Abstract：
:Background: miRNAs dysregulate in hepatocellular carcinoma (HCC), showing promise for diagnostic biomarkers which may be found through exploration of differentially expressed miRNAs when comparing HCC and normal liver tissues. Materials and Methods: In the present research, candidate miRNAs were selected and verified using screening dataset GSE12717 and training dataset GSE10694, respectively. A miRNA combination was constructed using stepwise logistic regression analysis and validated using two datasets GSE74618 and TCGA. Target genes of miRNAs in the combination were obtained using a miRNA target gene prediction database. Functional analysis was conducted using an online tool DAVID. We also analyzed the mRNA-Seq data of project LIHC from TCGA to identify the hub target genes of the miRNAs. Results: A miRNA combination, which is composed of hsa-miR-221 and hsa-miR-29c was defined in this study. The miRNA combination is more effective in discriminating HCC patients from normal individuals than individual miRNAs. Additionally, the combined miRNAs showed a lower misdiagnosis rate than AFP in HCC diagnosis. In terms of the functional analysis, a total of 27 target genes of hsa-miR-221 and 96 target genes of hsa-miR-29c were obtained. Among which, INSIG1 was the common target of the two miRNAs. It was also found that both previously mentioned miRNAs played important roles in the regulation of transcription, cell proliferation, and involvement in cancer-related pathways. Lastly, 2 hub target genes of hsa-miR-221 and 16 hub target genes of hsa-miR-29c were obtained. Conclusion: We established a miRNA combination as a promising tool for HCC diagnosis, and the target genes we predicted provide possible points of penetration for researching these two miRNAs in HCC.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Ji J,Chen H,Liu XP,Wang YH,Luo CL,Zhang WW,Xie W,Wang FBdoi
10.7150/jca.26101subject
Has Abstractpub_date
2018-09-08 00:00:00pages
3435-3446issue
19issn
1837-9664pii
jcav09p3435journal_volume
9pub_type
杂志文章abstract：:Background: The use of PCI in early operable patients with small cell lung cancer (SCLC) is still controversial. Therefore, we conducted a systematic review with meta-analysis to investigate the effects of PCI in resected SCLC patients. Methods: Relevant studies were identified from PubMed and EMBASE databases, the po...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.21465
更新日期：2018-01-01 00:00:00
abstract：:Background: Heavy metal pollution in farm soils is a grave concern in Taiwan. Previously, we found the incidence of oral cancer (OC) correlated positively with levels of nickel and arsenic in farm soils. Many OC patients have a second malignancy, among which esophageal cancer (EC) is the most common one in Taiwan. Obj...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.15441
更新日期：2016-08-06 00:00:00
abstract：:Cancer is a leading cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a safe anticancer drug has been long goal for oncologist and medical scientists. Among clinically used medicines with no or little tox...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.24488
更新日期：2018-04-06 00:00:00
abstract：:Background and Aim: Glioblastoma multiforme (GBM) is a highly aggressive brain malignancy that lacks reliable treatments. Resveratrol possesses anti-cancer effects, but its activity against glioblastoma cells is variable for unknown reasons. One mechanism through which anti-cancer drugs exert their effects is oxidativ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.45489
更新日期：2021-01-01 00:00:00
abstract：:Objectives: This study aims to evaluate influence factors for adjuvant chemotherapy regimen choice on the basis of trastuzumab in older human epidermal growth factor receptor 2 (HER2)-positive breast cancer under multi-disciplinary team (MDT) modality. Materials and Methods: HER2-positive breast cancer patients aged ≥...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.39509
更新日期：2020-02-14 00:00:00
abstract：:MicroRNAs (miRNAs) have been extensively studied over the decades and have been proposed as potential molecular targets for cancer treatment. Studies have shown that miR-378 participates in numerous biological processes in various cancers; whereas miR-1827 has only been reported in pediatric glioma. The mechanism of h...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.18188
更新日期：2018-01-01 00:00:00
abstract：:Background: Docetaxel (DOC), or Taxotere, is an anthracycline antibiotic used to treat multiple types of cancer. It is a first-line chemotherapy treatment for patients with metastasized, hormone-resistant prostate cancer (PCa) or for patients with high-risk, localized PCa that could benefit from early chemotherapy tre...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.26681
更新日期：2018-11-11 00:00:00
abstract：BACKGROUND AND AIMS:We compared clinicopathologic data and long-term clinical outcomes among patients with non-B and non-C hepatocellular carcinoma (NBNC-HCC) who underwent curative resection (group A, n=129), those with hepatitis B virus-related HCC (group B, n=62) and those with hepatitis C virus-related HCC (group C...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.6503
更新日期：2013-07-18 00:00:00
abstract：:Non epithelial ovarian tumors represent a small group of rare gynecological cancers but they have a high incidence in young childbearing women. The recent years fertility preservation surgeries have become a common practice in specific ovarian malignancies when the patients wish to maintain their fertility. Specific t...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.26674
更新日期：2018-11-24 00:00:00
abstract：:Background: Malnutrition and systemic inflammatory response are frequently associated with prognosis in patients with several types of cancer, including renal cell carcinoma (RCC). The study is aimed to investigate the ability of preoperative serum albumin to globulin ratio (AGR) to predict the long-term mortality of ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.16525
更新日期：2017-01-15 00:00:00
abstract：:Objective: The applicability of the linear quadratic (LQ) model to local control (LC) modeling after hypofractionated radiotherapy to treat lung cancer is highly debated. To date, the differences in predicted outcomes between the LQ model and other radiobiological models, which are characterized by additional dose mod...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.33001
更新日期：2019-08-08 00:00:00
abstract：:Endometrial and ovarian cancers are two most common cancers affecting women in their post-menopausal years. To date, there are no simple biochemical tests to detect these cancers at early stages. Our previous study has demonstrated that the activity of total proprotein convertases (PCs) is significantly increased in u...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.16331
更新日期：2016-08-12 00:00:00
abstract：:Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer, developed rapid disease progression following discontinuation of study ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.18196
更新日期：2017-07-05 00:00:00
abstract：:Background: Immunotherapy including immune checkpoint blockade, cancer vaccines, and adoptive cell therapy. However, no immune therapies support ovarian cancer. It is not clear whether the neutrophils, the component of the immune system derived from umbilical cord blood play a role in inhibiting the progression of ova...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.41035
更新日期：2020-05-18 00:00:00
abstract：:Butyrate, a product of dietary fiber and a histone deacetylase inhibitor, induces apoptosis of colorectal cancer cells; this effect of butyrate is in part mediated by its ability to hyperactivate Wnt signaling, and may in part explain the preventive action of dietary fiber against colorectal cancer. However, the mecha...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.37864
更新日期：2020-01-01 00:00:00
abstract：:Background: Our previous study demonstrated that the peroxiredoxin 6 (PRDX6) protein was downregulated in squamous cervical cancer samples after neoadjuvant chemotherapy compared with the expression level before chemotherapy. However, the effect of PRDX6 on the biological behavior of cervical cancer is still uncertain...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.39892
更新日期：2020-02-10 00:00:00
abstract：:Many studies, using different chemical agents, have shown excellent cancer prevention efficacy in mice and rats. However, equivalent tests of cancer prevention in humans require decades of intake of the agents while the rodents' short lifespans cannot give us information of the long-term safety. Therefore, animals wit...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.12519
更新日期：2015-09-01 00:00:00
abstract：:Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential enzyme in the base excision repair pathway. Epidemiological studies have suggested associations between APE1 rs1760944 polymorphism and cancer risk. This study was aimed to evaluate the relationship between APE1 rs1760944 polymorphism and cancer risk. We sear...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.8085
更新日期：2014-03-13 00:00:00
abstract：:Recent studies indicated that long noncoding RNAs (lncRNAs) played important regulatory roles in carcinogenesis and cancer progression. However, the contribution of small nucleolar RNA host gene 20 (SNHG20) to cancer development remains largely unknown. The aim of the study is to investigate the expression of SNHG20 a...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.13822
更新日期：2016-03-19 00:00:00
abstract：:Purpose Neuroblastoma is an embryonic solid tumor derived from the progenitors of the sympathetic nervous system. More than half of the patients developed metastatic disease at the time of initial diagnosis and had poor outcome with current therapeutic approaches. In recent years, some obligate and facultative anaerob...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.18776
更新日期：2017-06-03 00:00:00
abstract：:Cullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further recognize numerous substrates to participate in a variety of cellular processes, such as DNA damage and repair, cell death and cell cycle...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.11076
更新日期：2015-01-16 00:00:00
abstract：:Cancer is a genetic disease where genetic variations cause abnormally functioning genes that appear to alter expression. Proteins, the final products of gene expression, determine the phenotypes and biological processes. Therefore, detecting gene expression levels can be used for cancer diagnosis, prognosis, and treat...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.24744
更新日期：2018-06-05 00:00:00
abstract：:Ovarian cancer is a highly lethal malignancy in the female reproductive system. Platinum drugs, represented by cisplatin, are the first-line chemotherapeutic agents for treatment of various malignancies including ovarian cancer, but drug resistance leads to chemotherapy failure. MicroRNAs emerged as promising molecule...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.41135
更新日期：2020-03-13 00:00:00
abstract：:The authors retrospectively examined the contralateral prophylactic mastectomy (CPM) rate among 100 women with ductal carcinoma in situ who are BRCA negative. Of 100 women with ductal carcinoma in situ, 31 elected contralateral prophylactic mastectomy (CPM). Factors associated with increased likelihood of undergoing c...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.11710
更新日期：2015-05-23 00:00:00
abstract：:Background: IgA antibodies against Epstein-Barr virus (EBV) capsid antigen (VCA) and nuclear antigen 1 (EBNA1) have been proposed to facilitate the diagnosis and early detection of nasopharyngeal carcinoma (NPC) in high-incidence regions. However, while new methodologies and new platforms for the detection of VCA-IgA ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.47260
更新日期：2020-10-18 00:00:00
abstract：:Objective: Chemotherapy is a major therapeutic method for bladder urothelial carcinoma (BUC), which can effectively improve the prognosis of BUC patients, but the chemoresistance often leads to chemotherapy failure. This study will research the regulatory roles and molecular mechanism of miR-101-3p in BUC chemoresista...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.33117
更新日期：2019-06-02 00:00:00
abstract：:Aim: Skin cutaneous melanoma (SKCM) is one of the most life-threatening malignancies damaging human health. APOBEC3G (A3G) has been found in several cancers; however, the role of A3G in SKCM is rarely studied. This study aimed to investigate the expression of A3G in tumor tissue and its prognostic value in SKCM patien...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.46383
更新日期：2020-07-06 00:00:00
abstract：:Purpose: We examined the effect of GV1001 in castration castration-resistant prostate cancer (CRPC) cell growth and invasion and explored the potential molecular mechanisms of action. Materials and Methods: The in vitro anti-cancer effects of GV1001 in CRPC cells were examined using cell viability assay, TUNEL assay, ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.34859
更新日期：2019-10-17 00:00:00
abstract：:Background: Proverbially, the incidence rate of papillary thyroid carcinoma (PTC) has increased year by year. Many long noncoding RNAs (lncRNAs) have been discovered having a relationship with tumor genesis tightly recently. Thanks to the previous researches, we found long intergenic noncoding RNA 00511 (LINC00511) is...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.35364
更新日期：2020-01-01 00:00:00
abstract：:Accumulating evidence suggests that the malignant phenotypes of cancers are determined not only by the intrinsic properties of cancer cells but also by components in the tumor microenvironment (TME). In this study, we comprehensively characterized the TME of cutaneous melanoma (CM). As a result, tumor stage, tissue si...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.44413
更新日期：2020-04-06 00:00:00
