Relationship between weight status and anti-malarial drug efficacy and safety in children in Mali.

abstract：BACKGROUND:Malaria treatment policy recommends regular monitoring of drug utilization to generate information for ensuring effective use of anti-malarial drugs in Nigeria. This information is currently limited in the retail sector which constitutes a major source of malaria treatment in Nigeria, but are characterized b...

journal_title：Malaria journal

authors： Ezenduka CC,Ogbonna BO,Ekwunife OI,Okonta MJ,Esimone CO

更新日期：2014-06-24 00:00:00

abstract：BACKGROUND:Adequate coverage and proper use of long-lasting insecticidal nets (LLINs) and indoor residual spaying (IRS) reduce density of indoor-resting mosquitoes, man-mosquito contact and malaria infection. However, distribution, ownership and usage of the interventions may vary among households in a malarious area, ...

journal_title：Malaria journal

authors： Animut A,Negash Y,Kebede N

更新日期：2014-09-10 00:00:00

abstract：BACKGROUND:Tafenoquine is an 8-aminoquinoline being developed for radical cure (blood and liver stage elimination) of Plasmodium vivax. During monotherapy treatment, the compound exhibits slow parasite and fever clearance times, and toxicity in glucose-6-phosphate dehydrogenase (G6PD) deficiency is a concern. Combinati...

journal_title：Malaria journal

authors： Dow GS,Gettayacamin M,Hansukjariya P,Imerbsin R,Komcharoen S,Sattabongkot J,Kyle D,Milhous W,Cozens S,Kenworthy D,Miller A,Veazey J,Ohrt C

更新日期：2011-07-29 00:00:00

abstract：BACKGROUND:Regular anti-malarial therapy in pregnancy, a pillar of malaria control, may affect malaria immunity, with therapeutic implications in regions of reducing transmission. METHODS:Plasma antibodies to leading vaccine candidate merozoite antigens and opsonizing antibodies to endothelial-binding and placental-bi...

journal_title：Malaria journal

authors： Teo A,Hasang W,Randall LM,Unger HW,Siba PM,Mueller I,Brown GV,Rogerson SJ

更新日期：2015-05-26 00:00:00

abstract：BACKGROUND:Toll-like receptors (TLRs) signalling is reported to be primed by the infection of human malaria parasite, Plasmodium falciparum. However, little is known about the regulation of macrophages TLR signalling by the infection of lethal or non-lethal strain of rodent malaria parasites. METHODS:BALB/c mice were ...

journal_title：Malaria journal

authors： Fu Y,Ding Y,Zhou T,Fu X,Xu W

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to PfEMP1 antigens may contribute to natural immunity. The first N-t...

journal_title：Malaria journal

authors： Stucke EM,Niangaly A,Berry AA,Bailey JA,Coulibaly D,Ouattara A,Lyke KE,Laurens MB,Dara A,Adams M,Pablo J,Jasinskas A,Nakajima R,Zhou AE,Agrawal S,Friedman-Klabanoff DJ,Takala-Harrison S,Kouriba B,Kone AK,Rowe JA,D

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:Plasmodium malariae is the most neglected of the six human malaria species and it is still unknown which is the mechanism underlying the long latency of this Plasmodium. CASE PRESENTATION:A case of PCR-confirmed P. malariae recurrence in a 52-year old Italian man was observed 5 months after a primary attack...

journal_title：Malaria journal

authors： Grande R,Antinori S,Meroni L,Menegon M,Severini C

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:The objective of this study was to identify attitudes and misconceptions related to acceptance or refusal of indoor residual spraying (IRS) in Tanzania for both the general population and among certain groups (e.g., farmers, fishermen, community leaders, and women). METHODS:This study was a series of qualit...

journal_title：Malaria journal

authors： Kaufman MR,Rweyemamu D,Koenker H,Macha J

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by liver hypnozoites although scientific evidence for this paradigm is scarce. CASE PRESENTATION:He...

journal_title：Malaria journal

authors： Veletzky L,Groger M,Lagler H,Walochnik J,Auer H,Fuehrer HP,Ramharter M

更新日期：2018-02-09 00:00:00

abstract：:Recent WHO guidelines recommend a universal "test and treat" strategy for malaria, mainly by use of rapid diagnostic test (RDT) in all areas. The evidence for this approach is questioned here as there is a risk of over-reliance on parasitological diagnosis in high transmission situations, which still exist. In such ar...

journal_title：Malaria journal

authors： Graz B,Willcox M,Szeless T,Rougemont A

更新日期：2011-05-20 00:00:00

abstract：BACKGROUND:Malaria remains highly endemic in Cameroon. The rapid emergence and spread of drug resistance was responsible for the change from monotherapies to artemisinin-based combinations. This systematic review and meta-analysis aimed to determine the prevalence and distribution of Plasmodium falciparum drug resistan...

journal_title：Malaria journal

authors： Niba PTN,Nji AM,Evehe MS,Ali IM,Netongo PM,Ngwafor R,Moyeh MN,Ngum LN,Ndum OE,Acho FA,Mbu'u CM,Fosah DA,Atogho-Tiedeu B,Achonduh-Atijegbe O,Djokam-Dadjeu R,Chedjou JPK,Bigoga JD,Moukoko CEE,Ajua A,Achidi E,Tallah

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:Successful reduction of malaria transmission to very low levels has made Isabel Province, Solomon Islands, a target for early elimination by 2014. High malaria transmission in neighbouring provinces and the potential for local asymptomatic infections to cause malaria resurgence highlights the need for sub-na...

journal_title：Malaria journal

authors： Atkinson JA,Johnson ML,Wijesinghe R,Bobogare A,Losi L,O'Sullivan M,Yamaguchi Y,Kenilorea G,Vallely A,Cheng Q,Ebringer A,Bain L,Gray K,Harris I,Whittaker M,Reid H,Clements A,Shanks D

更新日期：2012-03-30 00:00:00

abstract：BACKGROUND:In many low-income countries, the private commercial sector plays an important role in the provision of malaria treatment. However, the quality of care it provides is often poor, with artemisinin combination therapy (ACT) generally being too costly for consumers. Decreasing ACT prices is critical for improvi...

journal_title：Malaria journal

authors： Patouillard E,Hanson K,Kleinschmidt I,Palafox B,Tougher S,Pok S,O'Connell K,Goodman C

更新日期：2015-05-30 00:00:00

abstract：BACKGROUND:Real-time PCR is a sensitive and specific method for the analysis of Plasmodium DNA. However, prior purification of genomic DNA from blood is necessary since PCR inhibitors and quenching of fluorophores from blood prevent efficient amplification and detection of PCR products. METHODS:Reagents designed to sp...

journal_title：Malaria journal

authors： Taylor BJ,Martin KA,Arango E,Agudelo OM,Maestre A,Yanow SK

更新日期：2011-08-19 00:00:00

abstract：BACKGROUND:There remains a need for techniques that improve the sensitive detection of viable Plasmodium falciparum as part of diagnosis and therapeutic monitoring in clinical studies and usual-care management of malaria infections. A non-invasive breath test based on P. falciparum-associated specific volatile organic ...

journal_title：Malaria journal

authors： Wong RP,Flematti GR,Davis TM

更新日期：2012-09-07 00:00:00

abstract：BACKGROUND:Diagnosis of Plasmodium falciparum is often based on detection of histidine-rich protein 2 (HRP2) in blood. Most HRP2-based assays have high sensitivity and specificity; however, authors have suggested that antibodies (Ab) to HRP2 could reduce assay sensitivity. This study sought to characterize the antibody...

journal_title：Malaria journal

authors： Taylor DW,Bobbili N,Khadka VS,Quakyi IA,Leke RG

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Clinical profiling of two components for a synthetic peptide-based virosomal malaria vaccine has yielded promising results, encouraging the search for additional components for inclusion in a final multi-valent vaccine formulation. This report describes the immunological characterization of linear and cycliz...

journal_title：Malaria journal

authors： Tamborrini M,Mueller MS,Stoffel SA,Westerfeld N,Vogel D,Boato F,Zurbriggen R,Robinson JA,Pluschke G

更新日期：2009-12-30 00:00:00

abstract：BACKGROUND:Environmental temperature is an important driver of malaria transmission dynamics. Both the parasite and vector are sensitive to mean ambient temperatures and daily temperature variation. To understand transmission ecology, therefore, it is important to determine the range of microclimatic temperatures exper...

journal_title：Malaria journal

authors： Cator LJ,Thomas S,Paaijmans KP,Ravishankaran S,Justin JA,Mathai MT,Read AF,Thomas MB,Eapen A

更新日期：2013-03-02 00:00:00

abstract：BACKGROUND:Malaria is reportedly receding in different epidemiological settings, but local long-term surveys are limited. At Mlomp dispensary in south-western Senegal, an area of moderate malaria transmission, year-round, clinically-suspected malaria was treated with monotherapy as per WHO and national policy in the 19...

journal_title：Malaria journal

authors： Brasseur P,Badiane M,Cisse M,Agnamey P,Vaillant MT,Olliaro PL

更新日期：2011-07-25 00:00:00

abstract：:April 25 marks World Malaria Day, an opportunity for those who work to defeat the illness, to review progress and renew commitments. After a decade of steady success, this year's commemoration of the date is also an opportunity to reconsider current approaches and assess the state of the science needed to keep pace in...

journal_title：Malaria journal

authors： Slutsker L,Kachur SP

更新日期：2013-04-24 00:00:00

abstract：BACKGROUND:The effectiveness of vector control on malaria transmission by long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) depends on the vectors entering houses to blood feed and rest when people are inside houses. In the Solomon Islands, significant reductions in malaria have been achieved in...

journal_title：Malaria journal

authors： Russell TL,Beebe NW,Bugoro H,Apairamo A,Chow WK,Cooper RD,Collins FH,Lobo NF,Burkot TR

更新日期：2016-03-10 00:00:00

abstract：BACKGROUND:The emergence of parasite drug resistance, especially Plasmodium falciparum, persists as a major obstacle for malaria control and elimination. To develop effective public health containment strategies, a clear understanding of factors that govern the emergence and spread of resistant parasites in the field i...

journal_title：Malaria journal

authors： Mharakurwa S,Sialumano M,Liu K,Scott A,Thuma P

更新日期：2013-12-19 00:00:00

abstract：:The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and opportunity for ultimately eradicating this species. It is silent and cannot be diagnosed until it awakens and provokes a clinical attack with attendant morbidity, risk of mortality, and opportunities for onward transmission. The on...

journal_title：Malaria journal

authors： Baird JK,Battle KE,Howes RE

更新日期：2018-01-22 00:00:00

abstract：BACKGROUND:Malaria is a leading cause of mortality and morbidity in Mozambique, with nearly three-quarters of the country's malaria-related deaths occurring in children younger than five years. A malaria vaccine is not yet available, but planning is underway for a possible introduction, as soon as one becomes available...

journal_title：Malaria journal

authors： Bingham A,Gaspar F,Lancaster K,Conjera J,Collymore Y,Ba-Nguz A

更新日期：2012-11-28 00:00:00

abstract：BACKGROUND:The effectiveness of malaria prevention with long-lasting insecticidal nets and indoor residual spraying is limited by emerging insecticide resistance, evasive mosquito behaviours that include outdoor biting, sub-optimal implementation and inappropriate use. New vector control interventions are required and ...

journal_title：Malaria journal

authors： Makungu C,Stephen S,Kumburu S,Govella NJ,Dongus S,Hildon ZJ,Killeen GF,Jones C

更新日期：2017-10-11 00:00:00

abstract：BACKGROUND:Kenya recently changed its antimalarial drug policy to a specific artemisinin-based combination therapy (ACT), artemether-lumefantrine (AL). New national guidelines on the diagnosis, treatment and prevention were developed and disseminated to health workers together with in-service training. METHODS:Between...

journal_title：Malaria journal

authors： Wasunna B,Zurovac D,Goodman CA,Snow RW

更新日期：2008-02-05 00:00:00

abstract：BACKGROUND:Asymptomatic carriage of Plasmodium falciparum is widespread in adults and children living in malaria-endemic countries. This study identified the prevalence of malaria parasites and the corresponding levels of naturally acquired anti-parasite antibody levels in afebrile adults living in two communities in t...

journal_title：Malaria journal

authors： Acquah FK,Lo AC,Akyea-Mensah K,Abagna HB,Faye B,Theisen M,Gyan BA,Amoah LE

更新日期：2020-02-10 00:00:00

abstract：BACKGROUND:Mass distribution campaigns of insecticide-treated nets for malaria prevention are usually accompanied by intensive behaviour change communication (BCC) to encourage hanging and use of nets. However, data on the effectiveness of these communication efforts are scarce. In preparation for the next round of mas...

journal_title：Malaria journal

authors： Kilian A,Lawford H,Ujuju CN,Abeku TA,Nwokolo E,Okoh F,Baba E

更新日期：2016-08-19 00:00:00

abstract：BACKGROUND:Antananarivo, the capital of Madagascar, is located at an altitude of over 1,200 m. The environment at this altitude is not particularly favourable to malaria transmission, but malaria nonetheless remains a major public health problem. The aim of this study was to evaluate exposure to malaria in the urban po...

journal_title：Malaria journal

authors： Domarle O,Razakandrainibe R,Rakotomalala E,Jolivet L,Randremanana RV,Rakotomanana F,Ramarokoto CE,Soares JL,Ariey F

更新日期：2006-11-10 00:00:00

abstract：BACKGROUND:Based on routine health facility case data, Rwanda has achieved a significant malaria burden reduction in the past ten years. However, community-based malaria parasitaemia burden and reasons for continued residual infections, despite a high coverage of control interventions, have yet to be characterized. Mea...

journal_title：Malaria journal

authors： Kateera F,Mens PF,Hakizimana E,Ingabire CM,Muragijemariya L,Karinda P,Grobusch MP,Mutesa L,van Vugt M

更新日期：2015-01-21 00:00:00