Abstract:
:Purpose: Aim of this study was to comprehensively analyze BRCA1-associated protein-1 (BAP1) somatic mutation in clear cell renal cell carcinoma (ccRCC) and explore potential therapeutic pathways and molecules. Patients and methods: In this study, we analyzed 445 ccRCC cases from The Cancer Genome Atlas (TCGA). Comprehensive analysis including survival, transcriptome and methylation between BAP1 mutated and wild-type cases was performed using bioinformatics tools in silico. Pathways and molecules related to BAP1 mutation were analyzed using Database for Annotation, Visualization and Integrated Discovery (DAVID) and protein-protein interaction (PPI) network. Results:BAP1 mutated ccRCC patients had a worse overall survival (OS) and disease free survival (DFS) than BAP1 wild-type patients. We found 583 up-regulated and 1216 down-regulated different expressed genes (DEGs) in BAP1 mutated tumors. Up-regulated DEGs were enriched in molecular functions and biological processes like protein binding, protein transport and ubiquitin protein ligase binding. Down-regulated DEGs were enriched in pathways like Rap1 signaling pathway, Notch pathway and altered molecular functions like metal ion binding and ubiquitin-protein transferase activity. Furthermore, CAD, TSPO, CTNNB1 and MAPK3 were top hub genes selected using PPI network analysis. Finally, BAP1 mutation had a strong correlation with CpG island methylator phenotype (CIMP). Conclusion: Our study provides a comprehensive understanding of BAP1 functional somatic mutation in ccRCC patients. Several hub genes like CAD and TSPO may become potential therapeutic targets.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Jin S,Wu J,Zhu Y,Gu W,Wan F,Xiao W,Dai B,Zhang H,Shi G,Shen Y,Zhu Y,Ye Ddoi
10.7150/jca.27281subject
Has Abstractpub_date
2018-10-18 00:00:00pages
4108-4116issue
22issn
1837-9664pii
jcav09p4108journal_volume
9pub_type
杂志文章abstract::Aim: BAP1 is frequently mutated in clear cell renal cell carcinoma (ccRCC) with a definitive role still unclear. Methods: In silico analysis of BAP1-mutant and wild-type gene enrichment and functional annotation in TCGA-KIRC dataset was performed. Target gene was studied based on functional clustering and was knowledg...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26275
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Mathematical models can be useful tools in exploring disease trends and health consequences of interventions in a population over time. Most cancers, in particular cervical cancer, have long incubation periods. The time from acquisition of HPV infection to development of invasive cancer can be up to two deca...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4161
更新日期:2012-01-01 00:00:00
abstract::MicroRNAs (miRNAs) have been extensively studied over the decades and have been proposed as potential molecular targets for cancer treatment. Studies have shown that miR-378 participates in numerous biological processes in various cancers; whereas miR-1827 has only been reported in pediatric glioma. The mechanism of h...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18188
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:To identify predictors for development of mastoiditis after intensity-modulated radiation therapy (IMRT) in nasopharyngeal carcinoma (NPC). METHODS:Data for 146 NPC patients treated with IMRT was retrospectively reviewed under institutional ethics committee approval. Clinical factors associated with mastoid...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13183
更新日期:2016-01-08 00:00:00
abstract::Objective: Pancreatic cancer (PC) is a malignant tumor with limited therapeutic choices and extremely poor prognosis. Personalized therapy based on gene alternations is a promising choice. Considering tumor heterogeneity, the practice of ctDNA analysis has drawn the attention. Here, we try to assess the applicability ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.43087
更新日期:2020-04-27 00:00:00
abstract::Colorectal cancer(CRC) is a prevalent malignancy in the world. There is growing evidence that microRNAs (miRNAs) as crucial modulator are in connection with many tumor-related diseases including CRC. Though miR-485-5p has been reported as an anti-oncogene in certain cancers, it remains unclear in CRC. In this research...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24918
更新日期:2018-06-23 00:00:00
abstract:PURPOSE:Methotrexate, vinblastine, doxorubicin plus cisplatin (MVAC) and gemcitabine plus cisplatin (GC) are both effective first-line chemotherapy. We explore the responsive variables of MVAC and GC for patients with metastatic urothelial carcinoma of bladder (mUCB). MATERIALS AND METHODS:Patients who were initially ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15213
更新日期:2016-06-27 00:00:00
abstract:BACKGROUND:Mitochondria play crucial roles in cell signaling events, interorganellar communication, aging, cell proliferation and apoptosis, and mitochondrial impairment has been shown to accelerate or modulate cancer progression. Ubiquitous mitochondrial creatine kinase (uMtCK) is predominantly localized in the interm...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13207
更新日期:2016-01-01 00:00:00
abstract::Background: We previously demonstrated that Proline rich 11 (PRR11) gene is associated with the development and progression of tongue squamous cell carcinoma (TSCC), but the underlying mechanism is unknown. This study aimed to investigate the molecular mechanism underlying oncogenic potential of PRR11 in TSCC cells. M...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29265
更新日期:2019-06-02 00:00:00
abstract:OBJECTIVE:With the survival rate of acute lymphoblastic leukemia (ALL) surpassing 90 percent within this decade, new research is emerging in the field of late effects. A review of the research investigating the relationship of treatment regimens for ALL to specific late effect deficits, underlying mechanisms, and possi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.292
更新日期:2011-01-01 00:00:00
abstract::We found that microRNA-320a (miR-320a) was an attractive prognostic biomarker in breast cancer (BC) previously, whereas its regulatory mechanism in BC was not well understood. Our aim was to identify miR-320a target gene, examine the clinical relationship between miR-320a and its target, and further explore the functi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15737
更新日期:2016-11-25 00:00:00
abstract::Several randomized studies have been completed in prostate cancer that show a benefit to immediate postoperative treatment in patients undergoing prostatectomy. In one of the studies, there was even a survival advantage. In spite of those positive findings, there has been some reluctance to uniformly offer adjuvant tr...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:
更新日期:2010-12-07 00:00:00
abstract::Background: The study of CTLA-4 inhibitors has been one of the hot spots in the field of tumor immunotherapy. As the most immunogenic subtype of breast cancer, Triple negative breast cancer (TNBC) has a great potential in the treatment strategy. The aim of this study was to explore the relevant genes and pathways of C...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46301
更新日期:2020-09-09 00:00:00
abstract::Clinical studies have confirmed epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) used in lung cancer patients with EGFR mutations can obtain a better result, but still part of the patients with poor efficacy. EGFR mutation is highly related to female, nonsmoking and adenocarcinoma. Thus, we hy...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25679
更新日期:2018-07-30 00:00:00
abstract::Background: miRNAs dysregulate in hepatocellular carcinoma (HCC), showing promise for diagnostic biomarkers which may be found through exploration of differentially expressed miRNAs when comparing HCC and normal liver tissues. Materials and Methods: In the present research, candidate miRNAs were selected and verified ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26101
更新日期:2018-09-08 00:00:00
abstract::Background/Purpose: In colon cancer (CC) patients preoperative (pre-op) levels of VEGF-A165 (VEGF) is a strong predictor for disease recurrence. Elevated postoperative (post-op) VEGF levels could have undesirable effects by enhancing tumor growth and metastasis formation. It has been suggested that thromboprophylaxis ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.20107
更新日期:2017-08-25 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathologica...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38856
更新日期:2020-01-14 00:00:00
abstract::Objectives: This study aims to evaluate influence factors for adjuvant chemotherapy regimen choice on the basis of trastuzumab in older human epidermal growth factor receptor 2 (HER2)-positive breast cancer under multi-disciplinary team (MDT) modality. Materials and Methods: HER2-positive breast cancer patients aged ≥...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39509
更新日期:2020-02-14 00:00:00
abstract::Objective: Although previous studies suggest that previous pulmonary tuberculosis was associated with increased risk of lung cancer. It remains controversial whether pulmonary tuberculosis is a risk factor for lung cancer. Our study was aimed to examine the association between pulmonary tuberculosis and lung cancer ri...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37022
更新日期:2020-01-20 00:00:00
abstract::Background: Given recent results indicating that diminished LKB1 expression in laryngeal cancer correlates with shorter survival. We aim to perform an analysis estimate the role of decreased liver kinase B1(LKB1) and in the prognostication of human laryngeal squamous cell carcinoma (LSCC). Methods: We conducted a retr...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.20535
更新日期:2017-09-30 00:00:00
abstract::Background: The transfusion of blood that has been stored for some time was found to be associated with transfusion-related immune modulation (TRIM) responses in cancer patients, which could result in poor clinical outcomes, such as tumor recurrence, metastasis and reduced survival rate. Given the prior observation of...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31360
更新日期:2019-06-02 00:00:00
abstract::For hepatocellular carcinoma (HCC) patients with macrovascular invasion (MaVI), hepatectomy and transcatheter arterial chemoembolization (TACE) remain the main treatment options in Asia. However, which could achieve better survivals remains controversial. In present study, we conducted a meta-analysis to clarify the s...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.20978
更新日期:2017-08-25 00:00:00
abstract::Background and aim: Understanding the molecular biological mechanisms underlying laryngeal squamous cell carcinoma (LSCC) invasion and metastasis is crucial for diagnosis, treatment, and prognosis. We aimed to examine the expression of the tumor suppressor microRNA-204-5p (miR-204-5p) and its target gene, forkhead box...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19470
更新日期:2017-07-21 00:00:00
abstract::Cervical cancer is a commonly diagnosed cancer among females. Polymorphisms in pre-microRNAs have been demonstrated to play critical roles in cancer. However, the roles of pre-microRNA polymorphisms in the aetiology of cervical cancer have not been well documented. We genotyped eight pre-microRNA polymorphisms in 290 ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39636
更新日期:2020-02-03 00:00:00
abstract::Traditional chemotherapy and radiotherapy for cancer treatment face serious challenges such as drug resistance and toxic side effects. Complementary / Alternative medicine is increasingly being practiced worldwide due to its safety beneficial therapeutic effects. We hypothesized that a super combination (SC) of known ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.7235
更新日期:2013-11-14 00:00:00
abstract::Tumor growth depends on angiogenesis, the growth of new blood vessels. Complement factor H (CFH) is a plasma glycoprotein that functions as a regulator of the complement system. The aim of this study is to delineate the role of CFH in angiogenesis. A conditional null allele of the Cfh gene was generated in C57BL/6J mi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19452
更新日期:2017-07-15 00:00:00
abstract::Objective: Multiple reports have described the proportion of T-regulatory cells (Tregs) in peripheral blood (PB) and tissues in patients with gynecological cancers (GCs) with controversial results. Thus, the aim of this study was to investigate the proportion of Tregs and its prognostic survival role in GCs patients. ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.42472
更新日期:2020-03-05 00:00:00
abstract::Background & Aims: Primary tumors of colorectal carcinoma (CRC) with liver metastasis might gain some liver-specific characteristics to adapt the liver micro-environment. This study aims to reveal potential liver-like transcriptional characteristics associated with the liver metastasis in primary colorectal carcinoma....
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23017
更新日期:2018-04-06 00:00:00
abstract::Purpose: Several new treatment options for patients with metastatic castration resistant prostate cancer (mCRPC) have been approved within the last years - among them cabazitaxel (CAB), abiraterone acetate, enzalutamide, and radium-223. The aim of this study was to assess factors predictive for efficacy of CAB. Method...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17644
更新日期:2017-02-11 00:00:00
abstract::We hypothesised that the blood levels of immune cells would be related to the progression of colorectal cancer and regional lymph node metastasis. We investigated the association between the blood levels of immune cells and regional lymph node metastasis in colorectal cancer patients. Patients with American Joint Comm...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18230
更新日期:2017-05-10 00:00:00