Abstract：
:Background: Surgery for pancreatic cancer with liver metastases (PCL) is not recommended in the international guidelines, and investigation of its clinical significance in patients with PCL is very limited. This study explored whether surgery, especially synchronous resection of the primary tumor and liver metastases (SPL), could improve survival in PCL. Methods: Data of 14,248 patients with PCL from Surveillance, Epidemiology, and End Results database was analyzed. Patients were divided into following groups: SPL, synchronous primary site, and other resection (SPO), single resection of the primary site (SPS), and no resection (NR). Results: In this study, only 93 (0.7%) underwent SPL, 88 (0.6%) for SPO, and 232 (1.6%) for SPS. Multivariate Cox analysis showed surgical procedures of both the primary site and other sites were independent protective prognostic factors for pancreatic cancer cause-specific survival (PCSS) (all P < 0.001). Patients in the SPL group showed the most survival benefit, with a significant and gradually increased difference as compared with the SPO, SPS, and NR groups (median survival: 54, 34, 15, and 3 months, respectively, all P < 0.001). Compared with the NR group, mortalities were significant and gradually declining in the SPS, SPO, and SPL groups, with hazard ratio 0.329 (95% confidence interval [CI], 0.281 to 0.386), 0.220 (95% CI, 0.164 to 0.294), and 0.162 (95% CI, 0.118 to 0.222), respectively (all P < 0.001). Conclusions: Surgical procedures for both primary site and other sites improved survival. SPL, particularly, showed a considerable survival benefit in well-selected patients with PCL.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Su BB,Bai DS,Yu JQ,Zhang C,Jin SJ,Zhou BH,Jiang GQdoi
10.7150/jca.51218subject
Has Abstractpub_date
2021-01-01 00:00:00pages
539-552issue
2issn
1837-9664pii
jcav12p0539journal_volume
12pub_type
杂志文章abstract：:Purpose: To evaluate long-term survival trends after primary total laryngectomy (TL) for locally advanced laryngeal carcinoma (LC). Methods: A total of 2094 patients diagnosed with locally advanced LC and underwent primary TL (1992-2011, at least 5-year follow-up) in the Surveillance, Epidemiology, and End Results (SE...
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更新日期：2020-04-27 00:00:00
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更新日期：2020-07-06 00:00:00
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更新日期：2020-01-13 00:00:00
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更新日期：2017-10-17 00:00:00
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更新日期：2018-10-06 00:00:00
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pub_type： 杂志文章
doi：10.7150/jca.27053
更新日期：2019-04-21 00:00:00
abstract：:Purpose: Several new treatment options for patients with metastatic castration resistant prostate cancer (mCRPC) have been approved within the last years - among them cabazitaxel (CAB), abiraterone acetate, enzalutamide, and radium-223. The aim of this study was to assess factors predictive for efficacy of CAB. Method...
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更新日期：2017-02-11 00:00:00
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pub_type： 杂志文章
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更新日期：2019-06-02 00:00:00
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pub_type： 杂志文章
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更新日期：2020-05-18 00:00:00
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pub_type： 杂志文章
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更新日期：2015-02-25 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
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更新日期：2019-06-02 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
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更新日期：2018-11-11 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
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更新日期：2020-04-14 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.44413
更新日期：2020-04-06 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.2.292
更新日期：2011-01-01 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
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更新日期：2020-10-04 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
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更新日期：2019-10-17 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2019-06-09 00:00:00
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更新日期：2019-01-29 00:00:00
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更新日期：2019-10-03 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
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更新日期：2017-09-15 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2015-05-12 00:00:00
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更新日期：2018-02-27 00:00:00
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更新日期：2015-05-23 00:00:00
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更新日期：2020-04-07 00:00:00
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更新日期：2017-08-02 00:00:00
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journal_title：Journal of Cancer
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更新日期：2018-02-12 00:00:00
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更新日期：2012-01-01 00:00:00
