Abstract:
BACKGROUND:Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. METHODS:Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-binding infected erythrocytes were quantified in pregnant Melanesian women receiving sulfadoxine-pyrimethamine (SP) with chloroquine taken once, or three courses of SP with azithromycin. RESULTS:Malaria prevalence was low. Between enrolment and delivery, antibodies to recombinant antigens declined in both groups (p<0.0001). In contrast, median levels of opsonizing antibodies did not change, although levels for some individuals changed significantly. In multivariate analysis, the malaria prevention regimen did not influence antibody levels. CONCLUSION:Different preventive anti-malarial chemotherapy regimens used during pregnancy had limited impact on malarial-immunity in a low-transmission region of Papua New Guinea. TRIAL REGISTRATIONS:NCT01136850.
journal_name
Malar Jjournal_title
Malaria journalauthors
Teo A,Hasang W,Randall LM,Unger HW,Siba PM,Mueller I,Brown GV,Rogerson SJdoi
10.1186/s12936-015-0736-xsubject
Has Abstractpub_date
2015-05-26 00:00:00pages
215issn
1475-2875pii
10.1186/s12936-015-0736-xjournal_volume
14pub_type
杂志文章,随机对照试验相关文献
MALARIA JOURNAL文献大全abstract:BACKGROUND:The development of insecticide resistance and the increased outdoor-biting behaviour of malaria vectors reduce the efficiency of indoor vector control methods. Attractive toxic sugar baits (ATSBs), a method targeting the sugar-feeding behaviours of vectors both indoors and outdoors, is a promising supplement...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-1012-9
更新日期:2015-12-08 00:00:00
abstract:BACKGROUND:In view of the need to continuously feed the pipeline with new anti-malarial agents adapted to differentiated and more stringent target product profiles (e.g., new modes of action, transmission-blocking activity or long-duration chemo-protection), a chemical library consisting of more than 250,000 compounds ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-190
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:The Plasmodium falciparum multidrug resistance 1 transporter, PfMDR1, contains five amino acid polymorphisms that are suggested to be involved in altered drug transport from the parasite's cytosol into the digestive vacuole (DV). Transport of a substrate into another intracellular compartment influences drug...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0791-3
更新日期:2015-07-15 00:00:00
abstract:BACKGROUND:Community-based service delivery is vital to the effectiveness, affordability and sustainability of vector control generally, and to labour-intensive larval source management (LSM) programmes in particular. CASE DESCRIPTION:The institutional evolution of a city-level, community-based LSM programme over 14 y...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-245
更新日期:2014-06-25 00:00:00
abstract:BACKGROUND:Single nucleotide polymorphism (SNP) genotyping provides the means to develop a practical, rapid, inexpensive assay that will uniquely identify any Plasmodium falciparum parasite using a small amount of DNA. Such an assay could be used to distinguish recrudescence from re-infection in drug trials, to monitor...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-223
更新日期:2008-10-29 00:00:00
abstract:BACKGROUND:Malaria is a widespread infectious disease that threatens a large proportion of the population in tropical and subtropical areas. Given the emerging resistance against the current standard anti-malaria chemotherapeutics, the development of alternative drugs is urgently needed. New anti-malarials representing...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1839-3
更新日期:2017-05-15 00:00:00
abstract:BACKGROUND:Numerous countries around the world are approaching malaria elimination. Until global eradication is achieved, countries that successfully eliminate the disease will contend with parasite reintroduction through international movement of infected people. Human-mediated parasite mobility is also important with...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1315-5
更新日期:2016-05-11 00:00:00
abstract:BACKGROUND:Colombia contributes a significant proportion of malaria cases in the Americas, which are predominantly rural. However, in the last 8 years ~ 10 % of the endemic municipalities have also reported urban and peri-urban malaria cases, a growing concern for health authorities. This study focused on the character...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0956-0
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:Prompt, quality assured laboratory diagnosis is key to effective malaria case management and control, especially since the introduction of the more expensive artemisinin combination therapy (ACT). The malaria programme and its non-government partners, on the basis of WHO recommended Lot Quality Assurance met...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-45
更新日期:2011-02-17 00:00:00
abstract:BACKGROUND:Invasion of host erythrocytes by Plasmodium falciparum is central to the pathogenesis of malaria. Invasion involves recognition events between erythrocyte receptors and ligands on the merozoite, the invasive blood form of the parasite. Identifying and characterizing host-parasite interactions is impeded by t...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0553-2
更新日期:2015-02-21 00:00:00
abstract:BACKGROUND:Nicotinamide adenine dinucleotide (NAD+) is an essential molecule in the energy metabolism of living beings, and it has various cellular functions. The main enzyme in the biosynthesis of this nucleotide is nicotinamide/nicotinate mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1/18) because it is the con...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-018-2307-4
更新日期:2018-04-11 00:00:00
abstract:BACKGROUND:Drug combination therapy is the frontline of malaria treatment. There is an ever-accelerating need for new, efficacious combination therapies active against drug resistant malaria. Proven drugs already in the treatment pipeline, such as the quinolines, are important components of current combination therapy ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-12-332
更新日期:2013-09-18 00:00:00
abstract:BACKGROUND:Real-time PCR is a sensitive and specific method for the analysis of Plasmodium DNA. However, prior purification of genomic DNA from blood is necessary since PCR inhibitors and quenching of fluorophores from blood prevent efficient amplification and detection of PCR products. METHODS:Reagents designed to sp...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-244
更新日期:2011-08-19 00:00:00
abstract:BACKGROUND:The north coast of Guadalcanal has some of the most intense malaria transmission in the Solomon Islands. And, there is a push for intensified vector control in Guadalcanal, to improve the livelihood of residents and to minimize the number of cases, which are regularly exported to the rest of the country. The...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-56
更新日期:2014-02-15 00:00:00
abstract:BACKGROUND:Falciparum malaria remains a major occupational illness that accounts for several deaths per year and numerous lost working days among the expatriate population, working or living in high-risk malarious areas. Compliance to preventive strategies is poor in travellers, especially business travellers, expatria...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-7-128
更新日期:2008-07-14 00:00:00
abstract:BACKGROUND:The diagnosis of malaria can be difficult in non-endemic areas, such as the United States, and delays in diagnosis and errors in treatment occur too often. METHODS:A nationwide survey of laboratories in the United States and its nine dependent territories was conducted in 2010 to determine factors that may ...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-10-340
更新日期:2011-11-10 00:00:00
abstract:BACKGROUND:The use of rapid diagnostic tests (RDTs) to diagnose malaria is common in sub-Saharan African laboratories, remote primary health facilities and in the community. Currently, there is a lack of reliable methods to ascertain health worker competency to accurately use RDTs in the testing and diagnosis of malari...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03569-y
更新日期:2021-01-20 00:00:00
abstract:BACKGROUND:Seasonal malaria chemoprevention (SMC) is a new strategy to reduce malaria burden in young children in Sahelian countries. It consists of the administration of full treatment courses of sulfadoxine-pyrimethamine plus amodiaquine to children at monthly intervals during the malaria season. However, it is not c...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1935-4
更新日期:2017-07-18 00:00:00
abstract:BACKGROUND:Malaria transmission in the peri-Iquitos region of Amazonian Peru has been designated as seasonal and hypo-endemic with recently described hyper-endemic hotspots. Despite relatively recent distribution of long-lasting insecticidal bed nets (LLINs), malaria in Amazonian Peru persists and increased substantial...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0804-2
更新日期:2015-07-30 00:00:00
abstract:BACKGROUND:Despite declining prevalence of malaria in The Gambia, non-adherence to anti-malarial treatment still remains a challenge to control efforts. There is limited evidence on the socio-cultural factors that influence adherence to anti-malarial treatment in pregnancy. This study explored perceptions of malaria in...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12936-016-1255-0
更新日期:2016-04-11 00:00:00
abstract:BACKGROUND:Monoclonal antibodies (mAbs) are essential tools in biological research, diagnosis and therapy, and are conventionally produced in murine hybridoma cell lines. Professional applications of mAbs depend on the steady supply of material. Because hybridoma cultures can stop producing the antibody or even die, pr...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-015-0577-7
更新日期:2015-02-05 00:00:00
abstract:BACKGROUND:Glucose 6-phosphate dehydrogenase (G6PD) is an enzyme involved in prevention of cellular oxidative damage, particularly protecting erythrocytes from haemolysis. An estimated 400 million people present variable degrees of inherited G6PD deficiency (G6PDd) which puts them at risk for developing haemolysis trig...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-016-1343-1
更新日期:2016-05-26 00:00:00
abstract:BACKGROUND:Pyrethroid-resistant mosquitoes are an increasing threat to malaria vector control. The Global Plan for Insecticide Resistance Management (GPIRM) recommends rotation of non-pyrethroid insecticides for indoor residual spraying (IRS). The options from other classes are limited. The carbamate bendiocarb and the...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-13-37
更新日期:2014-01-29 00:00:00
abstract:BACKGROUND:The impact of sulfadoxine-pyrimethamine (SP) used as intermittent preventive treatment during pregnancy (IPTp-SP) on mutant parasite selection has been poorly documented in Burkina Faso. This study sought first to explore the relationship between IPTp-SP and the presence of mutant parasites. Second, to asses...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1695-1
更新日期:2017-01-23 00:00:00
abstract::Following publication of the original article [1], one of the authors has highlighted an xml-related discrepancy concerning the author group titled 'Additional Tracking Resistance to Artemisinin Collaboration authors (TRAC Group Authorship)', listed under the Acknowledgements section. ...
journal_title:Malaria journal
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12936-018-2464-5
更新日期:2018-09-10 00:00:00
abstract:BACKGROUND:Models of Plasmodium falciparum malaria epidemiology that provide realistic quantitative predictions of likely epidemiological outcomes of existing vector control strategies have the potential to assist in planning for the control and elimination of malaria. This work investigates the applicability of mathem...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-11-357
更新日期:2012-10-29 00:00:00
abstract:BACKGROUND:Malaria rapid diagnostic tests (RDTs) enable point-of-care testing to be nearly as sensitive and specific as reference microscopy. The Senegal National Malaria Control Programme introduced RDTs in 2007, along with a case management algorithm for uncomplicated febrile illness, in which the first step stipulat...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-017-1750-y
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:The standard in vitro protocol currently in use for drug testing against Plasmodium falciparum, based on the incorporation of the purine [3H]-hypoxanthine, has two serious drawbacks. Firstly it is unsuitable for the testing of drugs that directly or indirectly impact on purine salvage or metabolism. Secondly...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/1475-2875-5-95
更新日期:2006-10-31 00:00:00
abstract:BACKGROUND:In clinical trials of therapy for uncomplicated Plasmodium falciparum, there are usually some patients who fail treatment even in the absence of drug resistance. Treatment failures, which can be due to recrudescence or re-infection, are categorized as 'clinical' or 'parasitological' failures, the former indi...
journal_title:Malaria journal
pub_type: 杂志文章
doi:10.1186/s12936-020-03520-1
更新日期:2020-12-09 00:00:00
abstract:BACKGROUND:Individual malaria interventions provide only partial protection in most epidemiological situations. Thus, there is a need to investigate whether combining interventions provides added benefit in reducing mortality and morbidity from malaria. The potential benefits of combining IPT in children (IPTc) with ho...
journal_title:Malaria journal
pub_type: 杂志文章,随机对照试验
doi:10.1186/1475-2875-10-2
更新日期:2011-01-07 00:00:00