Abstract:
BACKGROUND:There is evidence that suggests that undernutrition has a detrimental effect on malarial immunity in children. The aim of the study was to discover whether nutrient supplementation improved development of malarial antibody immunity in children up to 18 months of age. METHODS:The study was conducted with a subset of 432 Malawian children from a randomized controlled trial of nutritional supplements. The arms included pre- and postnatal small-quantity lipid-based nutrient supplements for both mother and child; prenatal supplementation with iron and folic acid; and pre- and postnatal supplementation with multiple micronutrients. Paired plasma samples were collected at 6 and 18 months of age. The levels of antibodies against merozoite surface protein 1 (MSP1 19kD) and MSP2, erythrocyte binding antigen 175 (EBA175), reticulocyte binding protein homologue 2A (Rh2A9), schizont extract and variant antigens expressed on the surface of infected erythrocytes were measured. RESULTS:At 18 months of age, 5.4% of children were parasitaemic by microscopy and 49.1% were anaemic. Antibodies to the tested merozoite antigens and schizont extract increased between 6 and 18 months and this increase was statistically significant for MSP1, MSP2 and EBA175 (p < 0.0001) whereas IgG to variant surface antigens decreased with increasing age (p < 0.0001). However, the supplementation type did not have any impact on the prevalence or levels of antibodies at either 6 or 18 months of age to any of the tested malaria antigens in either univariate analysis or multivariate analysis after adjusting for covariates. CONCLUSIONS:Pre- and postnatal lipid-based nutrient supplementation did not alter malaria antibody acquisition during infancy, compared to prenatal supplementation with iron and folic acid or pre- and postnatal supplementation with multiple micronutrients. Trail registeration Clinicaltrials.gov registration number NCT01239693.
journal_name
Malar Jjournal_title
Malaria journalauthors
Barua P,Chandrasiri UP,Beeson JG,Dewey KG,Maleta K,Ashorn P,Rogerson SJdoi
10.1186/s12936-018-2224-6subject
Has Abstractpub_date
2018-02-07 00:00:00pages
74issue
1issn
1475-2875pii
10.1186/s12936-018-2224-6journal_volume
17pub_type
杂志文章,随机对照试验相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:Data collected in clinical trials have been used to develop scoring systems that identify adults with malaria at greatest risk of death. One of these, the RCAM score, can be simply determined by measuring a patient's Glasgow Coma Score and respiratory rate on admission to hospital. However the safety of usin...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0549-y
更新日期:2015-02-07 00:00:00
abstract:BACKGROUND:Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country's malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is underway for a possible introduction, as soon as one becomes available...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-394
更新日期:2012-11-28 00:00:00
abstract:BACKGROUND:Pyrethroid-resistant mosquitoes are an increasing threat to malaria vector control. The Global Plan for Insecticide Resistance Management (GPIRM) recommends rotation of non-pyrethroid insecticides for indoor residual spraying (IRS). The options from other classes are limited. The carbamate bendiocarb and the...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-37
更新日期:2014-01-29 00:00:00
abstract:BACKGROUND:Chloroquine-resistant Plasmodium falciparum was first described in the Republic of Vanuatu in the early 1980s. In 1991, the Vanuatu Ministry of Health instituted new treatment guidelines for uncomplicated P. falciparum infection consisting of chloroquine/sulphadoxine-pyrimethamine combination therapy. Chloro...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-89
更新日期:2010-04-06 00:00:00
abstract:BACKGROUND:Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine (T) at the codon 76. Previous studies have shown that microsatellite (MS) haplotype variation can be used to study the evolution o...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-34
更新日期:2007-03-21 00:00:00
abstract:BACKGROUND:In south-eastern Senegal, malaria and onchocerciasis are co-endemic. Onchocerciasis in this region has been controlled by once or twice yearly mass drug administration (MDA) with ivermectin (IVM) for over fifteen years. Since laboratory-raised Anopheles gambiae s.s. are susceptible to ivermectin at concentra...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-365
更新日期:2010-12-20 00:00:00
abstract:BACKGROUND:In 2009, Santa Isabel Province in the Solomon Islands embarked on a malaria elimination programme. However, very little is known in the Province about the anopheline fauna, which species are vectors, their bionomics and how they may respond to intensified intervention measures. The purpose of this study was ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-287
更新日期:2011-09-30 00:00:00
abstract:BACKGROUND:Increasing access to health care services is considered central to improving the health of populations. Existing reviews to understand factors affecting access to health care have focused on attributes of patients and their communities that act as 'barriers' to access, such as education level, financial and ...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-11-55
更新日期:2012-02-23 00:00:00
abstract:BACKGROUND:Rapid diagnostic tests (RDTs) have become the most common diagnostic tool for detection of Plasmodium falciparum malaria, in particular in remote areas. RDT blood spots provide a source of parasite DNA for molecular analysis. In this study, the utility of RDTs for molecular analysis and the performance of di...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03259-9
更新日期:2020-05-27 00:00:00
abstract:BACKGROUND:Toll-like receptors (TLRs) signalling is reported to be primed by the infection of human malaria parasite, Plasmodium falciparum. However, little is known about the regulation of macrophages TLR signalling by the infection of lethal or non-lethal strain of rodent malaria parasites. METHODS:BALB/c mice were ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-104
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Knowledge of the population genetics and transmission dynamics of Plasmodium vivax is crucial in predicting the emergence of drug resistance, relapse pattern and novel parasite phenotypes, all of which are relevant to the control of vivax infections. The aim of this study was to analyse changes in the geneti...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1136-6
更新日期:2016-02-09 00:00:00
abstract:BACKGROUND:Each year, thousands of cases of uncomplicated malaria are imported into Europe by travellers. Atovaquone-proguanil (AP) has been one of the first-line regimens used in France for uncomplicated malaria for almost ten years. While AP's efficacy and tolerance were evaluated in several trials, its use in "real ...
journal_title:Malaria journal
pub_type: 杂志文章,多中心研究
doi:10.1186/1475-2875-12-399
更新日期:2013-11-07 00:00:00
abstract:BACKGROUND:In a recent trial of artemisinin-naphthoquine (artemisinin-NQ) and artemether-lumefantrine (AM-LM) therapy in young children from Papua New Guinea (PNG), there were no treatment failures in artemisinin-NQ-treated children with Plasmodium falciparum or Plasmodium vivax compared with 2.2% and 30.0%, respective...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-015-0624-4
更新日期:2015-03-21 00:00:00
abstract:BACKGROUND:Five species of Plasmodium are known to infect humans. For proper treatment of malaria, accurate identification of the parasite species is crucial. The current gold standard for malaria diagnosis is microscopic examination of Giemsa-stained blood smears. Since the parasite species are identified by microscop...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2381-7
更新日期:2018-06-19 00:00:00
abstract:BACKGROUND:Environmental temperature is an important driver of malaria transmission dynamics. Both the parasite and vector are sensitive to mean ambient temperatures and daily temperature variation. To understand transmission ecology, therefore, it is important to determine the range of microclimatic temperatures exper...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-84
更新日期:2013-03-02 00:00:00
abstract::Recent WHO guidelines recommend a universal "test and treat" strategy for malaria, mainly by use of rapid diagnostic test (RDT) in all areas. The evidence for this approach is questioned here as there is a risk of over-reliance on parasitological diagnosis in high transmission situations, which still exist. In such ar...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-136
更新日期:2011-05-20 00:00:00
abstract:BACKGROUND:Shandong Province experienced a declining malaria trend of local-acquired transmission, but the increasing imported malaria remains a challenge. Therefore, understanding the epidemiological characteristics of malaria and the control and elimination strategy and interventions is needed for better planning to ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1708-0
更新日期:2017-01-31 00:00:00
abstract:BACKGROUND:The erythrocytic stage of Plasmodium falciparum parasites in humans is clinically important, as the parasites at this growth stage causes malarial symptoms. Most of the currently available anti-malarial drugs target this stage, but the emergence and spread of parasites resistant to anti-malarial drugs are a ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2642-0
更新日期:2019-01-14 00:00:00
abstract:BACKGROUND:The effects that artemether-lumefantrine (AL) has on gametocyte dynamics in the short-term have recently been described. However there is limited long-term longitudinal data on the effect of AL on gametocyte dynamics in asymptomatic children. METHODS:An epidemiological study was conducted in Kombewa, Wester...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-13-265
更新日期:2014-07-09 00:00:00
abstract:BACKGROUND:Aggregated haemozoin crystals within malaria-infected erythrocytes confer susceptibility of parasitized cells to a magnetic field. Here the utility of this method for diagnosis of human malaria is evaluated in a malaria-endemic region of Papua New Guinea (PNG). METHODS AND FINDINGS:Individuals with Plasmodi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-66
更新日期:2008-04-25 00:00:00
abstract:BACKGROUND:Malaria was endemic in the Rhône-Alpes area of eastern France in the 19th century and life expectancy was particularly shortened in Alpine valleys. This study was designed to determine how the disease affected people in the area and to identify the factors influencing malaria transmission. METHODS:Demograph...
journal_title:Malaria journal
pub_type: 历史文章,杂志文章
doi:10.1186/1475-2875-6-115
更新日期:2007-08-29 00:00:00
abstract:BACKGROUND:In rural south-eastern Tanzania, Anopheles funestus is a major malaria vector, and has been implicated in nearly 90% of all infective bites. Unfortunately, little is known about the natural ecological requirements and survival strategies of this mosquito species. METHODS:Potential mosquito aquatic habitats ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03295-5
更新日期:2020-06-23 00:00:00
abstract:BACKGROUND:Between 2007 and 2013, the Tanzanian public sector received 93.1 million doses of first-line anti-malarial artemisinin-based combination therapy (ACT) in the form of artemether-lumefantrine entirely supplied by funding partners. The introduction of a health facility ACT stock monitoring system using SMS tech...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-181
更新日期:2014-05-11 00:00:00
abstract:BACKGROUND:Malaria that is caused by Plasmodium vivax is the most widely distributed human malaria. Its recent resurgence in many parts of the world, including the Republic of Korea (ROK), emphasizes the importance of improved access to the early and accurate detection of P. vivax to reduce disease burden. In this stud...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-248
更新日期:2014-06-30 00:00:00
abstract:BACKGROUND:Many malaria-related studies depend on infected red blood cells (iRBCs) as fundamental material; however, infected blood samples from human or animal models include leukocytes (white blood cells or WBCs), especially difficult to separate from iRBCs in cases involving Plasmodium vivax. These host WBCs are a s...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-251
更新日期:2011-08-25 00:00:00
abstract:BACKGROUND:The level of antibodies against PfEMP1 is routinely quantified by the conventional microtitre enzyme-linked immunosorbent assay (ELISA). However, ELISA only measures one analyte at a time and requires a relatively large plasma volume if the complete antibody profile of the sample is to be obtained. Furthermo...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-108
更新日期:2008-06-12 00:00:00
abstract:BACKGROUND:Previous efforts to eradicate malaria parasites, particularly Plasmodium falciparum, have failed in part due to the emergence of drug resistant parasites and mosquitoes resistant to insecticides. Using an artemisinin-based combination therapy (ACT) that kills parasites quickly, a strategy was designed to eli...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-57
更新日期:2010-02-23 00:00:00
abstract:BACKGROUND:The Kilombero Valley is a highly malaria-endemic agricultural area in south-eastern Tanzania. Seasonal flooding of the valley is favourable to malaria transmission. During the farming season, many households move to distant field sites (shamba in Swahili) in the fertile river floodplain for the cultivation o...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-7
更新日期:2008-01-09 00:00:00
abstract:BACKGROUND:Improving the way artemether-lumefantrine (AL) is provided to patients attending clinics is critical to maximize the benefit of this new medicine. In 2007, a new initiative was launched in one part of Kenya to improve malaria case-management through enhanced in-service training and provision of job aids. ME...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-261
更新日期:2010-09-18 00:00:00
abstract:BACKGROUND:Anti-malarial drugs are an important tool for malaria control and elimination. Alongside their direct benefit in the treatment of disease, drug use has a community-level effect, clearing the reservoir of infection and reducing onward transmission of the parasite. Different compounds potentially have differen...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1988-4
更新日期:2017-08-16 00:00:00