Pre-infection administration of asiatic acid retards parasitaemia induction in Plasmodium berghei murine malaria infected Sprague-Dawley rats.

abstract：:Anti-malarial drugs are now mainly deployed as combination therapy (CT), primarily as a mechanism to prevent or slow the spread of resistance. This strategy is justified by mathematical arguments that generally assume that drug 'resistance' is a binary all-or-nothing genetic trait. Herein, a pharmacological, rather th...

journal_title：Malaria journal

authors： Hastings IM,Hodel EM

更新日期：2014-02-20 00:00:00

abstract：BACKGROUND:The malaria vector Anopheles gambiae is polymorphic for chromosomal inversions on the right arm of chromosome 2 that segregate nonrandomly between assortatively mating populations in West Africa. One such inversion, 2Rj, is associated with the BAMAKO chromosomal form endemic to southern Mali and northern Gui...

journal_title：Malaria journal

authors： Coulibaly MB,Pombi M,Caputo B,Nwakanma D,Jawara M,Konate L,Dia I,Fofana A,Kern M,Simard F,Conway DJ,Petrarca V,della Torre A,Traoré S,Besansky NJ

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Antiplasmodial activities of angiotensin II and its analogues have been extensively investigated in Plasmodium gallinaceum and Plasmodium falciparum parasite species. Due to its vasoconstrictor property angiotensin II cannot be used as an anti-malarial drug. METHODS:This work presents the solid-phase synthe...

journal_title：Malaria journal

authors： Silva AF,Torres MD,Silva Lde S,Alves FL,Pinheiro AA,Miranda A,Capurro ML,Oliveira VX Jr

更新日期：2015-11-04 00:00:00

abstract：BACKGROUND:Prompt, quality assured laboratory diagnosis is key to effective malaria case management and control, especially since the introduction of the more expensive artemisinin combination therapy (ACT). The malaria programme and its non-government partners, on the basis of WHO recommended Lot Quality Assurance met...

journal_title：Malaria journal

authors： Khan MA,Walley JD,Munir MA,Khan MA,Khokar NG,Tahir Z,Nazir A,Shams N

更新日期：2011-02-17 00:00:00

abstract：BACKGROUND:Approximately 50 million people (60 %) live in malaria risk areas in Ethiopia, at altitudes below 2000 m. According to official data, 60-70 % of malaria cases are due to Plasmodium falciparum, and 40-30 % by Plasmodium vivax. The species Plasmodium ovale was detected in 2013 in the northwest of the country, ...

journal_title：Malaria journal

authors： Díaz PB,Lozano PM,Rincón JM,García L,Reyes F,Llanes AB

更新日期：2015-09-18 00:00:00

abstract：BACKGROUND:Mutations in the haemoglobin beta-globin (HbB) and glucose-6-phosphate dehydrogenase (G6PD) genes cause widespread human genetic disorders such as sickle cell diseases and G6PD deficiency. In sub-Saharan Africa, a few predominant polymorphic variants of each gene account for a majority of these deficiencies....

journal_title：Malaria journal

authors： Enevold A,Vestergaard LS,Lusingu J,Drakeley CJ,Lemnge MM,Theander TG,Bygbjerg IC,Alifrangis M

更新日期：2005-12-15 00:00:00

abstract：BACKGROUND:Individual malaria interventions provide only partial protection in most epidemiological situations. Thus, there is a need to investigate whether combining interventions provides added benefit in reducing mortality and morbidity from malaria. The potential benefits of combining IPT in children (IPTc) with ho...

journal_title：Malaria journal

authors： Sesay S,Milligan P,Touray E,Sowe M,Webb EL,Greenwood BM,Bojang KA

更新日期：2011-01-07 00:00:00

abstract：BACKGROUND:Fixed-dose combination antimalarial drugs have played an increasingly important role in the treatment and chemoprophylaxis of falciparum malaria since the worldwide failure of monotherapy with chloroquine. Atovaquone-proguanil is one such combination drug used both for prophylaxis in travellers, and for trea...

journal_title：Malaria journal

authors： Sutherland CJ,Laundy M,Price N,Burke M,Fivelman QL,Pasvol G,Klein JL,Chiodini PL

更新日期：2008-11-20 00:00:00

abstract：BACKGROUND:The relationship between mosquito development and temperature is one of the keys to understanding the current and future dynamics and distribution of vector-borne diseases such as malaria. Many process-based models use mean air temperature to estimate larval development times, and hence adult vector densitie...

journal_title：Malaria journal

authors： Paaijmans KP,Imbahale SS,Thomas MB,Takken W

更新日期：2010-07-09 00:00:00

abstract：BACKGROUND:Artemisinin-derivative formulations are now widely used to treat falciparum malaria. However, the dry powder suspensions developed for children are few and/or are of poor quality. In addition to the active compound, the presence of a suitable preservative in these medicines is essential. In this study, an ev...

journal_title：Malaria journal

authors： Atemnkeng MA,De Cock K,Plaizier-Vercammen J

更新日期：2007-01-26 00:00:00

abstract：BACKGROUND:Long regarded as an epicenter of drug-resistant malaria, Southeast Asia continues to provide new challenges to the control of Plasmodium falciparum malaria. Recently, resistance to the artemisinin combination therapy partner drug piperaquine has been observed in multiple locations across Southeast Asia. Gene...

journal_title：Malaria journal

authors： Ansbro MR,Jacob CG,Amato R,Kekre M,Amaratunga C,Sreng S,Suon S,Miotto O,Fairhurst RM,Wellems TE,Kwiatkowski DP

更新日期：2020-05-13 00:00:00

abstract：BACKGROUND:Experimental vaccines targeting Plasmodium falciparum have had some success in recent years. These vaccines use attenuated parasites, recombinant sporozoite proteins, or DNA and virus combinations to induce cell-mediated immune responses and/or antibodies targeting sporozoite surface proteins. To capitalize ...

journal_title：Malaria journal

authors： Zou X,House BL,Zyzak MD,Richie TL,Gerbasi VR

更新日期：2013-11-05 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s12936-016-1486-0.]. ...

journal_title：Malaria journal

authors： DellaValle B,Hempel C,Staalsoe T,Johansen FF,Kurtzhals JAL

更新日期：2016-09-27 00:00:00

abstract：BACKGROUND:The impact of sulfadoxine-pyrimethamine (SP) used as intermittent preventive treatment during pregnancy (IPTp-SP) on mutant parasite selection has been poorly documented in Burkina Faso. This study sought first to explore the relationship between IPTp-SP and the presence of mutant parasites. Second, to asses...

journal_title：Malaria journal

authors： Cisse M,Awandare GA,Soulama A,Tinto H,Hayette MP,Guiguemdé RT

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:The study of the biology, transmission and pathogenesis of Plasmodium vivax is hindered due to the lack of a robustly propagating, continuous culture of this parasite. The current culture system for P. vivax parasites still suffered from consistency and difficulties in long-term maintenance of parasites in c...

journal_title：Malaria journal

authors： Roobsoong W,Tharinjaroen CS,Rachaphaew N,Chobson P,Schofield L,Cui L,Adams JH,Sattabongkot J

更新日期：2015-08-05 00:00:00

abstract：BACKGROUND:North East Kenya is an area of semi-arid terrain, prone to malaria epidemics. The distribution of long-lasting insecticidal nets (LLINs) has long been a key malaria intervention, however, for nomadic populations who live and sleep outside, in harsh climates and areas with increasing reports of exophagic beha...

journal_title：Malaria journal

authors： Gore-Langton GR,Mungai J,Alenwi N,Abagira A,Bicknell OM,Harrison R,Hassan FA,Munga S,Njoroge F,Juma E,Allan R

更新日期：2015-02-05 00:00:00

abstract：BACKGROUND:The Democratic Republic of the Congo (DRC) bears a high burden of malaria, which is exacerbated in pregnant women. The VAR2CSA protein plays a crucial role in pregnancy-associated malaria (PAM), and hence quantifying diversity at the var2csa locus in the DRC is important in understanding the basic epidemiolo...

journal_title：Malaria journal

authors： Verity R,Hathaway NJ,Waltmann A,Doctor SM,Watson OJ,Patel JC,Mwandagalirwa K,Tshefu AK,Bailey JA,Ghani AC,Juliano JJ,Meshnick SR

更新日期：2018-01-24 00:00:00

abstract：BACKGROUND:Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analogous mutations can be found in the DHFR gene in...

journal_title：Malaria journal

authors： Choowongkomon K,Theppabutr S,Songtawee N,Day NP,White NJ,Woodrow CJ,Imwong M

更新日期：2010-03-02 00:00:00

abstract：BACKGROUND:Public health facilities are usually the first to receive interventions compared to private facilities, yet majority of health seeking care is first done with the latter. This study compared the capacity to manage acute febrile illnesses in children below 5 years in private vs public health facilities in ord...

journal_title：Malaria journal

authors： Buregyeya E,Rutebemberwa E,LaRussa P,Lal S,Clarke SE,Hansen KS,Magnussen P,Mbonye AK

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Severe anaemia can develop in the aftermath of Plasmodium falciparum malaria because of protracted bone marrow suppression, possibly due to residual subpatent parasites. MATERIALS AND METHODS:Blood was collected from patients with recent malaria and negative malaria microscopy. Detection of the Plasmodium a...

journal_title：Malaria journal

authors： Helleberg M,Goka BQ,Akanmori BD,Obeng-Adjei G,Rodriques O,Kurtzhals JA

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Over the last decade, the incidence of confirmed malaria has declined significantly in Nepal. The aim of this paper is to assess the spatio-temporal distribution of malaria and its association with climatic factors and vector control interventions in two high-risk districts of Nepal. METHODS:Hotspot analysi...

journal_title：Malaria journal

authors： Dhimal M,O'Hara RB,Karki R,Thakur GD,Kuch U,Ahrens B

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Understanding of malaria vector density, distribution, insecticide resistance, vector incrimination, infection status, and identification of sibling species are some of the essential components of vector control measures for achieving malaria elimination goals. METHODS:As part of the malaria elimination dem...

journal_title：Malaria journal

authors： Mishra AK,Bharti PK,Vishwakarma A,Nisar S,Rajvanshi H,Sharma RK,Saha KB,Shukla MM,Jayswar H,Das A,Kaur H,Wattal SL,Lal AA

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND:Molecular genotyping is performed in anti-malarial trials to determine whether recurrent parasitaemia after therapy represents a recrudescence (treatment failure) or new infection. The use of capillary instead of agarose gel electrophoresis for genotyping offers technical advantages, but it is unclear whethe...

journal_title：Malaria journal

authors： Gupta V,Dorsey G,Hubbard AE,Rosenthal PJ,Greenhouse B

更新日期：2010-01-15 00:00:00

abstract：BACKGROUND:The resistance of malaria parasites to sulphadoxine-pyrimethamine (SP) in 2007 led to the Malawi Ministry of Health changing to artemether-lumefantrine (AL) as first-line for uncomplicated malaria treatment. This study determined the efficacy and safety of AL for the treatment of uncomplicated Plasmodium fal...

journal_title：Malaria journal

authors： Dambe R,Sande J,Ali D,Chilima B,Dodoli W,Michelo C,Malenga G,Phiri KS

更新日期：2015-04-23 00:00:00

abstract：BACKGROUND:Mozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in 2009. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance. The prevalence of pfmdr1 d...

journal_title：Malaria journal

authors： Lobo E,de Sousa B,Rosa S,Figueiredo P,Lobo L,Pateira S,Fernandes N,Nogueira F

更新日期：2014-08-06 00:00:00

abstract：BACKGROUND:The receptors for adhesion of Plasmodium falciparum-infected red blood cells (RBC) in the placenta have been identified as chondroitin-4-sulphate (C4S) proteoglycans, and the more sulphate-rich chondroitin oligosaccharides have been reported to inhibit adhesion. Since the anti-malarial drug chloroquine accum...

journal_title：Malaria journal

authors： Bhattacharyya S,Solakyildirim K,Zhang Z,Linhardt RJ,Tobacman JK

更新日期：2009-12-17 00:00:00

abstract：:Most malaria-endemic countries have struggled in the past decade to establish effective national-scale continuous distribution mechanisms for long-lasting insecticidal nets (LLINs). Since the implementation of the Tanzania National Voucher Scheme in 2004 and mass-distribution campaigns in 2009-2011 and 2015-2016, Tanz...

journal_title：Malaria journal

authors： Yukich J,Stuck L,Scates S,Wisniewski J,Chacky F,Festo C,Kabulika G,Dimoso K,Mandike R,Greer G,Serbantez N,Elisaria E,Nyoni W,Dadi D,Akim I,Lengeler C,Brown N,Koenker H

更新日期：2020-04-17 00:00:00

abstract：BACKGROUND:Malaria rapid diagnostic tests (RDTs) enable point-of-care testing to be nearly as sensitive and specific as reference microscopy. The Senegal National Malaria Control Programme introduced RDTs in 2007, along with a case management algorithm for uncomplicated febrile illness, in which the first step stipulat...

journal_title：Malaria journal

authors： Thwing J,Ba F,Diaby A,Diedhiou Y,Sylla A,Sall G,Diouf MB,Gueye AB,Gaye S,Ndiop M,Cisse M,Ndiaye D,Ba M

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Post-malaria neurological syndrome (PMNS) is a debated entity, defined by neurological complications following a post-malaria symptom-free period and a negative blood smear. Four cases of PMNS are hereby reported and a review the literature performed to clarify the nosological framework of this syndrome. ME...

journal_title：Malaria journal

authors： Tamzali Y,Demeret S,Haddad E,Guillot H,Caumes E,Jauréguiberry S

更新日期：2018-10-26 00:00:00

abstract：INTRODUCTION:Malaria is the largest cause of health services attendance, hospital admissions and child deaths in Tanzania. At the Abuja Summit in April 2000 Tanzania committed itself to protect 60% of its population at high risk of malaria by 2005. The country is, therefore, determined to ensure that sustainable malari...

journal_title：Malaria journal

authors： Magesa SM,Lengeler C,deSavigny D,Miller JE,Njau RJ,Kramer K,Kitua A,Mwita A

更新日期：2005-07-22 00:00:00