A Clinical Study of a Cell-Based MAGE-A3 Active Immunotherapy in Advanced Melanoma Patients.

abstract：:Establishing an applicable preclinical model is vital for translational cancer research. Patient-derived xenograft has been important preclinical model systems and widely used for cancer research. Patient-derived xenograft models that represent the tumors of the patients are necessary to better translate research disc...

journal_title：Journal of Cancer

authors： Chen C,Lin W,Huang Y,Chen X,Wang H,Teng L

更新日期：2021-01-01 00:00:00

abstract：:Purpose: The early BCR-ABL1 reduction had the prognostic impact of the chronic-phase chronic myeloid leukemia (CML-CP) patients. This study was to find a more precise early prognosis index at 3 months in the patients with newly diagnosed CML-CP, especially for the patients with BCR-ABL1IS >10%. Methods: We retrospecti...

journal_title：Journal of Cancer

authors： Cai Z,Jia X,Zi J,Song H,Wang S,McGrath M,Zhao L,Song C,Ge Z

更新日期：2020-02-03 00:00:00

abstract：:Cancer-testis (CT) genes played important roles in the progression of malignant tumors and were recognized as promising therapeutic targets. However, the roles of genetic variants in CT genes in lung cancer susceptibility have not been well depicted. This study aimed to evaluate the associations between genetic varian...

journal_title：Journal of Cancer

authors： Li Z,Tang J,Wen W,Wu W,Wang J,Xu J,Yu Y,He Z,Pan X,Wei H,Zhu Y,Hu S,Cao J,Shen H,Que J,Wang W,Zhu Q,Chen L

更新日期：2020-02-03 00:00:00

abstract：:Purpose: Systemic therapy has often been used for patients with advanced hepatocellular carcinoma (HCC). However, due to drug resistance, the use of cytotoxic chemotherapy in the treatment of patients with advanced HCC has typically demonstrated low response rates. Secretory clusterin (sCLU) is expressed in aggressive...

journal_title：Journal of Cancer

authors： Wang X,Zou F,Zhong J,Yue L,Wang F,Wei H,Yang G,Jin T,Dong X,Li J,Xiu P

更新日期：2018-04-06 00:00:00

abstract：:Purpose: The aberrant of fibroblast growth factors and their receptors (FGF/FGFR) is an emerging target in the treatment of solid tumors. This study aimed to explore the landscape of FGF/FGFR alterations in a large cohort of cancer patients. Material and Methods: The formalin-fixed paraffin-embedded specimens of cance...

journal_title：Journal of Cancer

authors： Zuo W,He Y,Li W,Wu H,Zhao Z,Zhang Y,Chen S,Yin Y

更新日期：2020-09-23 00:00:00

abstract：OBJECTIVES:To study whether radical nephrectomy (RN) with lymph node dissection (LND) can benefit pT3 renal cell carcinoma (RCC) patients versus no LND under the 2018 American Joint Committee on Cancer TNM classification system. Subjects/Patients and Methods: We performed a retrospective cohort study of clinicopatholog...

journal_title：Journal of Cancer

authors： Li P,Peng C,Gu L,Xie Y,Nie W,Zhang Y,Xuan Y,Shen D,Du S,Tang L,Yao Y,Fan Y,Ma X,Zhang X

更新日期：2019-05-26 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) with its immunotherapeutic activities and sialic acid binding abilities is a promising cancer adjuvant. The HN was surfaced displayed on Lactococcus lactis and its cancer targeting ability was investigated via attachment to the MDA-MB231 bre...

journal_title：Journal of Cancer

authors： Baradaran A,Yusoff K,Shafee N,Rahim RA

更新日期：2016-01-29 00:00:00

abstract：:Background/Purpose: In colon cancer (CC) patients preoperative (pre-op) levels of VEGF-A165 (VEGF) is a strong predictor for disease recurrence. Elevated postoperative (post-op) VEGF levels could have undesirable effects by enhancing tumor growth and metastasis formation. It has been suggested that thromboprophylaxis ...

journal_title：Journal of Cancer

authors： Mitsis M,Koliou P,Bali C,Ntounousi E,Tatsis V,Nousias V,Lianos GD,Vartholomatos G,Nastos D

更新日期：2017-08-25 00:00:00

abstract：:Galectins are the member of soluble proteins that bind with β-galactoside containing glycans. These proteins have been considered to be associated in various important events such as different types of cancers. It has been found that galectins could contribute to neoplastic transformation or regulate cell growth, cell...

journal_title：Journal of Cancer

authors： Chetry M,Thapa S,Hu X,Song Y,Zhang J,Zhu H,Zhu X

更新日期：2018-11-25 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the sixth most common cancer, and the third most common cause of cancer related death worldwide. The multi-kinase inhibitor Sorafenib represents the only systemic treatment option until today, and results from clinical trials with allosteric mTOR inhibitors were sobering. Since the PI...

journal_title：Journal of Cancer

authors： Ewald F,Nörz D,Grottke A,Bach J,Herzberger C,Hofmann BT,Nashan B,Jücker M

更新日期：2015-09-16 00:00:00

abstract：:Liquid biopsy is becoming a promising method for non-invasive cancer detection. In several proof-of-concept studies, long non-coding RNAs (lncRNAs) were found to be potential biomarkers for bladder cancer detection. The objective of this study was to discover a panel of cell-free, urinary lncRNAs as liquid biopsy biom...

journal_title：Journal of Cancer

authors： Yu X,Wang R,Han C,Wang Z,Jin X

更新日期：2020-01-01 00:00:00

abstract：:Background and aim: Understanding the molecular biological mechanisms underlying laryngeal squamous cell carcinoma (LSCC) invasion and metastasis is crucial for diagnosis, treatment, and prognosis. We aimed to examine the expression of the tumor suppressor microRNA-204-5p (miR-204-5p) and its target gene, forkhead box...

journal_title：Journal of Cancer

authors： Gao W,Wu Y,He X,Zhang C,Zhu M,Chen B,Liu Q,Qu X,Li W,Wen S,Wang B

更新日期：2017-07-21 00:00:00

abstract：:Butyrate, a product of dietary fiber and a histone deacetylase inhibitor, induces apoptosis of colorectal cancer cells; this effect of butyrate is in part mediated by its ability to hyperactivate Wnt signaling, and may in part explain the preventive action of dietary fiber against colorectal cancer. However, the mecha...

journal_title：Journal of Cancer

authors： Bordonaro M

更新日期：2020-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is the fifth leading cause of cancer-related death in China. The incidence of Chinese CRC has increased dramatically with the changes of dietary and lifestyle. However, the genetic landscape of Chinese colorectal cancer mutation is still poorly understood. In this study, we have performed whole...

journal_title：Journal of Cancer

authors： Ma R,Jing C,Zhang Y,Cao H,Liu S,Wang Z,Chen D,Zhang J,Wu Y,Wu J,Feng J

更新日期：2020-01-01 00:00:00

abstract：:Red blood cell distribution width (RDW) has been recently demonstrated to be a predictor of inflammation. High pretreatment RDW level is associated with poor survival outcomes in various malignancies, although the results are controversial. We aimed to investigate the prognostic role of RDW. A systematic literature se...

journal_title：Journal of Cancer

authors： Wang PF,Song SY,Guo H,Wang TJ,Liu N,Yan CX

更新日期：2019-07-10 00:00:00

abstract：:Glioblastoma (GBM) is a common malignant brain tumor of the central nervous system with a poor prognosis. In order to identify the prognostic signatures of GBM, we screened differentially expressed genes (DEGs) that were based on a single-cell RNA sequencing (scRNA-seq) dataset. These genes characteristically represen...

journal_title：Journal of Cancer

authors： Liu H,Yang Q,Xiong Y,Xiong Z,Li X

更新日期：2020-04-06 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. The relationship between the gene methylation accumulation and HCC has been widely studied. In our study, we used the Sequenom EpiTYPER assay to investigate the methylation levels of the RASA3 in 164 HCC samples and paired adjacent non-cancerous ...

journal_title：Journal of Cancer

authors： Lin H,Fan X,He L,Zhou D

更新日期：2018-05-25 00:00:00

abstract：:Chemotherapy resistance represents a major obstacle for the treatment of patients with breast cancer (BC) and greatly restricts the therapeutic effect of the first-line chemotherapeutic agent doxorubicin (DOX). The present study aimed to investigate the feasibility of the recombinant dual-target murine double minute 2...

journal_title：Journal of Cancer

authors： Fan Y,Ma K,Jing J,Wang C,Hu Y,Shi Y,Li E,Geng Q

更新日期：2020-01-01 00:00:00

abstract：:Background and Aim: Glioblastoma multiforme (GBM) is a highly aggressive brain malignancy that lacks reliable treatments. Resveratrol possesses anti-cancer effects, but its activity against glioblastoma cells is variable for unknown reasons. One mechanism through which anti-cancer drugs exert their effects is oxidativ...

journal_title：Journal of Cancer

authors： Jia B,Zheng X,Wu ML,Tian XT,Song X,Liu YN,Li PN,Liu J

更新日期：2021-01-01 00:00:00

abstract：:The incidence of colorectal cancer (CRC) ranks third among all cancers in China and improvements in screening for CRC have an important impact on prevention and control of the disease. Paraoxonase 1 (PON1) is a calcium ion-dependent hydrolase that is widely distributed in tissue. Its diagnostic value in colorectal can...

journal_title：Journal of Cancer

authors： Zhang J,Yang X,Wei L,Tan H,Chen J,Li W,Chan K,Su Y,Zhao L,Hu S,Zhong S,Xiao Y,Liu H

更新日期：2020-09-17 00:00:00

abstract：:Background: IgA antibodies against Epstein-Barr virus (EBV) capsid antigen (VCA) and nuclear antigen 1 (EBNA1) have been proposed to facilitate the diagnosis and early detection of nasopharyngeal carcinoma (NPC) in high-incidence regions. However, while new methodologies and new platforms for the detection of VCA-IgA ...

journal_title：Journal of Cancer

authors： Yu X,Li F,Cheng W,Wu B,Fang H,Xia F,Gong Y,Yu W,Liao P,Cao Y,Yang F,Zhu H,Li J,Huang Y,Gan L,Zhang L,Lou Y,Ji M

更新日期：2020-10-18 00:00:00

abstract：:Cervical cancer is a commonly diagnosed cancer among females. Polymorphisms in pre-microRNAs have been demonstrated to play critical roles in cancer. However, the roles of pre-microRNA polymorphisms in the aetiology of cervical cancer have not been well documented. We genotyped eight pre-microRNA polymorphisms in 290 ...

journal_title：Journal of Cancer

authors： Chen G,Zhang M,Zhu J,Chen F,Yu D,Zhang A,He J,Hua W,Duan P

更新日期：2020-02-03 00:00:00

abstract：:Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely r...

journal_title：Journal of Cancer

authors： Liang J,Shi J,Wang N,Zhao H,Sun J

更新日期：2019-01-01 00:00:00

abstract：:Aims: We previously demonstrated that a loss of lean body mass loss at one month after gastrectomy was an independent risk factor for the continuation of adjuvant chemotherapy with S-1. However, it is unclear whether or not lean body mass loss after gastrectomy leads to a poor survival through poor compliance to adjuv...

journal_title：Journal of Cancer

authors： Aoyama T,Yoshikawa T,Maezawa Y,Kano K,Numata M,Hara K,Komori K,Yamada T,Hayashi T,Sato T,Tamagawa H,Yukawa N,Rino Y,Masuda M,Ogata T,Cho H,Oshima T

更新日期：2019-05-28 00:00:00

abstract：:Melanoma is the most aggressive and treatment-resistant form of skin cancer. Curcumol is a Chinese medicinal herb traditionally used as a cancer remedy. However, the molecular mechanisms underlying the anticancer activity of curcumol in melanoma remains largely unknown. In the present study, we observed that Curcumol ...

journal_title：Journal of Cancer

authors： Ning N,Liu S,Liu X,Tian Z,Jiang Y,Yu N,Tan B,Feng H,Feng X,Zou L

更新日期：2020-01-14 00:00:00

abstract：:Philadelphia chromosome-positive (Ph+) leukemia is characterized by reciprocal translocation between chromosomes 9 and 22. The resultant BCR/ABL fusion protein displays constitutive tyrosine kinase activity, leading to the induction of aberrant proliferation and neoplastic transformation. The bone marrow (BM) microenv...

journal_title：Journal of Cancer

authors： Kidan N,Khamaisie H,Ruimi N,Roitman S,Eshel E,Dally N,Ruthardt M,Mahajna J

更新日期：2017-10-23 00:00:00

abstract：:Breast cancer is considered as a heterogeneous disease comprising various types of neoplasms, which involves different profile changes in both mRNA and micro-RNA (miRNA) expression. Extensive studies on mRNA expression in breast tumor have yielded some very interesting findings, some of which have been validated and u...

journal_title：Journal of Cancer

authors： Fu SW,Chen L,Man YG

更新日期：2011-02-24 00:00:00

abstract：PURPOSE:To investigate prognostic impact of chemoradiotherapy-induced hemoglobin (Hb) decrease on treatment outcomes of endemic nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:Eight hundred and fifteen non-metastatic NPC, receiving neoadjuvant chemotherapy followed by radiotherapy (NACT+RT group) or concomitant ...

journal_title：Journal of Cancer

authors： Liang XX,Li Q,Su Z,Lan XW,Ouyang PY,Mao YP,Shi DB,Deng WG,Cheng ZB,Wang SY,Xie FY

更新日期：2015-04-02 00:00:00

abstract：:Objectives: We aimed to investigate the interaction between fasting blood glucose and tumor embolus, and the potential mediation effect of fasting blood glucose on tumor embolus in predicting gastrointestinal tract cancer-specific mortality risk postoperatively. Methods and Results: 4330 patients were consecutively re...

journal_title：Journal of Cancer

authors： Hu D,Zhang X,Lin X,Zhang H,Xia Y,Lin J,Zheng X,Peng F,Niu W

更新日期：2020-01-01 00:00:00

abstract：:Background: The Gustave Roussy Immune Score (GRIm-Score) was initially reported to select patients for immunotherapy. Therefore, the purpose of the current retrospective study was to determine whether GRIm-Score, a novel nutritional and inflammatory-based prognostic score, is a useful prognostic marker in patients wit...

journal_title：Journal of Cancer

authors： Feng JF,Wang L,Yang X,Chen S

更新日期：2020-01-01 00:00:00