Abstract:
:This meeting report presents the key findings and discussion points of a 1-day meeting entitled 'Fake anti-malarials: start with the facts' held on 28th May 2015, in Geneva, Switzerland, to disseminate the findings of the artemisinin combination therapy consortium's drug quality programme. The teams purchased over 10,000 samples, using representative sampling approaches, from six malaria endemic countries: Equatorial Guinea (Bioko Island), Cambodia, Ghana, Nigeria, Rwanda and Tanzania. Laboratory analyses of these samples showed that falsified anti-malarials (<8 %) were found in just two of the countries, whilst substandard artemisinin-based combinations were present in all six countries and, artemisinin-based monotherapy tablets are still available in some places despite the fact that the WHO has urged regulatory authorities in malaria-endemic countries to take measures to halt the production and marketing of these oral monotherapies since 2007. This report summarizes the presentations that reviewed the public health impact of falsified and substandard drugs, sampling strategies, techniques for drug quality analysis, approaches to strengthen health systems capacity for the surveillance of drug quality, and the ensuing discussion points from the dissemination meeting.
journal_name
Malar Jjournal_title
Malaria journalauthors
Kaur H,Clarke S,Lalani M,Phanouvong S,Guérin P,McLoughlin A,Wilson BK,Deats M,Plançon A,Hopkins H,Miranda D,Schellenberg Ddoi
10.1186/s12936-016-1096-xsubject
Has Abstractpub_date
2016-02-13 00:00:00pages
86issn
1475-2875pii
10.1186/s12936-016-1096-xjournal_volume
15pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:Malaria remains the most important public health problem in tropical and subtropical areas. Mothers' or caregivers' ability to recognize childhood malaria-related morbidity is crucial as knowledge, attitudes and health seeking behavior of caregivers towards childhood malaria could influence response to signs...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-47
更新日期:2010-02-11 00:00:00
abstract:BACKGROUND:A malaria eradication goal has been proposed, at the same time as a new global strategy and implementation framework. Countries are considering the strategies and tools that will enable progress towards malaria goals. The eliminating malaria case-study series reports were reviewed to identify successful prog...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1518-9
更新日期:2016-09-22 00:00:00
abstract:BACKGROUND:It is estimated that over 70% of patients with suspected malaria in sub-Saharan Africa, diagnose and manage their illness at home without referral to a formal health clinic. Of those patients who do attend a formal health clinic, malaria overdiagnosis rates are estimated to range between 30-70%. METHODS:Thi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-33
更新日期:2008-02-18 00:00:00
abstract:BACKGROUND:Real-time PCR is a sensitive and specific method for the analysis of Plasmodium DNA. However, prior purification of genomic DNA from blood is necessary since PCR inhibitors and quenching of fluorophores from blood prevent efficient amplification and detection of PCR products. METHODS:Reagents designed to sp...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-244
更新日期:2011-08-19 00:00:00
abstract:BACKGROUND:In the last decade, several epidemiological studies have demonstrated the potential of using seroprevalence (SP) and seroconversion rate (SCR) as informative indicators of malaria burden in low transmission settings or in populations on the cusp of elimination. However, most of studies are designed to contro...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0661-z
更新日期:2015-04-03 00:00:00
abstract:BACKGROUND:Increasing access to health care services is considered central to improving the health of populations. Existing reviews to understand factors affecting access to health care have focused on attributes of patients and their communities that act as 'barriers' to access, such as education level, financial and ...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-11-55
更新日期:2012-02-23 00:00:00
abstract:BACKGROUND:Urban malaria can be a serious public health problem in Africa. Human-landing catches of mosquitoes, a standard entomological method to assess human exposure to malaria vector bites, can lack sensitivity in areas where exposure is low. A simple and highly sensitive tool could be a complementary indicator for...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-72
更新日期:2012-03-16 00:00:00
abstract:BACKGROUND:Within the context of increasing antimalarial costs and or decreasing malaria transmission, the importance of limiting antimalarial treatment to only those confirmed as having malaria parasites becomes paramount. This motivates for this assessment of the cost-effectiveness of routine use of rapid diagnostic ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-176
更新日期:2008-09-15 00:00:00
abstract:BACKGROUND:Malaria transmission in the peri-Iquitos region of Amazonian Peru has been designated as seasonal and hypo-endemic with recently described hyper-endemic hotspots. Despite relatively recent distribution of long-lasting insecticidal bed nets (LLINs), malaria in Amazonian Peru persists and increased substantial...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0804-2
更新日期:2015-07-30 00:00:00
abstract:BACKGROUND:A high prevalence of spherocytes was detected in blood smears of children enrolled in a case control study conducted in the malaria holoendemic Lake Victoria basin. It was speculated that the spherocytes reflect intraerythrocytic removal of malarial parasites with a concurrent removal of RBC membrane through...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-5-64
更新日期:2006-07-31 00:00:00
abstract:BACKGROUND:Public health facilities are usually the first to receive interventions compared to private facilities, yet majority of health seeking care is first done with the latter. This study compared the capacity to manage acute febrile illnesses in children below 5 years in private vs public health facilities in ord...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1842-8
更新日期:2017-05-02 00:00:00
abstract:BACKGROUND:In rural south-eastern Tanzania, Anopheles funestus is a major malaria vector, and has been implicated in nearly 90% of all infective bites. Unfortunately, little is known about the natural ecological requirements and survival strategies of this mosquito species. METHODS:Potential mosquito aquatic habitats ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03295-5
更新日期:2020-06-23 00:00:00
abstract:BACKGROUND:Intensive malaria transmission along international borders is a significant impediment to malaria elimination in the Greater Mekong Subregion (GMS) of Southeast Asia. Passive case detection (PCD) was used to study the dynamics and trends of malaria transmission at the China-Myanmar border to provide epidemio...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2924-6
更新日期:2019-09-12 00:00:00
abstract:BACKGROUND:In south-eastern Senegal, malaria and onchocerciasis are co-endemic. Onchocerciasis in this region has been controlled by once or twice yearly mass drug administration (MDA) with ivermectin (IVM) for over fifteen years. Since laboratory-raised Anopheles gambiae s.s. are susceptible to ivermectin at concentra...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-365
更新日期:2010-12-20 00:00:00
abstract:BACKGROUND:Despite declining prevalence of malaria in The Gambia, non-adherence to anti-malarial treatment still remains a challenge to control efforts. There is limited evidence on the socio-cultural factors that influence adherence to anti-malarial treatment in pregnancy. This study explored perceptions of malaria in...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-016-1255-0
更新日期:2016-04-11 00:00:00
abstract:BACKGROUND:Premature death of Plasmodium-infected erythrocytes is considered to favourably influence the clinical course of malaria. Aurothiomalate has previously been shown to trigger erythrocyte death or eryptosis, which is characterized by cell membrane scrambling leading to phosphatidylserine exposure at the cell s...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-118
更新日期:2010-05-07 00:00:00
abstract:BACKGROUND:The successful control of insect disease vectors relies on a thorough understanding of their ecology and behaviour. However, knowledge of the ecology of many human disease vectors lags behind that of agricultural pests. This is partially due to the paucity of experimental tools for investigating their ecolog...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-356
更新日期:2010-12-08 00:00:00
abstract:BACKGROUND:Anopheles baimaii is a primary vector of human malaria in the forest settings of Southeast Asia including the north-eastern region of India. Here, the genetic population structure and the basic population genetic parameters of An. baimaii in north-east India were estimated using DNA sequences of the mitochon...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-76
更新日期:2012-03-20 00:00:00
abstract:BACKGROUND:In order to sustain the gains achieved by current malaria control strategies, robust surveillance systems that monitor dynamics of vectors and their roles in malaria transmission over time are essential. This longitudinal study demonstrates the trends in malaria vector dynamics and their relative contributio...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-331
更新日期:2014-08-24 00:00:00
abstract:BACKGROUND:The relationship between the burden of uncomplicated malaria and transmission intensity is unclear and a better understanding of this relationship is important for the implementation of intervention programmes. METHODS:A 6-month longitudinal study monitoring risk factors for anaemia and febrile malaria epis...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-3-26
更新日期:2004-07-28 00:00:00
abstract:BACKGROUND:Malaria rapid diagnostic tests (RDTs) are assumed to be simple-to-use and mobile technologies that have the capacity to standardize parasitological diagnosis for malaria across a variety of clinical settings. In order to evaluate these tests, it is important to consider how such assumptions play out in pract...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1083-2
更新日期:2016-02-05 00:00:00
abstract:BACKGROUND:The erythrocytic stage, where malaria parasites proliferate in human blood, is clinically significant as this causes the symptoms and illness of malaria. Experimental rodent models of malaria at the erythrocytic stage are used for the development of anti-malarial drugs and for biological analysis. An automat...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2313-6
更新日期:2018-04-16 00:00:00
abstract:BACKGROUND:Isolation of a concentrated, living preparation of malarial parasite-infected red blood cells (PRBCs) that have low contamination of white blood cells (WBCs) facilitates research on the molecular, biochemical and immunological aspects of malarial parasites. This is currently carried out by a two-step method,...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-3-7
更新日期:2004-03-17 00:00:00
abstract:BACKGROUND:Intensified efforts are urgently needed to contain and eliminate artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion. Médecins Sans Frontières plans to support the Ministry of Health in eliminating P. falciparum in an area with artemisinin resistance in the north-east of Cambodia. As ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-394
更新日期:2014-10-06 00:00:00
abstract:BACKGROUND:Artemisinin is the current drug of choice for treatment of malaria and a number of other diseases. It is obtained from the annual herb, Artemisia annua and some microbial sources by genetic engineering. There is a great concern that the artemisinin production at current rate will not meet the increasing dema...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-310
更新日期:2010-11-04 00:00:00
abstract:BACKGROUND:Defining the number and location of sprayable structures (houses) is foundational to plan and monitor indoor residual spray (IRS) implementation, a primary intervention used to control the transmission of malaria. Only by mapping the location and type of all sprayable structures can IRS operations be planned...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0831-z
更新日期:2015-09-17 00:00:00
abstract:BACKGROUND:Each year, thousands of cases of uncomplicated malaria are imported into Europe by travellers. Atovaquone-proguanil (AP) has been one of the first-line regimens used in France for uncomplicated malaria for almost ten years. While AP's efficacy and tolerance were evaluated in several trials, its use in "real ...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/1475-2875-12-399
更新日期:2013-11-07 00:00:00
abstract:BACKGROUND:Adequate coverage and proper use of long-lasting insecticidal nets (LLINs) and indoor residual spaying (IRS) reduce density of indoor-resting mosquitoes, man-mosquito contact and malaria infection. However, distribution, ownership and usage of the interventions may vary among households in a malarious area, ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-356
更新日期:2014-09-10 00:00:00
abstract:BACKGROUND:Understanding of malaria vector density, distribution, insecticide resistance, vector incrimination, infection status, and identification of sibling species are some of the essential components of vector control measures for achieving malaria elimination goals. METHODS:As part of the malaria elimination dem...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03517-w
更新日期:2020-12-02 00:00:00
abstract::Malaria is a public health problem in French Guiana. Plasmodium vivax is the most frequent parasite. The objective of this analysis was to estimate the proportion of relapses in the burden of vivax malaria using the statistical rule stating that any case of vivax malaria occurring less than 90 days following a first e...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-367
更新日期:2013-10-24 00:00:00