Abstract:
:The general paradigm that emerges from the analysis of the transcriptome of the malaria parasite Plasmodium falciparum is that the expression clusters of genes that code for enzymes engaged in the same cellular function is coordinated. Here the consistency of this perception is examined by analysing specific pathways that metabolically-linked. The pentose phosphate pathway (PPP) is a fundamental element of cell biochemistry since it is the major pathway for the recycling of NADP+ to NADPH and for the production of ribose-5-phosphate that is needed for the synthesis of nucleotides. The function of PPP depends on the synthesis of NADP+ and thiamine pyrophosphate, a co-enzyme of the PPP enzyme transketolase. In this essay, the transcription of gene coding for enzymes involved in the PPP, thiamine and NAD(P)+ syntheses are analysed. The genes coding for two essential enzymes in these pathways, transaldolase and NAD+ kinase could not be found in the genome of P. falciparum. It is found that the transcription of the genes of each pathway is not always coordinated and there is usually a gene whose transcription sets the latest time for the full deployment of the pathway's activity. The activity of PPP seems to involve only the oxidative arm of PPP that is geared for maximal NADP+ reduction and ribose-5-phosphate production during the early stages of parasite development. The synthesis of thiamine diphosphate is predicted to occur much later than the expression of transketolase. Later in the parasite cycle, the non-oxidative arm of PPP that can use fructose-6-phosphate and glyceraldehyde-3-phosphate supplied by glycolysis, becomes fully deployed allowing to maximize the production of ribose-5-phosphate. These discrepancies require direct biochemical investigations to test the activities of the various enzymes in the developing parasite. Notably, several transcripts of PPP enzyme-coding genes display biphasic pattern of transcription unlike most transcripts that peak only once during the parasite cycle. The physiological meaning of this pattern requires further investigation.
journal_name
Malar Jjournal_title
Malaria journalauthors
Bozdech Z,Ginsburg Hdoi
10.1186/1475-2875-4-17keywords:
subject
Has Abstractpub_date
2005-03-18 00:00:00pages
17issn
1475-2875pii
1475-2875-4-17journal_volume
4pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:Plasmodium ovale, considered the rarest of the malaria parasites of humans, consists of two morphologically identical but genetically distinct sympatric species, Plasmodium ovale curtisi and Plasmodium ovale wallikeri. These parasites resemble morphologically to Plasmodium vivax with which they also share a ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0985-8
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:P25 and P28 are related ookinete surface proteins highly conserved throughout the Plasmodium genus that are under consideration as candidates for inclusion in transmission-blocking vaccines. Previous research using transgenic rodent malaria parasites lacking P25 and P28 has demonstrated that these proteins h...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-4-15
更新日期:2005-02-25 00:00:00
abstract:BACKGROUND:The relationship between mosquito development and temperature is one of the keys to understanding the current and future dynamics and distribution of vector-borne diseases such as malaria. Many process-based models use mean air temperature to estimate larval development times, and hence adult vector densitie...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-196
更新日期:2010-07-09 00:00:00
abstract:BACKGROUND:Artemisinin-based combination therapy (ACT) has been recommended for the treatment of falciparum malaria by the World Health Organization. Though India has already switched to ACT for treating falciparum malaria, there is need to have multiple options of alternative forms of ACT. A randomized trial was condu...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-11-97
更新日期:2012-03-30 00:00:00
abstract:BACKGROUND:Malaria prevention has remained a critical area in the absence of efficacious vaccines against malaria. Drugs currently used as chemotherapeutics are also used in chemoprophylaxis increasing possible drug resistance. Asiatic acid is a natural phytochemical with oxidant, antioxidant and anti-inflammatory prop...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1278-6
更新日期:2016-04-21 00:00:00
abstract:BACKGROUND:Pyrethroid-resistant mosquitoes are an increasing threat to malaria vector control. The Global Plan for Insecticide Resistance Management (GPIRM) recommends rotation of non-pyrethroid insecticides for indoor residual spraying (IRS). The options from other classes are limited. The carbamate bendiocarb and the...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-37
更新日期:2014-01-29 00:00:00
abstract:BACKGROUND:The intermittent screening and treatment (IST) of school children for malaria is one possible intervention strategy that could help reduce the burden of malaria among school children. Future implementation of IST will not only depend on its efficacy and cost-effectiveness but also on its acceptability to par...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-185
更新日期:2012-06-08 00:00:00
abstract:BACKGROUND:Plasmodium falciparum merozoite antigens elicit antibody responses in malaria-endemic populations, some of which are clinically protective, which is one of the reasons why merozoite antigens are the focus of malaria vaccine development efforts. Polymorphisms in several merozoite antigen-encoding genes are th...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-016-1304-8
更新日期:2016-05-06 00:00:00
abstract:BACKGROUND:Plasmodium vivax is very rarely seen in West Africa, although specific detection methods are not widely applied in the region, and it is now considered to be absent from North Africa. However, this parasite species has recently been reported to account for most malaria cases in Nouakchott, the capital of Mau...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1118-8
更新日期:2016-02-09 00:00:00
abstract:BACKGROUND:Malaria presents a diagnostic challenge in tribal belt of central India where two Plasmodium species, Plasmodium falciparum and Plasmodium vivax, are prevalent. In these areas, rapid detection of the malaria parasites and early treatment of infection remain the most important goals of disease management. The...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-126
更新日期:2008-07-11 00:00:00
abstract:BACKGROUND:Intermittent preventive (or presumptive) treatment of infants (IPTi), the administration of a curative anti-malarial dose to infants whether or not they are known to be infected, is being considered as a new strategy for malaria control. Five of the six trials using sulphadoxine-pyrimethamine (SP) for IPTi s...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-54
更新日期:2008-04-03 00:00:00
abstract:BACKGROUND:In Uganda, over half of under-five child mortality is attributed to three infectious diseases: malaria, pneumonia and diarrhoea. Integrated community case management (iCCM) trains village health workers (VHWs) to provide in-home diagnosis and treatment of these common childhood illnesses. For severely ill ch...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1300-z
更新日期:2016-04-29 00:00:00
abstract:BACKGROUND:Automated detection of malaria and dengue infection has been actively researched for more than two decades. Although many improvements have been achieved, these solutions remain too expensive for most laboratories and clinics in developing countries. The low range HORIBA Medical Haematology Analyzer, Yumizen...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03502-3
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:The effectiveness of malaria prevention with long-lasting insecticidal nets and indoor residual spraying is limited by emerging insecticide resistance, evasive mosquito behaviours that include outdoor biting, sub-optimal implementation and inappropriate use. New vector control interventions are required and ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-2056-9
更新日期:2017-10-11 00:00:00
abstract:BACKGROUND:The accuracy of the World Health Organization method of estimating malaria parasite density from thick blood smears by assuming a white blood cell (WBC) count of 8,000/μL has been questioned in several studies. Since epidemiological investigations, anti-malarial efficacy trials and routine laboratory reporti...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-145
更新日期:2014-04-16 00:00:00
abstract:BACKGROUND:Coverage of vulnerable groups with insecticide-treated nets (ITNs) in Ghana, as in the majority of countries of sub-Saharan Africa is currently low. A voucher scheme was introduced in Volta Region as a possible sustainable delivery system for increasing this coverage through scale-up to other regions. Succes...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-14
更新日期:2007-02-02 00:00:00
abstract:BACKGROUND:Malaria is known as tazo or tazomoka in local terminology in Madagascar. Within the context of traditional practice, malaria (and/or malaria symptoms) is commonly treated by decoctions or infusions from bitter plants. One possible approach to the identification of new antimalarial drug candidates is to searc...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-2-25
更新日期:2003-07-24 00:00:00
abstract:BACKGROUND:The use of anti-malarial drug combinations with artemisinin or with one of its derivatives is now widely recommended to overcome drug resistance in falciparum as well as vivax malaria. The fixed oral dose artemisinin-naphthoquine combination (ANQ, ARCO) is a newer artemisinin-based combination (ACT) therapy ...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-8-196
更新日期:2009-08-12 00:00:00
abstract:BACKGROUND:The number of Plasmodium falciparum malaria cases around the world has decreased substantially over the last 15 years, but with the spread of resistance against anti-malarial drugs and insecticides, this decline may not continue. There is an urgent need to consider alternative, accelerated strategies to elim...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-2130-3
更新日期:2017-11-28 00:00:00
abstract:BACKGROUND:Rapid diagnostic tests (RDTs) for histidine rich protein 2 (HRP2) are often used to determine whether persons with fever should be treated with anti-malarials. However, Plasmodium falciparum parasites with a deletion of the hrp2 gene yield false-negative RDTs and there are concerns the sensitivity of HRP2-ba...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1768-1
更新日期:2017-03-20 00:00:00
abstract:BACKGROUND:Tumour necrosis factor (TNF) and interferon gamma (IFN-γ), encoded by TNF-836 C/A (rs 1800630) and IFN-γ -1616 C/T (rs2069705) genes, are key immunological mediators that are believed to both play protective and pathological roles in malaria. The aim of this study was to investigate the relationship between ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-314
更新日期:2014-08-13 00:00:00
abstract:BACKGROUND:In malaria-endemic areas, human populations are frequently exposed to immunomodulatory salivary components injected during mosquito blood feeding. The consequences on pathogen-specific immune responses are not well known. This study evaluated and compared the humoral responses specific to merozoite stage vac...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03160-5
更新日期:2020-02-21 00:00:00
abstract:BACKGROUND:The successful control of insect disease vectors relies on a thorough understanding of their ecology and behaviour. However, knowledge of the ecology of many human disease vectors lags behind that of agricultural pests. This is partially due to the paucity of experimental tools for investigating their ecolog...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-356
更新日期:2010-12-08 00:00:00
abstract:BACKGROUND:Prior studies have shown that annual entomological inoculation rates (EIRs) must be reduced to less than one to substantially reduce the prevalence of malaria infection. In this study, EIR values were used to quantify the impact of insecticide-treated bed nets (ITNs), indoor residual spraying (IRS), and sour...
journal_title:Malaria journal
pub_type: 杂志文章,评审
doi:10.1186/1475-2875-9-122
更新日期:2010-05-12 00:00:00
abstract:BACKGROUND:Malaria is a major cause of morbidity and mortality worldwide with over one million deaths annually, particularly in children under five years. This study was the first to examine plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum fr...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-12-5
更新日期:2013-01-07 00:00:00
abstract:BACKGROUND:Malaria transmission in the peri-Iquitos region of Amazonian Peru has been designated as seasonal and hypo-endemic with recently described hyper-endemic hotspots. Despite relatively recent distribution of long-lasting insecticidal bed nets (LLINs), malaria in Amazonian Peru persists and increased substantial...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0804-2
更新日期:2015-07-30 00:00:00
abstract:BACKGROUND:Antiplasmodial activities of angiotensin II and its analogues have been extensively investigated in Plasmodium gallinaceum and Plasmodium falciparum parasite species. Due to its vasoconstrictor property angiotensin II cannot be used as an anti-malarial drug. METHODS:This work presents the solid-phase synthe...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0974-y
更新日期:2015-11-04 00:00:00
abstract:BACKGROUND:Anopheles nuneztovari sensu lato comprises cryptic species in northern South America, and the Brazilian populations encompass distinct genetic lineages within the Brazilian Amazon region. This study investigated, based on two molecular markers, whether these lineages might actually deserve species status. M...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1217-6
更新日期:2016-04-12 00:00:00
abstract:BACKGROUND:This paper reports on the availability of diagnostic tools and recommended anti-malarials in the 12-month period immediately following the implementation of a new national malaria treatment protocol (NMTP) in Papua New Guinea (PNG). Health worker adherence to the new NMTP is also examined and comparisons mad...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-433
更新日期:2013-11-27 00:00:00
abstract:BACKGROUND:Insecticide-treated bed nets (ITN) have been shown to be efficacious in reducing malaria morbidity and mortality in many regions. Unfortunately in some areas, malaria has persisted despite the scale up of ITNs. Recent reports indicate that human behaviour and mosquito behaviour are potential threats to the e...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1575-0
更新日期:2016-11-08 00:00:00