Abstract：
:In 2006, a remarkable collaboration between University of Texas MD Anderson Cancer Center clinicians and Texas and New Mexico State legislators led to the formation of a dedicated IBC Research Program and Clinic at MD Anderson. This initiative provided funding and infrastructure to foster coordination of an IBC World Consortium of national and international experts, and launch the first ever IBC international conference in 2008, which brought together experts from around the world to facilitate collaborations and accelerate progress. Indeed great progress has been made since then. National and international experts in IBC convened at the 10th Anniversary Conference of the MD Anderson IBC Clinic and Research Program and presented the most extensive sequencing analysis to date comparing IBC to non-IBC, gene- and protein-based immunoprofiling of IBC versus non-IBC patients, and converging lines of evidence on the specific role of the microenvironment in IBC. Novel models, unique metabolic mechanisms, and prominent survival pathways have been identified and were presented. Multiple clinical trials based on the work of the last decade are in progress or in development. The important challenges ahead were discussed. This progress and a coordinated summary of these works are presented herein.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Woodward WA,Cristofanilli M,Merajver SD,Van Laere S,Pusztai L,Bertucci F,Berditchevski F,Polyak K,Overmoyer B,Devi GR,Sterneck E,Schneider R,Debeb BG,Wang X,van Golen KL,El-Zein R,Rahal OM,Alexander A,Reuben JM,Krisdoi
10.7150/jca.21200subject
Has Abstractpub_date
2017-10-09 00:00:00pages
3607-3614issue
17issn
1837-9664pii
jcav08p3607journal_volume
8pub_type
杂志文章abstract：:Glioblastoma multiforme (GBM) is commonly known as the most aggressive primary CNS tumor in adults. The mean survival of it is 14 to 15 months, following the standard therapy from surgery, chemotherapy, to radiotherapy. Efforts in recent decades have brought many novel therapies to light, however, with limitations. In...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.32475
更新日期：2019-08-27 00:00:00
abstract：:Trend analysis is the analysis using statistical models to estimate and predict potential trends over time, space or any independent continuous-variable. It has been widely used in epidemiology and public health, but much less so in clinical oncology and basic cancer research. Methodological imitations of the chosen s...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.43521
更新日期：2020-03-04 00:00:00
abstract：:Our previous study has demonstrated that cytochalasin H (CyH) isolated from mangrove-derived endophytic fungus induces apoptosis and inhibits migration in A549 non-small cell lung cancer (NSCLC) cells. In this study, we further explored the effect of CyH on angiogenesis in NSCLC cells and the underlying molecular mech...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.29933
更新日期：2019-05-12 00:00:00
abstract：:Background: Although biliary tract cancer (BTC) has a very aggressive nature, some patients maintain a relatively good performance status after failure with first-line treatment of gemcitabine plus cisplatin (GC). Thus, tolerable, feasible, and useful second-line treatments are needed for these patients. We investigat...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.37610
更新日期：2019-10-15 00:00:00
abstract：:Objective: Increasing evidence suggested that dysregulated small nucleolar RNAs (snoRNAs) were involved in tumor development. The roles of snoRNA 71A (SNORA71A) in the progression of non-small cell lung cancer (NSCLC) remained unclear. Methods: Dataset GSE19188 from Gene Expression Omnibus (GEO) database was downloade...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.31077
更新日期：2019-05-21 00:00:00
abstract：:Background: Protein kinase C zeta/lambda (PKCζ/λ) is a family of protein kinase enzymes that contributes to cell proliferation and regulation, which are important for cancer development. PKCζ/λ has been shown to be an important regulator of tumorigenesis in intestinal cancer. The phosphorylated form of PKCζ/λ, p-PKCζ/...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.20983
更新日期：2017-09-20 00:00:00
abstract：:Background: The effect of adjuvant chemotherapy on stage II colon cancer remains constantly controversial. Recently, however, several studies have reported the definite survival benefit of adjuvant chemotherapy (ACT) in T4 disease (stage IIB and IIC) among stage II colon cancer patients. The following study investigat...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.28917
更新日期：2019-01-29 00:00:00
abstract：:Chemo- and radio-therapy suffer from certain well-recognized drawbacks for lymphoma therapy. Passive immunotherapy with monoclonal antibody has improved outcome for patients with CD20+ B cell lymphoma, but not for T cell lymphoma. Therefore, novel treatment approaches are clearly required for T cell lymphoma. To date,...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.20015
更新日期：2017-09-15 00:00:00
abstract：:Purpose: Eukaryotic initiation factor 4A-3 (EIF4A3) is an RNA-binding protein (RBP) that is a core component of the exon junction complex (EJC). It has been identified as an important player in post-transcriptional regulation processes. Recently, investigations have focused on EIF4A3 dysfunction in carcinogenesis. The...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.27655
更新日期：2018-11-11 00:00:00
abstract：:Neural invasion (NI) is one of the important routes for local spread of gastric cancer (GC) correlated with poor prognosis. However, the exact cellular characteristics and molecular mechanisms of NI in GC are still unclear. Netrin-1(NTN1) as an axon guidance molecule was firstly found during neural system development....
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.30230
更新日期：2019-06-02 00:00:00
abstract：:There is limited literature documenting granulocytic sarcoma of the colon. We report a case of a 28 year-old female with a colonic granulocystic sarcoma of the colon as a complication of AML, as it is an important consideration with surgical management of typhilitis. ...
journal_title：Journal of Cancer
pub_type：
doi：10.7150/jca.1.98
更新日期：2010-07-14 00:00:00
abstract：:Oral cancer is one of the most frequent malignant diseases worldwide, and areca nut is a primary carcinogen causing this cancer in Southeast Asia. It has been widely reported that areca nut induced several cytotoxic effects in oral cells, including ROS generation, inflammation, tissue hypoxia, DNA damage, and cell inv...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.29765
更新日期：2019-07-08 00:00:00
abstract：:Despite advancement in the treatment of diffuse large B-cell lymphoma (DLBCL), many patients tend to relapse or become refractory after initial therapy. Therefore, it is essential to identify novel therapeutic targets and drugs, understand the molecular pathogenesis mechanism of DLBCL, and find ways to prevent and tre...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.48310
更新日期：2021-01-01 00:00:00
abstract：:Objective: The purpose of this study was to evaluate the efficacy and feasibility of the R.E.N.A.L. Nephrometry Score to postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods: The study included 288 patients diagnosed with ccRCC who had complete CT/CTA data and R.E.N.A.L. Nephrometry Scores an...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.21189
更新日期：2017-10-17 00:00:00
abstract：:Background: Esophageal squamous cell carcinoma (ESCC) has been having a high mortality rate in China. Most patients are diagnosed in advanced stages, leading to the poor prognosis and low 5-year survival rate. Detection of precancerous lesions or early cancers is the key to improving this situation. Although previous ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.29979
更新日期：2019-06-02 00:00:00
abstract：:To explore the role of phospholipase D1 (PLD1) mRNA in transition of prostate cancer (PCa) cells to androgen independence, we used Arraystar Human LncRNA Microarray V3.0 to detect and compare the differential expression of PLD1 and its signaling pathway-related gene in standard androgen dependence prostate cancer (ADP...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.26689
更新日期：2018-09-08 00:00:00
abstract：:Objective: Liposarcoma is a mesenchymal malignant tumor characterized by adipocyte differentiation which is divided into four subtypes with different prognosis. Accurate histopathological diagnosis is essential for precise treatment. Perilipins, including PLIN1, PLIN2, PLIN3, PLIN4, PLIN5, is a family of lipid droplet...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.41736
更新日期：2020-04-07 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used to treat non-small cell lung cancer (NSCLC) because they inhibit tumour growth and metastasis. However, the underlying mechanisms are not fully understood. Here, we investigate whether anti-lymphangiogenesis mechanisms cont...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.35448
更新日期：2020-01-01 00:00:00
abstract：:Lung cancer is a major cause of death worldwide, with lung adenocarcinoma being the most frequently diagnosed subtype in Japan. Finding the target of an anticancer drug can improve lung adenocarcinoma treatments. Polo-like kinase 1 (PLK1) is an essential mitotic kinase in mitotic progression, and PLK1 inhibition induc...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.21802
更新日期：2017-11-06 00:00:00
abstract：PURPOSE:We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopic colorectal surgery (LCRS) and conventional open surgery (OCRS) for colorectal cancer (CRC). METHODS:We searched relevant papers published between January 1990 and May 2011. We analyzed the outcomes of each typ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.2.425
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Statins are proposed as a chemoprevention agent for breast cancer due to their anti-inflammatory effect. The effects of lipophilic and hydrophilic statins on breast cancer risk might be different due to their different pharmacologic properties. Therefore, this study aimed to assess a casual-effect of lipophi...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.14941
更新日期：2016-06-06 00:00:00
abstract：:In this article, the use of different types of thermotherapies to treat breast cancer is reviewed. While hyperthermia is most commonly used as an adjuvant in combination with radiotherapy, chemotherapy, targeted therapy or cryotherapy to enhance the therapeutic effect of these therapies, thermoablation is usually carr...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.8693
更新日期：2014-05-29 00:00:00
abstract：:Objectives: To investigate the effect of the concurrent use of trastuzumab and anthracycline-based neoadjuvant chemotherapy (NAC) for HER2-positive breast cancer in terms of pCR and cardiotoxicity. Methods: We systematically searched Pubmed, Embase, Cochrane and SinoMed databases from inception until 1 July 2017 for r...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.24701
更新日期：2018-08-06 00:00:00
abstract：:Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) in candidate genes from these pathways can be used as predictors of radiation pneumonitis (RP), we conduc...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.20643
更新日期：2018-02-01 00:00:00
abstract：:Many studies, using different chemical agents, have shown excellent cancer prevention efficacy in mice and rats. However, equivalent tests of cancer prevention in humans require decades of intake of the agents while the rodents' short lifespans cannot give us information of the long-term safety. Therefore, animals wit...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.12519
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Neoadjuvant chemotherapy with concurrent docetaxel, doxorubicin and cyclophosphamide is commonly used for patients with locally advanced breast cancer. Epirubicin is another anthracycline used in breast cancer but the concurrent use of epirubicin and taxane is not well-established. We conducted a single inst...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.3980
更新日期：2012-01-01 00:00:00
abstract：:Junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein that plays an important role in tumor progression. JAM-B is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.40953
更新日期：2020-03-05 00:00:00
abstract：:Background: Radiotherapy is a standard treatment for a significant fraction of cancer patients. Nonetheless, to this day radiation resistance is a key impediment in gastric cancer (GC) treatment. Moreover, GC is characterized by its substantial neo-angiogenesis, driven by high levels of vascular endothelial growth fac...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.25370
更新日期：2018-10-18 00:00:00
abstract：:Background: Infiltration of immune cells and immune microenvironment determine the proliferative activity of the tumor and metastasis. The aim of this study was to analyze the influence of activation or suppression of the immune response mediators on the prognosis of biliary tract cancer (BTC). Methods: We searched Pu...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.16774
更新日期：2017-01-01 00:00:00
abstract：:Background/Purpose: In colon cancer (CC) patients preoperative (pre-op) levels of VEGF-A165 (VEGF) is a strong predictor for disease recurrence. Elevated postoperative (post-op) VEGF levels could have undesirable effects by enhancing tumor growth and metastasis formation. It has been suggested that thromboprophylaxis ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.20107
更新日期：2017-08-25 00:00:00
