Abstract:
:Background: Immune cells recognize tumor antigens presented on major histocompatibility complex class I (MHC-I) molecule. Increase of MHC-I molecular expression makes tumor cells more susceptible to lysis by immune cells. Methods: Tumor lysate vaccine was prepared to damage glioma cells including cell lines and primary cultured cells from surgical samples. The enhanced effect of histone deacetylase inhibitors (HDACi) to tumor lysate vaccine was observed. The expressions of MHC-I pathway molecules were detected by flow cytometry and western blot after HDACi treatment. Cell apoptosis and cell lysis were measured following blocking cytotoxic T lymphocyte (CTL) pathway. Tumor size and mice survival were analyzed in combinative treatment with HDACi and tumor lysate. Results: HDACi up-regulated the expressions of MHC-I pathway molecules, and enhanced the recognition and killing of immune cells, which was activated by tumor lysate. Activated antigen specific immune responses regulated CTL activity, and HDACi promoted immune response through cytotoxic effect of CTL. Anti-tumor effect of tumor lysate pulse immunogenicity in vivo was elevated by HDACi due to up-regulation of antigen presentation. Conclusions: Our study showed that HDACi enhanced recognition of glioma cell by immune cells and sensitivity of tumor immunotherapy, and improved the anti-tumor effect of tumor lysate vaccine through activating CTL immune response. These pharmacological molecular mechanisms of increasing immune recognition suggest that epigenetic modulation is a promising strategy for sensitizing immunotherapy for glioma treatment.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Sun T,Li Y,Yang W,Wu H,Li X,Huang Y,Zhou Y,Du Zdoi
10.7150/jca.34471subject
Has Abstractpub_date
2019-09-07 00:00:00pages
5638-5645issue
23issn
1837-9664pii
jcav10p5638journal_volume
10pub_type
杂志文章abstract::Objective: Chemotherapy is a major therapeutic method for bladder urothelial carcinoma (BUC), which can effectively improve the prognosis of BUC patients, but the chemoresistance often leads to chemotherapy failure. This study will research the regulatory roles and molecular mechanism of miR-101-3p in BUC chemoresista...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33117
更新日期:2019-06-02 00:00:00
abstract::Objective: This study aimed to evaluate the efficacy and safety of doxorubicin-loaded drug-eluting beads transarterial chemoembolization (DEB-TACE) with CalliSpheres microspheres (CSM) in treating unresectable intrahepatic cholangiocarcinoma (ICC). Methods: 88 unresectable ICC patients who received DEB-TACE treatment ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39410
更新日期:2020-05-18 00:00:00
abstract::Pokemon, also known as leukemia/lymphoma-related factor (LRF) is a pro-oncogenic protein highly expressed in several cancers. There have been few in vitro and animal studies about its malignant biological behavior and function, however, its role especially in prostate cancer has not been completely elucidated. Therefo...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29471
更新日期:2019-04-21 00:00:00
abstract:UNLABELLED:The mechanism of progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) remains largely unknown. We compared gene expression in tumors with simultaneous DCIS and IDC to decipher how diverse proteins participate in the local invasive process.Twenty frozen tumor specimens with conc...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4120
更新日期:2012-01-01 00:00:00
abstract:: Purpose: Differentiated thyroid cancer (DTC) accounts for approximately 95% of thyroid carcinomas. In the metastatic RAI-refractory disease, chemotherapy has very limited efficacy and is associated with substantial toxicity. With increasing knowledge of the molecular patho...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22318
更新日期:2018-01-01 00:00:00
abstract::Colorectal cancer (CRC) is an important health issue worldwide, accounting for the third place of cancer incidence. Chronic inflammation, as seen in Crohn's disease and ulcerative colitis, is the most important risk factor for developing CRC, as it favours neoplastic transformation by enhancing epithelial cell turnove...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13123
更新日期:2016-07-25 00:00:00
abstract::Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase and works as an oncogene in various cancers. Recently, PTK6 has been used as a therapeutic target for breast cancer patients in a clinical study. However, the prognostic value of PTK6 in bladder cancer (BC) remains vague. Therefore, we retrieved 3 inde...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21318
更新日期:2017-09-27 00:00:00
abstract::Even with the technological advances of dose-escalated IMRT with the addition of the latest image guidance technologies, local failures still occur. The combination of MRI-based imaging techniques can yield quantitative information that reflects on the biological properties of prostatic tissues. These techniques provi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.5419
更新日期:2013-01-01 00:00:00
abstract::PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with an increased cancer risk. We evaluated the chemopreventive effect of statins against all cancers in COPD patients and identified the statin with the strongest chemopreventive effect. PATIENTS AND METHODS: All patients diagnosed with COPD at healt...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15779
更新日期:2016-09-13 00:00:00
abstract::Background: The most common metastatic site in cervical cancers is lung. The aim of this study is to identify cervical cancer patients with high risk for developing lung metastasis and further explore their prognosis. Materials and Methods: At first, patients diagnosed with cervical cancer from 2010 to 2015 were ident...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46258
更新日期:2020-08-08 00:00:00
abstract:OBJECTIVES:To study whether radical nephrectomy (RN) with lymph node dissection (LND) can benefit pT3 renal cell carcinoma (RCC) patients versus no LND under the 2018 American Joint Committee on Cancer TNM classification system. Subjects/Patients and Methods: We performed a retrospective cohort study of clinicopatholog...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30375
更新日期:2019-05-26 00:00:00
abstract::Purpose: Aim of this study was to comprehensively analyze BRCA1-associated protein-1 (BAP1) somatic mutation in clear cell renal cell carcinoma (ccRCC) and explore potential therapeutic pathways and molecules. Patients and methods: In this study, we analyzed 445 ccRCC cases from The Cancer Genome Atlas (TCGA). Compreh...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27281
更新日期:2018-10-18 00:00:00
abstract::Metabolic syndrome has been previously identified as a risk factor for breast cancer and is increasingly a public health concern. This study aims to investigate the prevalence of metabolic syndrome and its components among primary breast cancer and control population. The clinical data of metabolic syndrome and its co...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22968
更新日期:2018-01-01 00:00:00
abstract::Cellular compartmentalization of biochemical processes in eukaryotic cells is critical for many functions including shuttling of reducing equivalents across membranes. Although coordination of metabolic flux between different organelles is vital for cell physiology, its impact on tumor cell survival is not well unders...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19373
更新日期:2017-07-05 00:00:00
abstract::In this article, the use of different types of thermotherapies to treat breast cancer is reviewed. While hyperthermia is most commonly used as an adjuvant in combination with radiotherapy, chemotherapy, targeted therapy or cryotherapy to enhance the therapeutic effect of these therapies, thermoablation is usually carr...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.8693
更新日期:2014-05-29 00:00:00
abstract::Background: Colorectal cancer (CRC) remains to be one of the most common malignancies worldwide. Various studies have demonstrated that microRNAs (miRs) play a critical role in regulating cancer progression and sensitivity to chemoradiotherapy. miR-1 was found to be aberrantly expressed in CRC. However, it has not bee...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44753
更新日期:2020-06-07 00:00:00
abstract::Dysbindin has been reported to be correlated with several malignancies. However, the clinical significance and biological role of dysbindin in epithelial ovarian cancer remains largely unknown. Here we demonstrated that the mRNA and protein levels of dysbindin were significantly upregulated in EOC tissues compared wit...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39269
更新日期:2020-02-21 00:00:00
abstract::Background: While curative resection is the established strategy for Hepatocellular carcinoma (HCC) patients, the prognosis still remains poor, and the efficiency of existing prediction models is unsatisfactory. Therefore, we aimed to develop a credible and easy-to-use prognostic index for patients with HCC undergoing...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22246
更新日期:2018-01-01 00:00:00
abstract::Liver kinase B1 (LKB1) is a critical tumor suppressor that is frequently mutated in human cancers. LKB1 has serine/threonine protein kinase activity, which regulates gene expression by phosphorylation of Yes-Associated protein (YAP). The phosphorylation-dependent YAP shuttling is critically important intracellular mec...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33237
更新日期:2019-06-09 00:00:00
abstract::Background: Inflammation might play an important role in promoting cancer growth partly by affecting tumor angiogenesis. We explored the role of Glasgow prognostic score (GPS) in metastatic colorectal cancer patients receiving first-linebevacizumab. Methods: All consecutive metastatic colorectal cancer patients treate...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31182
更新日期:2019-11-15 00:00:00
abstract::Clinical studies have confirmed epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) used in lung cancer patients with EGFR mutations can obtain a better result, but still part of the patients with poor efficacy. EGFR mutation is highly related to female, nonsmoking and adenocarcinoma. Thus, we hy...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25679
更新日期:2018-07-30 00:00:00
abstract::Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies. The metabolomic approaches are developed to discover the novel biomarkers of PDAC. Methods: 550 preoperative, postoperative PDAC and normal controls (NCs) serums were employed to characterize metabolic alterations in ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41250
更新日期:2020-05-19 00:00:00
abstract::Purpose: Hypoxia-inducible factor-1alpha (HIF-1A) is a transcription factor that plays an "angiogenic switch" role especially under hypoxia microenvironment in solid tumor. However, the functions and clinical significance of HIF-1A in gallbladder cancer (GBC) are still controversial, and it has not been studied in nor...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46749
更新日期:2021-01-01 00:00:00
abstract:PURPOSE:The current study examined quality of life, progression of disease, and survival rate during chemotherapy in newly diagnosed non-small cell lung cancer (NSCLC) patients with depression (n=48) and without depression (n=78). Further, the study explored the hypothesis that the survival benefit resulted from the ch...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11239
更新日期:2015-09-15 00:00:00
abstract::Non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation inevitably have a relapse due to the occurrence of acquired resistance, resulting in treatment failure. However, little is known about the mechanisms of acquired resistance of NSCLC patients. Here, we elucidated the expre...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35097
更新日期:2019-10-15 00:00:00
abstract::Objective: To measure hematologic parameters derived from the white blood cell (WBC) count and differential count (DC) as prognostic factors for survival in patients with stage IB and IIA cervical cancer. Methods: We retrospectively examined demographic, clinicopathologic, and laboratory parameters in a cohort of 233 ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22234
更新日期:2018-01-01 00:00:00
abstract::Angiogenesis, a highly regulated process, is exploited by tumors like breast cancer to ensure a constant supply of oxygen and nutrients and is key for tumor survival and progression. Estrogen and alcohol independently have been observed to contribute to angiogenesis in breast cancer but their combinatorial effects hav...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25581
更新日期:2018-10-06 00:00:00
abstract::Many preclinical and clinical studies are currently evaluating metformin in combination with classical therapeutic agents as anti-cancer therapy. In this study we used three distinct pancreatic cancer cell lines and evaluated cell death by trypan blue assay and Western Blots using antibodies directed against cleaved c...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17972
更新日期:2017-07-01 00:00:00
abstract::Background: Our previous study demonstrated that the peroxiredoxin 6 (PRDX6) protein was downregulated in squamous cervical cancer samples after neoadjuvant chemotherapy compared with the expression level before chemotherapy. However, the effect of PRDX6 on the biological behavior of cervical cancer is still uncertain...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39892
更新日期:2020-02-10 00:00:00
abstract::Background: Noninvasive stool-based DNA methylation testing emerges as a new approach for detecting colorectal cancer (CRC). However, its feasibility for early detection of CRC and precancerous lesions in the Chinese population remains inconclusive. Methods: In this study, we establish a possibilities screening method...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.50525
更新日期:2021-01-01 00:00:00