Abstract:
:Rac activation is precisely regulated temporally and spatially by intracellular signaling pathways in migrating cells to guarantee the formation of specific cell protrusions-lamellipodia at the leading edge. Integrins-mediated adhesions also control the signaling pathway for localized Rac activation in the cells, but very few studies have been addressed in this field. In the study, we aim to focus on how integrin-mediated signaling affects localized Rac activation by reducing the paxillin expression with shRNA targeting paxillin. The results revealed that reduction of the paxillin expression in the cells inhibited the formation of focal adhesions and Rac activation. By using Rac FRET biosensor, Rac activation was localized at the leading edge of the cell, within the lamellipodium. A ternary complex of paxillin-GIT1-PIX could establish the signaling pathway in front of the cells. Thus, we described a mechanism of integrin-mediated signaling for localized Rac activation that upon ligand binding, activated integrin via the signaling pathway paxillin-GIT1-PIX promotes localized Rac activation at the leading edge and cell migration.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Li Y,Wu X,Liu Z,Lu K,Liu R,Guo Xdoi
10.7150/jca.32853subject
Has Abstractpub_date
2020-01-01 00:00:00pages
345-352issue
2issn
1837-9664pii
jcav11p0345journal_volume
11pub_type
杂志文章abstract:PURPOSE:Our study is designed to develop and certify a promising prognostic signature for hepatocellular carcinoma (HCC). Materials and methods: We retrospectively analyzed mRNA expression profiles and clinicopathological data fetched from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. We fo...
journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2020-07-31 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2018-11-25 00:00:00
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更新日期:2018-07-16 00:00:00
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更新日期:2017-06-03 00:00:00
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abstract:BACKGROUND:The 2010 guidelines by ASCO-CAP have mandated that breast cancer specimens with ≥1% positively staining cells by immunohistochemistry should be considered Estrogen Receptor (ER) positive. This has led to a subclass of low-ER positive (1-10%) breast cancers. We have examined the biology and clinical behavior ...
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更新日期:2014-01-23 00:00:00
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pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Journal of Cancer
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doi:10.7150/jca.21318
更新日期:2017-09-27 00:00:00
abstract::Many studies, using different chemical agents, have shown excellent cancer prevention efficacy in mice and rats. However, equivalent tests of cancer prevention in humans require decades of intake of the agents while the rodents' short lifespans cannot give us information of the long-term safety. Therefore, animals wit...
journal_title:Journal of Cancer
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更新日期:2015-09-01 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41035
更新日期:2020-05-18 00:00:00
abstract::Background: Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and migration during cancer metastasis. Wnt3a is one of the ligands in canonical Wnt/β-catenin signaling pathway, which contributes to the carcinogenesis and progression of lung cancer cell lines. The aim of this study was to e...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18560
更新日期:2017-08-02 00:00:00
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pub_type: 杂志文章
doi:10.7150/jca.22246
更新日期:2018-01-01 00:00:00
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更新日期:2012-01-01 00:00:00
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更新日期:2017-04-09 00:00:00
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