Abstract:
BACKGROUND:We conducted this pooled analysis to investigate the impact of RECIST 1.1 on the selection of target lesions and classification of tumor response, in comparison with RECIST 1.0. Methods : We searched MEDLINE and EMBASE for articles with terms of RECIST 1.0 or RECIST 1.1. We looked into all abstracts and virtual meeting presentations from the conferences of ASCO and ESMO between 2009 and 2013. RESULTS:There were six articles in the literature comparing the clinical impacts of RECIST 1.0 and RECIST 1.1 in patients with metastatic cancer. A total of 359 patients were recruited from the six trials; 217 with non-small cell lung cancer, 61 with gastric cancer, 58 with colorectal cancer, and 23 with thyroid cancer. The number of target lesions by RECIST 1.1 was significantly lower than that by RECIST 1.0 (P<0.001). Because of new lymph node criteria, fourteen patients (3.1%) had no target lesions when adopting RECIST 1.1. RECIST 1.1 showed high concordance with RECIST 1.0 in the assessment of tumor responses (k = 0.903). Sixteen patients (4.8%) showed disagreement between the two criteria. CONCLUSION:This pooled study demonstrated that RECIST 1.1 showed a highly concordant response assessment with RECIST 1.0 in patients with metastatic cancer.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Kim JH,Min SJ,Jang HJ,Cho JW,Kim SH,Kim HSdoi
10.7150/jca.11316subject
Has Abstractpub_date
2015-02-25 00:00:00pages
387-93issue
4issn
1837-9664pii
jcav06p0387journal_volume
6pub_type
杂志文章abstract::Background/Aims: Autologous, tumor-derived, heat shock protein gp96 peptide complexes have antitumor potential. We conducted the first Phase II trial to evaluate the safety and efficacy of gp96 vaccination in adjuvant settings for patients with gastric cancer. Methods: We enrolled 73 consecutive patients from October ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18946
更新日期:2017-07-02 00:00:00
abstract::In this article, the use of different types of thermotherapies to treat breast cancer is reviewed. While hyperthermia is most commonly used as an adjuvant in combination with radiotherapy, chemotherapy, targeted therapy or cryotherapy to enhance the therapeutic effect of these therapies, thermoablation is usually carr...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.8693
更新日期:2014-05-29 00:00:00
abstract::Background: Early gastric carcinoma (EGC) with pure signet ring cell carcinoma (pSRCC) has been reported to have favourable prognosis and low risk of lymph node metastasis (LNM). However, risk factors of LNM and clinicopathological features for early gastric mixed signet ring cell carcinoma (mSRCC) remain poorly inves...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29245
更新日期:2019-01-29 00:00:00
abstract::Hedgehog (Hh) signalling plays an important role in cancer; however, its mechanism in ovarian cancer migration and invasion remains unclear. In the present study, we aimed to clarify the effect of the Hh signalling pathway on ovarian cancer migration and invasion through the regulation of CD24 expression, both in vitr...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17712
更新日期:2017-02-25 00:00:00
abstract::Background: Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and migration during cancer metastasis. Wnt3a is one of the ligands in canonical Wnt/β-catenin signaling pathway, which contributes to the carcinogenesis and progression of lung cancer cell lines. The aim of this study was to e...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18560
更新日期:2017-08-02 00:00:00
abstract::Background: The Gustave Roussy Immune Score (GRIm-Score) was initially reported to select patients for immunotherapy. Therefore, the purpose of the current retrospective study was to determine whether GRIm-Score, a novel nutritional and inflammatory-based prognostic score, is a useful prognostic marker in patients wit...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37898
更新日期:2020-01-01 00:00:00
abstract::Cancer cells express epithelial markers, and when progressing in malignancy they may express markers of the mesenchymal cell type. Therefore an epithelial-mesenchymal transition of the cancer cells is assumed. However the mesenchymal markers can equally well be interpreted as myeloid markers since they are common in b...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.8242
更新日期:2014-01-15 00:00:00
abstract:PURPOSE:The aim of this study was to clarify the risk factors for discontinuing tegafur/gimeracil/oteracil potassium (S-1) adjuvant chemotherapy following gastrectomy in patients with gastric cancer. METHODS:We retrospectively investigated patients with curatively-resected gastric cancer who received S-1 adjuvant chem...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11189
更新日期:2015-03-18 00:00:00
abstract:OBJECTIVE:Most prostate cancers originate from the prostatic peripheral zone (PZ). We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. METHODS:Stromal cells isolated from the PZ and TZ of normal human prostates mixed with DU145 c...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.9961
更新日期:2015-07-03 00:00:00
abstract::Background: Esophageal squamous cell carcinoma (ESCC) has been having a high mortality rate in China. Most patients are diagnosed in advanced stages, leading to the poor prognosis and low 5-year survival rate. Detection of precancerous lesions or early cancers is the key to improving this situation. Although previous ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29979
更新日期:2019-06-02 00:00:00
abstract::Background: Colorectal cancer (CRC) remains to be one of the most common malignancies worldwide. Various studies have demonstrated that microRNAs (miRs) play a critical role in regulating cancer progression and sensitivity to chemoradiotherapy. miR-1 was found to be aberrantly expressed in CRC. However, it has not bee...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44753
更新日期:2020-06-07 00:00:00
abstract::Background: Programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) is considered as a predictive biomarker of anti-PD-1/PD-L1 cancer therapies. However, the correlation of PD-L1 expression status between the primary and paired metastatic NSCLC is still not clear. The current study aims to a...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34793
更新日期:2020-01-01 00:00:00
abstract::Pokemon, also known as leukemia/lymphoma-related factor (LRF) is a pro-oncogenic protein highly expressed in several cancers. There have been few in vitro and animal studies about its malignant biological behavior and function, however, its role especially in prostate cancer has not been completely elucidated. Therefo...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29471
更新日期:2019-04-21 00:00:00
abstract::We use pulmonary interventional procedures for the diagnosis of pulmonary diseases either for benign or malignant lesions. Flexible bronchoscopy with or without radial endobronchial ultrasound, convex-probe endobronchial ultrasound and electromagnetic navigation are procedures performed in centers with experience in d...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23737
更新日期:2018-02-12 00:00:00
abstract::Establishing an applicable preclinical model is vital for translational cancer research. Patient-derived xenograft has been important preclinical model systems and widely used for cancer research. Patient-derived xenograft models that represent the tumors of the patients are necessary to better translate research disc...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.51749
更新日期:2021-01-01 00:00:00
abstract::Objective: This study aimed to evaluate the efficacy and safety of doxorubicin-loaded drug-eluting beads transarterial chemoembolization (DEB-TACE) with CalliSpheres microspheres (CSM) in treating unresectable intrahepatic cholangiocarcinoma (ICC). Methods: 88 unresectable ICC patients who received DEB-TACE treatment ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39410
更新日期:2020-05-18 00:00:00
abstract:PURPOSE:To investigate prognostic impact of chemoradiotherapy-induced hemoglobin (Hb) decrease on treatment outcomes of endemic nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:Eight hundred and fifteen non-metastatic NPC, receiving neoadjuvant chemotherapy followed by radiotherapy (NACT+RT group) or concomitant ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11403
更新日期:2015-04-02 00:00:00
abstract::Purpose: The early BCR-ABL1 reduction had the prognostic impact of the chronic-phase chronic myeloid leukemia (CML-CP) patients. This study was to find a more precise early prognosis index at 3 months in the patients with newly diagnosed CML-CP, especially for the patients with BCR-ABL1IS >10%. Methods: We retrospecti...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38752
更新日期:2020-02-03 00:00:00
abstract::The impact of albumin to globulin ratio (AGR) on the prognosis of various human cancers has not been well established. Here, a systemic review and meta-analysis has been performed to comprehensively assess the relationships between AGR and lymph node metastasis (LNM) or overall survival (OS). Systematical search throu...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.24889
更新日期:2018-06-12 00:00:00
abstract::Neural invasion (NI) is one of the important routes for local spread of gastric cancer (GC) correlated with poor prognosis. However, the exact cellular characteristics and molecular mechanisms of NI in GC are still unclear. Netrin-1(NTN1) as an axon guidance molecule was firstly found during neural system development....
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30230
更新日期:2019-06-02 00:00:00
abstract::Purpose: This study aimed to identify the survival benefit and safety of alternative dosage schedules for sunitinib in metastatic renal cell carcinoma. Materials and Methods: Clinicopathologic and survival data of patients treated with sunitinib as first-line therapy were retrospectively reviewed. Patients were classi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25693
更新日期:2018-09-07 00:00:00
abstract::Background: To identify associated risk factors and develop a predictive nomogram for the early death of metastatic gastric cancer patients. Methods: A total of 4575 patients in the SEER cohort and 220 patients in the Chinese cohort diagnosed with metastatic gastric cancer in our Cancer Center were obtained. Univariat...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46563
更新日期:2020-07-14 00:00:00
abstract::Background: The genetic heterogeneity between primary and metastatic lesions has rarely studied. Purpose: This study aims to compare the mutation profiling of key cancer-related genes in primary lung cancers and their matched lymph nodes (LN) metastasis. Methods: The gene mutation profiling of both primary cancers and...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.28266
更新日期:2019-03-03 00:00:00
abstract::Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.10419
更新日期:2015-01-05 00:00:00
abstract::Ovarian cancer is a highly lethal malignancy in the female reproductive system. Platinum drugs, represented by cisplatin, are the first-line chemotherapeutic agents for treatment of various malignancies including ovarian cancer, but drug resistance leads to chemotherapy failure. MicroRNAs emerged as promising molecule...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41135
更新日期:2020-03-13 00:00:00
abstract::EGFR mutation of Non-small cell lung cancers (NSCLC) was predominantly seen in Asian population and it was considered as a predictor of responsiveness. Eendothelial nitric oxide synthase (eNOS) plays a vital role in chronic inflammation and carcinogenesis. In this study, we aimed to explore the association between the...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25824
更新日期:2018-06-15 00:00:00
abstract::Multidrug resistance is a major obstacle to the effective treatment of esophageal carcinoma. It occurs more readily in hypoxia and acidosis microenvironment. TTLL6 is one of Tubulin tyrosine ligase-like family members. In this study, the effect of TTLL6 on the regulation of cisplatin (CDDP) sensitivity was evaluated i...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.47694
更新日期:2020-09-30 00:00:00
abstract::Breast cancer therapy has improved following the development of drugs with specific molecular targets, exemplified by inhibitors of human epidermal growth factor receptor-2 (HER2) or epidermal growth factor receptor (EGFR) such as trastuzumab and lapatinib. However, these drugs have little effect on brain metastasis d...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.6689
更新日期:2013-08-16 00:00:00
abstract::Recent studies indicated that long noncoding RNAs (lncRNAs) played important regulatory roles in carcinogenesis and cancer progression. However, the contribution of small nucleolar RNA host gene 20 (SNHG20) to cancer development remains largely unknown. The aim of the study is to investigate the expression of SNHG20 a...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13822
更新日期:2016-03-19 00:00:00
abstract::Background: Infiltration of immune cells and immune microenvironment determine the proliferative activity of the tumor and metastasis. The aim of this study was to analyze the influence of activation or suppression of the immune response mediators on the prognosis of biliary tract cancer (BTC). Methods: We searched Pu...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16774
更新日期:2017-01-01 00:00:00