High prevalence of mutation in the Plasmodium falciparum dhfr and dhps genes in field isolates from Sabah, Northern Borneo.

abstract：BACKGROUND:Diagnosis of Plasmodium falciparum is often based on detection of histidine-rich protein 2 (HRP2) in blood. Most HRP2-based assays have high sensitivity and specificity; however, authors have suggested that antibodies (Ab) to HRP2 could reduce assay sensitivity. This study sought to characterize the antibody...

journal_title：Malaria journal

authors： Taylor DW,Bobbili N,Khadka VS,Quakyi IA,Leke RG

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:There is evidence that suggests that undernutrition has a detrimental effect on malarial immunity in children. The aim of the study was to discover whether nutrient supplementation improved development of malarial antibody immunity in children up to 18 months of age. METHODS:The study was conducted with a s...

journal_title：Malaria journal

authors： Barua P,Chandrasiri UP,Beeson JG,Dewey KG,Maleta K,Ashorn P,Rogerson SJ

更新日期：2018-02-07 00:00:00

abstract：BACKGROUND:The study of the Plasmodium falciparum heavy metal transporter gene pfmdr2 employed radioactive labelled heavy metal. As the use of radioactive isotopes shrank considerably during the last few years, resulting in the cessation of the production of some isotopes, amongst them Cadmium109 which was used for tha...

journal_title：Malaria journal

authors： Rosental B,Hadad U,Sinay R,Braiman A,Porgador A,Pollack Y

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Data concerning antimalarial combination treatment for uncomplicated malaria in Madagascar are largely lacking. Randomized clinical trial was designed to assess therapeutic efficacies of chloroquine (CQ), amodiaquine (AQ), sulphadoxine-pyrimethamine (SP), amodiaquine plus sulphadoxine-pyrimethamine combinati...

journal_title：Malaria journal

authors： Ménard D,Andrianina NN,Ramiandrasoa Z,Randriamanantena A,Rasoarilalao N,Jahevitra M,Ratsimbasoa A,Tuseo L,Raveloson A

更新日期：2007-05-22 00:00:00

abstract：BACKGROUND:Molecular tools are very sensitive and specific and could be an alternative for the diagnosis of malaria. The complexity and need for expensive equipment may hamper implementation and, therefore, simplifications to current protocols are warranted. METHODS:A PCR detecting the different Plasmodium species and...

journal_title：Malaria journal

authors： Mens PF,Moers AP,de Bes LM,Flint J,Sak JR,Keereecharoen L,van Overmeir C,Verweij JJ,Hallett RL,Wihokhoen B,Proux S,Schallig HD,van Amerongen A

更新日期：2012-08-17 00:00:00

abstract：BACKGROUND:Resistance to multiple classes of insecticides has been detected in the malaria vector Anopheles albimanus in northwest Peru. Acetylcholinesterase (AChE) insensitivity has previously been associated with resistance to organophosphate (OP) and carbamate (CA) insecticides in arthropods. A single point mutation...

journal_title：Malaria journal

authors： Liebman KA,Pinto J,Valle J,Palomino M,Vizcaino L,Brogdon W,Lenhart A

更新日期：2015-02-14 00:00:00

abstract：:Most human Plasmodium infections in western Kenya are asymptomatic and are believed to contribute importantly to malaria transmission. Elimination of asymptomatic infections requires active treatment approaches, such as mass testing and treatment (MTaT) or mass drug administration (MDA), as infected persons do not see...

journal_title：Malaria journal

authors： Samuels AM,Awino N,Odongo W,Abong'o B,Gimnig J,Otieno K,Shi YP,Were V,Allen DR,Were F,Sang T,Obor D,Williamson J,Hamel MJ,Patrick Kachur S,Slutsker L,Lindblade KA,Kariuki S,Desai M

更新日期：2017-06-07 00:00:00

abstract：BACKGROUND:The development of insecticide resistance and the increased outdoor-biting behaviour of malaria vectors reduce the efficiency of indoor vector control methods. Attractive toxic sugar baits (ATSBs), a method targeting the sugar-feeding behaviours of vectors both indoors and outdoors, is a promising supplement...

journal_title：Malaria journal

authors： Zhu L,Marshall JM,Qualls WA,Schlein Y,McManus JW,Arheart KL,Hlaing WM,Traore SF,Doumbia S,Müller GC,Beier JC

更新日期：2015-12-08 00:00:00

abstract：BACKGROUND:Insecticide-treated nets (ITNs) are losing efficacy against pyrethroid-resistant malaria vector populations throughout Africa. Safeguarding bed net efficacy, vital for effective malaria control, requires greater knowledge of mosquito-ITN interactions and how this impacts on the mosquito. METHODS:A purpose-b...

journal_title：Malaria journal

authors： Hughes A,Foster GM,Guy A,Matope A,Abe M,Towers D,McCall PJ

更新日期：2020-04-07 00:00:00

abstract：:The Demographic and Health Surveys (DHS) Program has supported three household Malaria Indicator Surveys (MIS) in Madagascar. The results of 13 key malaria indicators from these surveys have been mapped as continuous surfaces using model-based geostatistical methods. The opportunities and limitations of these mapped o...

journal_title：Malaria journal

authors： Howes RE,Hawa K,Andriamamonjy VF,Franchard T,Miarimbola R,Mioramalala SA,Rafamatanantsoa JF,Rahantamalala MAM,Rajaobary SH,Rajaonera HDG,Rakotonindrainy AP,Rakotoson Andrianjatonavalona C,Randriamiarinjatovo DNAL,Randrianasolo

更新日期：2019-03-22 00:00:00

abstract：BACKGROUND:Several malaria vaccines are currently in clinical trials and are expected to provide an improved strategy for malaria control. Prior to introduction of a new vaccine, policymakers must consider the socio cultural environment of the region to ensure widespread community approval. This study investigated the ...

journal_title：Malaria journal

authors： Ojakaa DI,Jarvis JD,Matilu MI,Thiam S

更新日期：2014-05-05 00:00:00

abstract：BACKGROUND:Hypoglycaemia is a poor prognostic indicator in severe malaria. Intravenous infusions are rarely feasible in rural areas. The efficacy of sublingual sugar (SLS) was assessed in a pilot randomized controlled trial among hypoglycaemic children with severe malaria in Mali. METHODS:Of 151 patients with presumed...

journal_title：Malaria journal

authors： Graz B,Dicko M,Willcox ML,Lambert B,Falquet J,Forster M,Giani S,Diakite C,Dembele EM,Diallo D,Barennes H

更新日期：2008-11-23 00:00:00

abstract：BACKGROUND:The ACT recommended by WHO is very effective and well-tolerated. However, these combinations need to be administered for three days, which may limit adherence to treatment.The combination of dihydroartemisinin-piperaquine phosphate-trimethoprim (Artecom®, Odypharm Ltd), which involves treatment over two days...

journal_title：Malaria journal

authors： Menan H,Faye O,Same-Ekobo A,Oga AS,Faye B,Kiki Barro CP,Kuete T,N'diaye JL,Vicky AM,Tine R,Yavo W,Kane D,Kassi KF,Kone M

更新日期：2011-07-08 00:00:00

abstract：BACKGROUND:Indonesia is home to a variety of malaria vectors whose specific bionomic traits remain largely uncharacterized. Species-specific behaviours, such as host feeding preferences, impact the dynamics of malaria transmission and the effectiveness of vector control interventions. METHODS:To examine species-specif...

journal_title：Malaria journal

authors： St Laurent B,Burton TA,Zubaidah S,Miller HC,Asih PB,Baharuddin A,Kosasih S,Shinta,Firman S,Hawley WA,Burkot TR,Syafruddin D,Sukowati S,Collins FH,Lobo NF

更新日期：2017-08-02 00:00:00

abstract：BACKGROUND:Malaria is a major cause of morbidity and mortality worldwide with over one million deaths annually, particularly in children under five years. This study was the first to examine plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum fr...

journal_title：Malaria journal

authors： Noone C,Parkinson M,Dowling DJ,Aldridge A,Kirwan P,Molloy SF,Asaolu SO,Holland C,O'Neill SM

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:Malaria in Southeast Asia frequently clusters along international borders. For example, while most of Thailand is malaria free, the border region shared with Myanmar continues to have endemic malaria. This spatial pattern is the result of complex interactions between landscape, humans, mosquito vectors, and ...

journal_title：Malaria journal

authors： Parker DM,Carrara VI,Pukrittayakamee S,McGready R,Nosten FH

更新日期：2015-10-05 00:00:00

abstract：BACKGROUND:Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax. During monotherapy treatment, the compound exhibits slow parasite and fever clearance times, and toxicity in glucose-6-phosphate dehydrogenase (G6PD) deficiency is a concern. Combinati...

journal_title：Malaria journal

authors： Dow GS,Gettayacamin M,Hansukjariya P,Imerbsin R,Komcharoen S,Sattabongkot J,Kyle D,Milhous W,Cozens S,Kenworthy D,Miller A,Veazey J,Ohrt C

更新日期：2011-07-29 00:00:00

abstract：BACKGROUND:Malaria is a potentially lethal illness for which preventive measures are not optimally used among all travellers. Travellers visiting friends and relatives in their country of origin (VFRs) are known to use chemoprophylaxis less consistently compared to tourist travellers. In this study, factors explaining ...

journal_title：Malaria journal

authors： Wieten RW,Harting J,Biemond PM,Grobusch MP,van Vugt M

更新日期：2013-10-10 00:00:00

abstract：BACKGROUND:Early and accurate diagnosis of Plasmodium falciparum infection is important for providing appropriate treatment to patients with malaria. However, technical limitations of currently available diagnostic tests limit their use in control programs. One possible explanation for the vulnerability of current anti...

journal_title：Malaria journal

authors： Leow CH,Jones M,Cheng Q,Mahler S,McCarthy J

更新日期：2014-07-18 00:00:00

abstract：BACKGROUND:Colombia contributes a significant proportion of malaria cases in the Americas, which are predominantly rural. However, in the last 8 years ~ 10 % of the endemic municipalities have also reported urban and peri-urban malaria cases, a growing concern for health authorities. This study focused on the character...

journal_title：Malaria journal

authors： Padilla JC,Chaparro PE,Molina K,Arevalo-Herrera M,Herrera S

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:The effects that artemether-lumefantrine (AL) has on gametocyte dynamics in the short-term have recently been described. However there is limited long-term longitudinal data on the effect of AL on gametocyte dynamics in asymptomatic children. METHODS:An epidemiological study was conducted in Kombewa, Wester...

journal_title：Malaria journal

authors： Andagalu B,Mativo J,Kamau E,Ogutu B

更新日期：2014-07-09 00:00:00

abstract：BACKGROUND:Artemisinin-based combination therapy (ACT) has been adopted as the most effective treatment against malaria in many endemic countries like Kenya while quinine has remained the second line. The objective of the current study was to assess access to Kenya's policy recommended anti-malarials, ACT and quinine i...

journal_title：Malaria journal

authors： Watsierah CA,Ouma C

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:Since Plasmodium falciparum transmission relies exclusively on sexual-stage parasites, several malaria control strategies aim to disrupt this step of the life cycle. Thus, a better understanding of which individuals constitute the primary gametocyte reservoir within an endemic population, and the temporal dy...

journal_title：Malaria journal

authors： Adomako-Ankomah Y,Chenoweth MS,Tocker AM,Doumbia S,Konate D,Doumbouya M,Keita AS,Anderson JM,Fairhurst RM,Diakite M,Miura K,Long CA

更新日期：2017-11-21 00:00:00

abstract：BACKGROUND:Data collected in clinical trials have been used to develop scoring systems that identify adults with malaria at greatest risk of death. One of these, the RCAM score, can be simply determined by measuring a patient's Glasgow Coma Score and respiratory rate on admission to hospital. However the safety of usin...

journal_title：Malaria journal

authors： Kaung M,Kyi TT,Aung NM,Kyaw MP,Min M,Htet ZW,Anstey NM,Kyi MM,Hanson J

更新日期：2015-02-07 00:00:00

abstract：BACKGROUND:Real-time PCR is a sensitive and specific method for the analysis of Plasmodium DNA. However, prior purification of genomic DNA from blood is necessary since PCR inhibitors and quenching of fluorophores from blood prevent efficient amplification and detection of PCR products. METHODS:Reagents designed to sp...

journal_title：Malaria journal

authors： Taylor BJ,Martin KA,Arango E,Agudelo OM,Maestre A,Yanow SK

更新日期：2011-08-19 00:00:00

abstract：BACKGROUND:As South Africa strives to achieve malaria elimination by 2018 (zero local cases) the country needs to strengthen its disease surveillance system by reducing the timeliness from case diagnosis to notification of key stakeholders in the malaria programme. This study evaluated the feasibility of a 24-h mobile ...

journal_title：Malaria journal

authors： Baloyi RE,Shandukani MB,Graffy R,Misiani E,Mayet N,Mabunda E,Mabuza A,Qwabe B,Ngwenyama B,Reddy C,Moonasar D

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:There is an urgent need for an effective vaccine to control and eradicate malaria, one of the most serious global infectious diseases. Plasmodium merozoite surface protein 4 (MSP4) has been listed as a blood-stage subunit vaccine candidate for malaria. Infection with Plasmodium ovale species including P. ova...

journal_title：Malaria journal

authors： Uwase J,Chu R,Kassegne K,Lei Y,Shen F,Fu H,Sun Y,Xuan Y,Cao J,Cheng Y

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:In a recent trial of artemisinin-naphthoquine (artemisinin-NQ) and artemether-lumefantrine (AM-LM) therapy in young children from Papua New Guinea (PNG), there were no treatment failures in artemisinin-NQ-treated children with Plasmodium falciparum or Plasmodium vivax compared with 2.2% and 30.0%, respective...

journal_title：Malaria journal

authors： Laman M,Benjamin JM,Moore BR,Salib M,Tawat S,Davis WA,Siba PM,Robinson LJ,Davis TM

更新日期：2015-03-21 00:00:00

abstract：BACKGROUND:Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP) is recommended for reducing the risk of malaria in pregnancy and its consequences on mothers and babies (IPTp-SP). Indicators of implementation and effects of IPTp-SP were collected in a rural clinic in Southern Senegal. METHODS:Women se...

journal_title：Malaria journal

authors： Olliaro PL,Delenne H,Cisse M,Badiane M,Olliaro A,Vaillant M,Brasseur P

更新日期：2008-11-07 00:00:00

abstract：BACKGROUND:Reported malaria cases continue to decline globally, and this has been attributed to strategic implementation of multiple malaria control tools. Gains made would however need to be sustained through continuous monitoring to ensure malaria elimination and eradication. Entomological inoculation rate (EIR) is c...

journal_title：Malaria journal

authors： Kusi KA,Bosomprah S,Dodoo D,Kyei-Baafour E,Dickson EK,Mensah D,Angov E,Dutta S,Sedegah M,Koram KA

更新日期：2014-03-17 00:00:00