Transcatheter arterial chemoembolization (TACE) versus hepatectomy in hepatocellular carcinoma with macrovascular invasion: a meta-analysis of 1683 patients.

abstract：UNLABELLED:The mechanism of progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) remains largely unknown. We compared gene expression in tumors with simultaneous DCIS and IDC to decipher how diverse proteins participate in the local invasive process.Twenty frozen tumor specimens with conc...

journal_title：Journal of Cancer

authors： Castellana B,Escuin D,Peiró G,Garcia-Valdecasas B,Vázquez T,Pons C,Pérez-Olabarria M,Barnadas A,Lerma E

更新日期：2012-01-01 00:00:00

abstract：:The 21-gene recurrence score (RS) is increasingly being used for patients with early stage, hormone receptor-positive, Her-2-negative breast cancer. However, these results are largely from populations with infiltrating ductal carcinoma (IDC). The clinical value of RS testing in mucinous carcinoma has not been well inv...

journal_title：Journal of Cancer

authors： Wang W,Chen X,Lin L,Fei X,Garfield DH,Hong J,Gao W,Zhu S,Wu J,Huang O,He J,Li Y,Zhu L,Chen W,Shen K

更新日期：2018-08-06 00:00:00

abstract：:For unresectable Hepatocellular carcinoma (HCC), chemotherapy is still an important treatment strategy. Oxaliplatin (Oxa) is an effective treatment of HCC after sorafenib treatment failure. However, the intrinsic or acquired resistance of Oxa affected the chemotherapeutic sensitivity. By analyzing the data of GEO Data...

journal_title：Journal of Cancer

authors： Tao Y,Shan L,Xu X,Jiang H,Chen R,Qian Z,Yang Z,Liang B,Zheng H,Cai F,Yu Y,Ma L

更新日期：2018-10-10 00:00:00

abstract：:Purpose: The present study aims to explore the potential mechanisms contributing to prostate cancer (PCa), screen the hub genes, and identify potential biomarkers and correlated pathways of PCa progression. Methods: The PCa gene expression profile GSE3325 was operated to analyze the differentially expressed genes (DEG...

journal_title：Journal of Cancer

authors： Song Z,Huang Y,Zhao Y,Ruan H,Yang H,Cao Q,Liu D,Zhang X,Chen K

更新日期：2019-02-23 00:00:00

abstract：BACKGROUND:To identify predictors for development of mastoiditis after intensity-modulated radiation therapy (IMRT) in nasopharyngeal carcinoma (NPC). METHODS:Data for 146 NPC patients treated with IMRT was retrospectively reviewed under institutional ethics committee approval. Clinical factors associated with mastoid...

journal_title：Journal of Cancer

authors： Yao JJ,Zhou GQ,Jin YN,Zhang WJ,Lin L,Yu XL,Shao JY,Ma J,Sun Y

更新日期：2016-01-08 00:00:00

abstract：:Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC pat...

journal_title：Journal of Cancer

authors： Liang Y,Lin B,Ye Z,Chen S,Yu H,Chen C,Zhang X,Zhou K,Zeng J

更新日期：2020-01-13 00:00:00

abstract：:Background: miRNAs dysregulate in hepatocellular carcinoma (HCC), showing promise for diagnostic biomarkers which may be found through exploration of differentially expressed miRNAs when comparing HCC and normal liver tissues. Materials and Methods: In the present research, candidate miRNAs were selected and verified ...

journal_title：Journal of Cancer

authors： Ji J,Chen H,Liu XP,Wang YH,Luo CL,Zhang WW,Xie W,Wang FB

更新日期：2018-09-08 00:00:00

abstract：:Objective: To enquire into the clinical significance and potential molecular mechanism of microRNA (miRNA)-196b-5p in hepatocellular carcinoma (HCC). Methods: Quantitative reverse transcription and polymerase chain reaction (qRT-PCR) were utilized to examine miR-196b-5p expression level in 67 HCC paraffin embedded tis...

journal_title：Journal of Cancer

authors： Zhang L,Luo B,Dang YW,He RQ,Peng ZG,Chen G,Feng ZB

更新日期：2019-08-29 00:00:00

abstract：:Clinical outcomes of checkpoint blockade immunotherapy on colorectal cancer (CRC) are influenced by mismatch repair (MMR) gene status, which is associated with distinct tumor immune infiltrates and systemic inflammatory response status. However, the prognostic value of PD-L1 expression and the systemic inflammatory re...

journal_title：Journal of Cancer

authors： Kong P,Wang J,Song Z,Liu S,He W,Jiang C,Xie Q,Yang L,Xia X,Xia L

更新日期：2019-04-05 00:00:00

abstract：:Background: To develop and validate a radiomic nomogram incorporating radiomic features with clinical variables for individual local recurrence risk assessment in nasopharyngeal carcinoma (NPC) patients before initial treatment. Methods: One hundred and forty patients were randomly divided into a training cohort (n = ...

journal_title：Journal of Cancer

authors： Zhang L,Zhou H,Gu D,Tian J,Zhang B,Dong D,Mo X,Liu J,Luo X,Pei S,Dong Y,Huang W,Chen Q,Liang C,Lian Z,Zhang S

更新日期：2019-07-10 00:00:00

abstract：:Esophageal cancer is an aggressive disease featured by early lymphatic and hematogenous dissemination, and is the sixth leading cause of cancer-related deaths worldwide. The proper formation of apicobasal polarity is essential for normal epithelium physiology and tissue homeostasis, while loss of polarity is a hallmar...

journal_title：Journal of Cancer

authors： Li XM,Wang H,Zhu LL,Zhao RZ,Ji HL

更新日期：2015-06-11 00:00:00

abstract：:Objective: The purpose of this study was to evaluate the efficacy and feasibility of the R.E.N.A.L. Nephrometry Score to postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods: The study included 288 patients diagnosed with ccRCC who had complete CT/CTA data and R.E.N.A.L. Nephrometry Scores an...

journal_title：Journal of Cancer

authors： Chen SH,Wu YP,Li XD,Lin T,Guo QY,Chen YH,Huang JB,Wei Y,Xue XY,Zheng QS,Xu N

更新日期：2017-10-17 00:00:00

abstract：:Inhibition of aberrantly activated pathways cross-talking with hormone receptor (HR) improves response to endocrine therapy in patients with HR-positive advanced breast cancer. We performed a Pubmed database systematic review to ascertain the existence of a better clinical response when combining endocrine therapy wit...

journal_title：Journal of Cancer

authors： Grassadonia A,Caporale M,Tinari N,Zilli M,DeTursi M,Gamucci T,Vici P,Natoli C

更新日期：2015-05-12 00:00:00

abstract：PURPOSE:Chemotherapy regimens containing anthracyclines and taxanes represent the landmark of neoadjuvant systemic therapy of breast cancer. In advanced breast cancer patients liposomal anthracyclines (LA) have shown similar efficacy and less cardiac toxicity when compared to conventional anthracyclines. We performed t...

journal_title：Journal of Cancer

authors： Vici P,Pizzuti L,Gamucci T,Sergi D,Conti F,Zampa G,Del Medico P,De Vita R,Pozzi M,Botti C,Di Filippo S,Tomao F,Sperduti I,Di Lauro L

更新日期：2014-04-25 00:00:00

abstract：BACKGROUND:Heterogeneity of surgical care exists among surgeons regarding the conduct of thyroidectomy and parathyroidectomy. AIM:To identify the current patterns of technical conduct of operation amongst surgeons performing thyroidectomy or parathyroidectomy. METHODS:A survey was designed and beta-tested on five sur...

journal_title：Journal of Cancer

authors： Henry L,Helou L,Solomon N,Chang A,Libutti S,Stojadinovic A

更新日期：2012-01-01 00:00:00

abstract：:Rac activation is precisely regulated temporally and spatially by intracellular signaling pathways in migrating cells to guarantee the formation of specific cell protrusions-lamellipodia at the leading edge. Integrins-mediated adhesions also control the signaling pathway for localized Rac activation in the cells, but ...

journal_title：Journal of Cancer

authors： Li Y,Wu X,Liu Z,Lu K,Liu R,Guo X

更新日期：2020-01-01 00:00:00

abstract：:Background: Proverbially, the incidence rate of papillary thyroid carcinoma (PTC) has increased year by year. Many long noncoding RNAs (lncRNAs) have been discovered having a relationship with tumor genesis tightly recently. Thanks to the previous researches, we found long intergenic noncoding RNA 00511 (LINC00511) is...

journal_title：Journal of Cancer

authors： Xiang J,Guan Y,Bhandari A,Xia E,Wen J,Wang O

更新日期：2020-01-01 00:00:00

abstract：:Background: Overall survival of patients with primary CNS lymphoma (PCNSL) has improved since the introduction of immunochemotherapy. However, up to 10-15% of PCNSL patients still die shortly after diagnosis. In the present study, we aimed to investigate the risk factors of early mortality (death within 60 days after ...

journal_title：Journal of Cancer

authors： Lin CH,Yang CF,Yang HC,Fay LY,Yeh CM,Kuan AS,Wang HY,Gau JP,Hsiao LT,Chiou TJ,Chen PM,Liu YC,Ko PS,Liu JH,Liu CJ

更新日期：2019-07-05 00:00:00

abstract：:Background: Given recent results indicating that diminished LKB1 expression in laryngeal cancer correlates with shorter survival. We aim to perform an analysis estimate the role of decreased liver kinase B1(LKB1) and in the prognostication of human laryngeal squamous cell carcinoma (LSCC). Methods: We conducted a retr...

journal_title：Journal of Cancer

authors： He SS,Chen Y,Wang HZ,Shen XM,Sun P,Dong J,Liao XB,Guo GF,Chen JG,Xia LP,Hu PL,Qiu HJ,Liu SS,Zhou YX,Wang W,Hu WH,Cai XY

更新日期：2017-09-30 00:00:00

abstract：:Purpose: Several new treatment options for patients with metastatic castration resistant prostate cancer (mCRPC) have been approved within the last years - among them cabazitaxel (CAB), abiraterone acetate, enzalutamide, and radium-223. The aim of this study was to assess factors predictive for efficacy of CAB. Method...

journal_title：Journal of Cancer

authors： Zschäbitz S,Vallet S,Hadaschik B,Debatin D,Fuxius S,Karcher A,Pahernik S,Spath C,Duensing S,Jäger D,Hohenfellner M,Grüllich C

更新日期：2017-02-11 00:00:00

abstract：:For many years, the medical treatment of breast cancer was reliant solely on cytotoxic chemotherapy. However, over the past twenty years, treatment has evolved to a more target-directed approach. We now employ tailored therapy based on the presence or absence of receptors for estrogen, progesterone, and human epiderma...

journal_title：Journal of Cancer

authors： Tinoco G,Warsch S,Glück S,Avancha K,Montero AJ

更新日期：2013-01-01 00:00:00

abstract：:Colon cancer is one of the most common types of gastrointestinal cancers and the fourth cause of cancer death worldwide. To discover novel diagnostic biomarkers for colon cancer and investigate potential mechanisms of oncogenesis, quantitative proteomic approach using iTRAQ-tagging and 2D-LC-MS/MS was performed to cha...

journal_title：Journal of Cancer

authors： Li G,Li M,Liang X,Xiao Z,Zhang P,Shao M,Peng F,Chen Y,Li Y,Chen Z

更新日期：2017-02-11 00:00:00

abstract：:Colorectal cancer (CRC) is the fifth leading cause of cancer-related death in China. The incidence of Chinese CRC has increased dramatically with the changes of dietary and lifestyle. However, the genetic landscape of Chinese colorectal cancer mutation is still poorly understood. In this study, we have performed whole...

journal_title：Journal of Cancer

authors： Ma R,Jing C,Zhang Y,Cao H,Liu S,Wang Z,Chen D,Zhang J,Wu Y,Wu J,Feng J

更新日期：2020-01-01 00:00:00

abstract：:Breast cancer is considered as a heterogeneous disease comprising various types of neoplasms, which involves different profile changes in both mRNA and micro-RNA (miRNA) expression. Extensive studies on mRNA expression in breast tumor have yielded some very interesting findings, some of which have been validated and u...

journal_title：Journal of Cancer

authors： Fu SW,Chen L,Man YG

更新日期：2011-02-24 00:00:00

abstract：:Increasing studies indicate that long noncoding RNA (lncRNA) plays a critical role in aerobic glycolysis of various tumors. However, the contribution of lncRNA in gastric cancer (GC) cell glycolysis is still poorly understood. The objective of this research was to investigate the functional role and mechanism of lncRN...

journal_title：Journal of Cancer

authors： Qian C,Xu Z,Chen L,Wang Y,Yao J

更新日期：2020-08-27 00:00:00

abstract：:Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer, developed rapid disease progression following discontinuation of study ...

journal_title：Journal of Cancer

authors： Bashour SI,Doostan I,Keyomarsi K,Valero V,Ueno NT,Brown PH,Litton JK,Koenig KB,Karuturi M,Abouharb S,Tripathy D,Moulder-Thompson SL,Ibrahim NK

更新日期：2017-07-05 00:00:00

abstract：:Purpose: MicroRNAs (miRNAs) are key regulators of the growth and development of a wide range of cancer types such as colorectal cancer (CRC). A number of previously studies have observed that the levels of miR-365a-3p expression are dysregulated in many cancers, but the specific role of this miRNA in CRC and its assoc...

journal_title：Journal of Cancer

authors： Hong YG,Xin C,Zheng H,Huang ZP,Yang Y,Zhou JD,Gao XH,Hao L,Liu QZ,Zhang W,Hao LQ

更新日期：2020-03-26 00:00:00

abstract：:Clinical studies have confirmed epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) used in lung cancer patients with EGFR mutations can obtain a better result, but still part of the patients with poor efficacy. EGFR mutation is highly related to female, nonsmoking and adenocarcinoma. Thus, we hy...

journal_title：Journal of Cancer

authors： Yin ZJ,Tu HY,Fu M,Zhong WZ,An SJ,Yan HH,Chen HJ,Lin HR,Wu YL

更新日期：2018-07-30 00:00:00

abstract：PURPOSE:Methotrexate, vinblastine, doxorubicin plus cisplatin (MVAC) and gemcitabine plus cisplatin (GC) are both effective first-line chemotherapy. We explore the responsive variables of MVAC and GC for patients with metastatic urothelial carcinoma of bladder (mUCB). MATERIALS AND METHODS:Patients who were initially ...

journal_title：Journal of Cancer

authors： Hsieh MC,Huang CH,Chiang PH,Chen YY,Tang Y,Su YL

更新日期：2016-06-27 00:00:00

abstract：:Transarterial chemoembolization (TACE) has been considered the standard treatment for intermediate-stage hepatocellular carcinoma according to BCLC algorithm. However, it has been unclear about the TACE-related predictive bio-markers and underlying molecular mechanisms. This investigation revealed that HCCs with highe...

journal_title：Journal of Cancer

authors： Gai X,Zhou P,Xu M,Liu Z,Zheng X,Liu Q

更新日期：2020-01-01 00:00:00