miRNA Biomarkers in Breast Cancer Detection and Management.

Abstract:

:Breast cancer is considered as a heterogeneous disease comprising various types of neoplasms, which involves different profile changes in both mRNA and micro-RNA (miRNA) expression. Extensive studies on mRNA expression in breast tumor have yielded some very interesting findings, some of which have been validated and used in clinic. Recent miRNA research advances showed great potential for the development of novel biomarkers and therapeutic targets. miRNAs are a new class of small non-coding regulatory RNAs that are involved in regulating gene expression at the posttranscriptional level. It has been demonstrated that miRNA expression is frequently deregulated in breast cancer, which warrants further in-depth investigation to decipher their precise regulatory role in tumorigenesis. We address briefly the regulatory mechanism of miRNA, the expression of miRNAs in tumorigenesis, and their potential use as breast cancer biomarkers for early disease diagnosis and prognosis. In addition, we discuss the use of the Formalin-Fixed, Paraffin-Embedded (FFPE) tissue as an invaluable source for breast cancer biomarker discovery and validation, and the potential use of circulating miRNAs in blood for early breast cancer detection. We envision the potential use of miRNAs in breast cancer management in the near future, particularly in improving the early diagnosis, prognosis and treatment.

journal_name

J Cancer

journal_title

Journal of Cancer

authors

Fu SW,Chen L,Man YG

doi

10.7150/jca.2.116

subject

Has Abstract

pub_date

2011-02-24 00:00:00

pages

116-22

issn

1837-9664

journal_volume

2

pub_type

杂志文章
  • GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer.

    abstract::Cachexia is a metabolic mutiny that directly reduces life expectancy in chronic conditions such as cancer. The underlying mechanisms associated with cachexia involve inflammation, metabolism, and anorexia. Therefore, the need to identify cachexia biomarkers is warranted to better understand catabolism change and asses...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.50376

    authors: Ahmed DS,Isnard S,Lin J,Routy B,Routy JP

    更新日期:2021-01-01 00:00:00

  • Comparison of clinical characteristics and survival after surgery in patients with non-B and non-C hepatocellular carcinoma and hepatitis virus-related hepatocellular carcinoma.

    abstract:BACKGROUND AND AIMS:We compared clinicopathologic data and long-term clinical outcomes among patients with non-B and non-C hepatocellular carcinoma (NBNC-HCC) who underwent curative resection (group A, n=129), those with hepatitis B virus-related HCC (group B, n=62) and those with hepatitis C virus-related HCC (group C...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.6503

    authors: Nishikawa H,Arimoto A,Wakasa T,Kita R,Kimura T,Osaki Y

    更新日期:2013-07-18 00:00:00

  • Increased Reactive Oxygen Species and Distinct Oxidative Damage in Resveratrol-suppressed Glioblastoma Cells.

    abstract::Background and Aim: Glioblastoma multiforme (GBM) is a highly aggressive brain malignancy that lacks reliable treatments. Resveratrol possesses anti-cancer effects, but its activity against glioblastoma cells is variable for unknown reasons. One mechanism through which anti-cancer drugs exert their effects is oxidativ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.45489

    authors: Jia B,Zheng X,Wu ML,Tian XT,Song X,Liu YN,Li PN,Liu J

    更新日期:2021-01-01 00:00:00

  • Daily Pomegranate Intake Has No Impact on PSA Levels in Patients with Advanced Prostate Cancer - Results of a Phase IIb Randomized Controlled Trial.

    abstract::Pomegranate has been shown to prolong PSA doubling time in early prostate cancer, but no data from a placebo controlled trial has been published yet. The objective of this study was to prospectively evaluate the impact of pomegranate juice in patients with prostate cancer. We conducted a phase IIb, double blinded, ran...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.7123

    authors: Stenner-Liewen F,Liewen H,Cathomas R,Renner C,Petrausch U,Sulser T,Spanaus K,Seifert HH,Strebel RT,Knuth A,Samaras P,Müntener M

    更新日期:2013-08-29 00:00:00

  • Development and validation of a nomogram for predicting cancer-specific survival in patients with Wilms' tumor.

    abstract::Purpose: The objective of this study was to develop and validate a nomogram for predicting the cancer-specific survival (CSS) in patients with Wilms' tumor (WT). Methods: Patients with WT diagnosed between 2002 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were divided randomly into train...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.32741

    authors: Pan Z,You H,Bu Q,Feng X,Zhao F,Li Y,Lyu J

    更新日期:2019-08-28 00:00:00

  • Clinical study on the prevalence and comparative analysis of metabolic syndrome and its components among Chinese breast cancer women and control population.

    abstract::Metabolic syndrome has been previously identified as a risk factor for breast cancer and is increasingly a public health concern. This study aims to investigate the prevalence of metabolic syndrome and its components among primary breast cancer and control population. The clinical data of metabolic syndrome and its co...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.22968

    authors: Wu YT,Luo QQ,Li X,Arshad B,Xu Z,Ran L,Zhao CX,Wu H,Shi YL,Chen HR,Li H,Li HY,Wu KN,Kong LQ

    更新日期:2018-01-01 00:00:00

  • The impact of SPARC expression on the survival of pancreatic ductal adenocarcinoma patients after curative resection.

    abstract::Background: The predictive roles of secreted protein acidic and rich in cysteine (SPARC) in pancreatic ductal adenocarcinoma (PDAC) patients after curative resection have not been clarified. We investigated the correlations between the SPARC expression and the postoperative prognosis. Methods: We retrospectively analy...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.28660

    authors: Murakawa M,Aoyama T,Miyagi Y,Kobayashi S,Ueno M,Morimoto M,Numata M,Yamamoto N,Tamagawa H,Yukawa N,Rino Y,Masuda M,Morinaga S

    更新日期:2019-01-01 00:00:00

  • Stromal mesenchymal stem cells facilitate pancreatic cancer progression by regulating specific secretory molecules through mutual cellular interaction.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most intractable malignancies with a typical scirrhous pattern in histology. Due to its abundant tumor stroma and scant vascularization, chemotherapeutic agents are considered inefficiently permeable to cancer nests, making it highly difficult to cure the...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.24415

    authors: Saito K,Sakaguchi M,Maruyama S,Iioka H,Putranto EW,Sumardika IW,Tomonobu N,Kawasaki T,Homma K,Kondo E

    更新日期:2018-07-30 00:00:00

  • Up-regulation of LncRNA SNHG20 Predicts Poor Prognosis in Hepatocellular Carcinoma.

    abstract::Recent studies indicated that long noncoding RNAs (lncRNAs) played important regulatory roles in carcinogenesis and cancer progression. However, the contribution of small nucleolar RNA host gene 20 (SNHG20) to cancer development remains largely unknown. The aim of the study is to investigate the expression of SNHG20 a...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.13822

    authors: Zhang D,Cao C,Liu L,Wu D

    更新日期:2016-03-19 00:00:00

  • Compound Fuling Granule Suppresses Ovarian Cancer Development and Progression by disrupting mitochondrial function, galactose and fatty acid metabolism.

    abstract::Our previous studies have demonstrated that the compound fuling granule (CFG), a traditional Chinese medicine, suppresses ovarian cancer cell growth, migration and metastasis. However, the underlying mechanisms remain to be fully elucidated. In this study, we found that CFG could induce mitochondrial fragmentation, mi...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.25136

    authors: Ruan S,Zhang Z,Tian X,Huang D,Liu W,Yang B,Shen M,Tao F

    更新日期:2018-09-08 00:00:00

  • Metformin Inhibits Gemcitabine Induced Apoptosis in Pancreatic Cancer Cell Lines.

    abstract::Many preclinical and clinical studies are currently evaluating metformin in combination with classical therapeutic agents as anti-cancer therapy. In this study we used three distinct pancreatic cancer cell lines and evaluated cell death by trypan blue assay and Western Blots using antibodies directed against cleaved c...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.17972

    authors: Zechner D,Albert AC,Bürtin F,Vollmar B

    更新日期:2017-07-01 00:00:00

  • Capecitabine plus Oxaliplatin as a Second-Line Therapy for Advanced Biliary Tract Cancers: A Multicenter, Open-Label, Phase II Trial.

    abstract::Background: Although biliary tract cancer (BTC) has a very aggressive nature, some patients maintain a relatively good performance status after failure with first-line treatment of gemcitabine plus cisplatin (GC). Thus, tolerable, feasible, and useful second-line treatments are needed for these patients. We investigat...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.37610

    authors: Kim ST,Oh SY,Lee J,Kang JH,Lee HW,Lee MA,Sohn BS,Hong JH,Park YS,Park JO,Lim HY

    更新日期:2019-10-15 00:00:00

  • Gene Expression Detection Assay for Cancer Clinical Use.

    abstract::Cancer is a genetic disease where genetic variations cause abnormally functioning genes that appear to alter expression. Proteins, the final products of gene expression, determine the phenotypes and biological processes. Therefore, detecting gene expression levels can be used for cancer diagnosis, prognosis, and treat...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.24744

    authors: Narrandes S,Xu W

    更新日期:2018-06-05 00:00:00

  • Knockdown of long non-coding RNA PCAT-1 inhibits myeloma cell growth and drug resistance via p38 and JNK MAPK pathways.

    abstract::Objective: Both previous and recent literature showed long non-coding RNAs (lncRNAs) were crucial participants in multiple myeloma (MM) evolution. However, the dynamic regulation and mechanism of lncRNAs in MM progression was not fully understood. This study will explore the expression and effects of prostate cancer-a...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.35098

    authors: Shen X,Shen P,Yang Q,Yin Q,Wang F,Cong H,Wang X,Ju S

    更新日期:2019-10-20 00:00:00

  • LPS and IL-8 activated umbilical cord blood-derived neutrophils inhibit the progression of ovarian cancer.

    abstract::Background: Immunotherapy including immune checkpoint blockade, cancer vaccines, and adoptive cell therapy. However, no immune therapies support ovarian cancer. It is not clear whether the neutrophils, the component of the immune system derived from umbilical cord blood play a role in inhibiting the progression of ova...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.41035

    authors: Liu Q,Yang W,Luo N,Liu J,Wu Y,Ding J,Li C,Cheng Z

    更新日期:2020-05-18 00:00:00

  • Clinical and functional significance of CHK1-S, an alternatively spliced isoform of the CHK1 gene, in hepatocellular carcinoma.

    abstract::Alternative splicing plays critical roles in many disease processes and splicing dysregulation is a hallmark of cancer. The different splicing isoforms may have significantly different effects on the malignant progression of cancer. Checkpoint kinase 1 (CHK1) is a serine/threonine kinase and regulates DNA damage respo...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.39443

    authors: Hu G,Wang S,Wang Y,Gao Y,Zhu H,Liu M,Xu N,Wang L

    更新日期:2020-01-17 00:00:00

  • Aberrant CDK9 expression within chordoma tissues and the therapeutic potential of a selective CDK9 inhibitor LDC000067.

    abstract::Objectives: Chordomas are slow-growing malignancies that commonly affect vital neurological structures. These neoplasms are highly resistant to current chemotherapeutic regimens and often recur after surgical intervention. Therefore, there is an urgent need to identify molecular targets and more robust drugs to improv...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.35426

    authors: Shen S,Dean DC,Yu Z,Hornicek F,Kan Q,Duan Z

    更新日期:2020-01-01 00:00:00

  • High serum Androgen and Insulin concentrations increase the tendency of Endometrial Carcinoma.

    abstract::Purpose: The objective of the study was to evaluate the important role played by androgen and insulin in the development of endometrial carcinoma (EC), and their combined effect on EC risk. Methods: We enrolled 510 type I EC patients and 510 age-, time-, and nationality-matched subjects into this study. Metabolic and ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.46391

    authors: Teng F,Ma X,Yu X,Yan Y,Zhao J,Gao J,Gao C,Wang Y,Tian W,Xue F

    更新日期:2020-07-25 00:00:00

  • Ectopic Expression of Snail and Twist in Ph+ Leukemia Cells Upregulates CD44 Expression and Alters Their Differentiation Potential.

    abstract::Philadelphia chromosome-positive (Ph+) leukemia is characterized by reciprocal translocation between chromosomes 9 and 22. The resultant BCR/ABL fusion protein displays constitutive tyrosine kinase activity, leading to the induction of aberrant proliferation and neoplastic transformation. The bone marrow (BM) microenv...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.19633

    authors: Kidan N,Khamaisie H,Ruimi N,Roitman S,Eshel E,Dally N,Ruthardt M,Mahajna J

    更新日期:2017-10-23 00:00:00

  • Secretory Clusterin Mediates Oxaliplatin Resistance via the Gadd45a/PI3K/Akt Signaling Pathway in Hepatocellular Carcinoma.

    abstract::Purpose: Systemic therapy has often been used for patients with advanced hepatocellular carcinoma (HCC). However, due to drug resistance, the use of cytotoxic chemotherapy in the treatment of patients with advanced HCC has typically demonstrated low response rates. Secretory clusterin (sCLU) is expressed in aggressive...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.23849

    authors: Wang X,Zou F,Zhong J,Yue L,Wang F,Wei H,Yang G,Jin T,Dong X,Li J,Xiu P

    更新日期:2018-04-06 00:00:00

  • High expression of calreticulin indicates poor prognosis and modulates cell migration and invasion via activating Stat3 in nasopharyngeal carcinoma.

    abstract::Objective: Emerging evidence suggests that calreticulin (CALR) has great impacts on the tumor formation and progression of various cancers, but the role of CALR remains controversial. We investigated the expression and clinical significance of CALR in nasopharyngeal carcinoma (NPC). Methods: Immunohistochemistry was u...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.35362

    authors: Han Y,Liao Q,Wang H,Rao S,Yi P,Tang L,Tian Y,Oyang L,Wang H,Shi Y,Zhou Y

    更新日期:2019-08-29 00:00:00

  • New Prospect for Cancer Cachexia: Medical Cannabinoid.

    abstract::Cachexia is a common term for the wasting symptoms which may appear in almost every chronic illness, such as AIDS, tuberculosis, and cancer. Cancer cachexia (CCA) is a result of the interaction between the host and the tumor, mainly manifested in short-term wasting, malnutrition, and so on. Due to the chronic food sho...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.28246

    authors: Wang J,Wang Y,Tong M,Pan H,Li D

    更新日期:2019-01-01 00:00:00

  • RBP7 is a clinically prognostic biomarker and linked to tumor invasion and EMT in colon cancer.

    abstract::RBP7 is a member of the cellular retinol-binding protein (CRBP) family and previous data suggested a link between CRBPs and the malignant transformation of colon cancer cells. Here, we investigated the potential of RBP7 as a predictive biomarker for patients with colon cancer and determined its functional relevance fo...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.35180

    authors: Elmasry M,Brandl L,Engel J,Jung A,Kirchner T,Horst D

    更新日期:2019-08-27 00:00:00

  • Construction of a multiplex mutation hot spot PCR panel: the first step towards colorectal cancer genotyping on the GS Junior platform.

    abstract::Background: To support cancer therapy, development of low cost library preparation techniques for targeted next generation sequencing (NGS) is needed. In this study we designed and tested a PCR-based library preparation panel with limited target area for sequencing the top 12 somatic mutation hot spots in colorectal c...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.16037

    authors: Péterfia B,Kalmár A,Patai ÁV,Csabai I,Bodor A,Micsik T,Wichmann B,Egedi K,Hollósi P,Kovalszky I,Tulassay Z,Molnár B

    更新日期:2017-01-12 00:00:00

  • The Impact of Cetuximab Plus AKT- or mTOR- Inhibitor in a Patient-Derived Colon Cancer Cell Model with Wild-Type RAS and PIK3CA Mutation.

    abstract::Background: Anti-EGFR therapies have been recommended for advanced colorectal cancer (CRC) with wild-type RAS and PIK3CA mutation. However, PIK3CA mutations are a poor prognostic marker and a negative predictor of response to anti-EGFR therapies in RAS wild-type CRC. Therefore, new and advanced treatment strategies ar...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.19458

    authors: Kim JS,Kim JE,Kim K,Lee J,Park JO,Lim HY,Park YS,Kang WK,Kim ST

    更新日期:2017-08-22 00:00:00

  • Carbonic Anhydrase 4 serves as a Clinicopathological Biomarker for Outcomes and Immune Infiltration in Renal Cell Carcinoma, Lower Grade Glioma, Lung Adenocarcinoma and Uveal Melanoma.

    abstract::Background: Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. It is suggested to be a potential prognostic biomarker, while the correlations between CA4 and different cancers are indistinct. Methods: Differential mRNA expression of CA4 among different cancers and corresponding normal ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.46902

    authors: Xu Y,Xu WH,Shi SN,Yang XL,Ren YR,Zhuang XY,Qu YY,Zhang HL,Zhang XF

    更新日期:2020-08-25 00:00:00

  • Progression-free Survival Decreases with Each Subsequent Therapy in Patients Presenting for Phase I Clinical Trials.

    abstract:BACKGROUND:There is often a finite progression-free interval of time between one systemic therapy and the next when treating patients with advanced cancer. While it appears that progression-free survival (PFS) between systemic therapies tends to get shorter for a number of factors, there has not been a formal evaluatio...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.3.7

    authors: Bailey CH,Jameson G,Sima C,Fleck S,White E,Von Hoff DD,Weiss GJ

    更新日期:2012-01-01 00:00:00

  • Survival benefit of adjuvant chemotherapy for patients with poorly differentiated stage IIA colon cancer.

    abstract::Background: The effect of adjuvant chemotherapy on stage II colon cancer remains constantly controversial. Recently, however, several studies have reported the definite survival benefit of adjuvant chemotherapy (ACT) in T4 disease (stage IIB and IIC) among stage II colon cancer patients. The following study investigat...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.28917

    authors: Liu Q,Luo D,An H,Zhang S,Cai S,Li Q,Li X

    更新日期:2019-01-29 00:00:00

  • A meta-analysis of the short- and long-term results of randomized controlled trials that compared laparoscopy-assisted and open colectomy for colon cancer.

    abstract:PURPOSE:We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopy-assisted colectomy (LAC) and open colectomy (OC) for colon cancer. METHODS:We searched MEDLINE, EMBASE, Science Citation Index, and Cochrane Controlled Trial Register for relevant papers published between Janua...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.3621

    authors: Ohtani H,Tamamori Y,Arimoto Y,Nishiguchi Y,Maeda K,Hirakawa K

    更新日期:2012-01-01 00:00:00

  • Recombinant Dual-target MDM2/MDMX Inhibitor Reverses Doxorubicin Resistance through Activation of the TAB1/TAK1/p38 MAPK Pathway in Wild-type p53 Multidrug-resistant Breast Cancer Cells.

    abstract::Chemotherapy resistance represents a major obstacle for the treatment of patients with breast cancer (BC) and greatly restricts the therapeutic effect of the first-line chemotherapeutic agent doxorubicin (DOX). The present study aimed to investigate the feasibility of the recombinant dual-target murine double minute 2...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.32765

    authors: Fan Y,Ma K,Jing J,Wang C,Hu Y,Shi Y,Li E,Geng Q

    更新日期:2020-01-01 00:00:00