Abstract:
:Background: The Gustave Roussy Immune Score (GRIm-Score) was initially reported to select patients for immunotherapy. Therefore, the purpose of the current retrospective study was to determine whether GRIm-Score, a novel nutritional and inflammatory-based prognostic score, is a useful prognostic marker in patients with esophageal squamous cell carcinoma (ESCC) undergoing surgical resection. Methods: A retrospective single institutional study including 372 ESCC patients undergoing surgical resection was performed. The GRIm-Score was simply calculated by lactate dehydrogenase (LDH), neutrophil lymphocyte ratio (NLR) and albumin (ALB). The cancer-specific survival (CSS) was analyzed for the current study with Cox regression analyses with forward stepwise and Kaplan-Meier methods. Results: There were 284 (76.3%) men and 88 (23.7%) women with the mean age of 59.3 ± 8.0 years (range: 36-80 years). Patient with a high GRIm-Score had poor CSS (10.3% vs. 35.0%, P < 0.001). The GRIm-Score, in multivariate analyses, instead of NLR, LDH or ALB, was an independent prognostic factor for CSS (P = 0.004). Conclusion: The GRIm-Score was an independent prognostic marker in patients with ESCC undergoing surgical resection. Our study is also the first study to discuss the prognostic value of GRIm-Score in patients with resectable ESCC.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Feng JF,Wang L,Yang X,Chen Sdoi
10.7150/jca.37898subject
Has Abstractpub_date
2020-01-01 00:00:00pages
1334-1340issue
6issn
1837-9664pii
jcav11p1334journal_volume
11pub_type
杂志文章abstract::Objective: To measure hematologic parameters derived from the white blood cell (WBC) count and differential count (DC) as prognostic factors for survival in patients with stage IB and IIA cervical cancer. Methods: We retrospectively examined demographic, clinicopathologic, and laboratory parameters in a cohort of 233 ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22234
更新日期:2018-01-01 00:00:00
abstract::Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC pat...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33720
更新日期:2020-01-13 00:00:00
abstract::For unresectable Hepatocellular carcinoma (HCC), chemotherapy is still an important treatment strategy. Oxaliplatin (Oxa) is an effective treatment of HCC after sorafenib treatment failure. However, the intrinsic or acquired resistance of Oxa affected the chemotherapeutic sensitivity. By analyzing the data of GEO Data...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25909
更新日期:2018-10-10 00:00:00
abstract::Hedgehog (Hh) signalling plays an important role in cancer; however, its mechanism in ovarian cancer migration and invasion remains unclear. In the present study, we aimed to clarify the effect of the Hh signalling pathway on ovarian cancer migration and invasion through the regulation of CD24 expression, both in vitr...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17712
更新日期:2017-02-25 00:00:00
abstract:BACKGROUND:Due to the lack of studies, it remains unclear whether the additional neoadjuvant chemotherapy (NACT) to concurrent chemoradiotherapy (CCRT) is superior to CCRT alone for locoregionally advanced nasopharyngeal carcinoma (NPC). The main objective of this Bayesian network meta-analysis was to determine the eff...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11814
更新日期:2015-07-17 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is one of the most common types of aggressive cancer. The tumor tissue, which shows an active angiogenesis, is composed of neoplastic and stromal cells, and an abundant inflammatory infiltrate. Angiogenesis is important to support tumor growth, while infiltrating cells contribute to ...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.12286
更新日期:2015-08-07 00:00:00
abstract::Purpose: Hypoxia-inducible factor-1alpha (HIF-1A) is a transcription factor that plays an "angiogenic switch" role especially under hypoxia microenvironment in solid tumor. However, the functions and clinical significance of HIF-1A in gallbladder cancer (GBC) are still controversial, and it has not been studied in nor...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46749
更新日期:2021-01-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. However, science has not yet been able to substantially improve the prognosis of lung cancer patients. Accumulating evidence suggests that microRNAs (miRNAs) are key players in the regulation of tumor development and metastasis....
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16961
更新日期:2017-06-30 00:00:00
abstract:OBJECTIVE:Most prostate cancers originate from the prostatic peripheral zone (PZ). We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. METHODS:Stromal cells isolated from the PZ and TZ of normal human prostates mixed with DU145 c...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.9961
更新日期:2015-07-03 00:00:00
abstract::Purpose: This study aimed to identify the survival benefit and safety of alternative dosage schedules for sunitinib in metastatic renal cell carcinoma. Materials and Methods: Clinicopathologic and survival data of patients treated with sunitinib as first-line therapy were retrospectively reviewed. Patients were classi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25693
更新日期:2018-09-07 00:00:00
abstract::Transforming growth factor β1 (TGF-β1) plays an important role in tumor initiation and development by inducing epithelial-mesenchymal Transition (EMT). Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the invasion and metastasis of tumors, including e...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.48426
更新日期:2020-10-04 00:00:00
abstract::Lung cancer is the most common malignancy in China and is associated with a poor survival rate amongst Han Chinese. The high mortality is largely attributed to late-stage diagnosis, when treatment is largely ineffective. Identification of genetic variants could potentially assist with earlier diagnosis and thus more e...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31134
更新日期:2019-06-02 00:00:00
abstract:INTRODUCTION:Bioimpedance is a measure of the electrical properties of biological tissues. In the last two decades bioimpedance has been successfully introduced in clinical diagnosis of cancer. It has been demonstrated that tumoral tissues often show lower bioimpedance values than healthy tissues. The aim of this work ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11936
更新日期:2015-08-20 00:00:00
abstract::Purpose Increasing evidences revealed that cancer cells with the characteristics of epithelial-mesenchymal transition (EMT) or cancer stem cells (CSC) have high ability of progression, invasion, metastasis and chemoresistance. TWIST1 and BMI1 are crucial transcription factors required for EMT and CSC. Both TWIST1 and ...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.14031
更新日期:2016-05-25 00:00:00
abstract::Background: Radiotherapy is a primary treatment strategy for patients with unresectable hepatocellular carcinoma (HCC); however, the prognostic factors among HCC patients who have received radiotherapy but not undergone surgery have not been systematically studied. Thus, the prognostic factors were investigated in thi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30365
更新日期:2019-07-25 00:00:00
abstract::Objectives: We aimed to investigate the interaction between fasting blood glucose and tumor embolus, and the potential mediation effect of fasting blood glucose on tumor embolus in predicting gastrointestinal tract cancer-specific mortality risk postoperatively. Methods and Results: 4330 patients were consecutively re...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34843
更新日期:2020-01-01 00:00:00
abstract::Ovarian carcinoma is the most lethal gynecological malignancy worldwide. Recent advance in genomic/epigenomic researches will impact on our prevention, detection and intervention on ovarian carcinoma. Detection of germline mutations in BRCA1/BRCA2, mismatch repair genes, and other genes in the homologous recombination...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.15556
更新日期:2016-07-05 00:00:00
abstract::Peroxisome proliferator-activated receptor gamma (PPARγ), a member of the nuclear receptor superfamily, participates in multiple physiological and pathological processes. Extensive studies have revealed the relationship between PPARγ and various tumors. However, the expression and function of PPARγ in bladder cancer s...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.42663
更新日期:2020-04-06 00:00:00
abstract::Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.36469
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:To identify predictors for development of mastoiditis after intensity-modulated radiation therapy (IMRT) in nasopharyngeal carcinoma (NPC). METHODS:Data for 146 NPC patients treated with IMRT was retrospectively reviewed under institutional ethics committee approval. Clinical factors associated with mastoid...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13183
更新日期:2016-01-08 00:00:00
abstract::Our previous studies have demonstrated that the compound fuling granule (CFG), a traditional Chinese medicine, suppresses ovarian cancer cell growth, migration and metastasis. However, the underlying mechanisms remain to be fully elucidated. In this study, we found that CFG could induce mitochondrial fragmentation, mi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25136
更新日期:2018-09-08 00:00:00
abstract::[This retracts the article DOI: 10.7150/jca.29953.]. ...
journal_title:Journal of Cancer
pub_type: 撤回出版物
doi:10.7150/jca.38671
更新日期:2019-09-02 00:00:00
abstract::Clinical outcomes of checkpoint blockade immunotherapy on colorectal cancer (CRC) are influenced by mismatch repair (MMR) gene status, which is associated with distinct tumor immune infiltrates and systemic inflammatory response status. However, the prognostic value of PD-L1 expression and the systemic inflammatory re...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25187
更新日期:2019-04-05 00:00:00
abstract::To explore the role of phospholipase D1 (PLD1) mRNA in transition of prostate cancer (PCa) cells to androgen independence, we used Arraystar Human LncRNA Microarray V3.0 to detect and compare the differential expression of PLD1 and its signaling pathway-related gene in standard androgen dependence prostate cancer (ADP...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26689
更新日期:2018-09-08 00:00:00
abstract::Mechanistic target of rapamycin (mTOR) plays a critical role in the development of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell lines. Moreover, redu...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18031
更新日期:2017-05-12 00:00:00
abstract::Chemotherapy resistance represents a major obstacle for the treatment of patients with breast cancer (BC) and greatly restricts the therapeutic effect of the first-line chemotherapeutic agent doxorubicin (DOX). The present study aimed to investigate the feasibility of the recombinant dual-target murine double minute 2...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.32765
更新日期:2020-01-01 00:00:00
abstract::Purpose Neuroblastoma is an embryonic solid tumor derived from the progenitors of the sympathetic nervous system. More than half of the patients developed metastatic disease at the time of initial diagnosis and had poor outcome with current therapeutic approaches. In recent years, some obligate and facultative anaerob...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18776
更新日期:2017-06-03 00:00:00
abstract::Background: Programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) is considered as a predictive biomarker of anti-PD-1/PD-L1 cancer therapies. However, the correlation of PD-L1 expression status between the primary and paired metastatic NSCLC is still not clear. The current study aims to a...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34793
更新日期:2020-01-01 00:00:00
abstract::Many studies, using different chemical agents, have shown excellent cancer prevention efficacy in mice and rats. However, equivalent tests of cancer prevention in humans require decades of intake of the agents while the rodents' short lifespans cannot give us information of the long-term safety. Therefore, animals wit...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.12519
更新日期:2015-09-01 00:00:00
abstract::The use of polyADPribose polymerase inhibitors in cancer treatment provides a unique opportunity to target DNA repair processes in cancer cells while leaving normal tissue intact. The PARP-1 enzyme repairs DNA single strand breaks (SSB). Therefore PARP-1 inhibition in BRCA1 negative cancers results in the formation of...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21338
更新日期:2017-10-23 00:00:00