Statistics and pitfalls of trend analysis in cancer research: a review focused on statistical packages.

abstract：:Colorectal cancer is a commonly diagnosed malignancy and also the major cause of death worldwide. Chemotherapy is the primary therapy for advanced colorectal cancer. Although oxaliplatin has potential effect in colorectal cancer therapy, the molecular mechanisms involved in its cytotoxic effects are not well elucidate...

journal_title：Journal of Cancer

authors： Evert J,Pathak S,Sun XF,Zhang H

更新日期：2018-05-22 00:00:00

abstract：:There is limited literature documenting granulocytic sarcoma of the colon. We report a case of a 28 year-old female with a colonic granulocystic sarcoma of the colon as a complication of AML, as it is an important consideration with surgical management of typhilitis. ...

journal_title：Journal of Cancer

authors： Tsikitis VL,Corning C,Henderson J,Rose J

更新日期：2010-07-14 00:00:00

abstract：:Background: To support cancer therapy, development of low cost library preparation techniques for targeted next generation sequencing (NGS) is needed. In this study we designed and tested a PCR-based library preparation panel with limited target area for sequencing the top 12 somatic mutation hot spots in colorectal c...

journal_title：Journal of Cancer

authors： Péterfia B,Kalmár A,Patai ÁV,Csabai I,Bodor A,Micsik T,Wichmann B,Egedi K,Hollósi P,Kovalszky I,Tulassay Z,Molnár B

更新日期：2017-01-12 00:00:00

abstract：:Objective: Chemotherapy is a major therapeutic method for bladder urothelial carcinoma (BUC), which can effectively improve the prognosis of BUC patients, but the chemoresistance often leads to chemotherapy failure. This study will research the regulatory roles and molecular mechanism of miR-101-3p in BUC chemoresista...

journal_title：Journal of Cancer

authors： Li B,Xie D,Zhang H

更新日期：2019-06-02 00:00:00

abstract：:Purpose: This study aimed to comprehensively investigate the differential expression and prognostic indicators of the tripartite motif-containing (TRIM) gene family in non-small cell lung cancer (NSCLC). Methods: The Cancer Genome Atlas (TCGA) Research Network and three datasets from Gene Expression Omnibus (GEO) data...

journal_title：Journal of Cancer

authors： Han X,Huang C,Qu X,Liu S,Yang X,Wang Y,Bie F,Liu Q,Du J

更新日期：2019-01-29 00:00:00

abstract：:Background: Cancers may arise from cells with dysregulated telomeric functions due to shorten telomere length. We and others previously found that short leukocyte telomere length was associated with markedly evaluated risk of esophageal squamous cell carcinoma (ESCC). Hence, we hypothesized that single nucleotide poly...

journal_title：Journal of Cancer

authors： Li Z,Song Y,Xu Y,Shen Y,Zhang N,Yang M,Yu D

更新日期：2020-06-23 00:00:00

abstract：:Background: miRNAs dysregulate in hepatocellular carcinoma (HCC), showing promise for diagnostic biomarkers which may be found through exploration of differentially expressed miRNAs when comparing HCC and normal liver tissues. Materials and Methods: In the present research, candidate miRNAs were selected and verified ...

journal_title：Journal of Cancer

authors： Ji J,Chen H,Liu XP,Wang YH,Luo CL,Zhang WW,Xie W,Wang FB

更新日期：2018-09-08 00:00:00

abstract：:Amplified in breast cancer 1 (AIB1) gene, a coactivator for steroid receptor, is frequently amplified in diverse cancers and is considered as an oncogene in tumorigenesis. However, the prognostic significance of AIB1 amplification in gliomas remains totally unclear. In this study, 115 gliomas and 16 benign meningiomas...

journal_title：Journal of Cancer

authors： Chen L,Wang C,Zhang X,Gao K,Liu R,Shi B,Hou P

更新日期：2016-10-22 00:00:00

abstract：:Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC pat...

journal_title：Journal of Cancer

authors： Liang Y,Lin B,Ye Z,Chen S,Yu H,Chen C,Zhang X,Zhou K,Zeng J

更新日期：2020-01-13 00:00:00

abstract：:Background: The Aldehyde dehydrogenase 2 (ALDH2) mutant genotypes contain an allele encoding defective ALDH2 with reduced efficacy of alcohol metabolism leading to accumulation of highly toxic and carcinogenic acetaldehyde. It can induce unpleasant "Asian flush syndrome" and associate with increased risk of cancers. H...

journal_title：Journal of Cancer

authors： Huang PH,Hu CC,Chien CH,Chen LW,Chien RN,Lin YS,Chao M,Lin CL,Yeh CT

更新日期：2019-10-03 00:00:00

abstract：:Hedgehog (Hh) signalling plays an important role in cancer; however, its mechanism in ovarian cancer migration and invasion remains unclear. In the present study, we aimed to clarify the effect of the Hh signalling pathway on ovarian cancer migration and invasion through the regulation of CD24 expression, both in vitr...

journal_title：Journal of Cancer

authors： Zeng C,Chen T,Zhang Y,Chen Q

更新日期：2017-02-25 00:00:00

abstract：:Purpose: We retrospectively collected consecutive survival data of lung adenosquamous cell carcinoma (ASC) patients with brain metastasis (BM) in our institute and discussed the factors related to prognosis of these patients. Patients and Methods: A total of 42 patients diagnosed as lung ASC with BM between July 1, 20...

journal_title：Journal of Cancer

authors： Pan F,Cui S,Wang W,Gu A,Jiang L

更新日期：2018-09-08 00:00:00

abstract：:Colorectal cancer (CRC) is an important health issue worldwide, accounting for the third place of cancer incidence. Chronic inflammation, as seen in Crohn's disease and ulcerative colitis, is the most important risk factor for developing CRC, as it favours neoplastic transformation by enhancing epithelial cell turnove...

journal_title：Journal of Cancer

authors： Figueroa-González G,García-Castillo V,Coronel-Hernández J,López-Urrutia E,León-Cabrera S,Arias-Romero LE,Terrazas LI,Rodríguez-Sosa M,Campos-Parra AD,Zúñiga-Calzada E,Lopez-Camarillo C,Morales-González F,Jacobo-Herrera NJ,Pérez

更新日期：2016-07-25 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is one of the most common types of aggressive cancer. The tumor tissue, which shows an active angiogenesis, is composed of neoplastic and stromal cells, and an abundant inflammatory infiltrate. Angiogenesis is important to support tumor growth, while infiltrating cells contribute to ...

journal_title：Journal of Cancer

authors： Rivas-Fuentes S,Salgado-Aguayo A,Pertuz Belloso S,Gorocica Rosete P,Alvarado-Vásquez N,Aquino-Jarquin G

更新日期：2015-08-07 00:00:00

abstract：:Cancer is a genetic disease where genetic variations cause abnormally functioning genes that appear to alter expression. Proteins, the final products of gene expression, determine the phenotypes and biological processes. Therefore, detecting gene expression levels can be used for cancer diagnosis, prognosis, and treat...

journal_title：Journal of Cancer

authors： Narrandes S,Xu W

更新日期：2018-06-05 00:00:00

abstract：:Accumulating evidence suggests that the malignant phenotypes of cancers are determined not only by the intrinsic properties of cancer cells but also by components in the tumor microenvironment (TME). In this study, we comprehensively characterized the TME of cutaneous melanoma (CM). As a result, tumor stage, tissue si...

journal_title：Journal of Cancer

authors： Wang P,Zhang X,Sun N,Zhao Z,He J

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Neoadjuvant chemotherapy with concurrent docetaxel, doxorubicin and cyclophosphamide is commonly used for patients with locally advanced breast cancer. Epirubicin is another anthracycline used in breast cancer but the concurrent use of epirubicin and taxane is not well-established. We conducted a single inst...

journal_title：Journal of Cancer

authors： Yao X,Hosenpud J,Chitambar CR,Charlson J,Cheng YC

更新日期：2012-01-01 00:00:00

abstract：:Purpose: Aim of this study was to comprehensively analyze BRCA1-associated protein-1 (BAP1) somatic mutation in clear cell renal cell carcinoma (ccRCC) and explore potential therapeutic pathways and molecules. Patients and methods: In this study, we analyzed 445 ccRCC cases from The Cancer Genome Atlas (TCGA). Compreh...

journal_title：Journal of Cancer

authors： Jin S,Wu J,Zhu Y,Gu W,Wan F,Xiao W,Dai B,Zhang H,Shi G,Shen Y,Zhu Y,Ye D

更新日期：2018-10-18 00:00:00

abstract：:Objective: The applicability of the linear quadratic (LQ) model to local control (LC) modeling after hypofractionated radiotherapy to treat lung cancer is highly debated. To date, the differences in predicted outcomes between the LQ model and other radiobiological models, which are characterized by additional dose mod...

journal_title：Journal of Cancer

authors： Lu JY,Lin Z,Lin PX,Huang BT

更新日期：2019-08-08 00:00:00

abstract：:Lung cancer is a major cause of death worldwide, with lung adenocarcinoma being the most frequently diagnosed subtype in Japan. Finding the target of an anticancer drug can improve lung adenocarcinoma treatments. Polo-like kinase 1 (PLK1) is an essential mitotic kinase in mitotic progression, and PLK1 inhibition induc...

journal_title：Journal of Cancer

authors： Sekimoto N,Suzuki Y,Sugano S

更新日期：2017-11-06 00:00:00

abstract：:Background: Given recent results indicating that diminished LKB1 expression in laryngeal cancer correlates with shorter survival. We aim to perform an analysis estimate the role of decreased liver kinase B1(LKB1) and in the prognostication of human laryngeal squamous cell carcinoma (LSCC). Methods: We conducted a retr...

journal_title：Journal of Cancer

authors： He SS,Chen Y,Wang HZ,Shen XM,Sun P,Dong J,Liao XB,Guo GF,Chen JG,Xia LP,Hu PL,Qiu HJ,Liu SS,Zhou YX,Wang W,Hu WH,Cai XY

更新日期：2017-09-30 00:00:00

abstract：:Background: The predictive roles of secreted protein acidic and rich in cysteine (SPARC) in pancreatic ductal adenocarcinoma (PDAC) patients after curative resection have not been clarified. We investigated the correlations between the SPARC expression and the postoperative prognosis. Methods: We retrospectively analy...

journal_title：Journal of Cancer

authors： Murakawa M,Aoyama T,Miyagi Y,Kobayashi S,Ueno M,Morimoto M,Numata M,Yamamoto N,Tamagawa H,Yukawa N,Rino Y,Masuda M,Morinaga S

更新日期：2019-01-01 00:00:00

abstract：:Background: Immune cells recognize tumor antigens presented on major histocompatibility complex class I (MHC-I) molecule. Increase of MHC-I molecular expression makes tumor cells more susceptible to lysis by immune cells. Methods: Tumor lysate vaccine was prepared to damage glioma cells including cell lines and primar...

journal_title：Journal of Cancer

authors： Sun T,Li Y,Yang W,Wu H,Li X,Huang Y,Zhou Y,Du Z

更新日期：2019-09-07 00:00:00

abstract：:Our previous study has demonstrated that cytochalasin H (CyH) isolated from mangrove-derived endophytic fungus induces apoptosis and inhibits migration in A549 non-small cell lung cancer (NSCLC) cells. In this study, we further explored the effect of CyH on angiogenesis in NSCLC cells and the underlying molecular mech...

journal_title：Journal of Cancer

authors： Ma Y,Xiu Z,Zhou Z,Huang B,Liu J,Wu X,Li S,Tang X

更新日期：2019-05-12 00:00:00

abstract：:Levels of plasma cell-free DNA (cfDNA) of a large series of children with classical Hodgkin lymphoma (cHL) were evaluated and analyzed at diagnosis and during chemotherapy treatment in relation with clinical characteristics. CfDNA levels in cHL patients were significantly higher compared with controls (p=0.002). CfDNA...

journal_title：Journal of Cancer

authors： Primerano S,Burnelli R,Carraro E,Pillon M,Elia C,Farruggia P,Sala A,Vinti L,Buffardi S,Basso G,Mascarin M,Mussolin L

更新日期：2016-01-12 00:00:00

abstract：:Human papillomavirus (HPV) is a DNA virus that infects epithelial cells and has been implicated in the development of cervical cancer. Few therapeutic strategies have been designed for the treatment of cervical intraepithelial neoplasia, a precursor of cervical cancer. In these early stages, the HPV E2 protein is the ...

journal_title：Journal of Cancer

authors： Bermúdez-Morales VH,Fierros-Zarate G,García-Meléndrez C,Alcocer-Gonzalez JM,Morales-Ortega A,Peralta-Zaragoza O,Torres-Poveda K,Burguete-García AI,Hernández-Márquez E,Madrid-Marina V

更新日期：2016-09-27 00:00:00

abstract：:For hepatocellular carcinoma (HCC) patients with macrovascular invasion (MaVI), hepatectomy and transcatheter arterial chemoembolization (TACE) remain the main treatment options in Asia. However, which could achieve better survivals remains controversial. In present study, we conducted a meta-analysis to clarify the s...

journal_title：Journal of Cancer

authors： Chen J,Huang J,Chen M,Yang K,Chen J,Wang J,Xu L,Zhou Z,Zhang Y

更新日期：2017-08-25 00:00:00

abstract：:Tumor progression is often associated with chronic inflammation in the tumor microenvironment, which is mediated by numerous cytokines, chemokines and growth factors produced by cancer and stroma cells. All these mediators support tumor development and immunosuppression in autocrine and/or paracrine ways. Neutralizati...

journal_title：Journal of Cancer

authors： Sevko A,Umansky V

更新日期：2013-01-01 00:00:00

abstract：:Aim: BAP1 is frequently mutated in clear cell renal cell carcinoma (ccRCC) with a definitive role still unclear. Methods: In silico analysis of BAP1-mutant and wild-type gene enrichment and functional annotation in TCGA-KIRC dataset was performed. Target gene was studied based on functional clustering and was knowledg...

journal_title：Journal of Cancer

authors： Sun C,Zhao C,Li S,Wang J,Zhou Q,Sun J,Ding Q,Liu M,Ding G

更新日期：2018-10-01 00:00:00

abstract：:Objective: To enquire into the clinical significance and potential molecular mechanism of microRNA (miRNA)-196b-5p in hepatocellular carcinoma (HCC). Methods: Quantitative reverse transcription and polymerase chain reaction (qRT-PCR) were utilized to examine miR-196b-5p expression level in 67 HCC paraffin embedded tis...

journal_title：Journal of Cancer

authors： Zhang L,Luo B,Dang YW,He RQ,Peng ZG,Chen G,Feng ZB

更新日期：2019-08-29 00:00:00