Abstract:
:Clinical outcomes of checkpoint blockade immunotherapy on colorectal cancer (CRC) are influenced by mismatch repair (MMR) gene status, which is associated with distinct tumor immune infiltrates and systemic inflammatory response status. However, the prognostic value of PD-L1 expression and the systemic inflammatory response for patients with MMR deficiency has not been fully investigated. In this study, we examined the association of systemic inflammatory markers, PD-1/PD-L1 pathway expression, microsatellite instability (MSI) status, and clinicopathological characteristics of CRC with patient survival between MMR-deficient (dMMR) group (N=168) and MMR-proficient (pMMR) group (N=169). We found a large proportion of dMMR CRC patients displayed increased level of systemic inflammatory markers such as C-reactive protein, Neutrophil/Lymphocyte Ratio (NLR), Glasgow Prognostic Score (GPS), and low expression of PD-L1 in tumor stroma. Several systemic inflammatory markers were associated with AJCC stage only in dMMR patients. Similarly, Tumor infiltrating lymphocyte (TIL) PD-L1 or stroma PD-L1 expression was associated with AJCC stage only in dMMR patients. Circulating serum lymphocytes and TIL PD-L1 expression are both independent prognosis predictors for CRC patients. Overall, we found that dMMR CRC displayed a comprehensively distinct tumor immune microenvironment and systemic inflammatory response makers. PD-L1 expression at different location has different impacts on CRC patient survival, and the TIL PD-L1 expression might be a potential predictor for dMMR CRC patient response to anti-PD-1 therapy.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Kong P,Wang J,Song Z,Liu S,He W,Jiang C,Xie Q,Yang L,Xia X,Xia Ldoi
10.7150/jca.25187subject
Has Abstractpub_date
2019-04-05 00:00:00pages
1745-1754issue
7issn
1837-9664pii
jcav10p1745journal_volume
10pub_type
杂志文章abstract::Colorectal cancer (CRC) is an important health issue worldwide, accounting for the third place of cancer incidence. Chronic inflammation, as seen in Crohn's disease and ulcerative colitis, is the most important risk factor for developing CRC, as it favours neoplastic transformation by enhancing epithelial cell turnove...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13123
更新日期:2016-07-25 00:00:00
abstract::Cancer is a genetic disease where genetic variations cause abnormally functioning genes that appear to alter expression. Proteins, the final products of gene expression, determine the phenotypes and biological processes. Therefore, detecting gene expression levels can be used for cancer diagnosis, prognosis, and treat...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.24744
更新日期:2018-06-05 00:00:00
abstract::Purpose Increasing evidences revealed that cancer cells with the characteristics of epithelial-mesenchymal transition (EMT) or cancer stem cells (CSC) have high ability of progression, invasion, metastasis and chemoresistance. TWIST1 and BMI1 are crucial transcription factors required for EMT and CSC. Both TWIST1 and ...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.14031
更新日期:2016-05-25 00:00:00
abstract::There is abundant evidence that long non-coding RNAs play important roles in the development of tumors. In the present study, our main aim was to explore the relationship between lncRNA SNHG7 and human bladder cancer cells, thus finding a novel target for bladder cancer therapy and diagnosis. Expression of lncRNA SNHG...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25507
更新日期:2019-01-01 00:00:00
abstract::Glioblastoma (GBM) is a common malignant brain tumor of the central nervous system with a poor prognosis. In order to identify the prognostic signatures of GBM, we screened differentially expressed genes (DEGs) that were based on a single-cell RNA sequencing (scRNA-seq) dataset. These genes characteristically represen...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44034
更新日期:2020-04-06 00:00:00
abstract::Purpose: To evaluate long-term survival trends after primary total laryngectomy (TL) for locally advanced laryngeal carcinoma (LC). Methods: A total of 2094 patients diagnosed with locally advanced LC and underwent primary TL (1992-2011, at least 5-year follow-up) in the Surveillance, Epidemiology, and End Results (SE...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.50404
更新日期:2021-01-01 00:00:00
abstract::Stromal fibroblasts are suggested to be a key determinant in the malignant progression of breast cancer. To find an in vitro culture model that best mimics the in vivo tumor microenvironment so we can study the effects of stromal fibroblasts on breast cancer progression, we evaluated several three-dimensional (3D) co-...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.458
更新日期:2011-01-01 00:00:00
abstract::Objective: This study aimed to evaluate the efficacy and safety of doxorubicin-loaded drug-eluting beads transarterial chemoembolization (DEB-TACE) with CalliSpheres microspheres (CSM) in treating unresectable intrahepatic cholangiocarcinoma (ICC). Methods: 88 unresectable ICC patients who received DEB-TACE treatment ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39410
更新日期:2020-05-18 00:00:00
abstract::Objective: The purpose of this study was to evaluate the efficacy and feasibility of the R.E.N.A.L. Nephrometry Score to postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods: The study included 288 patients diagnosed with ccRCC who had complete CT/CTA data and R.E.N.A.L. Nephrometry Scores an...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21189
更新日期:2017-10-17 00:00:00
abstract::Many studies, using different chemical agents, have shown excellent cancer prevention efficacy in mice and rats. However, equivalent tests of cancer prevention in humans require decades of intake of the agents while the rodents' short lifespans cannot give us information of the long-term safety. Therefore, animals wit...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.12519
更新日期:2015-09-01 00:00:00
abstract::Background: We previously demonstrated that Proline rich 11 (PRR11) gene is associated with the development and progression of tongue squamous cell carcinoma (TSCC), but the underlying mechanism is unknown. This study aimed to investigate the molecular mechanism underlying oncogenic potential of PRR11 in TSCC cells. M...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29265
更新日期:2019-06-02 00:00:00
abstract::Background: Although biliary tract cancer (BTC) has a very aggressive nature, some patients maintain a relatively good performance status after failure with first-line treatment of gemcitabine plus cisplatin (GC). Thus, tolerable, feasible, and useful second-line treatments are needed for these patients. We investigat...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37610
更新日期:2019-10-15 00:00:00
abstract::We hypothesised that the blood levels of immune cells would be related to the progression of colorectal cancer and regional lymph node metastasis. We investigated the association between the blood levels of immune cells and regional lymph node metastasis in colorectal cancer patients. Patients with American Joint Comm...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18230
更新日期:2017-05-10 00:00:00
abstract::Background: Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. It is suggested to be a potential prognostic biomarker, while the correlations between CA4 and different cancers are indistinct. Methods: Differential mRNA expression of CA4 among different cancers and corresponding normal ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46902
更新日期:2020-08-25 00:00:00
abstract::Background: The predictive roles of secreted protein acidic and rich in cysteine (SPARC) in pancreatic ductal adenocarcinoma (PDAC) patients after curative resection have not been clarified. We investigated the correlations between the SPARC expression and the postoperative prognosis. Methods: We retrospectively analy...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.28660
更新日期:2019-01-01 00:00:00
abstract::Several randomized studies have been completed in prostate cancer that show a benefit to immediate postoperative treatment in patients undergoing prostatectomy. In one of the studies, there was even a survival advantage. In spite of those positive findings, there has been some reluctance to uniformly offer adjuvant tr...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:
更新日期:2010-12-07 00:00:00
abstract::Angiogenesis, a highly regulated process, is exploited by tumors like breast cancer to ensure a constant supply of oxygen and nutrients and is key for tumor survival and progression. Estrogen and alcohol independently have been observed to contribute to angiogenesis in breast cancer but their combinatorial effects hav...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25581
更新日期:2018-10-06 00:00:00
abstract::Background: Inflammation might play an important role in promoting cancer growth partly by affecting tumor angiogenesis. We explored the role of Glasgow prognostic score (GPS) in metastatic colorectal cancer patients receiving first-linebevacizumab. Methods: All consecutive metastatic colorectal cancer patients treate...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31182
更新日期:2019-11-15 00:00:00
abstract::Traditional chemotherapy and radiotherapy for cancer treatment face serious challenges such as drug resistance and toxic side effects. Complementary / Alternative medicine is increasingly being practiced worldwide due to its safety beneficial therapeutic effects. We hypothesized that a super combination (SC) of known ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.7235
更新日期:2013-11-14 00:00:00
abstract::Thyroid transcription factor-1 (TTF-1) is overexpressed in up to 95% of primary lung adenocarcinoma while negative for almost all squamous cell carcinomas. TTF-1 expression has been investigated as a prognostic factor in non-small-cell lung cancer (NSCLC) with conflicting results. We conducted this meta-analysis to ga...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26830
更新日期:2018-10-20 00:00:00
abstract:BACKGROUND:This study was performed to assess the impact of irradiation on the tissue penetration depth of doxorubicin delivered during Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC). METHODS:Fresh post mortem swine peritoneum was cut into 10 proportional sections. Except for 2 control samples, all received...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.14714
更新日期:2016-05-07 00:00:00
abstract::Hepatocellular Carcinoma is a major healthcare problem, representing the third most common cause of cancer-related mortality worldwide. There are 130 million Hepatitis C virus infected patients worldwide who are at a high-risk for developing Hepatocellular Carcinoma. Due to the fact that reliable parameters and/or too...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4280
更新日期:2012-01-01 00:00:00
abstract::Neural invasion (NI) is one of the important routes for local spread of gastric cancer (GC) correlated with poor prognosis. However, the exact cellular characteristics and molecular mechanisms of NI in GC are still unclear. Netrin-1(NTN1) as an axon guidance molecule was firstly found during neural system development....
journal_title:Journal of Cancer
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更新日期:2019-06-02 00:00:00
abstract::We discuss the hypothesis that ZEB1-Wnt-p300 signaling integrates epithelial to mesenchymal transition (EMT) and resistance to histone deacetylase inhibitors (HDACis) in colorectal cancer (CRC) cells. The HDACi butyrate, derived from dietary fiber, has been linked to CRC prevention, and other HDACis have been proposed...
journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2017-05-12 00:00:00
abstract::Clinical studies have confirmed epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) used in lung cancer patients with EGFR mutations can obtain a better result, but still part of the patients with poor efficacy. EGFR mutation is highly related to female, nonsmoking and adenocarcinoma. Thus, we hy...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25679
更新日期:2018-07-30 00:00:00
abstract::Despite advancement in the treatment of diffuse large B-cell lymphoma (DLBCL), many patients tend to relapse or become refractory after initial therapy. Therefore, it is essential to identify novel therapeutic targets and drugs, understand the molecular pathogenesis mechanism of DLBCL, and find ways to prevent and tre...
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更新日期:2021-01-01 00:00:00
abstract::Background and aim: Understanding the molecular biological mechanisms underlying laryngeal squamous cell carcinoma (LSCC) invasion and metastasis is crucial for diagnosis, treatment, and prognosis. We aimed to examine the expression of the tumor suppressor microRNA-204-5p (miR-204-5p) and its target gene, forkhead box...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19470
更新日期:2017-07-21 00:00:00
abstract::Background: Immunotherapy including immune checkpoint blockade, cancer vaccines, and adoptive cell therapy. However, no immune therapies support ovarian cancer. It is not clear whether the neutrophils, the component of the immune system derived from umbilical cord blood play a role in inhibiting the progression of ova...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41035
更新日期:2020-05-18 00:00:00
abstract::In this bi-institutional study, twenty-three stage IIIC-IV MAGE-A3(+) melanoma patients were vaccinated with M3TK-GML biweekly at three dose levels, with a subsequent phase of vaccinations at the maximum dose level. Anti-MAGE-A3 and anti-TK T cells were assessed by in vitro assay and delayed-type hypersensitivity skin...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.329
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:MicroRNA (miRNA) have been shown to regulate gene expression in many cancers. MiR-182 has recently been found to be prognostic for patients treated with radical prostatectomy for prostate cancer. We sought to assess miR-182 as a prognostic marker and understand its role in prostate cancer progression and met...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13176
更新日期:2015-10-25 00:00:00