Abstract:
:We studied combinatorial interactions of two phytochemicals, curcumin and silymarin, in their action against cancer cell proliferation. Curcumin is the major component of the spice turmeric. Silymarin is a bioactive component of milk thistle used as a protective supplement against liver disease. We studied antiproliferative effects of curcumin alone, silymarin alone and combinations of curcumin and silymarin using colon cancer cell lines (DLD-1, HCT116, LoVo). Curcumin inhibited colon cancer cell proliferation in a concentration-dependent manner, whereas silymarin showed significant inhibition only at the highest concentrations assessed. We found synergistic effects when colon cancer cells were treated with curcumin and silymarin together. The combination treatment led to inhibition of colon cancer cell proliferation and increased apoptosis compared to single compound treated cells. Combination treated cells exhibited marked cell rounding and membrane blebbing of apoptotic cells. Curcumin treated cells showed 3-fold more caspase3/7 activity whereas combination treated cells showed 5-fold more activity compared to control and silymarin treated cells. When DLD-1 cells were pre-exposed to curcumin, followed by treatment with silymarin, the cells underwent a high amount of cell death. The pre-exposure studies indicated curcumin sensitization of silymarin effect. Our results indicate that combinatorial treatments using phytochemicals are effective against colorectal cancer.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Montgomery A,Adeyeni T,San K,Heuertz RM,Ezekiel URdoi
10.7150/jca.15690subject
Has Abstractpub_date
2016-06-23 00:00:00pages
1250-7issue
10issn
1837-9664pii
jcav07p1250journal_volume
7pub_type
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journal_title:Journal of Cancer
pub_type: 撤回出版物
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更新日期:2019-09-02 00:00:00
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更新日期:2021-01-01 00:00:00
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journal_title:Journal of Cancer
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doi:10.7150/jca.17356
更新日期:2017-02-25 00:00:00
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更新日期:2020-07-09 00:00:00
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doi:10.7150/jca.16331
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pub_type: 杂志文章,评审
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