Abstract:
:We hypothesised that the blood levels of immune cells would be related to the progression of colorectal cancer and regional lymph node metastasis. We investigated the association between the blood levels of immune cells and regional lymph node metastasis in colorectal cancer patients. Patients with American Joint Committee on Cancer (AJCC) stages 1 and 2 colorectal cancer were assigned to Early stage group and those with AJCC stages 3 and 4 were assigned to Late stage group. Blood levels of circulating immune cells, such as cluster of differentiation (CD)4+ including T helper 1 (Th1) and 17 (Th17) cells, regulatory T (Treg) cells, CD8+ T cells, and natural killer (NK) cells were assessed using fluorescence-activated cell sorting (FACS). The blood levels of CD4+ T, Treg, CD8+ T, and NK cells did not significantly differ between the two groups. However, the blood levels of Th1 and Th17 cells did significantly differ between the groups. Specifically, Late stage group had higher levels of Th1 and Th17 cells than Early stage group (Th1, 11.14±1.22% vs. 16.25±1.57%, p = 0.015; Th17, 3.32±0.05% vs. 1.11±0.15%, p < 0.01). In conclusion, the blood levels of Th1 and Th17 cells significantly increased as the N stage increased. The blood levels of Th1 and Th17 cells might be useful as predictive markers of lymph node invasion in colorectal cancer.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Lee JY,Seo EH,Oh CS,Paik JH,Hwang DY,Lee SH,Kim SHdoi
10.7150/jca.18230subject
Has Abstractpub_date
2017-05-10 00:00:00pages
1249-1254issue
7issn
1837-9664pii
jcav08p1249journal_volume
8pub_type
杂志文章abstract::Background: Uterine cervical cancer (UCC) is a common malignant tumor in women. We conducted this work to provide a though description on the patterns of distant metastases and to investigate the relevant factors for prognosis of UCC patients based on a large population. Patients and methods: UCC patients with FIGO st...
journal_title:Journal of Cancer
pub_type: 杂志文章
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abstract::Pomegranate has been shown to prolong PSA doubling time in early prostate cancer, but no data from a placebo controlled trial has been published yet. The objective of this study was to prospectively evaluate the impact of pomegranate juice in patients with prostate cancer. We conducted a phase IIb, double blinded, ran...
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journal_title:Journal of Cancer
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doi:10.7150/jca.2.383
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pub_type: 杂志文章,评审
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更新日期:2018-11-25 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章,评审
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更新日期:2019-07-08 00:00:00
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journal_title:Journal of Cancer
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更新日期:2019-08-28 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2017-09-15 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34793
更新日期:2020-01-01 00:00:00
abstract::Objective: As a member of the N-myc downregulated gene family, N-Myc downstream-regulated gene 2 (NDRG2) contributes to tumorigenesis of various types of cancer. The expression status of NDRG2 in colorectal cancer (CRC) and its prognostic value remain to be elucidated. The goal of this study was to determine the expre...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31382
更新日期:2019-06-09 00:00:00
abstract::Cellular compartmentalization of biochemical processes in eukaryotic cells is critical for many functions including shuttling of reducing equivalents across membranes. Although coordination of metabolic flux between different organelles is vital for cell physiology, its impact on tumor cell survival is not well unders...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19373
更新日期:2017-07-05 00:00:00
abstract::Cullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further recognize numerous substrates to participate in a variety of cellular processes, such as DNA damage and repair, cell death and cell cycle...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.11076
更新日期:2015-01-16 00:00:00
abstract::Many preclinical and clinical studies are currently evaluating metformin in combination with classical therapeutic agents as anti-cancer therapy. In this study we used three distinct pancreatic cancer cell lines and evaluated cell death by trypan blue assay and Western Blots using antibodies directed against cleaved c...
journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33345
更新日期:2019-07-10 00:00:00
abstract:OBJECTIVE:The main aim of this study was to study swith of the ovarian cancer cell to a calcifying phenotype in the formation of calcification in ovarian cancer, and to offer some help for ovarian cancer's diagnosis and differentiation therapy. METHODS:The mineralization of ovarian cancer cell lines SKOV3 was induced ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22932
更新日期:2018-02-28 00:00:00
abstract::Purpose: To evaluate long-term survival trends after primary total laryngectomy (TL) for locally advanced laryngeal carcinoma (LC). Methods: A total of 2094 patients diagnosed with locally advanced LC and underwent primary TL (1992-2011, at least 5-year follow-up) in the Surveillance, Epidemiology, and End Results (SE...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.50404
更新日期:2021-01-01 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Journal of Cancer
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更新日期:2018-09-08 00:00:00
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journal_title:Journal of Cancer
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更新日期:2018-10-20 00:00:00
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