Abstract:
:Dysbindin has been reported to be correlated with several malignancies. However, the clinical significance and biological role of dysbindin in epithelial ovarian cancer remains largely unknown. Here we demonstrated that the mRNA and protein levels of dysbindin were significantly upregulated in EOC tissues compared with normal ovarian tissues. High levels of dysbindin were significantly correlated with worse clinicopathological characteristics and poor prognosis in EOC patients. Overexpression and silencing of dysbindin promoted and inhibited, respectively, invasion and metastasis of EOC cells in vitro and in vivo. Mechanistically, dysbindin activates phosphorylation of ERK to promote the epithelial-mesenchymal transition and to mediate the invasive and metastatic ability of EOC cells. Our findings suggest that dysbindin facilitates invasion and metastasis by promoting the EMT of EOC cells and may serve as a potential therapeutic target in EOC.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Lv X,Guo X,Ru Y,Zhou F,Yang X,Ge J,Li J,Liu S,Jiang K,Chen Bdoi
10.7150/jca.39269subject
Has Abstractpub_date
2020-02-21 00:00:00pages
2821-2829issue
10issn
1837-9664pii
jcav11p2821journal_volume
11pub_type
杂志文章abstract::Background: Identification of new predictive markers in melanoma is of great clinical importance. This study was aimed to analyze association between selected common variants in the cancer susceptibility genes and melanoma progression at the time of diagnosis. Material and Method: The study included 243 consecutive pa...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26404
更新日期:2018-08-06 00:00:00
abstract::The capture of peritoneal metastatic cancer stem cell of human gastric cancer (pMCSC-hGC) is important to further understand the mechanism of peritoneal metastasis in gastric cancer patients. Previously, cancer stem cells (CSCs) of gastric and rectal cancers were captured and identified. However, the bottleneck of cap...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21669
更新日期:2017-09-16 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is one of the most common types of aggressive cancer. The tumor tissue, which shows an active angiogenesis, is composed of neoplastic and stromal cells, and an abundant inflammatory infiltrate. Angiogenesis is important to support tumor growth, while infiltrating cells contribute to ...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.12286
更新日期:2015-08-07 00:00:00
abstract::For many years, the medical treatment of breast cancer was reliant solely on cytotoxic chemotherapy. However, over the past twenty years, treatment has evolved to a more target-directed approach. We now employ tailored therapy based on the presence or absence of receptors for estrogen, progesterone, and human epiderma...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4925
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Statins are proposed as a chemoprevention agent for breast cancer due to their anti-inflammatory effect. The effects of lipophilic and hydrophilic statins on breast cancer risk might be different due to their different pharmacologic properties. Therefore, this study aimed to assess a casual-effect of lipophi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.14941
更新日期:2016-06-06 00:00:00
abstract:OBJECTIVE:With the survival rate of acute lymphoblastic leukemia (ALL) surpassing 90 percent within this decade, new research is emerging in the field of late effects. A review of the research investigating the relationship of treatment regimens for ALL to specific late effect deficits, underlying mechanisms, and possi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.292
更新日期:2011-01-01 00:00:00
abstract::The highly conserved Hippo signaling pathway is an important pathway involved in tumorigenesis and development. In previous studies, YAP, the transcription coactivator of Hippo pathway, is found to be highly expressed in many clinical bladder cancer samples. To investigate the function of YAP and its cofactor Mask2 in...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16438
更新日期:2016-10-23 00:00:00
abstract::Chemotherapy resistance represents a major obstacle for the treatment of patients with breast cancer (BC) and greatly restricts the therapeutic effect of the first-line chemotherapeutic agent doxorubicin (DOX). The present study aimed to investigate the feasibility of the recombinant dual-target murine double minute 2...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.32765
更新日期:2020-01-01 00:00:00
abstract::Purpose Increasing evidences revealed that cancer cells with the characteristics of epithelial-mesenchymal transition (EMT) or cancer stem cells (CSC) have high ability of progression, invasion, metastasis and chemoresistance. TWIST1 and BMI1 are crucial transcription factors required for EMT and CSC. Both TWIST1 and ...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.14031
更新日期:2016-05-25 00:00:00
abstract::Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used to treat non-small cell lung cancer (NSCLC) because they inhibit tumour growth and metastasis. However, the underlying mechanisms are not fully understood. Here, we investigate whether anti-lymphangiogenesis mechanisms cont...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35448
更新日期:2020-01-01 00:00:00
abstract::Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patt...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.44727
更新日期:2020-10-21 00:00:00
abstract::Breast cancer is considered as a heterogeneous disease comprising various types of neoplasms, which involves different profile changes in both mRNA and micro-RNA (miRNA) expression. Extensive studies on mRNA expression in breast tumor have yielded some very interesting findings, some of which have been validated and u...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.116
更新日期:2011-02-24 00:00:00
abstract:INTRODUCTION:Hürthle cell carcinoma (HCC) is a rare tumor that tends to metastasize to the lymph nodes. Some studies have correlated size of Hürthle cell tumors with the risk of malignancy. Whether the size of HCC correlates with the risk of lymph node (LN) metastases, to our knowledge has not been addressed. METHODS:...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.1.23
更新日期:2010-06-02 00:00:00
abstract::Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely r...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.27633
更新日期:2019-01-01 00:00:00
abstract::Background: Our previous study demonstrated that the peroxiredoxin 6 (PRDX6) protein was downregulated in squamous cervical cancer samples after neoadjuvant chemotherapy compared with the expression level before chemotherapy. However, the effect of PRDX6 on the biological behavior of cervical cancer is still uncertain...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39892
更新日期:2020-02-10 00:00:00
abstract::Purpose: Systemic therapy has often been used for patients with advanced hepatocellular carcinoma (HCC). However, due to drug resistance, the use of cytotoxic chemotherapy in the treatment of patients with advanced HCC has typically demonstrated low response rates. Secretory clusterin (sCLU) is expressed in aggressive...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23849
更新日期:2018-04-06 00:00:00
abstract::Background: The Gustave Roussy Immune Score (GRIm-Score) was initially reported to select patients for immunotherapy. Therefore, the purpose of the current retrospective study was to determine whether GRIm-Score, a novel nutritional and inflammatory-based prognostic score, is a useful prognostic marker in patients wit...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37898
更新日期:2020-01-01 00:00:00
abstract::Background: Lung carcinoma is the leading cause of malignant tumor related mortality in China in recent decades, and the development of new and effective therapies for patients with advanced lung carcinoma is needed. We recently found that fluorofenidone (FD), a newly developed pyridine compound, reduced the activatio...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18040
更新日期:2017-07-04 00:00:00
abstract::Background: Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) are the main immunosuppressive cells in tumor microenvironment of gastric cancer (GC). In this prospective study, the association of prognosis with Tregs subsets and pDCs were further analyzed. Methods: pDCs, Tregs population and its expres...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34826
更新日期:2019-10-22 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most intractable malignancies with a typical scirrhous pattern in histology. Due to its abundant tumor stroma and scant vascularization, chemotherapeutic agents are considered inefficiently permeable to cancer nests, making it highly difficult to cure the...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24415
更新日期:2018-07-30 00:00:00
abstract::PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with an increased cancer risk. We evaluated the chemopreventive effect of statins against all cancers in COPD patients and identified the statin with the strongest chemopreventive effect. PATIENTS AND METHODS: All patients diagnosed with COPD at healt...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15779
更新日期:2016-09-13 00:00:00
abstract::Objectives: PD-1 and PD-L1 overexpression in malignant tumors in response to radiotherapy is correlated with a poor prognosis. Human papilloma virus (HPV) infection impacts intrinsic radiosensitivity of head and neck cancers (HNCs). Herein, this study aims to determine PD-1/PD-L1 expression differences in tumors with ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27199
更新日期:2019-01-29 00:00:00
abstract:BACKGROUND AND PURPOSE:There is increasing evidence that the presence of an inflammation-based prognostic score (modified Glasgow prognostic score, mGPS) is associated with survival in patients with advanced cancer. This study aimed to assess whether the mGPS has prognostic value in patients with thoracic esophageal sq...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.9569
更新日期:2014-09-06 00:00:00
abstract:OBJECTIVES:To study whether radical nephrectomy (RN) with lymph node dissection (LND) can benefit pT3 renal cell carcinoma (RCC) patients versus no LND under the 2018 American Joint Committee on Cancer TNM classification system. Subjects/Patients and Methods: We performed a retrospective cohort study of clinicopatholog...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30375
更新日期:2019-05-26 00:00:00
abstract::Background: IgA antibodies against Epstein-Barr virus (EBV) capsid antigen (VCA) and nuclear antigen 1 (EBNA1) have been proposed to facilitate the diagnosis and early detection of nasopharyngeal carcinoma (NPC) in high-incidence regions. However, while new methodologies and new platforms for the detection of VCA-IgA ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.47260
更新日期:2020-10-18 00:00:00
abstract::Amplified in breast cancer 1 (AIB1) gene, a coactivator for steroid receptor, is frequently amplified in diverse cancers and is considered as an oncogene in tumorigenesis. However, the prognostic significance of AIB1 amplification in gliomas remains totally unclear. In this study, 115 gliomas and 16 benign meningiomas...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16069
更新日期:2016-10-22 00:00:00
abstract::The impact of albumin to globulin ratio (AGR) on the prognosis of various human cancers has not been well established. Here, a systemic review and meta-analysis has been performed to comprehensively assess the relationships between AGR and lymph node metastasis (LNM) or overall survival (OS). Systematical search throu...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.24889
更新日期:2018-06-12 00:00:00
abstract:BACKGROUND:Due to the lack of studies, it remains unclear whether the additional neoadjuvant chemotherapy (NACT) to concurrent chemoradiotherapy (CCRT) is superior to CCRT alone for locoregionally advanced nasopharyngeal carcinoma (NPC). The main objective of this Bayesian network meta-analysis was to determine the eff...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11814
更新日期:2015-07-17 00:00:00
abstract::Triple negative breast cancer (TNBC) is characterized by distinctive biological features that confer an aggressive clinical behavior. In TNBC patients, the absence of well-defined driver pathways such as hormonal receptor expression or hyperactivation of the human epidermal growth factor receptor 2 (HER2) significantl...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.35109
更新日期:2019-10-12 00:00:00
abstract:BACKGROUND:Mathematical models can be useful tools in exploring disease trends and health consequences of interventions in a population over time. Most cancers, in particular cervical cancer, have long incubation periods. The time from acquisition of HPV infection to development of invasive cancer can be up to two deca...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4161
更新日期:2012-01-01 00:00:00