Analysis of antibody induction upon immunization with distinct NTS-DBL1α-domains of PfEMP1 from rosetting Plasmodium falciparum parasites.

abstract：BACKGROUND:Malaria elimination efforts can be undermined by imported malaria infections. Imported infections are classified based on travel history. METHODS:A genetic strategy was applied to better understand the contribution of imported infections and to test for local transmission in the very low prevalence region o...

journal_title：Malaria journal

authors： Daniels RF,Schaffner SF,Dieye Y,Dieng G,Hainsworth M,Fall FB,Diouf CN,Ndiop M,Cisse M,Gueye AB,Sarr O,Guinot P,Deme AB,Bei AK,Sy M,Thwing J,MacInnis B,Earle D,Guinovart C,Sene D,Hartl DL,Ndiaye D,Steketee RW,

更新日期：2020-08-03 00:00:00

abstract：:This opinion article deals with the diagnostic clinical challenges faced by clinicians or health care workers in malaria-endemic areas when a severely sick child presents to the clinic with fever, coma or respiratory distress. Indeed, the coexistence of malaria with other severe infections like meningitis, invasive ba...

journal_title：Malaria journal

authors： Ackerman H,Casals-Pascual C

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce. CASE PRESENTATION:He...

journal_title：Malaria journal

authors： Veletzky L,Groger M,Lagler H,Walochnik J,Auer H,Fuehrer HP,Ramharter M

更新日期：2018-02-09 00:00:00

abstract：BACKGROUND:Malaria rapid diagnostic tests (RDT) are used for diagnostic purpose in malaria-endemic areas where reliable microscopy is not available. Persistence of the antigenaemia causes over-diagnosis and may limit the usefulness of the RDT in monitoring treatment. In this study, the usefulness of histidine-rich prot...

journal_title：Malaria journal

authors： Nyunt MH,Kyaw MP,Win KK,Myint KM,Nyunt KM

更新日期：2013-04-11 00:00:00

abstract：BACKGROUND:Long-lasting insecticidal nets (LLINs) are the primary malaria prevention and control intervention in many parts of sub-Saharan Africa. While LLINs are expected to last at least 3 years under normal use conditions, they can lose effectiveness because they fall out of use, are discarded, repurposed, physicall...

journal_title：Malaria journal

authors： Briet O,Koenker H,Norris L,Wiegand R,Vanden Eng J,Thackeray A,Williamson J,Gimnig JE,Fortes F,Akogbeto M,Yadouleton AW,Ombok M,Bayoh MN,Mzilahowa T,Abílio AP,Mabunda S,Cuamba N,Diouf E,Konaté L,Hamainza B,Katebe-S

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:The objective of this work was to develop a model to predict malaria incidence in an area of unstable transmission by studying the association between environmental variables and disease dynamics. METHODS:The study was carried out in Karuzi, a province in the Burundi highlands, using time series of monthly ...

journal_title：Malaria journal

authors： Gomez-Elipe A,Otero A,van Herp M,Aguirre-Jaime A

更新日期：2007-09-24 00:00:00

abstract：BACKGROUND:Rapid diagnostic tests (RDTs) have become the most common diagnostic tool for detection of Plasmodium falciparum malaria, in particular in remote areas. RDT blood spots provide a source of parasite DNA for molecular analysis. In this study, the utility of RDTs for molecular analysis and the performance of di...

journal_title：Malaria journal

authors： Srisutham S,Suwannasin K,Mathema VB,Sriprawat K,Smithuis FM,Nosten F,White NJ,Dondorp AM,Imwong M

更新日期：2020-05-27 00:00:00

abstract：BACKGROUND:Prompt and effective malaria diagnosis not only alleviates individual suffering, but also decreases malaria transmission at the community level. The commonly used diagnostic methods, microscopy and rapid diagnostic tests, are usually insensitive at very low-density parasitaemia. Molecular techniques, on the ...

journal_title：Malaria journal

authors： Golassa L,Enweji N,Erko B,Aseffa A,Swedberg G

更新日期：2013-10-03 00:00:00

abstract：BACKGROUND:New World vultures (Cathartiformes: Cathartidae) are obligate scavengers comprised of seven species in five genera throughout the Americas. Of these, turkey vultures (Cathartes aura) and black vultures (Coragyps atratus) are the most widespread and, although ecologically similar, have evolved differences in ...

journal_title：Malaria journal

authors： Yabsley MJ,Vanstreels RET,Martinsen ES,Wickson AG,Holland AE,Hernandez SM,Thompson AT,Perkins SL,West CJ,Bryan AL,Cleveland CA,Jolly E,Brown JD,McRuer D,Behmke S,Beasley JC

更新日期：2018-01-08 00:00:00

abstract：BACKGROUND:Challenges persist in ensuring access to and optimal use of long-lasting, insecticidal bed nets (LLINs). Factors associated with ownership and use may differ depending on the history of malaria and prevention control efforts in a specific region. Understanding how the cultural and social-environmental contex...

journal_title：Malaria journal

authors： Ernst KC,Hayden MH,Olsen H,Cavanaugh JL,Ruberto I,Agawo M,Munga S

更新日期：2016-04-14 00:00:00

abstract：:Genetic manipulation of malaria parasites remains an inefficient, time-consuming and resource-intensive process. Presented here is a set of methods for 96-well plate-based transfection and culture that improve the efficiency of genetic manipulation of Plasmodium falciparum. Compared to standard protocols plate-based t...

journal_title：Malaria journal

authors： Caro F,Miller MG,DeRisi JL

更新日期：2012-01-18 00:00:00

abstract：BACKGROUND:Standard methods for defining clinical malaria in intervention trials in endemic areas do not guarantee that efficacy estimates will be unbiased, and do not indicate whether the intervention has its effect by modifying the force of infection, the parasite density, or the risk of pathology at given parasite d...

journal_title：Malaria journal

authors： Smith TA

更新日期：2007-05-02 00:00:00

abstract：BACKGROUND:The erythrocytic stage, where malaria parasites proliferate in human blood, is clinically significant as this causes the symptoms and illness of malaria. Experimental rodent models of malaria at the erythrocytic stage are used for the development of anti-malarial drugs and for biological analysis. An automat...

journal_title：Malaria journal

authors： Tougan T,Suzuki Y,Izuka M,Aono K,Okazaki T,Toya Y,Uchihashi K,Horii T

更新日期：2018-04-16 00:00:00

abstract：BACKGROUND:The Democratic Republic of the Congo (DRC) bears a high burden of malaria, which is exacerbated in pregnant women. The VAR2CSA protein plays a crucial role in pregnancy-associated malaria (PAM), and hence quantifying diversity at the var2csa locus in the DRC is important in understanding the basic epidemiolo...

journal_title：Malaria journal

authors： Verity R,Hathaway NJ,Waltmann A,Doctor SM,Watson OJ,Patel JC,Mwandagalirwa K,Tshefu AK,Bailey JA,Ghani AC,Juliano JJ,Meshnick SR

更新日期：2018-01-24 00:00:00

abstract：:The fight against malaria is increasingly threatened by failures in vector control due to growing insecticide resistance. This review examines the recent primary research that addresses the putative relationship between agricultural insecticide use and trends in insecticide resistance. To do so, descriptive evidence o...

journal_title：Malaria journal

authors： Reid MC,McKenzie FE

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:In order to sustain the gains achieved by current malaria control strategies, robust surveillance systems that monitor dynamics of vectors and their roles in malaria transmission over time are essential. This longitudinal study demonstrates the trends in malaria vector dynamics and their relative contributio...

journal_title：Malaria journal

authors： Lwetoijera DW,Harris C,Kiware SS,Dongus S,Devine GJ,McCall PJ,Majambere S

更新日期：2014-08-24 00:00:00

abstract：BACKGROUND:A key component of malaria elimination campaigns is the identification and targeting of high risk populations. To characterize high risk populations in north central Namibia, a prospective health facility-based case-control study was conducted from December 2012-July 2014. Cases (n = 107) were all patients p...

journal_title：Malaria journal

authors： Smith JL,Auala J,Haindongo E,Uusiku P,Gosling R,Kleinschmidt I,Mumbengegwi D,Sturrock HJ

更新日期：2017-02-10 00:00:00

abstract：BACKGROUND:Polymorphisms within the PfATP6 gene have been indicated as potential molecular markers for artemisinin efficacy. Since 2004, the use of artemisinin combination therapy (ACT) was introduced as first-line treatment of the uncomplicated malaria cases in Suriname. The aim of this research was to determine chang...

journal_title：Malaria journal

authors： Adhin MR,Labadie-Bracho M,Vreden SG

更新日期：2012-09-11 00:00:00

abstract：BACKGROUND:Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine (T) at the codon 76. Previous studies have shown that microsatellite (MS) haplotype variation can be used to study the evolution o...

journal_title：Malaria journal

authors： DaRe JT,Mehlotra RK,Michon P,Mueller I,Reeder J,Sharma YD,Stoneking M,Zimmerman PA

更新日期：2007-03-21 00:00:00

abstract：BACKGROUND:The sulphadoxine/pyrimethamine (SDX/PYR) combination had been chosen to treat uncomplicated falciparum malaria in Malaysia for more than 30 years. Non-silent mutations in dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) genes are responsible for the resistance to pyrimethamine and sulphadox...

journal_title：Malaria journal

authors： Lau TY,Sylvi M,William T

更新日期：2013-12-10 00:00:00

abstract：BACKGROUND:The Plasmodium falciparum multidrug resistance 1 transporter, PfMDR1, contains five amino acid polymorphisms that are suggested to be involved in altered drug transport from the parasite's cytosol into the digestive vacuole (DV). Transport of a substrate into another intracellular compartment influences drug...

journal_title：Malaria journal

authors： Reiling SJ,Rohrbach P

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:Subsistence rice farmers in south-eastern Tanzania are often migratory, spending weeks or months tending to crops in distant fields along the river valleys and living in improvised structures known as Shamba huts, not fully protected from mosquitoes. These farmers also experience poor access to organized pre...

journal_title：Malaria journal

authors： Swai JK,Finda MF,Madumla EP,Lingamba GF,Moshi IR,Rafiq MY,Majambere S,Okumu FO

更新日期：2016-11-22 00:00:00

abstract：BACKGROUND:In endemic areas, children develop slowly and naturally anti-Plasmodium antibodies and become semi-immune. Seasonal Malaria Chemoprevention (SMC) with sulfadoxine-pyrimethamine + amodiaquine (SPAQ) is a new strategy to reduce malaria morbidity in West African young children. However, SMC may impact on the na...

journal_title：Malaria journal

authors： Mahaman Moustapha L,Adamou R,Ibrahim ML,Abdoulaye Louis Padounou M,Diallo A,Courtin D,Testa J,Ndiaye JLA

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Increased resistance by Plasmodium falciparum parasites led to the withdrawal of the antimalarial drugs chloroquine and sulphadoxine-pyrimethamine in Ethiopia. Since 2004 artemether-lumefantrine has served to treat uncomplicated P. falciparum malaria. However, increasing reports on delayed parasite clearance...

journal_title：Malaria journal

authors： Mekonnen SK,Aseffa A,Berhe N,Teklehaymanot T,Clouse RM,Gebru T,Medhin G,Velavan TP

更新日期：2014-06-25 00:00:00

abstract：BACKGROUND:Sulfadoxine-pyrimethamine (SP) is a cornerstone of malaria chemoprophylaxis and is considered for programmes in the Democratic Republic of Congo (DRC). However, SP efficacy is threatened by drug resistance, that is conferred by mutations in the dhfr and dhps genes. The World Health Organization has specified...

journal_title：Malaria journal

authors： van Lenthe M,van der Meulen R,Lassovski M,Ouabo A,Bakula E,Badio C,Cibenda D,Okell L,Piriou E,Grignard L,Lanke K,Rao B,Bousema T,Roper C

更新日期：2019-12-18 00:00:00

abstract：BACKGROUND:The circumsporozoite protein (CS protein) on the malaria parasites in mosquitoes plays an important role in sporogony in mosquitoes. The RTS,S/AS01 malaria vaccine candidate, which has shown significant efficacy against clinical malaria in a large Phase 3 trial, targets the Plasmodium falciparum CS protein, ...

journal_title：Malaria journal

authors： Miura K,Jongert E,Deng B,Zhou L,Lusingu JP,Drakeley CJ,Fay MP,Long CA,Vekemans J

更新日期：2014-07-09 00:00:00

abstract：:This meeting report presents the key findings and discussion points of a 1-day meeting entitled 'Fake anti-malarials: start with the facts' held on 28th May 2015, in Geneva, Switzerland, to disseminate the findings of the artemisinin combination therapy consortium's drug quality programme. The teams purchased over 10,...

journal_title：Malaria journal

authors： Kaur H,Clarke S,Lalani M,Phanouvong S,Guérin P,McLoughlin A,Wilson BK,Deats M,Plançon A,Hopkins H,Miranda D,Schellenberg D

更新日期：2016-02-13 00:00:00

abstract：BACKGROUND:Determination of the genetic diversity of malaria parasites can inform the intensity of transmission and identify potential deficiencies in malaria control programmes. This study was conducted to characterize the genetic diversity and allele frequencies of Plasmodium falciparum in Northwest Ethiopia along th...

journal_title：Malaria journal

authors： Mohammed H,Kassa M,Mekete K,Assefa A,Taye G,Commons RJ

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:Artesunate plus sulphadoxine-pyrimethamine is one of the four artemisinin-based combination therapies currently recommended by WHO as first-line treatment for falciparum malaria. Sulphadoxine-pyrimethamine is also used for intermittent preventive treatment for malaria in pregnancy. Drug use patterns and drug...

journal_title：Malaria journal

authors： Gbotosho GO,Happi CT,Sijuade AO,Sowunmi A,Oduola AM

更新日期：2009-10-24 00:00:00

abstract：BACKGROUND:Data collected in clinical trials have been used to develop scoring systems that identify adults with malaria at greatest risk of death. One of these, the RCAM score, can be simply determined by measuring a patient's Glasgow Coma Score and respiratory rate on admission to hospital. However the safety of usin...

journal_title：Malaria journal

authors： Kaung M,Kyi TT,Aung NM,Kyaw MP,Min M,Htet ZW,Anstey NM,Kyi MM,Hanson J

更新日期：2015-02-07 00:00:00