Abstract:
BACKGROUND:The pro-inflammatory S100 calcium binding protein A8 (S100A8) is elevated in the serum of patients with Plasmodium falciparum malaria, but its function in Plasmodium vivax malaria is not yet clear. This function was investigated in P. vivax-infected patients in this study. METHODS:The level of S100A8 in the serum was measured with ELISA. Full amino acids of S100A8 were synthesized to verify the functions for maturation of immature dendritic cell (iDC) and evaluation of CD4(+)CD25(+)Foxp3(+) regulatory T (Treg) generation by mature DC (mDC). RESULTS:A higher amount of S100A8 was detected in vivax-infected patients (141.2 ± 61.849 ng/ml, n = 40) compared with normal control group (48.1 ± 27.384 ng/ml, n = 40). The level of S100A8 did not coincide with that of anti-malarial antibody measured by indirect fluorescent antibody test (IFAT) using parasite-infected red blood cells as antigen. Programmed death-ligand 1 (PD-L1) was up-regulated on the surface of iDCs following treatment with synthetic S100A8, not with synthetic MSP-1, AMA-1 and CSP, as compared to the expression seen for non-treated iDCs. The addition of red blood cells of infected patients to iDCs also elevated their surface expression of CD86. However, the serum levels of S100A8 decreased with increase in parasitaemia. DCs matured by sera containing S100A8 generated Treg cells from naïve T cells. The ratio of Treg cells generated was inversely proportional to the concentration of S100A8 in sera. CONCLUSIONS:Treg cells suppress the activity of cytotoxic T cells, which kill malaria parasites; therefore, the up-regulation of S100A8 in malaria patients may contribute to pathogen immune escape or tolerance.
journal_name
Malar Jjournal_title
Malaria journalauthors
Kim TS,Kang YJ,Kim JY,Lee S,Lee WJ,Sohn Y,Lee HWdoi
10.1186/s12936-015-0855-4subject
Has Abstractpub_date
2015-10-05 00:00:00pages
385issn
1475-2875pii
10.1186/s12936-015-0855-4journal_volume
14pub_type
杂志文章相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:Malaria is responsible for up to a 600,000 deaths per year; conveying an urgent need for the development of a malaria vaccine. Studies with whole sporozoite vaccines in mice and non-human primates have shown that sporozoite-induced CD8+ T cells targeting liver stage antigens can mediate sterile protection. T...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-376
更新日期:2013-10-29 00:00:00
abstract:BACKGROUND:Transmission of Plasmodium vivax malaria is dependent on vector availability, biting rates and parasite development. In turn, each of these is influenced by climatic conditions. Correlations have previously been detected between seasonal rainfall, temperature and malaria incidence patterns in various setting...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-452
更新日期:2013-12-18 00:00:00
abstract:BACKGROUND:Indoor-based anti-vector interventions remain the preferred means of reducing risk of malaria transmission in malaria endemic areas around the world. Despite demonstrated success in reducing human-mosquito interactions, these methods are effective solely against endophilic vectors. It may be that outdoor loc...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-184
更新日期:2011-07-07 00:00:00
abstract:BACKGROUND:The emergence of parasite drug resistance, especially Plasmodium falciparum, persists as a major obstacle for malaria control and elimination. To develop effective public health containment strategies, a clear understanding of factors that govern the emergence and spread of resistant parasites in the field i...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-453
更新日期:2013-12-19 00:00:00
abstract:BACKGROUND:Molecular detection of low-density Plasmodium falciparum infections is essential for surveillance studies conducted to inform malaria control strategies in close-to-elimination settings. Molecular monitoring of residual malaria infections usually requires a large study size, therefore sampling and diagnostic...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-3127-x
更新日期:2020-01-29 00:00:00
abstract:BACKGROUND:Congenital malaria is the direct infection of an infant with malaria parasites from their mother prior to or during birth. Neonatal malaria is due to an infective mosquito bite after birth. Neonatal and congenital malaria (NCM) are potentially life-threatening conditions that are believed to occur at relativ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2327-0
更新日期:2018-04-20 00:00:00
abstract:BACKGROUND:There is an urgent need for an effective vaccine to control and eradicate malaria, one of the most serious global infectious diseases. Plasmodium merozoite surface protein 4 (MSP4) has been listed as a blood-stage subunit vaccine candidate for malaria. Infection with Plasmodium ovale species including P. ova...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03207-7
更新日期:2020-03-30 00:00:00
abstract:BACKGROUND:Mosquitoes of the Anopheles gambiae species complex are the primary vectors of human malaria in sub-Saharan Africa. Many host genes have been shown to affect Plasmodium development in the mosquito, and so are expected to engage in an evolutionary arms race with the pathogen. However, there is little conclusi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-8-117
更新日期:2009-06-04 00:00:00
abstract:BACKGROUND:The adaptation of malaria vectors to urban areas is becoming a serious challenge for malaria control. The study presents the evolution of pyrethroid resistance in mosquito populations from the cities of Douala and Yaoundé between 2010 and 2013. METHODS:Susceptibility tests to permethrin and deltamethrin wer...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0675-6
更新日期:2015-04-14 00:00:00
abstract:BACKGROUND:In a malaria-endemic area the distribution of patients is neither constant in time nor homogeneous in space. The WHO recommends the stratification of malaria risk on a fine geographical scale. In the village of Cacao in French Guiana, the study of the spatial and temporal distribution of malaria cases, durin...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-90
更新日期:2013-03-11 00:00:00
abstract:BACKGROUND:Iron deficiency is the most widespread nutrient deficiency and an important cause of developmental impairment in children. However, some studies have indicated that iron deficiency can also protect against malaria, which is a leading cause of childhood morbidity and mortality in large parts of the world. Thi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2186-8
更新日期:2018-01-16 00:00:00
abstract:BACKGROUND:The use of anti-malarial drug combinations with artemisinin or with one of its derivatives is now widely recommended to overcome drug resistance in falciparum as well as vivax malaria. The fixed oral dose artemisinin-naphthoquine combination (ANQ, ARCO) is a newer artemisinin-based combination (ACT) therapy ...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-8-196
更新日期:2009-08-12 00:00:00
abstract:BACKGROUND:Over the last decade, the incidence of confirmed malaria has declined significantly in Nepal. The aim of this paper is to assess the spatio-temporal distribution of malaria and its association with climatic factors and vector control interventions in two high-risk districts of Nepal. METHODS:Hotspot analysi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-457
更新日期:2014-11-25 00:00:00
abstract:BACKGROUND:Rosetting is associated with severe malaria and a primary cause of death in Plasmodium falciparum infections. Detailed understanding of this adhesive phenomenon may enable the development of new therapies interfering with rosette formation. For this, it is crucial to determine parameters such as rosetting an...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1243-4
更新日期:2016-04-18 00:00:00
abstract:BACKGROUND:Plasmodium knowlesi is the fifth Plasmodium species that can infect humans. The Plasmodium merozoite surface protein-1(42) (MSP-1(42)) is a potential candidate for malaria vaccine. However, limited studies have focused on P. knowlesi MSP-1(42). METHODS:A ~42 kDa recombinant P. knowlesi MSP-1(42) (pkMSP-1(42...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-454
更新日期:2013-12-19 00:00:00
abstract:BACKGROUND:Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-174
更新日期:2008-09-11 00:00:00
abstract:BACKGROUND:The close relationship between vector-borne diseases and their environment is well documented, especially for diseases with water-dependent vectors such as avian malaria. Mosquitoes are the primary vectors of avian malaria and also the definitive hosts in the disease life cycle. Factors pertinent to mosquito...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-370
更新日期:2013-10-25 00:00:00
abstract::BACKGROUND: This study investigated causes of malaria and how cases were managed at household level, in order to improve the ability to identify malaria and ensure correct use of chloroquine. It was conducted in Nakonde District, Northern Province of Zambia, between 2000 and 2001. Nakonde district is in a hyperendemic...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-2-43
更新日期:2003-11-19 00:00:00
abstract:BACKGROUND:Measures of malaria burden using microscopy and rapid diagnostic tests (RDTs) in cross-sectional household surveys may incompletely describe the burden of malaria in low-transmission settings. This study describes the pattern of malaria transmission in Ethiopia using serological antibody estimates derived fr...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2874-z
更新日期:2019-07-22 00:00:00
abstract:INTRODUCTION:Malaria is the largest cause of health services attendance, hospital admissions and child deaths in Tanzania. At the Abuja Summit in April 2000 Tanzania committed itself to protect 60% of its population at high risk of malaria by 2005. The country is, therefore, determined to ensure that sustainable malari...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-4-34
更新日期:2005-07-22 00:00:00
abstract:BACKGROUND:The emergence of Plasmodium falciparum resistance to artemisinins threatens to undermine the effectiveness of artemisinin-based combination anti-malarial therapy. Developing suitable drugs to replace artemisinins requires the identification of new compounds that display rapid parasite killing kinetics. Howev...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0962-2
更新日期:2015-11-05 00:00:00
abstract:BACKGROUND:Malaria is a major cause of morbidity and mortality worldwide with over one million deaths annually, particularly in children under five years. This study was the first to examine plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum fr...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-12-5
更新日期:2013-01-07 00:00:00
abstract:BACKGROUND:Surveillance is a core component of an effective system to support malaria elimination. Poor surveillance data will prevent countries from monitoring progress towards elimination and targeting interventions to the last remaining at-risk places. An evaluation of the performance of surveillance systems in 16 c...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2960-2
更新日期:2019-09-18 00:00:00
abstract:BACKGROUND:Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under normal use conditions, they can lose effectiveness because they fall out of use, are discarded, repurposed, physicall...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03383-6
更新日期:2020-08-28 00:00:00
abstract:BACKGROUND:The immunological mechanisms responsible for protection against malaria infection vary among Plasmodium species, host species and the developmental stage of parasite, and are poorly understood. A challenge with live parasites is the most relevant approach to testing the efficacy of experimental malaria vacci...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-9-145
更新日期:2010-05-27 00:00:00
abstract:BACKGROUND:Malaria transmission in the peri-Iquitos region of Amazonian Peru has been designated as seasonal and hypo-endemic with recently described hyper-endemic hotspots. Despite relatively recent distribution of long-lasting insecticidal bed nets (LLINs), malaria in Amazonian Peru persists and increased substantial...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0804-2
更新日期:2015-07-30 00:00:00
abstract:BACKGROUND:Plasmodium falciparum circumsporozoite protein (CSP) is a leading malaria vaccine candidate antigen, known to elicit protective antibody responses in humans (RTS,S vaccine). Recently, a DNA prime / adenovirus (Ad) vector boost vaccine encoding CSP and a second P. falciparum antigen, apical membrane antigen-1...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-185
更新日期:2013-06-05 00:00:00
abstract:BACKGROUND:The malaria vector Anopheles gambiae is polymorphic for chromosomal inversions on the right arm of chromosome 2 that segregate nonrandomly between assortatively mating populations in West Africa. One such inversion, 2Rj, is associated with the BAMAKO chromosomal form endemic to southern Mali and northern Gui...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-6-133
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Slash and burn cultivators are a significant risk group for malaria in South-East Asia. As envisaged in the National Strategic Plan for Malaria Elimination, Bangladesh aims to achieve zero indigenous malaria transmission by 2030. For the national plan to move from malaria control to malaria elimination, targ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-019-2849-0
更新日期:2019-06-25 00:00:00
abstract:BACKGROUND:Due to the development of resistance to synthetic insecticides, adverse effects to human health, non-target organisms and the environment, there is an urgent need to develop new insecticides, which are effective, safe, biodegrable and target-specific. This study was undertaken to evaluate the adulticidal act...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-173
更新日期:2014-05-06 00:00:00