination therapy (ACT) has been adopted as the most effective treatment against malaria in many endemic countries like Kenya while quinine has remained the second line. The objective of the current study was to assess access to Kenya's policy recommended anti-malarials, ACT and quinine i...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-290
更新日期:2014-07-28 00:00:00
abstract:BACKGROUND:Inter-individual variability in plasma concentration-time profiles might contribute to differences in anti-malarial treatment response. This study investigated the pharmacokinetics of three different forms of artemisinin combination therapy (ACT) in Tanzania and Cambodia to quantify and identify potential so...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-235
更新日期:2013-07-10 00:00:00
abstract:BACKGROUND:Cerebral malaria (CM) is associated with morbidity and mortality despite the use of potent anti-malarial agents. Brain endothelial cell activation and dysfunction from oxidative and inflammatory host responses and products released by Plasmodium falciparum-infected erythrocytes (IE), are likely the major con...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03447-7
更新日期:2020-10-21 00:00:00
abstract:BACKGROUND:The development of insecticide resistance and the increased outdoor-biting behaviour of malaria vectors reduce the efficiency of indoor vector control methods. Attractive toxic sugar baits (ATSBs), a method targeting the sugar-feeding behaviours of vectors both indoors and outdoors, is a promising supplement...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-1012-9
更新日期:2015-12-08 00:00:00
abstract:BACKGROUND:Chloroquine has been the treatment of choice for acute vivax malaria for more than 60 years. Malaria caused by Plasmodium vivax has recently shown resistance to chloroquine in some places. This study compared the efficacy and safety of fixed dose combination (FDC) of arterolane maleate and piperaquine phosph...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/s12936-016-1084-1
更新日期:2016-01-27 00:00:00
abstract:BACKGROUND:Control of mosquitoes that transmit malaria has been the mainstay in the fight against the disease, but alternative methods are required in view of emerging insecticide resistance. Entomopathogenic fungi are candidate alternatives, but to date, few trials have translated the use of these agents to field-base...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-87
更新日期:2012-03-26 00:00:00
abstract:BACKGROUND:The emergence of parasite drug resistance, especially Plasmodium falciparum, persists as a major obstacle for malaria control and elimination. To develop effective public health containment strategies, a clear understanding of factors that govern the emergence and spread of resistant parasites in the field i...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-453
更新日期:2013-12-19 00:00:00
abstract:BACKGROUND:In recent years, malaria (Plasmodium vivax and Plasmodium falciparum) has been successfully controlled in the Ecuador-Peru coastal border region. The aim of this study was to document this control effort and to identify the best practices and lessons learned that are applicable to malaria control and to othe...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1630-x
更新日期:2016-11-28 00:00:00
abstract:BACKGROUND:In 2017, nearly 80% of malaria morbidity and mortality occurred in sub-Saharan African (SSA) countries and India. Rapid diagnostic tests (RDTs), especially those targeting histidine-rich protein 2 (PfHRP2) of Plasmodium falciparum, have become an important diagnostic tool in these malaria-endemic areas. Howe...
journal_title:Malaria journal
pub_type: 杂志文章,meta分析
doi:10.1186/s12936-019-3090-6
更新日期:2020-01-28 00:00:00
abstract:BACKGROUND:The circumsporozoite protein (CS protein) on the malaria parasites in mosquitoes plays an important role in sporogony in mosquitoes. The RTS,S/AS01 malaria vaccine candidate, which has shown significant efficacy against clinical malaria in a large Phase 3 trial, targets the Plasmodium falciparum CS protein, ...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/1475-2875-13-263
更新日期:2014-07-09 00:00:00
abstract:BACKGROUND:Despite the abundance of studies conducted on the role of mosquitoes in malaria transmission, the biology and interaction of Plasmodium with its insect host still holds many mysteries. This paper provides the first study to follow the sporogonic cycle of Plasmodium vivax in a wild insecticide-resistant mysor...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-131
更新日期:2008-07-15 00:00:00
abstract:BACKGROUND:Eradication of malaria is difficult because of the ability of hypnozoite, the dormant liver-stage form of Plasmodium vivax, to cause relapse in patients. Research efforts to better understand the biology of P. vivax hypnozoite and design relapse prevention strategies have been hampered by the lack of a robus...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2198-4
更新日期:2018-01-25 00:00:00
abstract:BACKGROUND:In order to sustain the gains achieved by current malaria control strategies, robust surveillance systems that monitor dynamics of vectors and their roles in malaria transmission over time are essential. This longitudinal study demonstrates the trends in malaria vector dynamics and their relative contributio...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-331
更新日期:2014-08-24 00:00:00
abstract:BACKGROUND:Traditional medicine is readily available in Tanzania, and local terms like degedege is widely used for malaria-like illnesses, often associated with supernatural forces. Malaria prevention and intervention efforts can benefit from policy-makers' awareness of local perceptions and beliefs in the rural areas ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-200
更新日期:2014-05-28 00:00:00
abstract:BACKGROUND:Artemisinin-derivative formulations are now widely used to treat falciparum malaria. However, the dry powder suspensions developed for children are few and/or are of poor quality. In addition to the active compound, the presence of a suitable preservative in these medicines is essential. In this study, an ev...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-12
更新日期:2007-01-26 00:00:00
abstract:BACKGROUND:The emergence of Plasmodium falciparum resistance to artemisinins threatens to undermine the effectiveness of artemisinin-based combination anti-malarial therapy. Developing suitable drugs to replace artemisinins requires the identification of new compounds that display rapid parasite killing kinetics. Howev...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0962-2
更新日期:2015-11-05 00:00:00
abstract:BACKGROUND:Malaria is a major health problem in sub-Saharan Africa where over 90% of the world's malaria cases occur. Artemisinin-based combination therapy (ACT) is recommended by the World Health Organization as first-line and second-line treatments for uncomplicated falciparum malaria. However, there are a growing nu...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2482-3
更新日期:2018-09-15 00:00:00
abstract:BACKGROUND:Antibody immunity is thought to be essential to prevent severe Plasmodium falciparum infection, but the exact correlates of protection are unknown. Over time, children in endemic areas acquire non-sterile immunity to malaria that correlates with development of antibodies to merozoite invasion proteins and pa...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2323-4
更新日期:2018-04-25 00:00:00
abstract:BACKGROUND:Severe malaria has been attributed to the expression of a restricted subset of the var multi-gene family, which encodes for Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 mediates cytoadherence and sequestration of infected erythrocytes into the post-capillary venules of vital organs s...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-230
更新日期:2012-07-16 00:00:00
abstract:BACKGROUND:Autoregressive regression coefficients for Anopheles arabiensis aquatic habitat models are usually assessed using global error techniques and are reported as error covariance matrices. A global statistic, however, will summarize error estimates from multiple habitat locations. This makes it difficult to iden...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-216
更新日期:2009-09-21 00:00:00
abstract::Malaria currently causes more harm to human beings than any other parasitic disease, and disproportionally affects low-income populations. The ethical issues raised by efforts to control or eliminate malaria have received little explicit analysis, in comparison with other major diseases of poverty. While some ethical ...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/s12936-015-1042-3
更新日期:2015-12-22 00:00:00
abstract:BACKGROUND:Over the last decade, the incidence of confirmed malaria has declined significantly in Nepal. The aim of this paper is to assess the spatio-temporal distribution of malaria and its association with climatic factors and vector control interventions in two high-risk districts of Nepal. METHODS:Hotspot analysi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-457
更新日期:2014-11-25 00:00:00
abstract:BACKGROUND:Malaria remains a major human health problem, with no licensed vaccine currently available. Malaria infections initiate when infectious Plasmodium sporozoites are transmitted by Anopheline mosquitoes during their blood meal. Investigations of the malaria sporozoite are, therefore, of clear medical importance...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-421
更新日期:2012-12-17 00:00:00
abstract:BACKGROUND:The objective of this study was to identify attitudes and misconceptions related to acceptance or refusal of indoor residual spraying (IRS) in Tanzania for both the general population and among certain groups (e.g., farmers, fishermen, community leaders, and women). METHODS:This study was a series of qualit...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-220
更新日期:2012-07-02 00:00:00
abstract:BACKGROUND:The incidence of malaria in the Amazon basin is closely related to social inequalities, given that precarious economic and socio-environmental conditions represent favourable factors for the transmission of the disease in tropical regions, such as the Brazilian state of Pará. In the present study, an associa...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-86
更新日期:2014-03-10 00:00:00
abstract:BACKGROUND:Rhoptries are the large, paired, secretory organelles located at the apical tip of the malaria merozoite that are considered important for parasite invasion processes. Plasmodium vivax rhoptry proteins have been shown to induce humoral immunity during natural infections. Therefore, these proteins may be pote...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-3009-2
更新日期:2019-11-29 00:00:00
abstract:BACKGROUND:To date, human peripheral blood mononuclear cells (PBMCs) have been used mainly in immune stimulation assays and the interpretation of data can be influenced by the previous immunological history of donors and cross reactivity with other infectious agents. Resolving these limitations requires an alternative ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1781-4
更新日期:2017-03-27 00:00:00
abstract:BACKGROUND:Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp. trophozoite, the stage when haemoglobin catabolism is maximal. H...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-94
更新日期:2008-05-27 00:00:00
abstract:BACKGROUND:The screening of lead compounds against in vitro parasite cultures is an essential step in the development of novel anti-malarial drugs, but currently relies on laboratory parasite lines established in vitro during the last century. This study sought to establish in continuous culture a series of recent Plas...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-320
更新日期:2013-09-13 00:00:00
abstract:BACKGROUND:Polymorphisms within the PfATP6 gene have been indicated as potential molecular markers for artemisinin efficacy. Since 2004, the use of artemisinin combination therapy (ACT) was introduced as first-line treatment of the uncomplicated malaria cases in Suriname. The aim of this research was to determine chang...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-322
更新日期:2012-09-11 00:00:00