"Test and treat" or presumptive treatment for malaria in high transmission situations? A reflection on the latest WHO guidelines.

abstract：BACKGROUND:In Vietnam, malaria transmission has been reduced to very low levels over the past 20 years, and as a consequence, the country aims to eliminate malaria by 2030. This study aimed to characterize the dynamics and extent of the parasite reservoir in Central Vietnam, in order to further target elimination strat...

journal_title：Malaria journal

authors： Kattenberg JH,Erhart A,Truong MH,Rovira-Vallbona E,Vu KAD,Nguyen THN,Nguyen VH,Nguyen VV,Bannister-Tyrrell M,Theisen M,Bennet A,Lover AA,Tran TD,Nguyen XX,Rosanas-Urgell A

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:Due to the development of resistance to synthetic insecticides, adverse effects to human health, non-target organisms and the environment, there is an urgent need to develop new insecticides, which are effective, safe, biodegrable and target-specific. This study was undertaken to evaluate the adulticidal act...

journal_title：Malaria journal

authors： Mavundza EJ,Maharaj R,Chukwujekwu JC,Finnie JF,Van Staden J

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:The erythrocytic stage, where malaria parasites proliferate in human blood, is clinically significant as this causes the symptoms and illness of malaria. Experimental rodent models of malaria at the erythrocytic stage are used for the development of anti-malarial drugs and for biological analysis. An automat...

journal_title：Malaria journal

authors： Tougan T,Suzuki Y,Izuka M,Aono K,Okazaki T,Toya Y,Uchihashi K,Horii T

更新日期：2018-04-16 00:00:00

abstract：BACKGROUND:The effectiveness of malaria control programmes through implementation of vector control activities is challenged by the emergence of insecticide resistance. In the South-Eastern region of Côte d'Ivoire, where palm oil plantations remain the predominant agricultural crop, the susceptibility of wild Anopheles...

journal_title：Malaria journal

authors： Sadia-Kacou CMA,Alou LPA,Edi AVC,Yobo CM,Adja MA,Ouattara AF,Malone D,Koffi AA,Tano Y,Koudou BG

更新日期：2017-04-20 00:00:00

abstract：BACKGROUND:Plasmodium falciparum circumsporozoite protein (CSP) is a leading malaria vaccine candidate antigen, known to elicit protective antibody responses in humans (RTS,S vaccine). Recently, a DNA prime / adenovirus (Ad) vector boost vaccine encoding CSP and a second P. falciparum antigen, apical membrane antigen-1...

journal_title：Malaria journal

authors： Sedegah M,Kim Y,Ganeshan H,Huang J,Belmonte M,Abot E,Banania JG,Farooq F,McGrath S,Peters B,Sette A,Soisson L,Diggs C,Doolan DL,Tamminga C,Villasante E,Hollingdale MR,Richie TL

更新日期：2013-06-05 00:00:00

abstract：BACKGROUND:While sub-microscopic malarial infections are frequent and potentially deleterious during pregnancy, routine molecular detection is still not feasible. This study aimed to assess the performance of a Histidine Rich Protein 2 (HRP2)-based ultrasensitive rapid diagnostic test (uRDT, Alere Malaria Ag Pf) for th...

journal_title：Malaria journal

authors： Briand V,Cottrell G,Tuike Ndam N,Martiáñez-Vendrell X,Vianou B,Mama A,Kouwaye B,Houzé S,Bailly J,Gbaguidi E,Sossou D,Massougbodji A,Accrombessi M,Mayor A,Ding XC,Fievet N

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:P25 and P28 are related ookinete surface proteins highly conserved throughout the Plasmodium genus that are under consideration as candidates for inclusion in transmission-blocking vaccines. Previous research using transgenic rodent malaria parasites lacking P25 and P28 has demonstrated that these proteins h...

journal_title：Malaria journal

authors： Baton LA,Ranford-Cartwright LC

更新日期：2005-02-25 00:00:00

abstract：BACKGROUND:Malaria presents a diagnostic challenge in tribal belt of central India where two Plasmodium species, Plasmodium falciparum and Plasmodium vivax, are prevalent. In these areas, rapid detection of the malaria parasites and early treatment of infection remain the most important goals of disease management. The...

journal_title：Malaria journal

authors： Bharti PK,Silawat N,Singh PP,Singh MP,Shukla M,Chand G,Dash AP,Singh N

更新日期：2008-07-11 00:00:00

abstract：BACKGROUND:Saglin, a 100 kDa protein composed of two 50 kDa homodimers, is present in the salivary glands of Anopheles gambiae and has been considered an essential receptor for sporozoites (SPZ) of Plasmodium berghei and Plasmodium falciparum (Pf), allowing SPZ to recognize, bind to, and infect mosquito salivary glands...

journal_title：Malaria journal

authors： O'Brochta DA,Alford R,Harrell R,Aluvihare C,Eappen AG,Li T,Chakravarty S,Sim BKL,Hoffman SL,Billingsley PF

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:Understanding of malaria vector density, distribution, insecticide resistance, vector incrimination, infection status, and identification of sibling species are some of the essential components of vector control measures for achieving malaria elimination goals. METHODS:As part of the malaria elimination dem...

journal_title：Malaria journal

authors： Mishra AK,Bharti PK,Vishwakarma A,Nisar S,Rajvanshi H,Sharma RK,Saha KB,Shukla MM,Jayswar H,Das A,Kaur H,Wattal SL,Lal AA

更新日期：2020-12-02 00:00:00

abstract：:April 25 marks World Malaria Day, an opportunity for those who work to defeat the illness, to review progress and renew commitments. After a decade of steady success, this year's commemoration of the date is also an opportunity to reconsider current approaches and assess the state of the science needed to keep pace in...

journal_title：Malaria journal

authors： Slutsker L,Kachur SP

更新日期：2013-04-24 00:00:00

abstract：:The fight against malaria is increasingly threatened by failures in vector control due to growing insecticide resistance. This review examines the recent primary research that addresses the putative relationship between agricultural insecticide use and trends in insecticide resistance. To do so, descriptive evidence o...

journal_title：Malaria journal

authors： Reid MC,McKenzie FE

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP) is recommended for reducing the risk of malaria in pregnancy and its consequences on mothers and babies (IPTp-SP). Indicators of implementation and effects of IPTp-SP were collected in a rural clinic in Southern Senegal. METHODS:Women se...

journal_title：Malaria journal

authors： Olliaro PL,Delenne H,Cisse M,Badiane M,Olliaro A,Vaillant M,Brasseur P

更新日期：2008-11-07 00:00:00

abstract：BACKGROUND:There remains a need for techniques that improve the sensitive detection of viable Plasmodium falciparum as part of diagnosis and therapeutic monitoring in clinical studies and usual-care management of malaria infections. A non-invasive breath test based on P. falciparum-associated specific volatile organic ...

journal_title：Malaria journal

authors： Wong RP,Flematti GR,Davis TM

更新日期：2012-09-07 00:00:00

abstract：BACKGROUND:Antiplasmodial activities of angiotensin II and its analogues have been extensively investigated in Plasmodium gallinaceum and Plasmodium falciparum parasite species. Due to its vasoconstrictor property angiotensin II cannot be used as an anti-malarial drug. METHODS:This work presents the solid-phase synthe...

journal_title：Malaria journal

authors： Silva AF,Torres MD,Silva Lde S,Alves FL,Pinheiro AA,Miranda A,Capurro ML,Oliveira VX Jr

更新日期：2015-11-04 00:00:00

abstract：BACKGROUND:Since Plasmodium falciparum transmission relies exclusively on sexual-stage parasites, several malaria control strategies aim to disrupt this step of the life cycle. Thus, a better understanding of which individuals constitute the primary gametocyte reservoir within an endemic population, and the temporal dy...

journal_title：Malaria journal

authors： Adomako-Ankomah Y,Chenoweth MS,Tocker AM,Doumbia S,Konate D,Doumbouya M,Keita AS,Anderson JM,Fairhurst RM,Diakite M,Miura K,Long CA

更新日期：2017-11-21 00:00:00

abstract：BACKGROUND:Malaria is known as tazo or tazomoka in local terminology in Madagascar. Within the context of traditional practice, malaria (and/or malaria symptoms) is commonly treated by decoctions or infusions from bitter plants. One possible approach to the identification of new antimalarial drug candidates is to searc...

journal_title：Malaria journal

authors： Randrianarivelojosia M,Rasidimanana VT,Rabarison H,Cheplogoi PK,Ratsimbason M,Mulholland DA,Mauclère P

更新日期：2003-07-24 00:00:00

abstract：BACKGROUND:DNA microarrays have been a valuable tool in malaria research for over a decade but remain in limited use in part due their relatively high cost, poor availability, and technical difficulty. With the aim of alleviating some of these factors next-generation DNA microarrays for genome-wide transcriptome analys...

journal_title：Malaria journal

authors： Kafsack BF,Painter HJ,Llinás M

更新日期：2012-06-08 00:00:00

abstract：BACKGROUND:Modelling risk of malaria in longitudinal studies is common, because individuals are at risk for repeated infections over time. Malaria infections result in acquired immunity to clinical malaria disease. Prospective cohorts are an ideal design to relate the historical exposure to infection and development of...

journal_title：Malaria journal

authors： Stanley CC,Kazembe LN,Mukaka M,Otwombe KN,Buchwald AG,Hudgens MG,Mathanga DP,Laufer MK,Chirwa TF

更新日期：2019-07-29 00:00:00

abstract：BACKGROUND:The malaria vector Anopheles gambiae is polymorphic for chromosomal inversions on the right arm of chromosome 2 that segregate nonrandomly between assortatively mating populations in West Africa. One such inversion, 2Rj, is associated with the BAMAKO chromosomal form endemic to southern Mali and northern Gui...

journal_title：Malaria journal

authors： Coulibaly MB,Pombi M,Caputo B,Nwakanma D,Jawara M,Konate L,Dia I,Fofana A,Kern M,Simard F,Conway DJ,Petrarca V,della Torre A,Traoré S,Besansky NJ

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:In clinical trials of therapy for uncomplicated Plasmodium falciparum, there are usually some patients who fail treatment even in the absence of drug resistance. Treatment failures, which can be due to recrudescence or re-infection, are categorized as 'clinical' or 'parasitological' failures, the former indi...

journal_title：Malaria journal

authors： Mumtaz R,Okell LC,Challenger JD

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITNs) and house modifications are proven vector control tools, yet in most regions, full coverage has not been achieved. This study investigates household factors associated with access to ITNs and house modification in Tanzania. METHODS:Baseline cross-sectional survey data from pr...

journal_title：Malaria journal

authors： Odufuwa OG,Ross A,Mlacha YP,Juma O,Mmbaga S,Msellemu D,Moore S

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:Widespread resistance of the main malaria vector Anopheles gambiae to pyrethroids reported in many African countries and operational drawbacks to current IRS methods suggest the convenience of exploring new products and approaches for vector control. Insecticide paint Inesfly 5A IGR™, containing two organoph...

journal_title：Malaria journal

authors： Mosqueira B,Chabi J,Chandre F,Akogbeto M,Hougard JM,Carnevale P,Mas-Coma S

更新日期：2010-11-25 00:00:00

abstract：BACKGROUND:There is growing concern that malaria vector resistance to pyrethroid insecticides may reduce the effectiveness of long-lasting insecticidal nets (LLINs). Combination LLINs are designed to control susceptible and pyrethroid-resistant mosquito populations through a mixture of pyrethroid with piperonyl butoxid...

journal_title：Malaria journal

authors： Cisse MBM,Sangare D,Oxborough RM,Dicko A,Dengela D,Sadou A,Mihigo J,George K,Norris L,Fornadel C

更新日期：2017-11-21 00:00:00

abstract：BACKGROUND:Fixed-dose combination antimalarial drugs have played an increasingly important role in the treatment and chemoprophylaxis of falciparum malaria since the worldwide failure of monotherapy with chloroquine. Atovaquone-proguanil is one such combination drug used both for prophylaxis in travellers, and for trea...

journal_title：Malaria journal

authors： Sutherland CJ,Laundy M,Price N,Burke M,Fivelman QL,Pasvol G,Klein JL,Chiodini PL

更新日期：2008-11-20 00:00:00

abstract：BACKGROUND:Malaria remains a worldwide public health concern and, in Colombia, despite the efforts to stop malaria transmission, the incidence of cases has increased over the last few years. In this context, it is necessary to evaluate vector diversity, infection rates, and spatial distribution, to better understand di...

journal_title：Malaria journal

authors： González C,Molina AG,León C,Salcedo N,Rondón S,Paz A,Atencia MC,Tovar C,Ortiz M

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Anopheles arabiensis is stereotypical of diverse vectors that mediate residual malaria transmission globally, because it can feed outdoors upon humans or cattle, or enter but then rapidly exit houses without fatal exposure to insecticidal nets or sprays. METHODS:Life histories of a well-characterized An. ar...

journal_title：Malaria journal

authors： Killeen GF,Govella NJ,Lwetoijera DW,Okumu FO

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) is the treatment of choice for uncomplicated falciparum malaria. Artemether-lumefantrine (AL), a fixed dose co-formulation, has recently been approved for marketing in India, although it is not included in the National Drug Policy for treatment of malaria. Efficacy...

journal_title：Malaria journal

authors： Valecha N,Srivastava P,Mohanty SS,Mittra P,Sharma SK,Tyagi PK,Pradhan K,Dev V,Singh R,Dash AP,Sharma YD

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:The efficient allocation of financial resources for malaria control and the optimal distribution of appropriate interventions require accurate information on the geographic distribution of malaria risk and of the human populations it affects. Low population densities in rural areas and high population densit...

journal_title：Malaria journal

authors： Tatem AJ,Guerra CA,Kabaria CW,Noor AM,Hay SI

更新日期：2008-10-27 00:00:00

abstract：BACKGROUND:Malaria control has been dramatically scaled up the past decade, mainly thanks to increasing international donor financing since 2003. This study assessed progress up to 2010 towards global malaria impact targets, in relation to Global Fund, other donor and domestic malaria programme financing over 2003 to 2...

journal_title：Malaria journal

authors： Korenromp EL,Hosseini M,Newman RD,Cibulskis RE

更新日期：2013-01-14 00:00:00