Intrarectal quinine for treating Plasmodium falciparum malaria: a systematic review.

abstract：BACKGROUND:In clinical trials of therapy for uncomplicated Plasmodium falciparum, there are usually some patients who fail treatment even in the absence of drug resistance. Treatment failures, which can be due to recrudescence or re-infection, are categorized as 'clinical' or 'parasitological' failures, the former indi...

journal_title：Malaria journal

authors： Mumtaz R,Okell LC,Challenger JD

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Many studies have tracked the distribution and persistence of avian haemosporidian communities across space and time at the population level, but few studies have investigated these aspects of infection at the individual level over time. Important aspects of parasite infection at the individual level can be ...

journal_title：Malaria journal

authors： van Rooyen J,Lalubin F,Glaizot O,Christe P

更新日期：2013-01-30 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated the deletion of the histidine-rich protein 2 (PfHRP2) gene (pfhrp2) in field isolates of Plasmodium falciparum, which could result in false negative test results when PfHRP2-based rapid diagnostic tests (RDTs) are used for malaria diagnosis. Although primary diagnosis of mala...

journal_title：Malaria journal

authors： Abdallah JF,Okoth SA,Fontecha GA,Torres RE,Banegas EI,Matute ML,Bucheli ST,Goldman IF,de Oliveira AM,Barnwell JW,Udhayakumar V

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Malaria in pregnancy is associated with immunological abnormalities in the newborns, such as hampered T-helper 1 responses and increased T-regulatory responses, while the effect of maternal Plasmodium falciparum infection on foetal innate immunity is still controversial. MATERIALS AND METHODS:The immunophen...

journal_title：Malaria journal

authors： Fievet N,Varani S,Ibitokou S,Briand V,Louis S,Perrin RX,Massougbogji A,Hosmalin A,Troye-Blomberg M,Deloron P

更新日期：2009-11-05 00:00:00

abstract：BACKGROUND:The evolution of drug resistance in malaria parasites highlights a need to identify and evaluate strategies that could extend the useful therapeutic life of anti-malarial drugs. Such strategies are deployed to best effect before resistance has emerged, under conditions of great uncertainty. METHODS:Here, th...

journal_title：Malaria journal

authors： Smith DL,Klein EY,McKenzie FE,Laxminarayan R

更新日期：2010-07-23 00:00:00

abstract：BACKGROUND:Anopheles arabiensis is stereotypical of diverse vectors that mediate residual malaria transmission globally, because it can feed outdoors upon humans or cattle, or enter but then rapidly exit houses without fatal exposure to insecticidal nets or sprays. METHODS:Life histories of a well-characterized An. ar...

journal_title：Malaria journal

authors： Killeen GF,Govella NJ,Lwetoijera DW,Okumu FO

更新日期：2016-04-19 00:00:00

abstract：:The global health community is interested in the health impact of the billions of dollars invested to fight malaria in Africa. A recent publication used trends in malaria cases and deaths based on health facility records to evaluate the impact of malaria control efforts in Rwanda and Ethiopia. Although the authors dem...

journal_title：Malaria journal

authors： Rowe AK,Kachur SP,Yoon SS,Lynch M,Slutsker L,Steketee RW

更新日期：2009-09-03 00:00:00

abstract：BACKGROUND:Mosquito-feeding assays are important tools to guide the development and support the evaluation of transmission-blocking interventions. These functional bioassays measure the sporogonic development of gametocytes in blood-fed mosquitoes. Measuring the infectivity of low gametocyte densities has become increa...

journal_title：Malaria journal

authors： Reuling IJ,Stone WJR,van de Vegte-Bolmer M,van Gemert GJ,Siebelink-Stoter R,Graumans W,Lanke K,Bousema T,Sauerwein RW

更新日期：2017-08-05 00:00:00

abstract：BACKGROUND:The current target of universal access to long-lasting, insecticide-treated nets (LLIN) is 80% coverage to reduce malaria deaths by 75% by 2015. So far, campaigns have been the main channel for large-scale delivery of LLINs, however the World Health Organization has recommended that equal priority should be ...

journal_title：Malaria journal

authors： Okell LC,Paintain LS,Webster J,Hanson K,Lines J

更新日期：2012-09-13 00:00:00

abstract：BACKGROUND:Adequate coverage and proper use of long-lasting insecticidal nets (LLINs) and indoor residual spaying (IRS) reduce density of indoor-resting mosquitoes, man-mosquito contact and malaria infection. However, distribution, ownership and usage of the interventions may vary among households in a malarious area, ...

journal_title：Malaria journal

authors： Animut A,Negash Y,Kebede N

更新日期：2014-09-10 00:00:00

abstract：BACKGROUND:Antananarivo, the capital of Madagascar, is located at an altitude of over 1,200 m. The environment at this altitude is not particularly favourable to malaria transmission, but malaria nonetheless remains a major public health problem. The aim of this study was to evaluate exposure to malaria in the urban po...

journal_title：Malaria journal

authors： Domarle O,Razakandrainibe R,Rakotomalala E,Jolivet L,Randremanana RV,Rakotomanana F,Ramarokoto CE,Soares JL,Ariey F

更新日期：2006-11-10 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s12936-016-1486-0.]. ...

journal_title：Malaria journal

authors： DellaValle B,Hempel C,Staalsoe T,Johansen FF,Kurtzhals JAL

更新日期：2016-09-27 00:00:00

abstract：BACKGROUND:Malaria is a major cause of morbidity and mortality worldwide with over one million deaths annually, particularly in children under five years. This study was the first to examine plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum fr...

journal_title：Malaria journal

authors： Noone C,Parkinson M,Dowling DJ,Aldridge A,Kirwan P,Molloy SF,Asaolu SO,Holland C,O'Neill SM

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:Real-time PCR is a sensitive and specific method for the analysis of Plasmodium DNA. However, prior purification of genomic DNA from blood is necessary since PCR inhibitors and quenching of fluorophores from blood prevent efficient amplification and detection of PCR products. METHODS:Reagents designed to sp...

journal_title：Malaria journal

authors： Taylor BJ,Martin KA,Arango E,Agudelo OM,Maestre A,Yanow SK

更新日期：2011-08-19 00:00:00

abstract：BACKGROUND:In 2001, the World Health Organization (WHO) has recommended the use of artemisinin-based combination therapy (ACT) as the first-line treatment of uncomplicated malaria cases, as monotherapies had become ineffective in many parts of the world. As a result, the Democratic Republic of Congo (DRC) withdrew chlo...

journal_title：Malaria journal

authors： Mvumbi DM,Boreux R,Sacheli R,Lelo M,Lengu B,Nani-Tuma S,Melin P,Ntumba K,Lunganza K,DeMol P,Hayette MP

更新日期：2013-12-20 00:00:00

abstract：BACKGROUND:Over the last decade, the incidence of confirmed malaria has declined significantly in Nepal. The aim of this paper is to assess the spatio-temporal distribution of malaria and its association with climatic factors and vector control interventions in two high-risk districts of Nepal. METHODS:Hotspot analysi...

journal_title：Malaria journal

authors： Dhimal M,O'Hara RB,Karki R,Thakur GD,Kuch U,Ahrens B

更新日期：2014-11-25 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy is the first-line anti-malarial treatment for uncomplicated Plasmodium falciparum infection in Angola. To date, the prevalence of polymorphisms in the pfk13 gene, associated with artemisinin resistance, and pfmdr1, associated with lumefantrine resistance, have not been s...

journal_title：Malaria journal

authors： Ljolje D,Dimbu PR,Kelley J,Goldman I,Nace D,Macaia A,Halsey ES,Ringwald P,Fortes F,Udhayakumar V,Talundzic E,Lucchi NW,Plucinski MM

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:Arthropod vectors of disease may encounter more than one infected host during the course of their lifetime. The consequences of super-infection to parasite development are rarely investigated, but may have substantial epidemiological and evolutionary consequences. METHODS:Using a rodent malaria model system...

journal_title：Malaria journal

authors： Ferguson HM,Read AF

更新日期：2004-05-19 00:00:00

abstract：BACKGROUND:The close relationship between vector-borne diseases and their environment is well documented, especially for diseases with water-dependent vectors such as avian malaria. Mosquitoes are the primary vectors of avian malaria and also the definitive hosts in the disease life cycle. Factors pertinent to mosquito...

journal_title：Malaria journal

authors： Okanga S,Cumming GS,Hockey PA

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Declining in clinical efficacy of artesunate-mefloquine combination has been documented in areas along the eastern border (Thai-Cambodian) of Thailand. In the present study, the clinical efficacy of the three-day combination regimen of artesunate-mefloquine as first-line treatment for acute uncomplicated fal...

journal_title：Malaria journal

authors： Na-Bangchang K,Ruengweerayut R,Mahamad P,Ruengweerayut K,Chaijaroenkul W

更新日期：2010-10-08 00:00:00

abstract：BACKGROUND:The conserved centromere-associated proteins, CENH3 (or CENP-A) and CENP-C are indispensable for the functional centromere-kinetochore assembly, chromosome segregation, cell cycle progression, and viability. The presence and functions of centromere proteins in Plasmodium falciparum are not well studied. Iden...

journal_title：Malaria journal

authors： Verma G,Surolia N

更新日期：2014-12-04 00:00:00

abstract：BACKGROUND:Residents of malaria-endemic communities spend several hours outdoors performing different activities, e.g. cooking, story-telling or eating, thereby exposing themselves to potentially-infectious mosquitoes. This compromises effectiveness of indoor interventions, notably long-lasting insecticide-treated nets...

journal_title：Malaria journal

authors： Masalu JP,Finda M,Killeen GF,Ngowo HS,Pinda PG,Okumu FO

更新日期：2020-03-10 00:00:00

abstract：BACKGROUND:The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Mal...

journal_title：Malaria journal

authors： Lima RB,Rocha e Silva LF,Melo MR,Costa JS,Picanço NS,Lima ES,Vasconcellos MC,Boleti AP,Santos JM,Amorim RC,Chaves FC,Coutinho JP,Tadei WP,Krettli AU,Pohlit AM

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:In order to sustain the gains achieved by current malaria control strategies, robust surveillance systems that monitor dynamics of vectors and their roles in malaria transmission over time are essential. This longitudinal study demonstrates the trends in malaria vector dynamics and their relative contributio...

journal_title：Malaria journal

authors： Lwetoijera DW,Harris C,Kiware SS,Dongus S,Devine GJ,McCall PJ,Majambere S

更新日期：2014-08-24 00:00:00

abstract：BACKGROUND:Mass distribution campaigns of insecticide-treated nets for malaria prevention are usually accompanied by intensive behaviour change communication (BCC) to encourage hanging and use of nets. However, data on the effectiveness of these communication efforts are scarce. In preparation for the next round of mas...

journal_title：Malaria journal

authors： Kilian A,Lawford H,Ujuju CN,Abeku TA,Nwokolo E,Okoh F,Baba E

更新日期：2016-08-19 00:00:00

abstract：BACKGROUND:Cases of transfusion-transmitted malaria have been described around the world and highlighted in some studies. Semi-immune individuals are more likely to transmit malaria as they may be asymptomatic. Some countries allow blood donations only based on epidemiological criteria while others reinforce their crit...

journal_title：Malaria journal

authors： Portugal-Calisto D,Ferreira AR,Silva MS,Teodósio R

更新日期：2016-11-09 00:00:00

abstract：BACKGROUND:Increases in the coverage of long-lasting insecticidal nets (LLINs) have significantly reduced the abundance of Anopheles gambiae sensu stricto in several African settings, leaving its more zoophagic sibling species Anopheles arabiensis as the primary vector. This study investigated the impact of livestock o...

journal_title：Malaria journal

authors： Mayagaya VS,Nkwengulila G,Lyimo IN,Kihonda J,Mtambala H,Ngonyani H,Russell TL,Ferguson HM

更新日期：2015-01-21 00:00:00

abstract：BACKGROUND:Hypoglycaemia is a poor prognostic indicator in severe malaria. Intravenous infusions are rarely feasible in rural areas. The efficacy of sublingual sugar (SLS) was assessed in a pilot randomized controlled trial among hypoglycaemic children with severe malaria in Mali. METHODS:Of 151 patients with presumed...

journal_title：Malaria journal

authors： Graz B,Dicko M,Willcox ML,Lambert B,Falquet J,Forster M,Giani S,Diakite C,Dembele EM,Diallo D,Barennes H

更新日期：2008-11-23 00:00:00

abstract：BACKGROUND:Prompt, quality assured laboratory diagnosis is key to effective malaria case management and control, especially since the introduction of the more expensive artemisinin combination therapy (ACT). The malaria programme and its non-government partners, on the basis of WHO recommended Lot Quality Assurance met...

journal_title：Malaria journal

authors： Khan MA,Walley JD,Munir MA,Khan MA,Khokar NG,Tahir Z,Nazir A,Shams N

更新日期：2011-02-17 00:00:00

abstract：BACKGROUND:Control of mosquitoes that transmit malaria has been the mainstay in the fight against the disease, but alternative methods are required in view of emerging insecticide resistance. Entomopathogenic fungi are candidate alternatives, but to date, few trials have translated the use of these agents to field-base...

journal_title：Malaria journal

authors： Mnyone LL,Lyimo IN,Lwetoijera DW,Mpingwa MW,Nchimbi N,Hancock PA,Russell TL,Kirby MJ,Takken W,Koenraadt CJ

更新日期：2012-03-26 00:00:00