Compound Fuling Granule Suppresses Ovarian Cancer Development and Progression by disrupting mitochondrial function, galactose and fatty acid metabolism.

abstract：:Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...

journal_title：Journal of Cancer

authors： Yan J,Zhou Y,Chen D,Li L,Yang X,You Y,Ling X

更新日期：2015-01-05 00:00:00

abstract：:The highly conserved Hippo signaling pathway is an important pathway involved in tumorigenesis and development. In previous studies, YAP, the transcription coactivator of Hippo pathway, is found to be highly expressed in many clinical bladder cancer samples. To investigate the function of YAP and its cofactor Mask2 in...

journal_title：Journal of Cancer

authors： Dong L,Lin F,Wu W,Huang W,Cai Z

更新日期：2016-10-23 00:00:00

abstract：:Yes-associated protein (YAP) is a transcriptional coactivator that promotes cell proliferation, migration, and tissue homeostasis in colorectal cancer (CRC). Here, we established 5-Fu resistant CRC cell line (SW620R) and examined the role of YAP in chemotherapy resistance. We showed that YAP promoted cell proliferatio...

journal_title：Journal of Cancer

authors： Huang C,Chen Z,Yang C,Chen L,Lai C,Zhang Y,Yuan W,Jeong JH

更新日期：2020-07-11 00:00:00

abstract：:Traditional chemotherapy and radiotherapy for cancer treatment face serious challenges such as drug resistance and toxic side effects. Complementary / Alternative medicine is increasingly being practiced worldwide due to its safety beneficial therapeutic effects. We hypothesized that a super combination (SC) of known ...

journal_title：Journal of Cancer

authors： Ouhtit A,Gaur RL,Abdraboh M,Ireland SK,Rao PN,Raj SG,Al-Riyami H,Shanmuganathan S,Gupta I,Murthy SN,Hollenbach A,Raj MH

更新日期：2013-11-14 00:00:00

abstract：:We hypothesised that the blood levels of immune cells would be related to the progression of colorectal cancer and regional lymph node metastasis. We investigated the association between the blood levels of immune cells and regional lymph node metastasis in colorectal cancer patients. Patients with American Joint Comm...

journal_title：Journal of Cancer

authors： Lee JY,Seo EH,Oh CS,Paik JH,Hwang DY,Lee SH,Kim SH

更新日期：2017-05-10 00:00:00

abstract：PURPOSE:Methotrexate, vinblastine, doxorubicin plus cisplatin (MVAC) and gemcitabine plus cisplatin (GC) are both effective first-line chemotherapy. We explore the responsive variables of MVAC and GC for patients with metastatic urothelial carcinoma of bladder (mUCB). MATERIALS AND METHODS:Patients who were initially ...

journal_title：Journal of Cancer

authors： Hsieh MC,Huang CH,Chiang PH,Chen YY,Tang Y,Su YL

更新日期：2016-06-27 00:00:00

abstract：:Background: Protein kinase C zeta/lambda (PKCζ/λ) is a family of protein kinase enzymes that contributes to cell proliferation and regulation, which are important for cancer development. PKCζ/λ has been shown to be an important regulator of tumorigenesis in intestinal cancer. The phosphorylated form of PKCζ/λ, p-PKCζ/...

journal_title：Journal of Cancer

authors： Yeo MK,Kim JY,Seong IO,Kim JM,Kim KH

更新日期：2017-09-20 00:00:00

abstract：:Purpose: MicroRNAs (miRNAs) are key regulators of the growth and development of a wide range of cancer types such as colorectal cancer (CRC). A number of previously studies have observed that the levels of miR-365a-3p expression are dysregulated in many cancers, but the specific role of this miRNA in CRC and its assoc...

journal_title：Journal of Cancer

authors： Hong YG,Xin C,Zheng H,Huang ZP,Yang Y,Zhou JD,Gao XH,Hao L,Liu QZ,Zhang W,Hao LQ

更新日期：2020-03-26 00:00:00

abstract：:The process of neoplastic transformation of the colon involves a progression through hyperproliferative epithelium through the aberrant crypt foci→small adenoma→large adenoma→invasive cancer→metastatic disease. These are orchestrated by sequential genetic and epigenetic events which provide the underpinnings of cellul...

journal_title：Journal of Cancer

authors： Backman V,Roy HK

更新日期：2013-01-01 00:00:00

abstract：:Background: Integrative oncology (IO) is a relatively new field that seeks to bring evidence-based, non-conventional approaches into conventional oncology care in a coordinated and safe manner. Though complementary and alternative medicine (CAM) are highly utilized by cancer patients, little is known about the charact...

journal_title：Journal of Cancer

authors： Lopez G,McQuade J,Cohen L,Williams JT,Spelman AR,Fellman B,Li Y,Bruera E,Lee RT

更新日期：2017-02-10 00:00:00

abstract：:Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patt...

journal_title：Journal of Cancer

authors： Zhu DL,Tuo XM,Rong Y,Zhang K,Guo Y

更新日期：2020-10-21 00:00:00

abstract：:We discuss the hypothesis that ZEB1-Wnt-p300 signaling integrates epithelial to mesenchymal transition (EMT) and resistance to histone deacetylase inhibitors (HDACis) in colorectal cancer (CRC) cells. The HDACi butyrate, derived from dietary fiber, has been linked to CRC prevention, and other HDACis have been proposed...

journal_title：Journal of Cancer

authors： Lazarova D,Bordonaro M

更新日期：2017-05-12 00:00:00

abstract：:Osteosarcoma (OS) is the most common primary bone malignancy, predominately affecting children and adolescents. Due to the introduction of chemotherapy, the 5-year survival rate of OS patients has dramatically improved to 60-70%. Unfortunately, OS patients with recurrence or metastatic disease have less than a 20% cha...

journal_title：Journal of Cancer

authors： Zhang Y,Zhao H,Xu W,Jiang D,Huang L,Li L

更新日期：2019-05-12 00:00:00

abstract：:Human papillomavirus (HPV) is a DNA virus that infects epithelial cells and has been implicated in the development of cervical cancer. Few therapeutic strategies have been designed for the treatment of cervical intraepithelial neoplasia, a precursor of cervical cancer. In these early stages, the HPV E2 protein is the ...

journal_title：Journal of Cancer

authors： Bermúdez-Morales VH,Fierros-Zarate G,García-Meléndrez C,Alcocer-Gonzalez JM,Morales-Ortega A,Peralta-Zaragoza O,Torres-Poveda K,Burguete-García AI,Hernández-Márquez E,Madrid-Marina V

更新日期：2016-09-27 00:00:00

abstract：:Distant metastasis is the primary cause of cancer-related death among patients with colorectal cancer (CRC), and the discovery of novel therapeutic targets by further exploring the molecular mechanisms of CRC metastasis is therefore urgently needed. We previously illustrated that CDC27 overexpression promoted prolifer...

journal_title：Journal of Cancer

authors： Qiu L,Tan X,Lin J,Liu RY,Chen S,Geng R,Wu J,Huang W

更新日期：2017-08-21 00:00:00

abstract：:Background: Malignant biliary and/or pancreatic obstruction has often encountered in the advanced stages of periampullary and cholangicarcinomas. HabibTM Radiofrequency (RF) ablation has been successfully used in the management of various cancers of liver and pancreas. Percutaneous HPB probe (EMcision Ltd, London, UK)...

journal_title：Journal of Cancer

authors： Mizandari M,Kumar J,Pai M,Chikovani T,Azrumelashvili T,Reccia I,Habib N

更新日期：2018-01-05 00:00:00

abstract：:Purpose: Several new treatment options for patients with metastatic castration resistant prostate cancer (mCRPC) have been approved within the last years - among them cabazitaxel (CAB), abiraterone acetate, enzalutamide, and radium-223. The aim of this study was to assess factors predictive for efficacy of CAB. Method...

journal_title：Journal of Cancer

authors： Zschäbitz S,Vallet S,Hadaschik B,Debatin D,Fuxius S,Karcher A,Pahernik S,Spath C,Duensing S,Jäger D,Hohenfellner M,Grüllich C

更新日期：2017-02-11 00:00:00

abstract：:Objective: The purpose of this study was to evaluate the efficacy and feasibility of the R.E.N.A.L. Nephrometry Score to postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods: The study included 288 patients diagnosed with ccRCC who had complete CT/CTA data and R.E.N.A.L. Nephrometry Scores an...

journal_title：Journal of Cancer

authors： Chen SH,Wu YP,Li XD,Lin T,Guo QY,Chen YH,Huang JB,Wei Y,Xue XY,Zheng QS,Xu N

更新日期：2017-10-17 00:00:00

abstract：:In this article, the use of different types of thermotherapies to treat breast cancer is reviewed. While hyperthermia is most commonly used as an adjuvant in combination with radiotherapy, chemotherapy, targeted therapy or cryotherapy to enhance the therapeutic effect of these therapies, thermoablation is usually carr...

journal_title：Journal of Cancer

authors： Alphandéry E

更新日期：2014-05-29 00:00:00

abstract：:Objectives: Lung cancer in young adults is a distinct disease with particular socioeconomic implications. This study aimed to clarify the clinicopathological characteristics, best interventions, and outcomes of this distinctive entity. Methods: A retrospective review of patients with lung cancer was performed in our i...

journal_title：Journal of Cancer

authors： Liu B,Quan X,Xu C,Lv J,Li C,Dong L,Liu M

更新日期：2019-06-09 00:00:00

abstract：:Purpose: Systemic therapy has often been used for patients with advanced hepatocellular carcinoma (HCC). However, due to drug resistance, the use of cytotoxic chemotherapy in the treatment of patients with advanced HCC has typically demonstrated low response rates. Secretory clusterin (sCLU) is expressed in aggressive...

journal_title：Journal of Cancer

authors： Wang X,Zou F,Zhong J,Yue L,Wang F,Wei H,Yang G,Jin T,Dong X,Li J,Xiu P

更新日期：2018-04-06 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) have been reported to be involved in tumorigenesis and tumor progression. Single nucleotide polymorphisms (SNPs) in the lncRNAs also play a vital role in carcinogenesis. The aim of this study was to assess the relationships between the four selected tagSNPs (rs944289, rs3787016, rs145631...

journal_title：Journal of Cancer

authors： Xu T,Hu XX,Liu XX,Wang HJ,Lin K,Pan YQ,Sun HL,Peng HX,Chen XX,Wang SK,He BS

更新日期：2017-04-09 00:00:00

abstract：:MicroRNA-519d (miR-519d) has been reported to play important roles in tumor development and progression in multiple cancers, either as tumor suppressor or tumor promotor. However, the expression level, biological function and molecular mechanisms of miR-519d in oral squamous cell carcinoma (OSCC) remain unclear. There...

journal_title：Journal of Cancer

authors： Jin Y,Li Y,Wang X,Yang Y

更新日期：2019-06-02 00:00:00

abstract：:Objectives: LncRNA associated with microvascular invasion in hepatocellular carcinoma (lncRNA MVIH) is a newly discovered long non-coding RNA that aberrantly up-regulates and holds prognostic value in various tumors. The aim of the review and meta-analysis is to assess its prognostic potential and functions in maligna...

journal_title：Journal of Cancer

authors： Zhang Y,Lin S,Yang X,Zhang X

更新日期：2019-02-26 00:00:00

abstract：:Galectins are the member of soluble proteins that bind with β-galactoside containing glycans. These proteins have been considered to be associated in various important events such as different types of cancers. It has been found that galectins could contribute to neoplastic transformation or regulate cell growth, cell...

journal_title：Journal of Cancer

authors： Chetry M,Thapa S,Hu X,Song Y,Zhang J,Zhu H,Zhu X

更新日期：2018-11-25 00:00:00

abstract：:Endocrine resistance in hormone receptor positive breast cancer patients urges us to develop novel approaches such as inhibitors of the cyclin-dependent kinases (CDK) 4/6 to reverse its resistance. Nowadays, three selective CDK4/6 inhibitors (Palbociclib, Ribociclib and Abemaciclib) are approved by Federal Drug Admini...

journal_title：Journal of Cancer

authors： Chen X,Xu D,Li X,Zhang J,Xu W,Hou J,Zhang W,Tang J

更新日期：2019-10-21 00:00:00

abstract：:Objective: Citron Rho-Interacting Serine/Threonine Kinase (CIT) was originally identified as a binding partner of active forms of the small GTPases Rho and Rac. This kinase participated in the regulation of cytokinesis and loss of CIT was associated with chromosomal instability. Here, we assume that CIT might be a pot...

journal_title：Journal of Cancer

authors： Shou J,Yu C,Zhang D,Zhang Q

更新日期：2020-04-14 00:00:00

abstract：BACKGROUND:MALAT-1 is significantly overexpressed in various cancers, suggesting that it might be a potential biomarker of cancer. METHODS:A meta-analysis was performed using microarray data obtained via the Affymetrix Human Genome U133 Plus 2.0 platform found in the Gene Expression Omnibus (GEO) database and data obt...

journal_title：Journal of Cancer

authors： Wang Y,Xue D,Li Y,Pan X,Zhang X,Kuang B,Zhou M,Li X,Xiong W,Li G,Zeng Z,Yang T

更新日期：2016-05-20 00:00:00

abstract：:Glioblastoma multiforme (GBM) is commonly known as the most aggressive primary CNS tumor in adults. The mean survival of it is 14 to 15 months, following the standard therapy from surgery, chemotherapy, to radiotherapy. Efforts in recent decades have brought many novel therapies to light, however, with limitations. In...

journal_title：Journal of Cancer

authors： Zhang H,Wang R,Yu Y,Liu J,Luo T,Fan F

更新日期：2019-08-27 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used to treat non-small cell lung cancer (NSCLC) because they inhibit tumour growth and metastasis. However, the underlying mechanisms are not fully understood. Here, we investigate whether anti-lymphangiogenesis mechanisms cont...

journal_title：Journal of Cancer

authors： Zhang Y,Yang X,Liu H,Cai M,Shentu Y

更新日期：2020-01-01 00:00:00