Abstract:
BACKGROUND:Malaria elimination efforts can be undermined by imported malaria infections. Imported infections are classified based on travel history. METHODS:A genetic strategy was applied to better understand the contribution of imported infections and to test for local transmission in the very low prevalence region of Richard Toll, Senegal. RESULTS:Genetic relatedness analysis, based upon molecular barcode genotyping data derived from diagnostic material, provided evidence for both imported infections and ongoing local transmission in Richard Toll. Evidence for imported malaria included finding that a large proportion of Richard Toll parasites were genetically related to parasites from Thiès, Senegal, a region of moderate transmission with extensive available genotyping data. Evidence for ongoing local transmission included finding parasites of identical genotype that persisted across multiple transmission seasons as well as enrichment of highly related infections within the households of non-travellers compared to travellers. CONCLUSIONS:These data indicate that, while a large number of infections may have been imported, there remains ongoing local malaria transmission in Richard Toll. These proof-of-concept findings underscore the value of genetic data to identify parasite relatedness and patterns of transmission to inform optimal intervention selection and placement.
journal_name
Malar Jjournal_title
Malaria journalauthors
Daniels RF,Schaffner SF,Dieye Y,Dieng G,Hainsworth M,Fall FB,Diouf CN,Ndiop M,Cisse M,Gueye AB,Sarr O,Guinot P,Deme AB,Bei AK,Sy M,Thwing J,MacInnis B,Earle D,Guinovart C,Sene D,Hartl DL,Ndiaye D,Steketee RW,doi
10.1186/s12936-020-03346-xsubject
Has Abstractpub_date
2020-08-03 00:00:00pages
276issue
1issn
1475-2875pii
10.1186/s12936-020-03346-xjournal_volume
19pub_type
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