Radiomic Nomogram: Pretreatment Evaluation of Local Recurrence in Nasopharyngeal Carcinoma based on MR Imaging.

abstract：:Background: Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and migration during cancer metastasis. Wnt3a is one of the ligands in canonical Wnt/β-catenin signaling pathway, which contributes to the carcinogenesis and progression of lung cancer cell lines. The aim of this study was to e...

journal_title：Journal of Cancer

authors： Xu J,Lv W,Hu Y,Wang L,Wang Y,Cao J,Hu J

更新日期：2017-08-02 00:00:00

abstract：:Background and Aim: Glioblastoma multiforme (GBM) is a highly aggressive brain malignancy that lacks reliable treatments. Resveratrol possesses anti-cancer effects, but its activity against glioblastoma cells is variable for unknown reasons. One mechanism through which anti-cancer drugs exert their effects is oxidativ...

journal_title：Journal of Cancer

authors： Jia B,Zheng X,Wu ML,Tian XT,Song X,Liu YN,Li PN,Liu J

更新日期：2021-01-01 00:00:00

abstract：:Oncogenic activation of the ETS Related Gene (ERG) in humans was originally identified in subsets of Ewing sarcomas, myeloid leukemias and, recently, in the majority of prostate cancers. Expression of human ERG protein and consequently its functions in normal and disease states needs to be better understood in light o...

journal_title：Journal of Cancer

authors： Mohamed AA,Tan SH,Mikhalkevich N,Ponniah S,Vasioukhin V,Bieberich CJ,Sesterhenn IA,Dobi A,Srivastava S,Sreenath TL

更新日期：2010-10-25 00:00:00

abstract：:Objective: The purpose of this study was to evaluate the efficacy and feasibility of the R.E.N.A.L. Nephrometry Score to postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods: The study included 288 patients diagnosed with ccRCC who had complete CT/CTA data and R.E.N.A.L. Nephrometry Scores an...

journal_title：Journal of Cancer

authors： Chen SH,Wu YP,Li XD,Lin T,Guo QY,Chen YH,Huang JB,Wei Y,Xue XY,Zheng QS,Xu N

更新日期：2017-10-17 00:00:00

abstract：:Transarterial chemoembolization (TACE) has been considered the standard treatment for intermediate-stage hepatocellular carcinoma according to BCLC algorithm. However, it has been unclear about the TACE-related predictive bio-markers and underlying molecular mechanisms. This investigation revealed that HCCs with highe...

journal_title：Journal of Cancer

authors： Gai X,Zhou P,Xu M,Liu Z,Zheng X,Liu Q

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Our study is designed to develop and certify a promising prognostic signature for hepatocellular carcinoma (HCC). Materials and methods: We retrospectively analyzed mRNA expression profiles and clinicopathological data fetched from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. We fo...

journal_title：Journal of Cancer

authors： Xie H,Liu S,Zhang Z,Chen P,Tao Y

更新日期：2020-07-31 00:00:00

abstract：:Esophageal cancer (EC) is a unique and heterogeneous disease diagnosed mostly at advanced stages. Altered glycans presented on cell surfaces are involved in the occurrence and development of malignancy. However, the effects of glycans on EC progression are largely unexplored. Here, a lectin array was utilized to detec...

journal_title：Journal of Cancer

authors： Xia M,Shao J,Qiao M,Luo Z,Deng X,Ke Q,Dong X,Shen L

更新日期：2020-06-01 00:00:00

abstract：:Cellular compartmentalization of biochemical processes in eukaryotic cells is critical for many functions including shuttling of reducing equivalents across membranes. Although coordination of metabolic flux between different organelles is vital for cell physiology, its impact on tumor cell survival is not well unders...

journal_title：Journal of Cancer

authors： Zhang B,Tornmalm J,Widengren J,Vakifahmetoglu-Norberg H,Norberg E

更新日期：2017-07-05 00:00:00

abstract：:Levels of plasma cell-free DNA (cfDNA) of a large series of children with classical Hodgkin lymphoma (cHL) were evaluated and analyzed at diagnosis and during chemotherapy treatment in relation with clinical characteristics. CfDNA levels in cHL patients were significantly higher compared with controls (p=0.002). CfDNA...

journal_title：Journal of Cancer

authors： Primerano S,Burnelli R,Carraro E,Pillon M,Elia C,Farruggia P,Sala A,Vinti L,Buffardi S,Basso G,Mascarin M,Mussolin L

更新日期：2016-01-12 00:00:00

abstract：:Background: Lysosome-associated protein transmembrane-4β-35(LAPTM4B-35) has been observed overexpressed in multiple malignant tumors. However, the prognostic value of LAPTM4B-35 remains controversial. Therefore, we conducted a meta-analysis to evaluate the prognostic value of LAPTM4B-35 in human cancers. Methods: The ...

journal_title：Journal of Cancer

authors： Zhou L,Dai C,Tian T,Wang M,Lin S,Deng Y,Xu P,Hao Q,Wu Y,Yang T,Zhu W,Dai Z

更新日期：2018-10-21 00:00:00

abstract：OBJECTIVES:To study whether radical nephrectomy (RN) with lymph node dissection (LND) can benefit pT3 renal cell carcinoma (RCC) patients versus no LND under the 2018 American Joint Committee on Cancer TNM classification system. Subjects/Patients and Methods: We performed a retrospective cohort study of clinicopatholog...

journal_title：Journal of Cancer

authors： Li P,Peng C,Gu L,Xie Y,Nie W,Zhang Y,Xuan Y,Shen D,Du S,Tang L,Yao Y,Fan Y,Ma X,Zhang X

更新日期：2019-05-26 00:00:00

abstract：:Background: Surgery for pancreatic cancer with liver metastases (PCL) is not recommended in the international guidelines, and investigation of its clinical significance in patients with PCL is very limited. This study explored whether surgery, especially synchronous resection of the primary tumor and liver metastases ...

journal_title：Journal of Cancer

authors： Su BB,Bai DS,Yu JQ,Zhang C,Jin SJ,Zhou BH,Jiang GQ

更新日期：2021-01-01 00:00:00

abstract：:Our previous studies have demonstrated that the compound fuling granule (CFG), a traditional Chinese medicine, suppresses ovarian cancer cell growth, migration and metastasis. However, the underlying mechanisms remain to be fully elucidated. In this study, we found that CFG could induce mitochondrial fragmentation, mi...

journal_title：Journal of Cancer

authors： Ruan S,Zhang Z,Tian X,Huang D,Liu W,Yang B,Shen M,Tao F

更新日期：2018-09-08 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC), is one of the most common malignant tumor in southern China and southeast Asia. MYH10 is a coding gene of the NMMHC-IIB protein. Previous studies have shown that MYH10 expression was up-regulated in breast cancer, glioma and meningioma. Moreover, it was targeted by miR200 family. Howeve...

journal_title：Journal of Cancer

authors： Liu W,Cai T,Li L,Chen H,Chen R,Zhang M,Zhang W,Zhao L,Xiong H,Qin P,Gao X,Jiang Q

更新日期：2020-03-04 00:00:00

abstract：:In this short communication we report a quick, cost-free method of purification of DNA fragments from agarose gel. Unlike those procedures that involve commercial kits, this method uses glass wool or absorbent cotton to filter agarose gel during a quick spinning-down of DNA, thus significantly simplifying the routine ...

journal_title：Journal of Cancer

authors： Sun Y,Sriramajayam K,Luo D,Liao DJ

更新日期：2012-01-01 00:00:00

abstract：:Background: Overall survival of patients with primary CNS lymphoma (PCNSL) has improved since the introduction of immunochemotherapy. However, up to 10-15% of PCNSL patients still die shortly after diagnosis. In the present study, we aimed to investigate the risk factors of early mortality (death within 60 days after ...

journal_title：Journal of Cancer

authors： Lin CH,Yang CF,Yang HC,Fay LY,Yeh CM,Kuan AS,Wang HY,Gau JP,Hsiao LT,Chiou TJ,Chen PM,Liu YC,Ko PS,Liu JH,Liu CJ

更新日期：2019-07-05 00:00:00

abstract：:In 2006, a remarkable collaboration between University of Texas MD Anderson Cancer Center clinicians and Texas and New Mexico State legislators led to the formation of a dedicated IBC Research Program and Clinic at MD Anderson. This initiative provided funding and infrastructure to foster coordination of an IBC World ...

journal_title：Journal of Cancer

authors： Woodward WA,Cristofanilli M,Merajver SD,Van Laere S,Pusztai L,Bertucci F,Berditchevski F,Polyak K,Overmoyer B,Devi GR,Sterneck E,Schneider R,Debeb BG,Wang X,van Golen KL,El-Zein R,Rahal OM,Alexander A,Reuben JM,Kris

更新日期：2017-10-09 00:00:00

abstract：:Ovarian cancer is a highly lethal malignancy in the female reproductive system. Platinum drugs, represented by cisplatin, are the first-line chemotherapeutic agents for treatment of various malignancies including ovarian cancer, but drug resistance leads to chemotherapy failure. MicroRNAs emerged as promising molecule...

journal_title：Journal of Cancer

authors： Xiang Y,Chen YJ,Yan YB,Liu Y,Qiu J,Tan RQ,Tian Q,Guan L,Niu SS,Xin HW

更新日期：2020-03-13 00:00:00

abstract：:Background: Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. It is suggested to be a potential prognostic biomarker, while the correlations between CA4 and different cancers are indistinct. Methods: Differential mRNA expression of CA4 among different cancers and corresponding normal ...

journal_title：Journal of Cancer

authors： Xu Y,Xu WH,Shi SN,Yang XL,Ren YR,Zhuang XY,Qu YY,Zhang HL,Zhang XF

更新日期：2020-08-25 00:00:00

abstract：:Hedgehog (Hh) signalling plays an important role in cancer; however, its mechanism in ovarian cancer migration and invasion remains unclear. In the present study, we aimed to clarify the effect of the Hh signalling pathway on ovarian cancer migration and invasion through the regulation of CD24 expression, both in vitr...

journal_title：Journal of Cancer

authors： Zeng C,Chen T,Zhang Y,Chen Q

更新日期：2017-02-25 00:00:00

abstract：:Distant metastasis is the primary cause of cancer-related death among patients with colorectal cancer (CRC), and the discovery of novel therapeutic targets by further exploring the molecular mechanisms of CRC metastasis is therefore urgently needed. We previously illustrated that CDC27 overexpression promoted prolifer...

journal_title：Journal of Cancer

authors： Qiu L,Tan X,Lin J,Liu RY,Chen S,Geng R,Wu J,Huang W

更新日期：2017-08-21 00:00:00

abstract：UNLABELLED:The mechanism of progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) remains largely unknown. We compared gene expression in tumors with simultaneous DCIS and IDC to decipher how diverse proteins participate in the local invasive process.Twenty frozen tumor specimens with conc...

journal_title：Journal of Cancer

authors： Castellana B,Escuin D,Peiró G,Garcia-Valdecasas B,Vázquez T,Pons C,Pérez-Olabarria M,Barnadas A,Lerma E

更新日期：2012-01-01 00:00:00

abstract：:Background: The study of CTLA-4 inhibitors has been one of the hot spots in the field of tumor immunotherapy. As the most immunogenic subtype of breast cancer, Triple negative breast cancer (TNBC) has a great potential in the treatment strategy. The aim of this study was to explore the relevant genes and pathways of C...

journal_title：Journal of Cancer

authors： Peng Z,Su P,Yang Y,Yao X,Zhang Y,Jin F,Yang B

更新日期：2020-09-09 00:00:00

abstract：:Purpose: We explored the influence of age on clinicopathologic features and survival of patients with M0 gastric cancer (GC). Methods: 16856 GC patients from Surveillance, Epidemiology and End Results (SEER) database and 1037 GC patients from Chinese multiple centers were enrolled in the U.S. and Chinese cohort, respe...

journal_title：Journal of Cancer

authors： Zhang J,Gan L,Xu MD,Huang M,Zhang X,Gong Y,Wang X,Yu G,Guo W

更新日期：2018-03-08 00:00:00

abstract：:Objective: To enquire into the clinical significance and potential molecular mechanism of microRNA (miRNA)-196b-5p in hepatocellular carcinoma (HCC). Methods: Quantitative reverse transcription and polymerase chain reaction (qRT-PCR) were utilized to examine miR-196b-5p expression level in 67 HCC paraffin embedded tis...

journal_title：Journal of Cancer

authors： Zhang L,Luo B,Dang YW,He RQ,Peng ZG,Chen G,Feng ZB

更新日期：2019-08-29 00:00:00

abstract：:Despite advancement in the treatment of diffuse large B-cell lymphoma (DLBCL), many patients tend to relapse or become refractory after initial therapy. Therefore, it is essential to identify novel therapeutic targets and drugs, understand the molecular pathogenesis mechanism of DLBCL, and find ways to prevent and tre...

journal_title：Journal of Cancer

authors： Xu L,Gao X,Yang P,Sang W,Jiao J,Niu M,Liu M,Qin Y,Yan D,Song X,Sun C,Tian Y,Zhu F,Sun X,Zeng L,Li Z,Xu K

更新日期：2021-01-01 00:00:00

abstract：:We studied combinatorial interactions of two phytochemicals, curcumin and silymarin, in their action against cancer cell proliferation. Curcumin is the major component of the spice turmeric. Silymarin is a bioactive component of milk thistle used as a protective supplement against liver disease. We studied antiprolife...

journal_title：Journal of Cancer

authors： Montgomery A,Adeyeni T,San K,Heuertz RM,Ezekiel UR

更新日期：2016-06-23 00:00:00

abstract：:Background: Although biliary tract cancer (BTC) has a very aggressive nature, some patients maintain a relatively good performance status after failure with first-line treatment of gemcitabine plus cisplatin (GC). Thus, tolerable, feasible, and useful second-line treatments are needed for these patients. We investigat...

journal_title：Journal of Cancer

authors： Kim ST,Oh SY,Lee J,Kang JH,Lee HW,Lee MA,Sohn BS,Hong JH,Park YS,Park JO,Lim HY

更新日期：2019-10-15 00:00:00

abstract：:Macrophages play a critical role in the initiation and progression in various human solid tumors; however, their role and transformation in pancreatic ductal adenocarcinoma (PDAC) were still illusive. Here, immunohistochemistry was used to determine CD206 (specific marker of M2 macrophage) and PKM2 expression in PDAC ...

journal_title：Journal of Cancer

authors： Hu H,Tu W,Chen Y,Zhu M,Jin H,Huang T,Zou Z,Xia Q

更新日期：2020-02-03 00:00:00

abstract：OBJECTIVE:To elucidate the oncologic behavior of Micropapillary Urothelial Bladder Carcinoma (MPBC), a rare aggressive variant histology. METHODS:All MPBC patients in SEER 17 database were compared with those with traditional urothelial carcinoma (UC). Kaplan-Meier curves were used to determine OS and CSS. A Cox propo...

journal_title：Journal of Cancer

authors： Vourganti S,Harbin A,Singer EA,Shuch B,Metwalli AR,Agarwal PK

更新日期：2013-05-06 00:00:00